Reviewed, UniProtKB/Swiss-Prot P24061 (HXA7_COTJA)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A7
Alternative name(s):
    Quox-1

Gene names

Name:	HOXA7
Synonyms:	QUOX-1

Organism

Coturnix coturnix japonica (Japanese quail)

Taxonomic identifier

93934 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Perdicinae › Coturnix

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Tissue specificity	Central nervous system including forebrain.
Developmental stage	Embryo.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox Repeat
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 242	242	Homeobox protein Hox-A7		PRO_0000200076
Regions
	Repeat	183 – 186	4	Motif KWKK
	Repeat	210 – 213	4	Motif KWKK
	DNA binding	129 – 188	60	Homeobox
	Motif	118 – 123	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	P24061-1 [UniParc]. Last modified March 1, 1992. Version 1. Checksum: BCB4DBEB6B985F7F	FASTA	242	28,241
	10 20 30 40 50 60 MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FASNSQRSGY GPGAGAFASS MPGLYNVNST 70 80 90 100 110 120 IYQSPFSSGY SLGSDAYNLH CSSFDQNIPV LCNDLTKPSC EKAEERQPAQ PGRGQFRIYP 130 140 150 160 170 180 WMRSSGPDRK RGRQTYTRYQ TLELEKEFHF NRYLTRRRRI EYAHALCLTE RQIKIWFQNR 190 200 210 220 230 240 RMKWKKEHKE ESSSTPAPNE SRQQQRLWRK WKKMKKRRIR ESHSRKQSLE ITYARDSCKS SL

References

[1]	"Quox-1, a quail homeobox gene expressed in the embryonic central nervous system, including the forebrain." Xue Z.-G., Gehring W.J., le Douarin N.M. Proc. Natl. Acad. Sci. U.S.A. 88:2427-2431(1991) [PubMed: 1672453] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Spinal cord.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M59714 Genomic DNA. Translation: AAA49501.1.
PIR	A39164.
3D structure databases
SMR	P24061. Positions 129-189.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P24061.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA7_COTJA

Accession

Primary (citable) accession number: P24061

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	March 1, 1992
Last modified:	November 24, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)