Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Delta-1 crystallin

Gene

ASL1

Organism
Anas platyrhynchos (Mallard) (Anas boschas)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. Despite possessing the necessary catalytic residues, this protein does not function as an enzymatically active argininosuccinate lyase.1 Publication

GO - Molecular functioni

  • catalytic activity Source: InterPro
  • structural constituent of eye lens Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Eye lens protein

Enzyme and pathway databases

SABIO-RKP24057.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-1 crystallin
Alternative name(s):
Delta crystallin I
Gene namesi
Name:ASL1
OrganismiAnas platyrhynchos (Mallard) (Anas boschas)
Taxonomic identifieri8839 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeAnseriformesAnatidaeAnas
Proteomesi
  • UP000016666 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466Delta-1 crystallinPRO_0000137716Add
BLAST

Expressioni

Tissue specificityi

Eye lens.1 Publication

Interactioni

Subunit structurei

Homotetramer.2 Publications

Structurei

Secondary structure

1
466
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi19 – 235Combined sources
Helixi28 – 336Combined sources
Helixi35 – 5117Combined sources
Helixi57 – 7519Combined sources
Beta strandi85 – 873Combined sources
Helixi88 – 10013Combined sources
Helixi101 – 1088Combined sources
Helixi113 – 14937Combined sources
Turni150 – 1523Combined sources
Beta strandi154 – 1596Combined sources
Beta strandi162 – 1687Combined sources
Helixi169 – 19426Combined sources
Turni202 – 2054Combined sources
Helixi213 – 2208Combined sources
Beta strandi223 – 2253Combined sources
Helixi229 – 2346Combined sources
Helixi237 – 26327Combined sources
Turni266 – 2683Combined sources
Beta strandi270 – 2723Combined sources
Helixi275 – 2773Combined sources
Helixi291 – 31424Combined sources
Beta strandi319 – 3213Combined sources
Helixi323 – 3275Combined sources
Helixi328 – 35225Combined sources
Helixi357 – 3637Combined sources
Helixi366 – 3694Combined sources
Helixi370 – 37910Combined sources
Helixi384 – 40118Combined sources
Turni405 – 4073Combined sources
Helixi410 – 4145Combined sources
Helixi422 – 4276Combined sources
Helixi430 – 4356Combined sources
Beta strandi442 – 4443Combined sources
Helixi445 – 46319Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HY0X-ray2.20A/B1-466[»]
1U15X-ray2.50A/B/C/D1-466[»]
1U16X-ray2.20A1-466[»]
ProteinModelPortaliP24057.
SMRiP24057. Positions 18-465.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24057.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG004281.
KOiK01755.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24057-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEGDKLMG GRFVGSTDPI MQMLSTSIST EQRLSEVDIQ ASIAYAKALE
60 70 80 90 100
KAGILTKTEL EKILSGLEKI SEELSKGVIV VTQSDEDIQT ANERRLKELI
110 120 130 140 150
GDIAGKLHTG RSRNEQVVTD LKLFMKNSLS IISTHLLQLI KTLVERAAIE
160 170 180 190 200
IDVILPGYTH LQKAQPIRWS QFLLSHAVAL TRDSERLGEV KKRINVLPLG
210 220 230 240 250
SGALAGNPLD IDREMLRSEL EFASISLNSM DAISERDFVV EFLSVATLLL
260 270 280 290 300
IHLSKMAEDL IIYSTSEFGF LTLSDAFSTG SSLMPQKKNP DSLELIRSKA
310 320 330 340 350
GRVFGRLASI LMVLKGLPST YNKDLQEDKE AVIDVVDTLT AVLQVATGVI
360 370 380 390 400
STLQISKENM EKALTPEMLA TDLALYLVRK GMPFRQAHTA SGKAVHLAET
410 420 430 440 450
KGIAINNLTL EDLKSISPLF SSDVSQVFNF VNSVEQYTAL GGTAKSSVTT
460
QIEQLRELMK KQKEQA
Length:466
Mass (Da):51,136
Last modified:March 1, 1992 - v1
Checksum:i4663F87DED299879
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111G → Q AA sequence (PubMed:7944404).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35133 mRNA. Translation: AAC31659.1.
PIRiJU0452. CYDKD1.
RefSeqiNP_001297344.1. NM_001310415.1.
XP_012963492.1. XM_013108038.1.

Genome annotation databases

GeneIDi101796068.
KEGGiapla:101796068.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35133 mRNA. Translation: AAC31659.1.
PIRiJU0452. CYDKD1.
RefSeqiNP_001297344.1. NM_001310415.1.
XP_012963492.1. XM_013108038.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HY0X-ray2.20A/B1-466[»]
1U15X-ray2.50A/B/C/D1-466[»]
1U16X-ray2.20A1-466[»]
ProteinModelPortaliP24057.
SMRiP24057. Positions 18-465.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101796068.
KEGGiapla:101796068.

Organism-specific databases

CTDi435.

Phylogenomic databases

HOVERGENiHBG004281.
KOiK01755.

Enzyme and pathway databases

SABIO-RKP24057.

Miscellaneous databases

EvolutionaryTraceiP24057.

Family and domain databases

Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiIPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERiPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamiPF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARLY1_ANAPL
AccessioniPrimary (citable) accession number: P24057
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: May 11, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.