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P24010

- COX1_BACSU

UniProt

P24010 - COX1_BACSU

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Protein

Cytochrome c oxidase subunit 1

Gene

ctaD

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme a of subunit 1 to the bimetallic center formed by heme a3 and copper B. This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu2+Note: Binds 1 copper B ion per subunit.
  • hemeNote: Binds 2 heme groups per subunit.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi73 – 731Iron (heme A axial ligand)Curated
Metal bindingi249 – 2491Copper BCurated
Metal bindingi253 – 2531Copper BCurated
Metal bindingi298 – 2981Copper BCurated
Metal bindingi299 – 2991Copper BCurated
Metal bindingi384 – 3841Iron (heme A3 axial ligand)Curated
Metal bindingi386 – 3861Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Hydrogen ion transport, Ion transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBSUB:BSU14900-MONOMER.
RETL1328306-WGS:GSTH-6904-MONOMER.
UniPathwayiUPA00705.

Protein family/group databases

TCDBi3.D.4.4.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Caa-3605 subunit 1
Cytochrome aa3 subunit 1
Cytochrome c oxidase polypeptide I
Oxidase aa(3) subunit 1
Gene namesi
Name:ctaD
Ordered Locus Names:BSU14900
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU14900. [Micado]

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei28 – 4619HelicalSequence AnalysisAdd
BLAST
Topological domaini47 – 6822CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei69 – 8820HelicalSequence AnalysisAdd
BLAST
Topological domaini89 – 11022ExtracellularSequence AnalysisAdd
BLAST
Transmembranei111 – 12818HelicalSequence AnalysisAdd
BLAST
Topological domaini129 – 15931CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei160 – 17819HelicalSequence AnalysisAdd
BLAST
Topological domaini179 – 19618ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21519HelicalSequence AnalysisAdd
BLAST
Topological domaini216 – 24126CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei242 – 26120HelicalSequence AnalysisAdd
BLAST
Topological domaini262 – 28423ExtracellularSequence AnalysisAdd
BLAST
Transmembranei285 – 30420HelicalSequence AnalysisAdd
BLAST
Topological domaini305 – 3128CytoplasmicSequence Analysis
Transmembranei313 – 33119HelicalSequence AnalysisAdd
BLAST
Topological domaini332 – 34615ExtracellularSequence AnalysisAdd
BLAST
Transmembranei347 – 36620HelicalSequence AnalysisAdd
BLAST
Topological domaini367 – 3748CytoplasmicSequence Analysis
Transmembranei375 – 39420HelicalSequence AnalysisAdd
BLAST
Topological domaini395 – 42127ExtracellularSequence AnalysisAdd
BLAST
Transmembranei422 – 44120HelicalSequence AnalysisAdd
BLAST
Topological domaini442 – 45918CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei460 – 47920HelicalSequence AnalysisAdd
BLAST
Topological domaini480 – 55273ExtracellularSequence AnalysisAdd
BLAST
Transmembranei553 – 57220HelicalSequence AnalysisAdd
BLAST
Topological domaini573 – 5808CytoplasmicSequence Analysis
Transmembranei581 – 60424HelicalSequence AnalysisAdd
BLAST
Topological domaini605 – 62218CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622Cytochrome c oxidase subunit 1PRO_0000183436Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki249 ↔ 2531'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

PaxDbiP24010.

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU14900.

