P24030 (VNCS_ADVG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Non-capsid protein NS-1

Alternative name(s):
NCVP1
Non-structural protein NS1

Gene names

Name:

NS1

Organism

Aleutian mink disease parvovirus (strain G) (ADV)

Taxonomic identifier

10783 [NCBI]

Taxonomic lineage

Viruses › ssDNA viruses › Parvoviridae › Parvovirinae › Amdovirus

Virus host

Mustela [TaxID: 9665]

Protein attributes

Sequence length	590 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Seems necessary for viral DNA replication.
Sequence similarities	Belongs to the parvoviruses non-capsid protein family. Contains 1 SF3 helicase domain.

Ontologies

Keywords
Biological process	DNA replication Initiation of viral infection Viral penetration into host cytoplasm Viral penetration via permeabilization of host organellar membrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW viral genome replication Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 590	590	Non-capsid protein NS-1		PRO_0000222461
Regions
	Domain	405 – 560	156	SF3 helicase
	Nucleotide binding	432 – 439	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P24030 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: 9898818AFD5343B0	FASTA	590	67,364
	10 20 30 40 50 60 MAQAQIDEQR RLQDLYVQLK KEINDGEGVA WLFQQKTYTD KDNKPTKATP PLRTTSSDLR 70 80 90 100 110 120 LAFDSIEENL TASNEHLTNN EINFCKLTLG KTLLLIDKHV KSHRWDSNKV NLIWQIEKGK 130 140 150 160 170 180 TQQFHIHCCL GYFDKNEDPK DVQKSLGWFM KRLNKDLAVI YSNHHCDIQD IKDPEDRAKN 190 200 210 220 230 240 LKVWIEDGPT KPYKYFNKQT KQDYNKPVHL RDYTFIYLFN KDKINTDSMD GYFAAGNGGI 250 260 270 280 290 300 VDNLTNKERK TLRKMYLDEQ SSDIMDANID WEDGQDAPKV TDQTDSATTK TGTSLIWKSC 310 320 330 340 350 360 ATKVTSKKEV ANPVQQPSKK LYSAQSTLDA LFNVGCFTPE DMIIKQSDKY LELSLEPNGP 370 380 390 400 410 420 QKINTLLHMN QVKTSTMITA FDCIIKFNEE EDDKPLLATI KDMGLNEQYL KKVLCTILTK 430 440 450 460 470 480 QGGKRGCIWF YGPGGTGKTL LASLICKATV NYGMVTTSNP NFPWTDCGNR NIIWAEECGN 490 500 510 520 530 540 FGNWVEDFKA ITGGGDVKVD TKNKQPQSIK GCVIVTSNTN ITKVTVGCVE TNAHAEPLKQ 550 560 570 580 590 RMIKIRCMKT INPKTKITPG MLKRWLNTWD RQPIQLSHEM PELYLGKCRW

References

[1]

"Nucleotide sequence and genomic organization of Aleutian mink disease parvovirus (ADV): sequence comparisons between a nonpathogenic and a pathogenic strain of ADV." Bloom M.E., Alexandersen S., Perryman S., Lechner D., Wolfinbarger J.B. J. Virol. 62:2903-2915(1988) [PubMed: 2839709] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M20036 Genomic DNA. Translation: AAA66612.1.
PIR	UYPVAP. A36760.
RefSeq	NP_042872.1. NC_001662.1.
3D structure databases
ProteinModelPortal	P24030.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1494586.
Family and domain databases
InterPro	IPR020960. Amdovirus_NS. IPR014015. Helicase_SF3_DNA-vir. IPR001257. Parvovirus_NS1_helicase. IPR021076. Parvovirus_NS1_N. [Graphical view]
Pfam	PF12475. Amdo_NSP. 2 hits. PF01057. Parvo_NS1. 1 hit. PF12433. PV_NSP1. 1 hit. [Graphical view]
PROSITE	PS51206. SF3_HELICASE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VNCS_ADVG

Accession

Primary (citable) accession number: P24030

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	February 1, 1996
Last modified:	September 21, 2011
This is version 49 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program