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Protein

Protein slit

Gene

sli

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

A short-range repellent, controlling axon crossing of the midline and a long-range chemorepellent, controlling mesoderm migration and patterning away from the midline. May interact with extracellular matrix molecules. Repulsive ligand for the guidance receptor roundabout (robo) and prevents inappropriate midline crossing by Robo-expressing axons.4 Publications

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • heparin binding Source: FlyBase
  • Roundabout binding Source: FlyBase

GO - Biological processi

  • axon extension involved in axon guidance Source: GO_Central
  • axon guidance Source: FlyBase
  • axon midline choice point recognition Source: FlyBase
  • dendrite morphogenesis Source: FlyBase
  • digestive tract mesoderm development Source: FlyBase
  • embryonic heart tube development Source: FlyBase
  • epithelial cell migration, open tracheal system Source: FlyBase
  • glial cell migration Source: UniProtKB
  • gonad development Source: FlyBase
  • induction of negative chemotaxis Source: UniProtKB
  • lateral inhibition Source: FlyBase
  • mesodermal cell migration Source: FlyBase
  • mesoderm migration involved in gastrulation Source: UniProtKB
  • neuron differentiation Source: FlyBase
  • neuron migration Source: FlyBase
  • outflow tract morphogenesis Source: FlyBase
  • positive regulation of cell-cell adhesion Source: FlyBase
  • regulation of axonogenesis Source: GO_Central
  • regulation of epithelial cell migration Source: FlyBase
  • regulation of epithelial cell migration, open tracheal system Source: FlyBase
  • Roundabout signaling pathway Source: FlyBase
  • salivary gland boundary specification Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-DME-373752. Netrin-1 signaling.
R-DME-376176. Signaling by Robo receptor.
R-DME-428540. Activation of Rac.
R-DME-428543. Inactivation of Cdc42 and Rac.
R-DME-428890. Role of Abl in Robo-Slit signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein slit
Short name:
dSlit
Cleaved into the following 2 chains:
Gene namesi
Name:sli
ORF Names:CG43758
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0264089. sli.

Subcellular locationi

GO - Cellular componenti

  • extracellular matrix Source: FlyBase
  • extracellular region Source: UniProtKB
  • extracellular space Source: GO_Central
  • plasma membrane Source: Reactome
  • proteinaceous extracellular matrix Source: FlyBase
  • Slit-Robo signaling complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Flies lacking sli exhibit disruption of the developing midline cells and the commissural axon pathways.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 36Add BLAST36
ChainiPRO_000000771937 – 1504Protein slitAdd BLAST1468
ChainiPRO_000000772037 – 1135Protein slit N-productBy similarityAdd BLAST1099
ChainiPRO_00000077211136 – 1504Protein slit C-productBy similarityAdd BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi111N-linked (GlcNAc...)Sequence analysis1
Glycosylationi231N-linked (GlcNAc...)Sequence analysis1
Glycosylationi381N-linked (GlcNAc...)Sequence analysis1
Glycosylationi459N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi543 ↔ 5491 Publication
Disulfide bondi547 ↔ 5561 Publication
Disulfide bondi657 ↔ 7331 Publication
Disulfide bondi681 ↔ 7041 Publication
Disulfide bondi683 ↔ 7251 Publication
Glycosylationi807N-linked (GlcNAc...)Sequence analysis1
Glycosylationi812N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi935 ↔ 946By similarity
Disulfide bondi940 ↔ 956By similarity
Disulfide bondi958 ↔ 967By similarity
Disulfide bondi974 ↔ 985By similarity
Disulfide bondi979 ↔ 995By similarity
Glycosylationi982N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi997 ↔ 1006By similarity
Disulfide bondi1013 ↔ 1025By similarity
Disulfide bondi1019 ↔ 1034By similarity
Glycosylationi1022N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1036 ↔ 1045By similarity
Disulfide bondi1052 ↔ 1065By similarity
Disulfide bondi1059 ↔ 1074By similarity
Disulfide bondi1076 ↔ 1085By similarity
Glycosylationi1084N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1092 ↔ 1103By similarity
Disulfide bondi1097 ↔ 1112By similarity
Disulfide bondi1114 ↔ 1123By similarity
Disulfide bondi1139 ↔ 1149By similarity
Disulfide bondi1144 ↔ 1161By similarity
Disulfide bondi1163 ↔ 1172By similarity
Glycosylationi1183N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1199N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1267N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1316N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi1323 ↔ 1349By similarity
Disulfide bondi1381 ↔ 1392By similarity
Disulfide bondi1386 ↔ 1404By similarity
Disulfide bondi1406 ↔ 1415By similarity
Disulfide bondi1433 ↔ 1467By similarity
Disulfide bondi1447 ↔ 1481By similarity
Disulfide bondi1458 ↔ 1497By similarity
Disulfide bondi1462 ↔ 1499By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1135 – 1136CleavageBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP24014.
PRIDEiP24014.