Structurei

3D structure databases

ProteinModelPortaliP24010.
SMRiP24010. Positions 22-516.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085275.
InParanoidiP24010.
KOiK02274.
OrthoDBiEOG6B35XR.
PhylomeDBiP24010.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P24010-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLNALTEKRT RGSMLWDYLT TVDHKKIAIL YLVAGGFFFL VGGIEAMFIR
60 70 80 90 100
IQLAKPENAF LSAQAYNEVM TMHGTTMIFL AAMPLLFALM NAVVPLQIGA
110 120 130 140 150
RDVSFPFLNA LGFWLFFFGG IFLNLSWFLG GAPDAGWTSY ASLSLHSKGH
160 170 180 190 200
GIDFFVLGLQ ISGLGTLIAG INFLATIINM RAPGMTYMRL PLFTWTTFVA
210 220 230 240 250
SALILFAFPP LTVGLALMML DRLFGTNFFN PELGGNTVIW EHLFWIFGHP
260 270 280 290 300
EVYILILPAF GIFSEVIPVF ARKRLFGYSS MVFAIVLIGF LGFMVWVHHM
310 320 330 340 350
FTTGLGPIAN AIFAVATMAI AIPTGIKIFN WLLTIWGGNV KYTTAMLYAV
360 370 380 390 400
SFIPSFVLGG VTGVMLAAAA ADYQFHDTYF VVAHFHYVII GGVVFGLLAG
410 420 430 440 450
VHFWWPKMFG KILHETMGKI SFVLFFIGFH LTFFIQHFVG LMGMPRRVYT
460 470 480 490 500
FLPGQGLETG NLISTIGAFF MAAAVILLLV NVIWTSVKGE YVGADPWHDG
510 520 530 540 550
RTLEWTVSSP PPEYNFKQLP FVRGLDPLWI EKQAGHKSMT PAEPVDDIHM
560 570 580 590 600
PNGSILPLII SFGLFVAAFG LLYRSDYAWG LPVIFIGLGI TFITMLLRSV
610 620
IDDHGYHIHK EELPNDDKGV KA
Length:622
Mass (Da):69,028
Last modified:June 16, 2009 - v3
Checksum:iDF159F21D191332D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti120 – 1201G → H in CAB11343. 1 PublicationCurated
Sequence conflicti155 – 1562FV → SI in CAA38077. (PubMed:1847686)Curated
Sequence conflicti288 – 2881Missing in CAA38077. (PubMed:1847686)Curated
Sequence conflicti474 – 4741A → R in CAA38077. (PubMed:1847686)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54140 Genomic DNA. Translation: CAA38077.1.
Z98682 Genomic DNA. Translation: CAB11343.1.
AL009126 Genomic DNA. Translation: CAB13363.2.
PIRiE69609.
RefSeqiNP_389373.2. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB13363; CAB13363; BSU14900.
GeneIDi936898.
KEGGibsu:BSU14900.
PATRICi18974781. VBIBacSub10457_1582.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54140 Genomic DNA. Translation: CAA38077.1 .
Z98682 Genomic DNA. Translation: CAB11343.1 .
AL009126 Genomic DNA. Translation: CAB13363.2 .
PIRi E69609.
RefSeqi NP_389373.2. NC_000964.3.

3D structure databases

ProteinModelPortali P24010.
SMRi P24010. Positions 22-516.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU14900.

Protein family/group databases

TCDBi 3.D.4.4.1. the proton-translocating cytochrome oxidase (cox) superfamily.

Proteomic databases

PaxDbi P24010.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB13363 ; CAB13363 ; BSU14900 .
GeneIDi 936898.
KEGGi bsu:BSU14900.
PATRICi 18974781. VBIBacSub10457_1582.

Organism-specific databases

GenoListi BSU14900. [Micado ]

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085275.
InParanoidi P24010.
KOi K02274.
OrthoDBi EOG6B35XR.
PhylomeDBi P24010.

Enzyme and pathway databases

UniPathwayi UPA00705 .
BioCyci BSUB:BSU14900-MONOMER.
RETL1328306-WGS:GSTH-6904-MONOMER.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Bacillus subtilis cytochrome-c oxidase. Variations on a conserved protein theme."
    Saraste M., Metso T., Nakari T., Jalli T., Lauraeus M., van der Oost J.
    Eur. J. Biochem. 195:517-525(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "Bacillus subtilis chromosomal region downstream nprE."
    Bertero M., Presecan E., Glaser P., Richou A., Danchin A.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  3. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  4. "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
    Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
    Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 120.

Entry informationi

Entry nameiCOX1_BACSU
AccessioniPrimary (citable) accession number: P24010
Secondary accession number(s): O34467
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: June 16, 2009
Last modified: November 26, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3