P24008 (S5A1_RAT) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 94.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: 3-oxo-5-alpha-steroid 4-dehydrogenase 1 EC=1.3.99.5 Alternative name(s): SR type 1 Steroid 5-alpha-reductase 1 Short name=S5AR 1 | ||
| Gene names |
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| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 259 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. |
| Catalytic activity | A 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-Delta(4)-steroid + reduced acceptor. |
| Subcellular location | Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein Potential. |
| Tissue specificity | Liver and prostate (at a low level). |
| Developmental stage | After the establishment of chromosomal sex at fertilization. |
| Induction | Its expression is regulated by androgens such as testosterone. |
| Sequence similarities | Belongs to the steroid 5-alpha reductase family. |
| Biophysicochemical properties | pH dependence: Optimally active at alkaline pHs. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative initiation. [Align] [Select] | ||||||
| Isoform Long (identifier: P24008-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform Short (identifier: P24008-2) The sequence of this isoform differs from the canonical sequence as follows: 1-4: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 259 | 259 | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | PRO_0000031565 | |||||
Regions | |||||||||
| Transmembrane | 10 – 30 | 21 | Helical; Potential | ||||||
| Transmembrane | 86 – 106 | 21 | Helical; Potential | ||||||
| Transmembrane | 111 – 131 | 21 | Helical; Potential | ||||||
| Transmembrane | 146 – 166 | 21 | Helical; Potential | ||||||
| Transmembrane | 206 – 226 | 21 | Helical; Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 4 | 4 | Missing in isoform Short. | VSP_018884 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Expression cloning and regulation of steroid 5 alpha-reductase, an enzyme essential for male sexual differentiation." Andersson S., Bishop R.W., Russell D.W. J. Biol. Chem. 264:16249-16255(1989) [PubMed: 2476440] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT). |
| [2] | "Heterogeneity of rat type I 5 alpha-reductase cDNA: cloning, expression and regulation by pituitary implants and dihydrotestosterone." Lopez-Solache I., Luu-The V., Seralini G.E., Labrie F. Biochim. Biophys. Acta 1305:139-144(1996) [PubMed: 8597599] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG). Tissue: Liver. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT). Tissue: Brain. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | J05035 mRNA. Translation: AAA42102.1. S81448 mRNA. Translation: AAB36218.1. BC127454 mRNA. Translation: AAI27455.1. |
| IPI | IPI00210851. IPI00760114. |
| PIR | S65744. |
| RefSeq | NP_058766.2. NM_017070.3. |
| UniGene | Rn.4620. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P24008. |
Proteomic databases | |
| PRIDE | P24008. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 24950. |
| KEGG | rno:24950. |
| UCSC | NM_017070. rat. |
Organism-specific databases | |
| CTD | 6715. |
| RGD | 3757. Srd5a1. |
Phylogenomic databases | |
| eggNOG | roNOG12983. |
| HOVERGEN | HBG003402. |
| InParanoid | P24008. |
| OrthoDB | EOG4VX25X. |
Gene expression databases | |
| ArrayExpress | P24008. |
| Genevestigator | P24008. |
| GermOnline | ENSRNOG00000017601. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR016636. 3-oxo-5-alpha-steroid_4-DH. IPR001104. 3-oxo-5_a-steroid_4-DH_C. [Graphical view] |
| KO | K12343. |
| Pfam | PF02544. Steroid_dh. 1 hit. [Graphical view] |
| PIRSF | PIRSF015596. 5_alpha-SR2. 1 hit. |
| PROSITE | PS50244. S5A_REDUCTASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 604965. |
Entry information
| Entry name | S5A1_RAT | ||||||||
| Accession | Primary (citable) accession number: P24008 Secondary accession number(s): A0JPJ6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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