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P24031

- PPA3_YEAST

UniProt

P24031 - PPA3_YEAST

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Protein
Constitutive acid phosphatase
Gene
PHO3, YBR092C, YBR0813
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei75 – 751Nucleophile By similarity
Active sitei338 – 3381Proton donor By similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: SGD
Complete GO annotation...

GO - Biological processi

  1. dephosphorylation Source: GOC
  2. phosphate-containing compound metabolic process Source: SGD
  3. thiamine-containing compound metabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciYEAST:YBR092C-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Constitutive acid phosphatase (EC:3.1.3.2)
Gene namesi
Name:PHO3
Ordered Locus Names:YBR092C
ORF Names:YBR0813
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome II

Organism-specific databases

CYGDiYBR092c.
SGDiS000000296. PHO3.

Subcellular locationi

GO - Cellular componenti

  1. cell wall-bounded periplasmic space Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 467450Constitutive acid phosphatase
PRO_0000023953Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi97 – 971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi103 – 1031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi162 – 1621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi192 – 1921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi250 – 2501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi315 – 3151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi356 – 3561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi390 – 3901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi439 – 4391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi445 – 4451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi456 – 4561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi461 – 4611N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP24031.
PaxDbiP24031.
PeptideAtlasiP24031.

Expressioni

Gene expression databases

GenevestigatoriP24031.

Interactioni

Protein-protein interaction databases

BioGridi32798. 33 interactions.
MINTiMINT-664223.
STRINGi4932.YBR092C.

Structurei

3D structure databases

ProteinModelPortaliP24031.
SMRiP24031. Positions 37-458.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG260296.
GeneTreeiENSGT00510000050349.
HOGENOMiHOG000189191.
KOiK01078.
OMAiWDEDAND.
OrthoDBiEOG7TQV9N.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000894. Acid_phosphatase. 1 hit.
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24031-1 [UniParc]FASTAAdd to Basket

« Hide

MFKSVVYSVL AAALVNAGTI PLGELADVAK IGTQEDIFPF LGGAGPYFSF    50
PGDYGISRDL PEGCEMKQLQ MLARHGERYP TYSKGATIMK TWYKLSNYTR 100
QFNGSLSFLN DDYEFFIRDD DDLEMETTFA NSDNVLNPYT GEMDAKRHAR 150
EFLAQYGYMF ENQTSFPIFA ASSERVHDTA QYFIDGLGDQ FNISLQTVSE 200
AMSAGANTLS AGNACPGWDE DANDDILDKY DTTYLDDIAK RLNKENKGLN 250
LTSKDANTLF AWCAYELNAR GYSDVCDIFT EDELVRYSYG QDLVSFYQDG 300
PGYDMIRSVG ANLFNATLKL LKQSETQDLK VWLSFTHDTD ILNYLTTAGI 350
IDDKNNLTAE YVPFMGNTFH KSWYVPQGAR VYTEKFQCSN DTYVRYVIND 400
AVVPIETCST GPGFSCEIND FYDYAEKRVA GTDFLKVCNV SSVSNVTELT 450
FYWDWNTTHY NDTLLKQ 467
Length:467
Mass (Da):52,777
Last modified:October 1, 1994 - v2
Checksum:i05FBB80DEB41B0FF
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti219 – 2213DED → MKT in CAA25557. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01080 Genomic DNA. Translation: CAA25557.1.
X78993 Genomic DNA. Translation: CAA55597.1.
Z35961 Genomic DNA. Translation: CAA85045.1.
BK006936 Genomic DNA. Translation: DAA07213.1.
PIRiS48259. PABYCC.
RefSeqiNP_009650.1. NM_001178440.1.

Genome annotation databases

EnsemblFungiiYBR092C; YBR092C; YBR092C.
GeneIDi852389.
KEGGisce:YBR092C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01080 Genomic DNA. Translation: CAA25557.1 .
X78993 Genomic DNA. Translation: CAA55597.1 .
Z35961 Genomic DNA. Translation: CAA85045.1 .
BK006936 Genomic DNA. Translation: DAA07213.1 .
PIRi S48259. PABYCC.
RefSeqi NP_009650.1. NM_001178440.1.

3D structure databases

ProteinModelPortali P24031.
SMRi P24031. Positions 37-458.
ModBasei Search...

Protein-protein interaction databases

BioGridi 32798. 33 interactions.
MINTi MINT-664223.
STRINGi 4932.YBR092C.

Proteomic databases

MaxQBi P24031.
PaxDbi P24031.
PeptideAtlasi P24031.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YBR092C ; YBR092C ; YBR092C .
GeneIDi 852389.
KEGGi sce:YBR092C.

Organism-specific databases

CYGDi YBR092c.
SGDi S000000296. PHO3.

Phylogenomic databases

eggNOGi NOG260296.
GeneTreei ENSGT00510000050349.
HOGENOMi HOG000189191.
KOi K01078.
OMAi WDEDAND.
OrthoDBi EOG7TQV9N.

Enzyme and pathway databases

BioCyci YEAST:YBR092C-MONOMER.

Miscellaneous databases

NextBioi 971204.

Gene expression databases

Genevestigatori P24031.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
InterProi IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
IPR016274. Histidine_acid_Pase_euk.
[Graphical view ]
Pfami PF00328. His_Phos_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000894. Acid_phosphatase. 1 hit.
SUPFAMi SSF53254. SSF53254. 1 hit.
PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of the two tandemly repeated acid phosphatase genes in yeast."
    Bajwa W., Meyhack B., Rudolph H., Schweingruber A.-M., Hinnen A.
    Nucleic Acids Res. 12:7721-7739(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Analysis of a 70 kb region on the right arm of yeast chromosome II."
    Mannhaupt G., Stucka R., Ehnle S., Vetter I., Feldmann H.
    Yeast 10:1363-1381(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPPA3_YEAST
AccessioniPrimary (citable) accession number: P24031
Secondary accession number(s): D6VQ93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: October 1, 1994
Last modified: June 11, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 952 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

External Data

Dasty 3
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