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Protein

Neuromedin-B receptor

Gene

Nmbr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for neuromedin-B.

GO - Molecular functioni

  • bombesin receptor activity Source: InterPro
  • neuropeptide receptor activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-B receptor
Short name:
NMB-R
Alternative name(s):
Neuromedin-B-preferring bombesin receptor
Gene namesi
Name:Nmbr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3181. Nmbr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 65Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini66 – 79CytoplasmicSequence analysisAdd BLAST14
Transmembranei80 – 99Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini100 – 117ExtracellularSequence analysisAdd BLAST18
Transmembranei118 – 139Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini140 – 156CytoplasmicSequence analysisAdd BLAST17
Transmembranei157 – 177Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini178 – 211ExtracellularSequence analysisAdd BLAST34
Transmembranei212 – 235Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini236 – 266CytoplasmicSequence analysisAdd BLAST31
Transmembranei267 – 287Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini288 – 299ExtracellularSequence analysisAdd BLAST12
Transmembranei300 – 327Helical; Name=7Sequence analysisAdd BLAST28
Topological domaini328 – 390CytoplasmicSequence analysisAdd BLAST63

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4440.
GuidetoPHARMACOLOGYi38.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699051 – 390Neuromedin-B receptorAdd BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi116 ↔ 198PROSITE-ProRule annotation
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1
Lipidationi341S-palmitoyl cysteineBy similarity1
Modified residuei352PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

PTM databases

PhosphoSitePlusiP24053.

Expressioni

Tissue specificityi

Brain (olfactory bulb and central thalamic regions), and esophagus.

Interactioni

Chemistry databases

BindingDBiP24053.

Structurei

3D structure databases

ProteinModelPortaliP24053.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004898.
InParanoidiP24053.
KOiK04168.
PhylomeDBiP24053.

Family and domain databases

InterProiIPR001556. Bombsn_rcpt-like.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001642. NeuroB_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00358. BOMBESINR.
PR00237. GPCRRHODOPSN.
PR00639. NEUROMEDINBR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24053-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPRSLPNLS LPTEASESEL EPEVWENDFL PDSDGTTAEL VIRCVIPSLY
60 70 80 90 100
LIIISVGLLG NIMLVKIFLT NSTMRSVPNI FISNLAAGDL LLLLTCVPVD
110 120 130 140 150
ASRYFFDEWV FGKLGCKLIP AIQLTSVGVS VFTLTALSAD RYRAIVNPMD
160 170 180 190 200
MQTSGVVLWT SLKAVGIWVV SVLLAVPEAV FSEVARIGSS DNSSFTACIP
210 220 230 240 250
YPQTDELHPK IHSVLIFLVY FLIPLVIISI YYYHIAKTLI RSAHNLPGEY
260 270 280 290 300
NEHTKKQMET RKRLAKIVLV FVGCFVFCWF PNHILYLYRS FNYKEIDPSL
310 320 330 340 350
GHMIVTLVAR VLSFSNSCVN PFALYLLSES FRKHFNSQLC CGQKSYPERS
360 370 380 390
TSYLLSSSAV RMTSLKSNAK NVVTNSVLLN GHSTKQEIAL
Length:390
Mass (Da):43,535
Last modified:March 1, 1992 - v1
Checksum:iEEAEC625014614B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37058 mRNA. Translation: AAA79881.1.
PIRiJH0374.
RefSeqiNP_036931.1. NM_012799.1.
XP_017444304.1. XM_017588815.1.
UniGeneiRn.89709.

Genome annotation databases

GeneIDi25264.
KEGGirno:25264.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37058 mRNA. Translation: AAA79881.1.
PIRiJH0374.
RefSeqiNP_036931.1. NM_012799.1.
XP_017444304.1. XM_017588815.1.
UniGeneiRn.89709.

3D structure databases

ProteinModelPortaliP24053.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiP24053.
ChEMBLiCHEMBL4440.
GuidetoPHARMACOLOGYi38.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP24053.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25264.
KEGGirno:25264.

Organism-specific databases

CTDi4829.
RGDi3181. Nmbr.

Phylogenomic databases

HOVERGENiHBG004898.
InParanoidiP24053.
KOiK04168.
PhylomeDBiP24053.

Miscellaneous databases

PROiP24053.

Family and domain databases

InterProiIPR001556. Bombsn_rcpt-like.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001642. NeuroB_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00358. BOMBESINR.
PR00237. GPCRRHODOPSN.
PR00639. NEUROMEDINBR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNMBR_RAT
AccessioniPrimary (citable) accession number: P24053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.