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Protein

Cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi176Copper ACurated1
Metal bindingi217Copper ACurated1
Metal bindingi221Copper ACurated1
Metal bindingi225Copper ACurated1
Binding sitei271Heme (covalent)Curated1
Binding sitei274Heme (covalent)Curated1
Metal bindingi275Iron (heme axial ligand)Curated1
Metal bindingi329Iron (heme axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBSUB:BSU14890-MONOMER
SABIO-RKiP24011

Protein family/group databases

TCDBi3.D.4.4.1 the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Caa-3605 subunit 2
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene namesi
Name:ctaC
Ordered Locus Names:BSU14890
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 47ExtracellularSequence analysisAdd BLAST27
Transmembranei48 – 66HelicalSequence analysisAdd BLAST19
Topological domaini67 – 87CytoplasmicSequence analysisAdd BLAST21
Transmembranei88 – 106HelicalSequence analysisAdd BLAST19
Topological domaini107 – 356ExtracellularSequence analysisAdd BLAST250

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20PROSITE-ProRule annotationAdd BLAST20
ChainiPRO_000000605121 – 356Cytochrome c oxidase subunit 2Add BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi21N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi21S-diacylglycerol cysteinePROSITE-ProRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP24011
PRIDEiP24011

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100008241

Structurei

3D structure databases

ProteinModelPortaliP24011
SMRiP24011
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini258 – 356Cytochrome cPROSITE-ProRule annotationAdd BLAST99

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 257Cytochrome c oxidase subunit IIAdd BLAST237

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622 LUCA
COG2857 LUCA
HOGENOMiHOG000268576
InParanoidiP24011
KOiK02275
OMAiKMTGTYP
PhylomeDBiP24011

Family and domain databases

CDDicd04213 CuRO_CcO_Caa3_II, 1 hit
Gene3Di1.10.287.90, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR034236 CuRO_CcO_Caa3_II
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
PF00034 Cytochrom_C, 1 hit
SUPFAMiSSF46626 SSF46626, 1 hit
SSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit
PS51007 CYTC, 1 hit
PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24011-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKHWRLILL LALVPLLLSG CGKPFLSTLK PAGEVADKQY DLTVLSTLIM
60 70 80 90 100
VVVVAVVSVI FFYVIVRFRR SRVGENTIPK QVEGNKFLEI TWTVIPILLL
110 120 130 140 150
IILVIPVVLY TLELADTSPM DKKGRKAEDA LVVNVRANLY WWEFEYPDYG
160 170 180 190 200
IITSQELIVP TDQRVYFNLK ASDVKHSFWI PSVGGKLDTN TDNENKFFLT
210 220 230 240 250
FDSKRSKEAG DMFFGKCAEL CGPSHALMDF KVKTMSAKEF QGWTKEMKNY
260 270 280 290 300
KSTAESDLAK QGEELFKEKN CLSCHAVEPN DKRAEAARTA PNLATFGERT
310 320 330 340 350
KVAGVKEANK ENVKAWLKDP DSIKPGNKMT GTYPKLSDSE TNALYEYLKG

LKAESK
Length:356
Mass (Da):40,095
Last modified:May 30, 2000 - v2
Checksum:iDEF74EAF4C8414E9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti257D → H in CAA38076 (PubMed:1847686).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54140 Genomic DNA Translation: CAA38076.1
Z98682 Genomic DNA Translation: CAB11342.1
AL009126 Genomic DNA Translation: CAB13362.1
PIRiS14396
RefSeqiNP_389372.1, NC_000964.3
WP_003232248.1, NZ_JNCM01000035.1

Genome annotation databases

EnsemblBacteriaiCAB13362; CAB13362; BSU14890
GeneIDi936789
KEGGibsu:BSU14890
PATRICifig|224308.179.peg.1624

Entry informationi

Entry nameiCOX2_BACSU
AccessioniPrimary (citable) accession number: P24011
Secondary accession number(s): O34404
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: May 30, 2000
Last modified: May 23, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

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