Expressioni

Tissue specificityi

In embryos, highest expression occurs around the midline glia and low expression is observed around CNS axons lateral to the midline. Expression can be seen on the commissural axons traversing the glial cells but it is absent from the cell bodies of these neurons.3 Publications

Gene expression databases

BgeeiFBgn0264089.
ExpressionAtlasiP24014. baseline.
GenevisibleiP24014. DM.

Interactioni

Subunit structurei

Interacts with robo.1 Publication

GO - Molecular functioni

  • Roundabout binding Source: FlyBase

Protein-protein interaction databases

BioGridi62473. 14 interactors.
IntActiP24014. 7 interactors.
STRINGi7227.FBpp0303578.

Structurei

Secondary structure

11504
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi547 – 550Combined sources4
Beta strandi553 – 555Combined sources3
Beta strandi573 – 576Combined sources4
Helixi591 – 593Combined sources3
Beta strandi599 – 601Combined sources3
Turni612 – 617Combined sources6
Beta strandi623 – 625Combined sources3
Beta strandi636 – 639Combined sources4
Beta strandi647 – 649Combined sources3
Beta strandi671 – 673Combined sources3
Helixi683 – 685Combined sources3
Helixi686 – 695Combined sources10
Helixi699 – 701Combined sources3
Turni708 – 712Combined sources5
Helixi715 – 717Combined sources3
Turni720 – 722Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W8AX-ray2.80A542-733[»]
ProteinModelPortaliP24014.
SMRiP24014.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP24014.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 100LRRNT 1Add BLAST37
Repeati101 – 122LRR 1Add BLAST22
Repeati125 – 146LRR 2Add BLAST22
Repeati149 – 170LRR 3Add BLAST22
Repeati173 – 194LRR 4Add BLAST22
Repeati197 – 218LRR 5Add BLAST22
Repeati221 – 242LRR 6Add BLAST22
Domaini254 – 304LRRCT 1Add BLAST51
Domaini310 – 346LRRNT 2Add BLAST37
Repeati347 – 368LRR 7Add BLAST22
Repeati371 – 392LRR 8Add BLAST22
Repeati395 – 416LRR 9Add BLAST22
Repeati419 – 440LRR 10Add BLAST22
Repeati443 – 464LRR 11Add BLAST22
Domaini476 – 526LRRCT 2Add BLAST51
Domaini534 – 570LRRNT 3Add BLAST37
Repeati571 – 592LRR 12Add BLAST22
Repeati596 – 617LRR 13Add BLAST22
Repeati620 – 641LRR 14Add BLAST22
Repeati644 – 665LRR 15Add BLAST22
Domaini677 – 727LRRCT 3Add BLAST51
Domaini730 – 766LRRNT 4Add BLAST37
Repeati767 – 788LRR 16Add BLAST22
Repeati791 – 812LRR 17Add BLAST22
Repeati815 – 836LRR 18Add BLAST22
Repeati839 – 860LRR 19Add BLAST22
Domaini872 – 922LRRCT 4Add BLAST51
Domaini931 – 968EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini970 – 1007EGF-like 2PROSITE-ProRule annotationAdd BLAST38
Domaini1009 – 1046EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini1048 – 1086EGF-like 4PROSITE-ProRule annotationAdd BLAST39
Domaini1088 – 1124EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini1135 – 1173EGF-like 6PROSITE-ProRule annotationAdd BLAST39
Domaini1176 – 1349Laminin G-likePROSITE-ProRule annotationAdd BLAST174
Domaini1377 – 1416EGF-like 7PROSITE-ProRule annotationAdd BLAST40
Domaini1433 – 1504CTCKPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
Contains 7 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.PROSITE-ProRule annotation
Contains 19 LRR (leucine-rich) repeats.Curated
Contains 4 LRRCT domains.Curated
Contains 4 LRRNT domains.Curated

Keywords - Domaini

EGF-like domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG4237. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129708.
InParanoidiP24014.
KOiK06839.
OrthoDBiEOG091G0MHP.
PhylomeDBiP24014.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
3.80.10.10. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000483. Cys-rich_flank_reg_C.
IPR006207. Cys_knot_C.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR032675. L_dom-like.
IPR001791. Laminin_G.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00008. EGF. 4 hits.
PF12661. hEGF. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF13855. LRR_8. 6 hits.
PF01463. LRRCT. 4 hits.
PF01462. LRRNT. 4 hits.
[Graphical view]
SMARTiSM00041. CT. 1 hit.
SM00181. EGF. 7 hits.
SM00179. EGF_CA. 6 hits.
SM00282. LamG. 1 hit.
SM00369. LRR_TYP. 16 hits.
SM00082. LRRCT. 4 hits.
SM00013. LRRNT. 4 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF52058. SSF52058. 4 hits.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 7 hits.
PS01186. EGF_2. 5 hits.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS51450. LRR. 20 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform C (identifier: P24014-1) [UniParc]FASTAAdd to basket
Also known as: E

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPSRTTLM PPPFRLQLRL LILPILLLLR HDAVHAEPYS GGFGSSAVSS
60 70 80 90 100
GGLGSVGIHI PGGGVGVITE ARCPRVCSCT GLNVDCSHRG LTSVPRKISA
110 120 130 140 150
DVERLELQGN NLTVIYETDF QRLTKLRMLQ LTDNQIHTIE RNSFQDLVSL
160 170 180 190 200
ERLRLNNNRL KAIPENFVTS SASLLRLDIS NNVITTVGRR VFKGAQSLRS
210 220 230 240 250
LQLDNNQITC LDEHAFKGLV ELEILTLNNN NLTSLPHNIF GGLGRLRALR
260 270 280 290 300
LSDNPFACDC HLSWLSRFLR SATRLAPYTR CQSPSQLKGQ NVADLHDQEF
310 320 330 340 350
KCSGLTEHAP MECGAENSCP HPCRCADGIV DCREKSLTSV PVTLPDDTTE
360 370 380 390 400
LRLEQNFITE LPPKSFSSFR RLRRIDLSNN NISRIAHDAL SGLKQLTTLV
410 420 430 440 450
LYGNKIKDLP SGVFKGLGSL QLLLLNANEI SCIRKDAFRD LHSLSLLSLY
460 470 480 490 500
DNNIQSLANG TFDAMKSIKT VHLAKNPFIC DCNLRWLADY LHKNPIETSG
510 520 530 540 550
ARCESPKRMH RRRIESLREE KFKCSWDELR MKLSGECRMD SDCPAMCHCE
560 570 580 590 600
GTTVDCTGRG LKEIPRDIPL HTTELLLNDN ELGRISSDGL FGRLPHLVKL
610 620 630 640 650
ELKRNQLTGI EPNAFEGASH IQELQLGENK IKEISNKMFL GLHQLKTLNL
660 670 680 690 700
YDNQISCVMP GSFEHLNSLT SLNLASNPFN CNCHLAWFAE WLRKKSLNGG
710 720 730 740 750
AARCGAPSKV RDVQIKDLPH SEFKCSSENS EGCLGDGYCP PSCTCTGTVV
760 770 780 790 800
RCSRNQLKEI PRGIPAETSE LYLESNEIEQ IHYERIRHLR SLTRLDLSNN
810 820 830 840 850
QITILSNYTF ANLTKLSTLI ISYNKLQCLQ RHALSGLNNL RVLSLHGNRI
860 870 880 890 900
SMLPEGSFED LKSLTHIALG SNPLYCDCGL KWFSDWIKLD YVEPGIARCA
910 920 930 940 950
EPEQMKDKLI LSTPSSSFVC RGRVRNDILA KCNACFEQPC QNQAQCVALP
960 970 980 990 1000
QREYQCLCQP GYHGKHCEFM IDACYGNPCR NNATCTVLEE GRFSCQCAPG
1010 1020 1030 1040 1050
YTGARCETNI DDCLGEIKCQ NNATCIDGVE SYKCECQPGF SGEFCDTKIQ
1060 1070 1080 1090 1100
FCSPEFNPCA NGAKCMDHFT HYSCDCQAGF HGTNCTDNID DCQNHMCQNG
1110 1120 1130 1140 1150
GTCVDGINDY QCRCPDDYTG KYCEGHNMIS MMYPQTSPCQ NHECKHGVCF
1160 1170 1180 1190 1200
QPNAQGSDYL CRCHPGYTGK WCEYLTSISF VHNNSFVELE PLRTRPEANV
1210 1220 1230 1240 1250
TIVFSSAEQN GILMYDGQDA HLAVELFNGR IRVSYDVGNH PVSTMYSFEM
1260 1270 1280 1290 1300
VADGKYHAVE LLAIKKNFTL RVDRGLARSI INEGSNDYLK LTTPMFLGGL
1310 1320 1330 1340 1350
PVDPAQQAYK NWQIRNLTSF KGCMKEVWIN HKLVDFGNAQ RQQKITPGCA
1360 1370 1380 1390 1400
LLEGEQQEEE DDEQDFMDET PHIKEEPVDP CLENKCRRGS RCVPNSNARD
1410 1420 1430 1440 1450
GYQCKCKHGQ RGRYCDQGEG STEPPTVTAA STCRKEQVRE YYTENDCRSR
1460 1470 1480 1490 1500
QPLKYAKCVG GCGNQCCAAK IVRRRKVRMV CSNNRKYIKN LDIVRKCGCT

KKCY
Length:1,504
Mass (Da):168,599
Last modified:February 28, 2003 - v2
Checksum:i836A3F5022BF234F
GO
Isoform A (identifier: P24014-2) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     152-175: Missing.

Show »
Length:1,480
Mass (Da):165,890
Checksum:iF456BC617D8453ED
GO
Isoform B (identifier: P24014-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-175: Missing.
     1418-1428: Missing.

Show »
Length:1,469
Mass (Da):164,834
Checksum:i14DBA99CE1DAEAC4
GO

Sequence cautioni

The sequence AAA72722 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti350 – 351EL → DV in CAA37910 (PubMed:2176636).Curated2
Sequence conflicti350 – 351EL → DV in AAD26567 (PubMed:10102267).Curated2
Sequence conflicti421Q → R in CAA37910 (PubMed:2176636).Curated1
Sequence conflicti468I → M in CAA37910 (PubMed:2176636).Curated1
Sequence conflicti527D → G in CAA37910 (PubMed:2176636).Curated1
Sequence conflicti560G → R in CAA37910 (PubMed:2176636).Curated1
Sequence conflicti691 – 692WL → CV in CAA37910 (PubMed:2176636).Curated2
Sequence conflicti751R → A in CAA37910 (PubMed:2176636).Curated1
Sequence conflicti843L → V in CAA37910 (PubMed:2176636).Curated1
Sequence conflicti1207 – 1208AE → G in AAA72722 (PubMed:3144436).Curated2
Sequence conflicti1429 – 1435AASTCRK → GTYIYHA in AAA72722 (PubMed:3144436).Curated7

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001408152 – 175Missing in isoform A and isoform B. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_0014091418 – 1428Missing in isoform B. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53959 mRNA. Translation: CAA37910.1.
AF126540 mRNA. Translation: AAD26567.1.
AE013599 Genomic DNA. Translation: AAF58097.1.
AE013599 Genomic DNA. Translation: AAF58098.1.
AE013599 Genomic DNA. Translation: AAM70966.1.
AE013599 Genomic DNA. Translation: ABV53816.1.
AE013599 Genomic DNA. Translation: ABV53817.1.
M23543 Genomic DNA. Translation: AAA72722.1. Different initiation.
PIRiA36665.
B36665.
RefSeqiNP_001097333.1. NM_001103863.3. [P24014-2]
NP_001097334.1. NM_001103864.3. [P24014-1]
NP_476727.1. NM_057379.4. [P24014-1]
NP_476728.1. NM_057380.4. [P24014-2]
NP_476729.1. NM_057381.4. [P24014-3]
UniGeneiDm.4729.

Genome annotation databases

EnsemblMetazoaiFBtr0330731; FBpp0303575; FBgn0264089. [P24014-1]
FBtr0330733; FBpp0303577; FBgn0264089. [P24014-1]
GeneIDi36746.
KEGGidme:Dmel_CG43758.
UCSCiCG8355-RD. d. melanogaster.
CG8355-RE. d. melanogaster.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53959 mRNA. Translation: CAA37910.1.
AF126540 mRNA. Translation: AAD26567.1.
AE013599 Genomic DNA. Translation: AAF58097.1.
AE013599 Genomic DNA. Translation: AAF58098.1.
AE013599 Genomic DNA. Translation: AAM70966.1.
AE013599 Genomic DNA. Translation: ABV53816.1.
AE013599 Genomic DNA. Translation: ABV53817.1.
M23543 Genomic DNA. Translation: AAA72722.1. Different initiation.
PIRiA36665.
B36665.
RefSeqiNP_001097333.1. NM_001103863.3. [P24014-2]
NP_001097334.1. NM_001103864.3. [P24014-1]
NP_476727.1. NM_057379.4. [P24014-1]
NP_476728.1. NM_057380.4. [P24014-2]
NP_476729.1. NM_057381.4. [P24014-3]
UniGeneiDm.4729.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1W8AX-ray2.80A542-733[»]
ProteinModelPortaliP24014.
SMRiP24014.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi62473. 14 interactors.
IntActiP24014. 7 interactors.
STRINGi7227.FBpp0303578.

Proteomic databases

PaxDbiP24014.
PRIDEiP24014.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0330731; FBpp0303575; FBgn0264089. [P24014-1]
FBtr0330733; FBpp0303577; FBgn0264089. [P24014-1]
GeneIDi36746.
KEGGidme:Dmel_CG43758.
UCSCiCG8355-RD. d. melanogaster.
CG8355-RE. d. melanogaster.

Organism-specific databases

CTDi36746.
FlyBaseiFBgn0264089. sli.

Phylogenomic databases

eggNOGiKOG4237. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129708.
InParanoidiP24014.
KOiK06839.
OrthoDBiEOG091G0MHP.
PhylomeDBiP24014.

Enzyme and pathway databases

ReactomeiR-DME-373752. Netrin-1 signaling.
R-DME-376176. Signaling by Robo receptor.
R-DME-428540. Activation of Rac.
R-DME-428543. Inactivation of Cdc42 and Rac.
R-DME-428890. Role of Abl in Robo-Slit signaling.

Miscellaneous databases

EvolutionaryTraceiP24014.
GenomeRNAii36746.
PROiP24014.

Gene expression databases

BgeeiFBgn0264089.
ExpressionAtlasiP24014. baseline.
GenevisibleiP24014. DM.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
3.80.10.10. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000483. Cys-rich_flank_reg_C.
IPR006207. Cys_knot_C.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR032675. L_dom-like.
IPR001791. Laminin_G.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00008. EGF. 4 hits.
PF12661. hEGF. 1 hit.
PF00054. Laminin_G_1. 1 hit.
PF13855. LRR_8. 6 hits.
PF01463. LRRCT. 4 hits.
PF01462. LRRNT. 4 hits.
[Graphical view]
SMARTiSM00041. CT. 1 hit.
SM00181. EGF. 7 hits.
SM00179. EGF_CA. 6 hits.
SM00282. LamG. 1 hit.
SM00369. LRR_TYP. 16 hits.
SM00082. LRRCT. 4 hits.
SM00013. LRRNT. 4 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF52058. SSF52058. 4 hits.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00022. EGF_1. 7 hits.
PS01186. EGF_2. 5 hits.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
PS51450. LRR. 20 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLIT_DROME
AccessioniPrimary (citable) accession number: P24014
Secondary accession number(s): A8DYF5
, A8DYF6, Q24526, Q8MLB9, Q9V7F8, Q9V7F9, Q9XYV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: February 28, 2003
Last modified: November 30, 2016
This is version 187 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.