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P24011 (COX2_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Caa-3605 subunit 2
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene names
Name:ctaC
Ordered Locus Names:BSU14890
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Heme group.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Contains 1 cytochrome c domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 356336Cytochrome c oxidase subunit 2
PRO_0000006051

Regions

Topological domain21 – 4727Extracellular Potential
Transmembrane48 – 6619Helical; Potential
Topological domain67 – 8721Cytoplasmic Potential
Transmembrane88 – 10619Helical; Potential
Topological domain107 – 356250Extracellular Potential
Domain258 – 35699Cytochrome c
Region21 – 257237Cytochrome c oxidase subunit II

Sites

Metal binding1761Copper A Probable
Metal binding2171Copper A Probable
Metal binding2211Copper A Probable
Metal binding2251Copper A Probable
Metal binding2751Iron (heme axial ligand) Probable
Metal binding3291Iron (heme axial ligand) Probable
Binding site2711Heme (covalent) Probable
Binding site2741Heme (covalent) Probable

Amino acid modifications

Lipidation211N-palmitoyl cysteine Potential
Lipidation211S-diacylglycerol cysteine Potential

Experimental info

Sequence conflict2571D → H in CAA38076. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P24011 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: DEF74EAF4C8414E9

FASTA35640,095
        10         20         30         40         50         60 
MVKHWRLILL LALVPLLLSG CGKPFLSTLK PAGEVADKQY DLTVLSTLIM VVVVAVVSVI 

        70         80         90        100        110        120 
FFYVIVRFRR SRVGENTIPK QVEGNKFLEI TWTVIPILLL IILVIPVVLY TLELADTSPM 

       130        140        150        160        170        180 
DKKGRKAEDA LVVNVRANLY WWEFEYPDYG IITSQELIVP TDQRVYFNLK ASDVKHSFWI 

       190        200        210        220        230        240 
PSVGGKLDTN TDNENKFFLT FDSKRSKEAG DMFFGKCAEL CGPSHALMDF KVKTMSAKEF 

       250        260        270        280        290        300 
QGWTKEMKNY KSTAESDLAK QGEELFKEKN CLSCHAVEPN DKRAEAARTA PNLATFGERT 

       310        320        330        340        350 
KVAGVKEANK ENVKAWLKDP DSIKPGNKMT GTYPKLSDSE TNALYEYLKG LKAESK 

« Hide

References

« Hide 'large scale' references
[1]"The Bacillus subtilis cytochrome-c oxidase. Variations on a conserved protein theme."
Saraste M., Metso T., Nakari T., Jalli T., Lauraeus M., van der Oost J.
Eur. J. Biochem. 195:517-525(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"Bacillus subtilis chromosomal region downstream nprE."
Bertero M., Presecan E., Glaser P., Richou A., Danchin A.
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[3]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X54140 Genomic DNA. Translation: CAA38076.1.
Z98682 Genomic DNA. Translation: CAB11342.1.
AL009126 Genomic DNA. Translation: CAB13362.1.
PIRS14396.
RefSeqNP_389372.1. NC_000964.3.

3D structure databases

ProteinModelPortalP24011.
SMRP24011. Positions 26-352.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224308.BSU14890.

Protein family/group databases

TCDB3.D.4.4.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

PaxDbP24011.

Protocols and materials databases

DNASU936789.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB13362; CAB13362; BSU14890.
GeneID936789.
KEGGbsu:BSU14890.
PATRIC18974779. VBIBacSub10457_1581.

Organism-specific databases

GenoListBSU14890. [Micado]

Phylogenomic databases

eggNOGCOG2857.
HOGENOMHOG000268576.
KOK02275.
OMAFWIPSVG.
OrthoDBEOG6S52JN.
PhylomeDBP24011.

Enzyme and pathway databases

BioCycBSUB:BSU14890-MONOMER.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
1.10.760.10. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR009056. Cyt_c-like_dom.
IPR003088. Cyt_c_dom.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
PF00034. Cytochrom_C. 1 hit.
[Graphical view]
SUPFAMSSF46626. SSF46626. 1 hit.
SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
PS51007. CYTC. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_BACSU
AccessionPrimary (citable) accession number: P24011
Secondary accession number(s): O34404
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: May 30, 2000
Last modified: July 9, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList