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P24011

- COX2_BACSU

UniProt

P24011 - COX2_BACSU

Protein

Cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.
    Heme group.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi176 – 1761Copper ACurated
    Metal bindingi217 – 2171Copper ACurated
    Metal bindingi221 – 2211Copper ACurated
    Metal bindingi225 – 2251Copper ACurated
    Binding sitei271 – 2711Heme (covalent)Curated
    Binding sitei274 – 2741Heme (covalent)Curated
    Metal bindingi275 – 2751Iron (heme axial ligand)Curated
    Metal bindingi329 – 3291Iron (heme axial ligand)Curated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciBSUB:BSU14890-MONOMER.

    Protein family/group databases

    TCDBi3.D.4.4.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Caa-3605 subunit 2
    Cytochrome aa3 subunit 2
    Cytochrome c oxidase polypeptide II
    Oxidase aa(3) subunit 2
    Gene namesi
    Name:ctaC
    Ordered Locus Names:BSU14890
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU14890. [Micado]

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020PROSITE-ProRule annotationAdd
    BLAST
    Chaini21 – 356336Cytochrome c oxidase subunit 2PRO_0000006051Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi21 – 211N-palmitoyl cysteinePROSITE-ProRule annotation
    Lipidationi21 – 211S-diacylglycerol cysteinePROSITE-ProRule annotation

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP24011.

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU14890.

    Structurei

    3D structure databases

    ProteinModelPortaliP24011.
    SMRiP24011. Positions 26-352.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 4727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini67 – 8721CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini107 – 356250ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei48 – 6619HelicalSequence AnalysisAdd
    BLAST
    Transmembranei88 – 10619HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini258 – 35699Cytochrome cPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni21 – 257237Cytochrome c oxidase subunit IIAdd
    BLAST

    Sequence similaritiesi

    Contains 1 cytochrome c domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2857.
    HOGENOMiHOG000268576.
    KOiK02275.
    OMAiFWIPSVG.
    OrthoDBiEOG6S52JN.
    PhylomeDBiP24011.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    1.10.760.10. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR009056. Cyt_c-like_dom.
    IPR003088. Cyt_c_dom.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    PF00034. Cytochrom_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF46626. SSF46626. 1 hit.
    SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsiTIGR02866. CoxB. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    PS51007. CYTC. 1 hit.
    PS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P24011-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKHWRLILL LALVPLLLSG CGKPFLSTLK PAGEVADKQY DLTVLSTLIM    50
    VVVVAVVSVI FFYVIVRFRR SRVGENTIPK QVEGNKFLEI TWTVIPILLL 100
    IILVIPVVLY TLELADTSPM DKKGRKAEDA LVVNVRANLY WWEFEYPDYG 150
    IITSQELIVP TDQRVYFNLK ASDVKHSFWI PSVGGKLDTN TDNENKFFLT 200
    FDSKRSKEAG DMFFGKCAEL CGPSHALMDF KVKTMSAKEF QGWTKEMKNY 250
    KSTAESDLAK QGEELFKEKN CLSCHAVEPN DKRAEAARTA PNLATFGERT 300
    KVAGVKEANK ENVKAWLKDP DSIKPGNKMT GTYPKLSDSE TNALYEYLKG 350
    LKAESK 356
    Length:356
    Mass (Da):40,095
    Last modified:May 30, 2000 - v2
    Checksum:iDEF74EAF4C8414E9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti257 – 2571D → H in CAA38076. (PubMed:1847686)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54140 Genomic DNA. Translation: CAA38076.1.
    Z98682 Genomic DNA. Translation: CAB11342.1.
    AL009126 Genomic DNA. Translation: CAB13362.1.
    PIRiS14396.
    RefSeqiNP_389372.1. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB13362; CAB13362; BSU14890.
    GeneIDi936789.
    KEGGibsu:BSU14890.
    PATRICi18974779. VBIBacSub10457_1581.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X54140 Genomic DNA. Translation: CAA38076.1 .
    Z98682 Genomic DNA. Translation: CAB11342.1 .
    AL009126 Genomic DNA. Translation: CAB13362.1 .
    PIRi S14396.
    RefSeqi NP_389372.1. NC_000964.3.

    3D structure databases

    ProteinModelPortali P24011.
    SMRi P24011. Positions 26-352.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU14890.

    Protein family/group databases

    TCDBi 3.D.4.4.1. the proton-translocating cytochrome oxidase (cox) superfamily.

    Proteomic databases

    PaxDbi P24011.

    Protocols and materials databases

    DNASUi 936789.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB13362 ; CAB13362 ; BSU14890 .
    GeneIDi 936789.
    KEGGi bsu:BSU14890.
    PATRICi 18974779. VBIBacSub10457_1581.

    Organism-specific databases

    GenoListi BSU14890. [Micado ]

    Phylogenomic databases

    eggNOGi COG2857.
    HOGENOMi HOG000268576.
    KOi K02275.
    OMAi FWIPSVG.
    OrthoDBi EOG6S52JN.
    PhylomeDBi P24011.

    Enzyme and pathway databases

    BioCyci BSUB:BSU14890-MONOMER.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    1.10.760.10. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR009056. Cyt_c-like_dom.
    IPR003088. Cyt_c_dom.
    IPR014222. Cyt_c_oxidase_su2.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    PF00034. Cytochrom_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46626. SSF46626. 1 hit.
    SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    TIGRFAMsi TIGR02866. CoxB. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    PS51007. CYTC. 1 hit.
    PS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Bacillus subtilis cytochrome-c oxidase. Variations on a conserved protein theme."
      Saraste M., Metso T., Nakari T., Jalli T., Lauraeus M., van der Oost J.
      Eur. J. Biochem. 195:517-525(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    2. "Bacillus subtilis chromosomal region downstream nprE."
      Bertero M., Presecan E., Glaser P., Richou A., Danchin A.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    3. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.

    Entry informationi

    Entry nameiCOX2_BACSU
    AccessioniPrimary (citable) accession number: P24011
    Secondary accession number(s): O34404
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3