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Protein

Outer membrane protein A

Gene

ompA

Organism
Klebsiella pneumoniae
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for the action of colicins K and L and for the stabilization of mating aggregates in conjugation. Serves as a receptor for a number of T-even like phages. Also acts as a porin with low permeability that allows slow penetration of small solutes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Conjugation, Ion transport, Transport

Protein family/group databases

TCDBi1.B.6.1.11. the ompa-ompf porin (oop) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane protein A
Alternative name(s):
Outer membrane protein II
Gene namesi
Name:ompA
OrganismiKlebsiella pneumoniae
Taxonomic identifieri573 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 28Beta strandedSequence analysisAdd BLAST14
Transmembranei48 – 60Beta strandedSequence analysisAdd BLAST13
Transmembranei63 – 78Beta strandedSequence analysisAdd BLAST16
Transmembranei90 – 100Beta strandedSequence analysisAdd BLAST11
Transmembranei104 – 119Beta strandedSequence analysisAdd BLAST16
Transmembranei140 – 151Beta strandedSequence analysisAdd BLAST12
Transmembranei157 – 173Beta strandedSequence analysisAdd BLAST17
Transmembranei179 – 190Beta strandedSequence analysisAdd BLAST12

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000020097? – 344Outer membrane protein A
Signal peptidei1 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi309 ↔ 321By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP24017.

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

STRINGi272620.KPN_00986.

Structurei

Secondary structure

1344
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 9Combined sources3
Beta strandi16 – 23Combined sources8
Beta strandi50 – 60Combined sources11
Beta strandi63 – 71Combined sources9
Beta strandi90 – 117Combined sources28
Beta strandi127 – 129Combined sources3
Beta strandi136 – 149Combined sources14
Beta strandi151 – 153Combined sources3
Beta strandi155 – 162Combined sources8
Beta strandi182 – 188Combined sources7
Beta strandi199 – 201Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K0LNMR-A1-207[»]
ProteinModelPortaliP24017.
SMRiP24017.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24017.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati199 – 20012
Repeati201 – 20222
Repeati203 – 20432
Repeati205 – 20642
Domaini208 – 336OmpA-likePROSITE-ProRule annotationAdd BLAST129

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni199 – 2064 X 2 AA tandem repeats of A-P8

Sequence similaritiesi

Belongs to the OmpA family.Curated
Contains 1 OmpA-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105UYK. Bacteria.
COG2885. LUCA.

Family and domain databases

CDDicd07185. OmpA_C-like. 1 hit.
Gene3Di2.40.160.20. 1 hit.
3.30.1330.60. 1 hit.
InterProiIPR011250. OMP/PagP_b-brl.
IPR006664. OMP_bac.
IPR002368. OmpA.
IPR006665. OmpA-like.
IPR006690. OMPA-like_CS.
IPR000498. OmpA-like_TM_dom.
[Graphical view]
PfamiPF00691. OmpA. 1 hit.
PF01389. OmpA_membrane. 1 hit.
[Graphical view]
PRINTSiPR01021. OMPADOMAIN.
PR01022. OUTRMMBRANEA.
SUPFAMiSSF103088. SSF103088. 1 hit.
SSF56925. SSF56925. 1 hit.
PROSITEiPS01068. OMPA_1. 1 hit.
PS51123. OMPA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24017-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAIFVLNAA PKDNTWYAGG KLGWSQYHDT GFYGNGFQNN NGPTRNDQLG
60 70 80 90 100
AGAFGGYQVN PYLGFEMGYD WLGRMAYKGS VDNGAFKAQG VQLTAKLGYP
110 120 130 140 150
ITDDLDIYTR LGGMVWRADS KGNYASTGVS RSEHDTGVSP VFAGGVEWAV
160 170 180 190 200
TRDIATRLEY QWVNNIGDAG TVGTRPDNGM LSLGVSYRFG QEDAAPVVAP
210 220 230 240 250
APAPAPEVAT KHFTLKSDVL FNFNKATLKP EGQQALDQLY TQLSNMDPKD
260 270 280 290 300
GSAVVLGYTD RIGSEAYNQQ LSEKRAQSVV DYLVAKGIPA GKISARGMGE
310 320 330 340
SNPVTGNTCD NVKARAALID CLAPDRRVEI EVKGYKEVVT QPQA
Length:344
Mass (Da):37,061
Last modified:December 15, 1998 - v2
Checksum:iAC88AAE3B7871B16
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti335Y → I in AAA25119 (PubMed:1955870).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000998 Genomic DNA. Translation: CAA04450.1.
M63355 Genomic DNA. Translation: AAA25119.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000998 Genomic DNA. Translation: CAA04450.1.
M63355 Genomic DNA. Translation: AAA25119.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K0LNMR-A1-207[»]
ProteinModelPortaliP24017.
SMRiP24017.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272620.KPN_00986.

Protein family/group databases

TCDBi1.B.6.1.11. the ompa-ompf porin (oop) family.

Proteomic databases

PRIDEiP24017.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105UYK. Bacteria.
COG2885. LUCA.

Miscellaneous databases

EvolutionaryTraceiP24017.

Family and domain databases

CDDicd07185. OmpA_C-like. 1 hit.
Gene3Di2.40.160.20. 1 hit.
3.30.1330.60. 1 hit.
InterProiIPR011250. OMP/PagP_b-brl.
IPR006664. OMP_bac.
IPR002368. OmpA.
IPR006665. OmpA-like.
IPR006690. OMPA-like_CS.
IPR000498. OmpA-like_TM_dom.
[Graphical view]
PfamiPF00691. OmpA. 1 hit.
PF01389. OmpA_membrane. 1 hit.
[Graphical view]
PRINTSiPR01021. OMPADOMAIN.
PR01022. OUTRMMBRANEA.
SUPFAMiSSF103088. SSF103088. 1 hit.
SSF56925. SSF56925. 1 hit.
PROSITEiPS01068. OMPA_1. 1 hit.
PS51123. OMPA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOMPA_KLEPN
AccessioniPrimary (citable) accession number: P24017
Secondary accession number(s): O69435
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: December 15, 1998
Last modified: November 2, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.