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P24001 (IL32_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-32

Short name=IL-32
Alternative name(s):
Natural killer cells protein 4
Tumor necrosis factor alpha-inducing factor
Gene names
Name:IL32
Synonyms:NK4, TAIF
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK. Ref.2

Subcellular location

Secreted Ref.2.

Tissue specificity

Selectively expressed in lymphocytes. Expression is more prominent in immune cells than in non-immune cells. Ref.2

Induction

Expression increased after activation of T-cells by mitogens or activation of NK cells by IL2/interleukin-2. Ref.1

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainSignal
   Molecular functionCytokine
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Traceable author statement Ref.1. Source: ProtInc

defense response

Traceable author statement Ref.1. Source: ProtInc

immune response

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentextracellular space

Traceable author statement Ref.1. Source: ProtInc

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 24396867PubMed 24396867PubMed 24396867. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PRKCDQ056553EBI-8800907,EBI-704279

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P24001-1)

Also known as: Gamma;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P24001-2)

Also known as: Beta;

The sequence of this isoform differs from the canonical sequence as follows:
     19-64: Missing.
Isoform 3 (identifier: P24001-3)

Also known as: Delta;

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.
     19-64: Missing.
Isoform 4 (identifier: P24001-4)

Also known as: Alpha;

The sequence of this isoform differs from the canonical sequence as follows:
     19-64: Missing.
     154-210: Missing.
Isoform 5 (identifier: P24001-5)

The sequence of this isoform differs from the canonical sequence as follows:
     19-64: Missing.
     65-84: Missing.
Note: No experimental confirmation available.
Isoform 6 (identifier: P24001-6)

The sequence of this isoform differs from the canonical sequence as follows:
     19-64: Missing.
     85-93: Missing.
Note: No experimental confirmation available.
Isoform 7 (identifier: P24001-7)

The sequence of this isoform differs from the canonical sequence as follows:
     19-84: Missing.
     94-113: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 234204Interleukin-32
PRO_0000021487

Natural variations

Alternative sequence1 – 1010Missing in isoform 3.
VSP_022005
Alternative sequence19 – 8466Missing in isoform 7.
VSP_047855
Alternative sequence19 – 6446Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6.
VSP_022006
Alternative sequence65 – 8420Missing in isoform 5.
VSP_043318
Alternative sequence85 – 939Missing in isoform 6.
VSP_045785
Alternative sequence94 – 11320Missing in isoform 7.
VSP_047856
Alternative sequence154 – 21057Missing in isoform 4.
VSP_022007
Natural variant1521D → N. Ref.1
VAR_005506

Experimental info

Sequence conflict2331S → L in BM825040. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Gamma) [UniParc].

Last modified December 12, 2006. Version 3.
Checksum: 5F339FE2D348A761

FASTA23426,676
        10         20         30         40         50         60 
MCFPKVLSDD MKKLKARMVM LLPTSAQGLG AWVSACDTED TVGHLGPWRD KDPALWCQLC 

        70         80         90        100        110        120 
LSSQHQAIER FYDKMQNAES GRGQVMSSLA ELEDDFKEGY LETVAAYYEE QHPELTPLLE 

       130        140        150        160        170        180 
KERDGLRCRG NRSPVPDVED PATEEPGESF CDKVMRWFQA MLQRLQTWWH GVLAWVKEKV 

       190        200        210        220        230 
VALVHAVQAL WKQFQSFCCS LSELFMSSFQ SYGAPRGDKE ELTPQKCSEP QSSK 

« Hide

Isoform 2 (Beta) [UniParc].

Checksum: 601340225A3BB1CD
Show »

FASTA18821,737
Isoform 3 (Delta) [UniParc].

Checksum: 0B04D770664399C4
Show »

FASTA17820,600
Isoform 4 (Alpha) [UniParc].

Checksum: A31708A3A25CFF6F
Show »

FASTA13114,909
Isoform 5 [UniParc].

Checksum: 5998CF072214C612
Show »

FASTA16819,389
Isoform 6 [UniParc].

Checksum: DE570457CCC5F59F
Show »

FASTA17920,777
Isoform 7 [UniParc].

Checksum: 5384285DC256FD2B
Show »

