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Protein

Cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi176Copper ACurated1
Metal bindingi217Copper ACurated1
Metal bindingi221Copper ACurated1
Metal bindingi225Copper ACurated1
Binding sitei271Heme (covalent)Curated1
Binding sitei274Heme (covalent)Curated1
Metal bindingi275Iron (heme axial ligand)Curated1
Metal bindingi329Iron (heme axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBSUB:BSU14890-MONOMER.
SABIO-RKP24011.

Protein family/group databases

TCDBi3.D.4.4.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Caa-3605 subunit 2
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene namesi
Name:ctaC
Ordered Locus Names:BSU14890
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 47ExtracellularSequence analysisAdd BLAST27
Transmembranei48 – 66HelicalSequence analysisAdd BLAST19
Topological domaini67 – 87CytoplasmicSequence analysisAdd BLAST21
Transmembranei88 – 106HelicalSequence analysisAdd BLAST19
Topological domaini107 – 356ExtracellularSequence analysisAdd BLAST250

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20PROSITE-ProRule annotationAdd BLAST20
ChainiPRO_000000605121 – 356Cytochrome c oxidase subunit 2Add BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi21N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi21S-diacylglycerol cysteinePROSITE-ProRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP24011.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100008241.

Structurei

3D structure databases

ProteinModelPortaliP24011.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini258 – 356Cytochrome cPROSITE-ProRule annotationAdd BLAST99

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 257Cytochrome c oxidase subunit IIAdd BLAST237

Sequence similaritiesi

Contains 1 cytochrome c domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622. LUCA.
COG2857. LUCA.
HOGENOMiHOG000268576.
InParanoidiP24011.
KOiK02275.
OMAiKMTGTYP.
PhylomeDBiP24011.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
1.10.760.10. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR009056. Cyt_c-like_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
PF00034. Cytochrom_C. 1 hit.
[Graphical view]
SUPFAMiSSF46626. SSF46626. 1 hit.
SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
PS51007. CYTC. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P24011-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKHWRLILL LALVPLLLSG CGKPFLSTLK PAGEVADKQY DLTVLSTLIM
60 70 80 90 100
VVVVAVVSVI FFYVIVRFRR SRVGENTIPK QVEGNKFLEI TWTVIPILLL
110 120 130 140 150
IILVIPVVLY TLELADTSPM DKKGRKAEDA LVVNVRANLY WWEFEYPDYG
160 170 180 190 200
IITSQELIVP TDQRVYFNLK ASDVKHSFWI PSVGGKLDTN TDNENKFFLT
210 220 230 240 250
FDSKRSKEAG DMFFGKCAEL CGPSHALMDF KVKTMSAKEF QGWTKEMKNY
260 270 280 290 300
KSTAESDLAK QGEELFKEKN CLSCHAVEPN DKRAEAARTA PNLATFGERT
310 320 330 340 350
KVAGVKEANK ENVKAWLKDP DSIKPGNKMT GTYPKLSDSE TNALYEYLKG

LKAESK
Length:356
Mass (Da):40,095
Last modified:May 30, 2000 - v2
Checksum:iDEF74EAF4C8414E9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti257D → H in CAA38076 (PubMed:1847686).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54140 Genomic DNA. Translation: CAA38076.1.
Z98682 Genomic DNA. Translation: CAB11342.1.
AL009126 Genomic DNA. Translation: CAB13362.1.
PIRiS14396.
RefSeqiNP_389372.1. NC_000964.3.
WP_003232248.1. NZ_JNCM01000035.1.

Genome annotation databases

EnsemblBacteriaiCAB13362; CAB13362; BSU14890.
GeneIDi936789.
KEGGibsu:BSU14890.
PATRICi18974779. VBIBacSub10457_1581.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54140 Genomic DNA. Translation: CAA38076.1.
Z98682 Genomic DNA. Translation: CAB11342.1.
AL009126 Genomic DNA. Translation: CAB13362.1.
PIRiS14396.
RefSeqiNP_389372.1. NC_000964.3.
WP_003232248.1. NZ_JNCM01000035.1.

3D structure databases

ProteinModelPortaliP24011.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100008241.

Protein family/group databases

TCDBi3.D.4.4.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

PaxDbiP24011.

Protocols and materials databases

DNASUi936789.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB13362; CAB13362; BSU14890.
GeneIDi936789.
KEGGibsu:BSU14890.
PATRICi18974779. VBIBacSub10457_1581.

Phylogenomic databases

eggNOGiCOG1622. LUCA.
COG2857. LUCA.
HOGENOMiHOG000268576.
InParanoidiP24011.
KOiK02275.
OMAiKMTGTYP.
PhylomeDBiP24011.

Enzyme and pathway databases

BioCyciBSUB:BSU14890-MONOMER.
SABIO-RKP24011.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
1.10.760.10. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR009056. Cyt_c-like_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
PF00034. Cytochrom_C. 1 hit.
[Graphical view]
SUPFAMiSSF46626. SSF46626. 1 hit.
SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
PS51007. CYTC. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX2_BACSU
AccessioniPrimary (citable) accession number: P24011
Secondary accession number(s): O34404
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: May 30, 2000
Last modified: November 30, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.