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Protein

SPARC-like protein 1

Gene

Sparcl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi605 – 61612PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SPARC-like protein 1
Alternative name(s):
Matrix glycoprotein Sc1
Gene namesi
Name:Sparcl1
Synonyms:Sc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2531. Sparcl1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: InterPro
  • proteinaceous extracellular matrix Source: UniProtKB-SubCell
  • synapse Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 634618SPARC-like protein 1PRO_0000020314Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei68 – 681PhosphoserineCombined sources
Modified residuei76 – 761PhosphoserineCombined sources
Modified residuei84 – 841PhosphoserineCombined sources
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence analysis
Modified residuei151 – 1511PhosphoserineCombined sources
Modified residuei159 – 1591PhosphoserineCombined sources
Modified residuei259 – 2591PhosphoserineCombined sources
Modified residuei333 – 3331PhosphoserineCombined sources
Modified residuei340 – 3401PhosphoserineCombined sources
Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence analysis
Modified residuei370 – 3701PhosphoserineCombined sources
Modified residuei390 – 3901PhosphoserineBy similarity
Disulfide bondi403 ↔ 414PROSITE-ProRule annotation
Disulfide bondi408 ↔ 424PROSITE-ProRule annotation
Disulfide bondi426 ↔ 460PROSITE-ProRule annotation
Disulfide bondi432 ↔ 453PROSITE-ProRule annotation
Disulfide bondi442 ↔ 479PROSITE-ProRule annotation
Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence analysis
Disulfide bondi485 ↔ 596PROSITE-ProRule annotation
Disulfide bondi604 ↔ 620PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP24054.
PRIDEiP24054.

PTM databases

iPTMnetiP24054.
PhosphoSiteiP24054.

Expressioni

Tissue specificityi

Expressed in many types of neurons in the brain.

Developmental stagei

Expressed throughout postnatal development of the brain and present at high levels in the adult.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020357.

Structurei

3D structure databases

ProteinModelPortaliP24054.
SMRiP24054. Positions 403-633.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini402 – 42423Follistatin-likeAdd
BLAST
Domaini420 – 48162Kazal-likePROSITE-ProRule annotationAdd
BLAST
Domaini592 – 62736EF-handPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SPARC family.Curated
Contains 1 EF-hand domain.PROSITE-ProRule annotation
Contains 1 follistatin-like domain.Curated
Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4004. Eukaryota.
ENOG41101WW. LUCA.
HOGENOMiHOG000063702.
HOVERGENiHBG079212.
InParanoidiP24054.
PhylomeDBiP24054.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
IPR001999. Osteonectin_CS.
IPR016359. SPARC-like_p1.
IPR019577. SPARC/Testican_Ca-bd-dom.
[Graphical view]
PfamiPF09289. FOLN. 1 hit.
PF00050. Kazal_1. 1 hit.
PF10591. SPARC_Ca_bdg. 1 hit.
[Graphical view]
PIRSFiPIRSF002574. SPARC-like_p1. 1 hit.
SMARTiSM00274. FOLN. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS51465. KAZAL_2. 1 hit.
PS00612. OSTEONECTIN_1. 1 hit.
PS00613. OSTEONECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24054-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAVLLLLYA LGIAAAVPTT FLSDHSNPTS ATLPTLEDAT VPTVPAEAAA
60 70 80 90 100
DIEKHPNHKA EKPSALNSEE EAHEQSTEQD KTYSFEVDLK DEEDGDGDLS
110 120 130 140 150
VDPTERTLDL QEGTSEPQQK RLPENADFPA TVSTPFVDSD QPANITKGEE
160 170 180 190 200
SQEQPVSDSH QQQDESGKQT QDSMTEESHK QDPGIPNEEK EEEEDPEDVG
210 220 230 240 250
APSDNQEEEK EPPEEQPTSK WEGNGDQSED ILQESSQPTQ ISKTKNDFEQ
260 270 280 290 300
GSQGQEGDSN AEGEDKAAGS KEHLPHTEWQ GQEGRAGLDA IGNRKDTDEE
310 320 330 340 350
KAVSTEPTDA AVVPRNHGAS DNGGGDDSKH GASDDYFIPS QEFLEAERMH
360 370 380 390 400
SLSYYLKYGE ETPDESENRS EAGDNQGAKK AESSPNAEPS DEGNSRGHSA
410 420 430 440 450
DSCMNFQCKR GHTCKTDQHG KPHCVCQDPE TCPPAKILDQ ACGTDNQTYA
460 470 480 490 500
SSCHLFATKC MLEGTKKGHQ LQLDYFGACK SIPACTDFEV AQFPLRMRDW
510 520 530 540 550
LKNILMQLYE PNPKHGGYLN EKQRSKVKKI YLDEKRLLAG DHPIELLLRD
560 570 580 590 600
FKKNYHMYVY PVHWQFNELD QHPADRILTH SELAPLRASL VPMEHCITRF
610 620 630
FEECDPNKDK HITLKEWGHC FGIKEEDIDE NLLF
Length:634
Mass (Da):70,634
Last modified:March 1, 1992 - v1
Checksum:i0EE63805AA91957D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27562 mRNA. Translation: AAA68708.1.
PIRiI58173. GERTX1.
RefSeqiNP_037078.1. NM_012946.1.
UniGeneiRn.3091.

Genome annotation databases

GeneIDi25434.
KEGGirno:25434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27562 mRNA. Translation: AAA68708.1.
PIRiI58173. GERTX1.
RefSeqiNP_037078.1. NM_012946.1.
UniGeneiRn.3091.

3D structure databases

ProteinModelPortaliP24054.
SMRiP24054. Positions 403-633.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020357.

PTM databases

iPTMnetiP24054.
PhosphoSiteiP24054.

Proteomic databases

PaxDbiP24054.
PRIDEiP24054.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25434.
KEGGirno:25434.

Organism-specific databases

CTDi8404.
RGDi2531. Sparcl1.

Phylogenomic databases

eggNOGiKOG4004. Eukaryota.
ENOG41101WW. LUCA.
HOGENOMiHOG000063702.
HOVERGENiHBG079212.
InParanoidiP24054.
PhylomeDBiP24054.

Miscellaneous databases

PROiP24054.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
IPR001999. Osteonectin_CS.
IPR016359. SPARC-like_p1.
IPR019577. SPARC/Testican_Ca-bd-dom.
[Graphical view]
PfamiPF09289. FOLN. 1 hit.
PF00050. Kazal_1. 1 hit.
PF10591. SPARC_Ca_bdg. 1 hit.
[Graphical view]
PIRSFiPIRSF002574. SPARC-like_p1. 1 hit.
SMARTiSM00274. FOLN. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS51465. KAZAL_2. 1 hit.
PS00612. OSTEONECTIN_1. 1 hit.
PS00613. OSTEONECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPRL1_RAT
AccessioniPrimary (citable) accession number: P24054
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.