FASTA14817,003

References

« Hide 'large scale' references
[1]"Identification of a novel gene expressed in activated natural killer cells and T cells."
Dahl C.A., Schall R.P., He H., Cairns J.S.
J. Immunol. 148:597-603(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INDUCTION, VARIANT ASN-152.
[2]"Interleukin-32: a cytokine and inducer of TNFalpha."
Kim S.-H., Han S.-Y., Azam T., Yoon D.-Y., Dinarello C.A.
Immunity 22:131-142(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 2; 3 AND 4), ALTERNATIVE SPLICING, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[3]"A new variant of interleukin 32."
Mao W., Han W., Salama A., Moldenhauer A.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
Tissue: Thalamus.
[5]"Transcriptome analysis of human gastric cancer."
Oh J.H., Yang J.O., Hahn Y., Kim M.R., Byun S.S., Jeon Y.J., Kim J.M., Song K.S., Noh S.M., Kim S., Yoo H.S., Kim Y.S., Kim N.S.
Mamm. Genome 16:942-954(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
Tissue: Stomach.
[6]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Eye and Pancreas.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M59807 mRNA. Translation: AAA36367.2.
AY495331 mRNA. Translation: AAS80143.1.
AY495332 mRNA. Translation: AAS80144.1.
AY495333 mRNA. Translation: AAS80145.1.
AY495334 Genomic DNA. Translation: AAS80146.1.
AY495334 Genomic DNA. Translation: AAS80147.1.
AY495334 Genomic DNA. Translation: AAS80148.1.
EU339107 mRNA. Translation: ACA50721.1.
AK296143 mRNA. Translation: BAG58883.1.
BM825040 mRNA. No translation available.
AC108134 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85405.1.
CH471112 Genomic DNA. Translation: EAW85406.1.
CH471112 Genomic DNA. Translation: EAW85407.1.
CH471112 Genomic DNA. Translation: EAW85408.1.
CH471112 Genomic DNA. Translation: EAW85409.1.
CH471112 Genomic DNA. Translation: EAW85410.1.
BC009401 mRNA. Translation: AAH09401.1.
BC018782 mRNA. Translation: AAH18782.1.
BC105602 mRNA. Translation: AAI05603.1.
CCDSCCDS32377.1. [P24001-2]
CCDS32378.1. [P24001-4]
CCDS32379.1. [P24001-6]
CCDS45394.1. [P24001-5]
PIRI56140.
RefSeqNP_001012649.1. NM_001012631.1. [P24001-2]
NP_001012650.1. NM_001012632.1. [P24001-2]
NP_001012651.1. NM_001012633.1. [P24001-4]
NP_001012652.1. NM_001012634.1. [P24001-5]
NP_001012653.1. NM_001012635.1. [P24001-5]
NP_001012654.1. NM_001012636.1. [P24001-6]
NP_001012736.1. NM_001012718.1. [P24001-2]
NP_004212.4. NM_004221.4. [P24001-2]
XP_005255743.1. XM_005255686.1. [P24001-1]
UniGeneHs.943.

3D structure databases

ProteinModelPortalP24001.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114664. 1 interaction.
IntActP24001. 2 interactions.
STRING9606.ENSP00000324742.

PTM databases

PhosphoSiteP24001.

Polymorphism databases

DMDM119364597.

Proteomic databases

MaxQBP24001.
PaxDbP24001.
PRIDEP24001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000008180; ENSP00000008180; ENSG00000008517. [P24001-5]
ENST00000325568; ENSP00000324742; ENSG00000008517. [P24001-2]
ENST00000382213; ENSP00000371648; ENSG00000008517. [P24001-6]
ENST00000396887; ENSP00000380096; ENSG00000008517. [P24001-4]
ENST00000396890; ENSP00000380099; ENSG00000008517. [P24001-1]
ENST00000440815; ENSP00000405063; ENSG00000008517. [P24001-2]
ENST00000444393; ENSP00000411958; ENSG00000008517. [P24001-2]
ENST00000525643; ENSP00000432218; ENSG00000008517. [P24001-2]
ENST00000526464; ENSP00000450364; ENSG00000008517. [P24001-2]
ENST00000528163; ENSP00000432850; ENSG00000008517. [P24001-2]
ENST00000529550; ENSP00000437020; ENSG00000008517. [P24001-2]
ENST00000530538; ENSP00000436929; ENSG00000008517. [P24001-2]
ENST00000530890; ENSP00000433747; ENSG00000008517. [P24001-5]
ENST00000531965; ENSP00000433177; ENSG00000008517. [P24001-3]
ENST00000533097; ENSP00000432917; ENSG00000008517. [P24001-2]
ENST00000534507; ENSP00000431775; ENSG00000008517. [P24001-1]
ENST00000548246; ENSP00000447979; ENSG00000008517. [P24001-7]
ENST00000548476; ENSP00000449483; ENSG00000008517. [P24001-1]
ENST00000548652; ENSP00000446624; ENSG00000008517. [P24001-6]
ENST00000549213; ENSP00000447812; ENSG00000008517. [P24001-4]
ENST00000551122; ENSP00000447496; ENSG00000008517. [P24001-4]
ENST00000552356; ENSP00000446978; ENSG00000008517. [P24001-5]
ENST00000552664; ENSP00000448683; ENSG00000008517. [P24001-2]
GeneID9235.
KEGGhsa:9235.
UCSCuc002ctk.3. human. [P24001-4]
uc002ctl.3. human. [P24001-2]
uc002cto.3. human. [P24001-1]
uc002ctp.3. human. [P24001-5]
uc002ctu.3. human.
uc010btb.3. human. [P24001-3]

Organism-specific databases

CTD9235.
GeneCardsGC16P003131.
HGNCHGNC:16830. IL32.
HPACAB030029.
HPA029397.
MIM606001. gene.
neXtProtNX_P24001.
PharmGKBPA128395754.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG285840.
HOGENOMHOG000293381.
HOVERGENHBG081790.
OMACDKVMRW.
OrthoDBEOG741Z57.
PhylomeDBP24001.
TreeFamTF341753.

Gene expression databases

ArrayExpressP24001.
BgeeP24001.
CleanExHS_IL32.
GenevestigatorP24001.

Family and domain databases

InterProIPR028067. IL-32.
[Graphical view]
PfamPF15225. IL32. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIL32. human.
GenomeRNAi9235.
NextBio34609.
PROP24001.
SOURCESearch...

Entry information

Entry nameIL32_HUMAN
AccessionPrimary (citable) accession number: P24001
Secondary accession number(s): A6NNM0 expand/collapse secondary AC list , A8MPX0, B4DJM1, B8Q191, D3DUB0, D3DUB2, Q5VFH7, Q5VFH8, Q8WV38, Q96GK9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: December 12, 2006
Last modified: July 9, 2014
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM