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P24013 (COX4_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 4B

EC=1.9.3.1
Alternative name(s):
Caa-3605 subunit 4B
Cytochrome aa3 subunit 4B
Cytochrome c oxidase polypeptide IVB
Gene names
Name:ctaF
Ordered Locus Names:BSU14920
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length110 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase bacterial subunit 4 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncytochrome-c oxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 110110Cytochrome c oxidase subunit 4B
PRO_0000183902

Regions

Transmembrane27 – 4721Helical; Potential
Transmembrane50 – 7021Helical; Potential
Transmembrane88 – 10821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P24013 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: 1142CF36A63C3AF9

FASTA11012,620
        10         20         30         40         50         60 
MVDKKSRGHI NSDLEFKKKK HAREMKYQVL SFGLMIGLTI VAFLTVATDG VGSWFTIPFI 

        70         80         90        100        110 
ILLAAIQVIF QLYYFMHMNQ KGHEAPALFL YSGVFVAFIT VLAFVTIIWW 

« Hide

References

« Hide 'large scale' references
[1]"The Bacillus subtilis cytochrome-c oxidase. Variations on a conserved protein theme."
Saraste M., Metso T., Nakari T., Jalli T., Lauraeus M., van der Oost J.
Eur. J. Biochem. 195:517-525(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"Bacillus subtilis chromosomal region downstream nprE."
Bertero M., Presecan E., Glaser P., Richou A., Danchin A.
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[3]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X54140 Genomic DNA. Translation: CAA38079.1.
Z98682 Genomic DNA. Translation: CAB11345.1.
AL009126 Genomic DNA. Translation: CAB13365.1.
PIRG69609.
RefSeqNP_389375.1. NC_000964.3.

3D structure databases

ProteinModelPortalP24013.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224308.BSU14920.

Protein family/group databases

TCDB3.D.4.4.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

PaxDbP24013.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB13365; CAB13365; BSU14920.
GeneID936259.
KEGGbsu:BSU14920.
PATRIC18974785. VBIBacSub10457_1584.

Organism-specific databases

GenoListBSU14920. [Micado]

Phylogenomic databases

eggNOGCOG3125.
HOGENOMHOG000261855.
KOK02277.
OMAIQVIFQL.
OrthoDBEOG6JX7N4.

Enzyme and pathway databases

BioCycBSUB:BSU14920-MONOMER.

Family and domain databases

InterProIPR014257. Cyt_c_oxidase_su4_bacillaceae.
IPR005171. Cyt_c_oxidase_suIV_prok.
[Graphical view]
PfamPF03626. COX4_pro. 1 hit.
[Graphical view]
TIGRFAMsTIGR02908. CoxD_Bacillus. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCOX4_BACSU
AccessionPrimary (citable) accession number: P24013
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: May 14, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList