Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Delta-1 crystallin

Gene

ASL1

Organism
Anas platyrhynchos (Mallard) (Anas boschas)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. Despite possessing the necessary catalytic residues, this protein does not function as an enzymatically active argininosuccinate lyase.1 Publication

GO - Molecular functioni

  • catalytic activity Source: InterPro
  • structural constituent of eye lens Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Eye lens protein

Enzyme and pathway databases

SABIO-RKP24057.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-1 crystallin
Alternative name(s):
Delta crystallin I
Gene namesi
Name:ASL1
OrganismiAnas platyrhynchos (Mallard) (Anas boschas)
Taxonomic identifieri8839 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeAnseriformesAnatidaeAnas
Proteomesi
  • UP000016666 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001377161 – 466Delta-1 crystallinAdd BLAST466

Expressioni

Tissue specificityi

Eye lens.1 Publication

Interactioni

Subunit structurei

Homotetramer.2 Publications

Structurei

Secondary structure

1466
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi19 – 23Combined sources5
Helixi28 – 33Combined sources6
Helixi35 – 51Combined sources17
Helixi57 – 75Combined sources19
Beta strandi85 – 87Combined sources3
Helixi88 – 100Combined sources13
Helixi101 – 108Combined sources8
Helixi113 – 149Combined sources37
Turni150 – 152Combined sources3
Beta strandi154 – 159Combined sources6
Beta strandi162 – 168Combined sources7
Helixi169 – 194Combined sources26
Turni202 – 205Combined sources4
Helixi213 – 220Combined sources8
Beta strandi223 – 225Combined sources3
Helixi229 – 234Combined sources6
Helixi237 – 263Combined sources27
Turni266 – 268Combined sources3
Beta strandi270 – 272Combined sources3
Helixi275 – 277Combined sources3
Helixi291 – 314Combined sources24
Beta strandi319 – 321Combined sources3
Helixi323 – 327Combined sources5
Helixi328 – 352Combined sources25
Helixi357 – 363Combined sources7
Helixi366 – 369Combined sources4
Helixi370 – 379Combined sources10
Helixi384 – 401Combined sources18
Turni405 – 407Combined sources3
Helixi410 – 414Combined sources5
Helixi422 – 427Combined sources6
Helixi430 – 435Combined sources6
Beta strandi442 – 444Combined sources3
Helixi445 – 463Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HY0X-ray2.20A/B1-466[»]
1U15X-ray2.50A/B/C/D1-466[»]
1U16X-ray2.20A1-466[»]
ProteinModelPortaliP24057.
SMRiP24057.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24057.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG004281.
KOiK01755.

Family and domain databases

CDDicd01359. Argininosuccinate_lyase. 1 hit.
Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEGDKLMG GRFVGSTDPI MQMLSTSIST EQRLSEVDIQ ASIAYAKALE
60 70 80 90 100
KAGILTKTEL EKILSGLEKI SEELSKGVIV VTQSDEDIQT ANERRLKELI
110 120 130 140 150
GDIAGKLHTG RSRNEQVVTD LKLFMKNSLS IISTHLLQLI KTLVERAAIE
160 170 180 190 200
IDVILPGYTH LQKAQPIRWS QFLLSHAVAL TRDSERLGEV KKRINVLPLG
210 220 230 240 250
SGALAGNPLD IDREMLRSEL EFASISLNSM DAISERDFVV EFLSVATLLL
260 270 280 290 300
IHLSKMAEDL IIYSTSEFGF LTLSDAFSTG SSLMPQKKNP DSLELIRSKA
310 320 330 340 350
GRVFGRLASI LMVLKGLPST YNKDLQEDKE AVIDVVDTLT AVLQVATGVI
360 370 380 390 400
STLQISKENM EKALTPEMLA TDLALYLVRK GMPFRQAHTA SGKAVHLAET
410 420 430 440 450
KGIAINNLTL EDLKSISPLF SSDVSQVFNF VNSVEQYTAL GGTAKSSVTT
460
QIEQLRELMK KQKEQA
Length:466
Mass (Da):51,136
Last modified:March 1, 1992 - v1
Checksum:i4663F87DED299879
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11G → Q AA sequence (PubMed:7944404).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35133 mRNA. Translation: AAC31659.1.
PIRiJU0452. CYDKD1.
RefSeqiNP_001297344.1. NM_001310415.1.
XP_012963492.1. XM_013108038.1.

Genome annotation databases

GeneIDi101796068.
KEGGiapla:101796068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35133 mRNA. Translation: AAC31659.1.
PIRiJU0452. CYDKD1.
RefSeqiNP_001297344.1. NM_001310415.1.
XP_012963492.1. XM_013108038.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HY0X-ray2.20A/B1-466[»]
1U15X-ray2.50A/B/C/D1-466[»]
1U16X-ray2.20A1-466[»]
ProteinModelPortaliP24057.
SMRiP24057.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101796068.
KEGGiapla:101796068.

Organism-specific databases

CTDi435.

Phylogenomic databases

HOVERGENiHBG004281.
KOiK01755.

Enzyme and pathway databases

SABIO-RKP24057.

Miscellaneous databases

EvolutionaryTraceiP24057.

Family and domain databases

CDDicd01359. Argininosuccinate_lyase. 1 hit.
Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARLY1_ANAPL
AccessioniPrimary (citable) accession number: P24057
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.