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Protein

SPARC-like protein 1

Gene

Sparcl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi605 – 616PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SPARC-like protein 1
Alternative name(s):
Matrix glycoprotein Sc1
Gene namesi
Name:Sparcl1
Synonyms:Sc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2531 Sparcl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000002031417 – 634SPARC-like protein 1Add BLAST618

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68PhosphoserineCombined sources1
Modified residuei76PhosphoserineCombined sources1
Modified residuei84PhosphoserineCombined sources1
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei151PhosphoserineCombined sources1
Modified residuei159PhosphoserineCombined sources1
Modified residuei259PhosphoserineCombined sources1
Modified residuei333PhosphoserineCombined sources1
Modified residuei340PhosphoserineCombined sources1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei370PhosphoserineCombined sources1
Modified residuei390PhosphoserineBy similarity1
Disulfide bondi403 ↔ 414PROSITE-ProRule annotation
Disulfide bondi408 ↔ 424PROSITE-ProRule annotation
Disulfide bondi426 ↔ 460PROSITE-ProRule annotation
Disulfide bondi432 ↔ 453PROSITE-ProRule annotation
Disulfide bondi442 ↔ 479PROSITE-ProRule annotation
Glycosylationi446N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi485 ↔ 596PROSITE-ProRule annotation
Disulfide bondi604 ↔ 620PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP24054
PRIDEiP24054

PTM databases

iPTMnetiP24054
PhosphoSitePlusiP24054

Expressioni

Tissue specificityi

Expressed in many types of neurons in the brain.

Developmental stagei

Expressed throughout postnatal development of the brain and present at high levels in the adult.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020357

Structurei

3D structure databases

ProteinModelPortaliP24054
SMRiP24054
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini402 – 424Follistatin-likeAdd BLAST23
Domaini420 – 481Kazal-likePROSITE-ProRule annotationAdd BLAST62
Domaini592 – 627EF-handPROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the SPARC family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4004 Eukaryota
ENOG41101WW LUCA
HOGENOMiHOG000063702
HOVERGENiHBG079212
InParanoidiP24054
PhylomeDBiP24054

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR003645 Fol_N
IPR015369 Follistatin/Osteonectin_EGF
IPR002350 Kazal_dom
IPR036058 Kazal_dom_sf
IPR001999 Osteonectin_CS
IPR037641 SPARC
IPR016359 SPARC-like_p1
IPR019577 SPARC/Testican_Ca-bd-dom
PANTHERiPTHR13866 PTHR13866, 1 hit
PfamiView protein in Pfam
PF09289 FOLN, 1 hit
PF00050 Kazal_1, 1 hit
PF10591 SPARC_Ca_bdg, 1 hit
PIRSFiPIRSF002574 SPARC-like_p1, 1 hit
SMARTiView protein in SMART
SM00274 FOLN, 1 hit
SM00280 KAZAL, 1 hit
SUPFAMiSSF100895 SSF100895, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS51465 KAZAL_2, 1 hit
PS00612 OSTEONECTIN_1, 1 hit
PS00613 OSTEONECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24054-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAVLLLLYA LGIAAAVPTT FLSDHSNPTS ATLPTLEDAT VPTVPAEAAA
60 70 80 90 100
DIEKHPNHKA EKPSALNSEE EAHEQSTEQD KTYSFEVDLK DEEDGDGDLS
110 120 130 140 150
VDPTERTLDL QEGTSEPQQK RLPENADFPA TVSTPFVDSD QPANITKGEE
160 170 180 190 200
SQEQPVSDSH QQQDESGKQT QDSMTEESHK QDPGIPNEEK EEEEDPEDVG
210 220 230 240 250
APSDNQEEEK EPPEEQPTSK WEGNGDQSED ILQESSQPTQ ISKTKNDFEQ
260 270 280 290 300
GSQGQEGDSN AEGEDKAAGS KEHLPHTEWQ GQEGRAGLDA IGNRKDTDEE
310 320 330 340 350
KAVSTEPTDA AVVPRNHGAS DNGGGDDSKH GASDDYFIPS QEFLEAERMH
360 370 380 390 400
SLSYYLKYGE ETPDESENRS EAGDNQGAKK AESSPNAEPS DEGNSRGHSA
410 420 430 440 450
DSCMNFQCKR GHTCKTDQHG KPHCVCQDPE TCPPAKILDQ ACGTDNQTYA
460 470 480 490 500
SSCHLFATKC MLEGTKKGHQ LQLDYFGACK SIPACTDFEV AQFPLRMRDW
510 520 530 540 550
LKNILMQLYE PNPKHGGYLN EKQRSKVKKI YLDEKRLLAG DHPIELLLRD
560 570 580 590 600
FKKNYHMYVY PVHWQFNELD QHPADRILTH SELAPLRASL VPMEHCITRF
610 620 630
FEECDPNKDK HITLKEWGHC FGIKEEDIDE NLLF
Length:634
Mass (Da):70,634
Last modified:March 1, 1992 - v1
Checksum:i0EE63805AA91957D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27562 mRNA Translation: AAA68708.1
PIRiI58173 GERTX1
RefSeqiNP_037078.1, NM_012946.1
UniGeneiRn.3091

Genome annotation databases

GeneIDi25434
KEGGirno:25434

Similar proteinsi

Entry informationi

Entry nameiSPRL1_RAT
AccessioniPrimary (citable) accession number: P24054
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: June 20, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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