P24029 (CAPSD_ADVG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Capsid protein VP2 Alternative name(s): Coat protein VP2
Organism	Aleutian mink disease parvovirus (strain G) (ADV)
Taxonomic identifier	10783 [NCBI]
Taxonomic lineage	Viruses › ssDNA viruses › Parvoviridae › Parvovirinae › Amdovirus
Virus host	Mustela [TaxID: 9665]

Protein attributes

Sequence length	647 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of size variants of the capsid proteins, which differ in the N-terminushe capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis By similarity.
Subcellular location	Virion Potential.
Sequence similarities	Belongs to the parvoviridae capsid protein family.

Ontologies

Keywords
Biological process	Clathrin-mediated endocytosis of virus by host Host-virus interaction Initiation of viral infection Viral attachment to host cell Viral penetration into host cytoplasm Viral penetration via permeabilization of host organellar membrane Virus endocytosis by host
Cellular component	Virion
Molecular function	Capsid protein T=1 icosahedral capsid protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	viral capsid Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 647	647	Capsid protein VP2		PRO_0000222456
Regions
	Compositional bias	22 – 39	18	Gly-rich

Sequences

	Sequence		Length	Mass (Da)
	P24029 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: 22CE812094FFBFCA	FASTA	647	73,518
	10 20 30 40 50 60 MDSTEAEQMD TEQATNQTAE AGGGGGGGGG GGGGGGGVGN STGGFNNTTE FKVINNEVYI 70 80 90 100 110 120 TCHATRMVHI NQADTDEYLI FNAGRTTDTK THQQKLNLEF FVYDDFHQQV MTPWYIVDSN 130 140 150 160 170 180 AWGVWMSPKD FQQMKTLCSE ISLVTLEQEI DNVTIKTVTE TNQGNASTKQ FNNDLTASLQ 190 200 210 220 230 240 VALDTNNILP YTPAAPLGET LGFVPWRATK PTQYRYYHPC YIYNRYPNIQ KVATETLTWD 250 260 270 280 290 300 AVQDDYLSVD EQYFNFITIE NNIPINILRT GDNFHTGLYE FNSKPCKLTL SYQSTRCLGL 310 320 330 340 350 360 PPLCKPKTDT THKVTSKENG ADLIYIQGQD NTRLGHFWGE ERGKKNAEMN RIRPYNIGYQ 370 380 390 400 410 420 YPEWIIPAGL QGSYFAGGPR QWSDTTKGAG THSQHLQQNF STRYIYDRNH GGDNEVDLLD 430 440 450 460 470 480 GIPIHERSNY YSDNEIEQHT AKQPKLRTPP IHHSKIDSWE EEGWPAASGT HFEDEVIYLD 490 500 510 520 530 540 YFNFSGEQEL NFPHEVLDDA AQMKKLLNSY QPTVAQDNVG PVYPWGQIWD KKPHMDHKPS 550 560 570 580 590 600 MNNNAPFVCK NNPPGQLFVK LTENLTDTFN YDENPDRIKT YGYFTWRGKL VLKGKLSQVT 610 620 630 640 CWNPVKRELI GEPGVFTKDK YHKQIPNNKG NFEIGLQYGR STIKYIY

References

[1]	"Nucleotide sequence and genomic organization of Aleutian mink disease parvovirus (ADV): sequence comparisons between a nonpathogenic and a pathogenic strain of ADV." Bloom M.E., Alexandersen S., Perryman S., Lechner D., Wolfinbarger J.B. J. Virol. 62:2903-2915(1988) [PubMed: 2839709] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M20036 Genomic DNA. Translation: AAA66615.1.
PIR	VCPVAP. B36760.
RefSeq	NP_042875.1. NC_001662.1.
3D structure databases
ProteinModelPortal	P24029.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1494587.
Family and domain databases
InterPro	IPR016184. Capsid/spike_ssDNA_virus. IPR001403. Parvovirus_coat. [Graphical view]
Gene3D	G3DSA:2.170.30.10. Parvo_coat. 1 hit.
Pfam	PF00740. Parvo_coat. 1 hit. [Graphical view]
SUPFAM	SSF88645. Capsid/spike_ssDNA_virus. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CAPSD_ADVG

Accession

Primary (citable) accession number: P24029

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	February 1, 1996
Last modified:	September 21, 2011
This is version 53 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program