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Protein

Constitutive acid phosphatase

Gene

PHO3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 952 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75NucleophileBy similarity1
Active sitei338Proton donorBy similarity1

GO - Molecular functioni

  • acid phosphatase activity Source: SGD

GO - Biological processi

  • phosphate-containing compound metabolic process Source: SGD
  • thiamine-containing compound metabolic process Source: SGD

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciYEAST:YBR092C-MONOMER
BRENDAi3.1.3.2 984

Names & Taxonomyi

Protein namesi
Recommended name:
Constitutive acid phosphatase (EC:3.1.3.2)
Gene namesi
Name:PHO3
Ordered Locus Names:YBR092C
ORF Names:YBR0813
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR092C
SGDiS000000296 PHO3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002395318 – 467Constitutive acid phosphataseAdd BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi250N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi315N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi356N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi390N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi445N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi456N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi461N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP24031
PaxDbiP24031
PRIDEiP24031

PTM databases

iPTMnetiP24031

Interactioni

Protein-protein interaction databases

BioGridi32798, 61 interactors
STRINGi4932.YBR092C

Structurei

3D structure databases

ProteinModelPortaliP24031
SMRiP24031
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000189191
InParanoidiP24031
KOiK01078
OMAiPVLRFYK
OrthoDBiEOG092C2L5B

Family and domain databases

CDDicd07061 HP_HAP_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
InterProiView protein in InterPro
IPR033379 Acid_Pase_AS
IPR000560 His_Pase_clade-2
IPR029033 His_PPase_superfam
IPR016274 Histidine_acid_Pase_euk
PfamiView protein in Pfam
PF00328 His_Phos_2, 1 hit
PIRSFiPIRSF000894 Acid_phosphatase, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
PROSITEiView protein in PROSITE
PS00616 HIS_ACID_PHOSPHAT_1, 1 hit
PS00778 HIS_ACID_PHOSPHAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24031-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKSVVYSVL AAALVNAGTI PLGELADVAK IGTQEDIFPF LGGAGPYFSF
60 70 80 90 100
PGDYGISRDL PEGCEMKQLQ MLARHGERYP TYSKGATIMK TWYKLSNYTR
110 120 130 140 150
QFNGSLSFLN DDYEFFIRDD DDLEMETTFA NSDNVLNPYT GEMDAKRHAR
160 170 180 190 200
EFLAQYGYMF ENQTSFPIFA ASSERVHDTA QYFIDGLGDQ FNISLQTVSE
210 220 230 240 250
AMSAGANTLS AGNACPGWDE DANDDILDKY DTTYLDDIAK RLNKENKGLN
260 270 280 290 300
LTSKDANTLF AWCAYELNAR GYSDVCDIFT EDELVRYSYG QDLVSFYQDG
310 320 330 340 350
PGYDMIRSVG ANLFNATLKL LKQSETQDLK VWLSFTHDTD ILNYLTTAGI
360 370 380 390 400
IDDKNNLTAE YVPFMGNTFH KSWYVPQGAR VYTEKFQCSN DTYVRYVIND
410 420 430 440 450
AVVPIETCST GPGFSCEIND FYDYAEKRVA GTDFLKVCNV SSVSNVTELT
460
FYWDWNTTHY NDTLLKQ
Length:467
Mass (Da):52,777
Last modified:October 1, 1994 - v2
Checksum:i05FBB80DEB41B0FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti219 – 221DED → MKT in CAA25557 (PubMed:6093051).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01080 Genomic DNA Translation: CAA25557.1
X78993 Genomic DNA Translation: CAA55597.1
Z35961 Genomic DNA Translation: CAA85045.1
BK006936 Genomic DNA Translation: DAA07213.1
PIRiS48259 PABYCC
RefSeqiNP_009650.1, NM_001178440.1

Genome annotation databases

EnsemblFungiiYBR092C; YBR092C; YBR092C
GeneIDi852389
KEGGisce:YBR092C

Similar proteinsi

Entry informationi

Entry nameiPPA3_YEAST
AccessioniPrimary (citable) accession number: P24031
Secondary accession number(s): D6VQ93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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