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Protein

Interleukin-32

Gene

IL32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK.1 Publication

GO - Biological processi

  • cell adhesion Source: ProtInc
  • defense response Source: ProtInc
  • immune response Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

BioCyciZFISH:ENSG00000008517-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-32
Short name:
IL-32
Alternative name(s):
Natural killer cells protein 4
Tumor necrosis factor alpha-inducing factor
Gene namesi
Name:IL32
Synonyms:NK4, TAIF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:16830. IL32.

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular space Source: ProtInc
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi9235.
OpenTargetsiENSG00000008517.
PharmGKBiPA128395754.

Polymorphism and mutation databases

BioMutaiIL32.
DMDMi119364597.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000002148731 – 234Interleukin-32Add BLAST204

Proteomic databases

MaxQBiP24001.
PeptideAtlasiP24001.
PRIDEiP24001.

PTM databases

iPTMnetiP24001.
PhosphoSitePlusiP24001.
SwissPalmiP24001.

Expressioni

Tissue specificityi

Selectively expressed in lymphocytes. Expression is more prominent in immune cells than in non-immune cells.1 Publication

Inductioni

Expression increased after activation of T-cells by mitogens or activation of NK cells by IL2/interleukin-2.1 Publication

Gene expression databases

BgeeiENSG00000008517.
CleanExiHS_IL32.
ExpressionAtlasiP24001. baseline and differential.
GenevisibleiP24001. HS.

Organism-specific databases

HPAiCAB030029.
HPA029397.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CEBPAP497157EBI-8800907,EBI-1172054
PRKCDQ056557EBI-8800907,EBI-704279

Protein-protein interaction databases

BioGridi114664. 14 interactors.
DIPiDIP-61119N.
IntActiP24001. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliP24001.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000000661.
HOGENOMiHOG000293381.
HOVERGENiHBG081790.
InParanoidiP24001.
OMAiELERFCC.
OrthoDBiEOG091G14OI.
PhylomeDBiP24001.
TreeFamiTF341753.

Family and domain databases

InterProiIPR028067. IL-32.
[Graphical view]
PfamiPF15225. IL32. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P24001-1) [UniParc]FASTAAdd to basket
Also known as: Gamma

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCFPKVLSDD MKKLKARMVM LLPTSAQGLG AWVSACDTED TVGHLGPWRD
60 70 80 90 100
KDPALWCQLC LSSQHQAIER FYDKMQNAES GRGQVMSSLA ELEDDFKEGY
110 120 130 140 150
LETVAAYYEE QHPELTPLLE KERDGLRCRG NRSPVPDVED PATEEPGESF
160 170 180 190 200
CDKVMRWFQA MLQRLQTWWH GVLAWVKEKV VALVHAVQAL WKQFQSFCCS
210 220 230
LSELFMSSFQ SYGAPRGDKE ELTPQKCSEP QSSK
Length:234
Mass (Da):26,676
Last modified:December 12, 2006 - v3
Checksum:i5F339FE2D348A761
GO
Isoform 2 (identifier: P24001-2) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     19-64: Missing.

Show »
Length:188
Mass (Da):21,737
Checksum:i601340225A3BB1CD
GO
Isoform 3 (identifier: P24001-3) [UniParc]FASTAAdd to basket
Also known as: Delta

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.
     19-64: Missing.

Show »
Length:178
Mass (Da):20,600
Checksum:i0B04D770664399C4
GO
Isoform 4 (identifier: P24001-4) [UniParc]FASTAAdd to basket
Also known as: Alpha

The sequence of this isoform differs from the canonical sequence as follows:
     19-64: Missing.
     154-210: Missing.

Show »
Length:131
Mass (Da):14,909
Checksum:iA31708A3A25CFF6F
GO
Isoform 5 (identifier: P24001-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-64: Missing.
     65-84: Missing.

Note: No experimental confirmation available.
Show »
Length:168
Mass (Da):19,389
Checksum:i5998CF072214C612
GO
Isoform 6 (identifier: P24001-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-64: Missing.
     85-93: Missing.

Note: No experimental confirmation available.
Show »
Length:179
Mass (Da):20,777
Checksum:iDE570457CCC5F59F
GO
Isoform 7 (identifier: P24001-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-84: Missing.
     94-113: Missing.

Show »
Length:148
Mass (Da):17,003
Checksum:i5384285DC256FD2B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti233S → L in BM825040 (PubMed:16341674).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_005506152D → N.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0220051 – 10Missing in isoform 3. 1 Publication10
Alternative sequenceiVSP_04785519 – 84Missing in isoform 7. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_02200619 – 64Missing in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 4 PublicationsAdd BLAST46
Alternative sequenceiVSP_04331865 – 84Missing in isoform 5. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_04578585 – 93Missing in isoform 6. 1 Publication9
Alternative sequenceiVSP_04785694 – 113Missing in isoform 7. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_022007154 – 210Missing in isoform 4. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59807 mRNA. Translation: AAA36367.2.
AY495331 mRNA. Translation: AAS80143.1.
AY495332 mRNA. Translation: AAS80144.1.
AY495333 mRNA. Translation: AAS80145.1.
AY495334 Genomic DNA. Translation: AAS80146.1.
AY495334 Genomic DNA. Translation: AAS80147.1.
AY495334 Genomic DNA. Translation: AAS80148.1.
EU339107 mRNA. Translation: ACA50721.1.
AK296143 mRNA. Translation: BAG58883.1.
BM825040 mRNA. No translation available.
AC108134 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85405.1.
CH471112 Genomic DNA. Translation: EAW85406.1.
CH471112 Genomic DNA. Translation: EAW85407.1.
CH471112 Genomic DNA. Translation: EAW85408.1.
CH471112 Genomic DNA. Translation: EAW85409.1.
CH471112 Genomic DNA. Translation: EAW85410.1.
BC009401 mRNA. Translation: AAH09401.1.
BC018782 mRNA. Translation: AAH18782.1.
BC105602 mRNA. Translation: AAI05603.1.
CCDSiCCDS32377.1. [P24001-2]
CCDS32378.1. [P24001-4]
CCDS32379.1. [P24001-6]
CCDS45394.1. [P24001-5]
CCDS76811.1. [P24001-1]
PIRiI56140.
RefSeqiNP_001012649.1. NM_001012631.1. [P24001-2]
NP_001012650.1. NM_001012632.1. [P24001-2]
NP_001012651.1. NM_001012633.1. [P24001-4]
NP_001012652.1. NM_001012634.1. [P24001-5]
NP_001012653.1. NM_001012635.1. [P24001-5]
NP_001012654.1. NM_001012636.1. [P24001-6]
NP_001012736.1. NM_001012718.1. [P24001-2]
NP_001295007.1. NM_001308078.1. [P24001-1]
NP_004212.4. NM_004221.4. [P24001-2]
UniGeneiHs.943.

Genome annotation databases

EnsembliENST00000008180; ENSP00000008180; ENSG00000008517. [P24001-5]
ENST00000325568; ENSP00000324742; ENSG00000008517. [P24001-2]
ENST00000382213; ENSP00000371648; ENSG00000008517. [P24001-6]
ENST00000396887; ENSP00000380096; ENSG00000008517. [P24001-4]
ENST00000396890; ENSP00000380099; ENSG00000008517. [P24001-1]
ENST00000440815; ENSP00000405063; ENSG00000008517. [P24001-2]
ENST00000444393; ENSP00000411958; ENSG00000008517. [P24001-2]
ENST00000525643; ENSP00000432218; ENSG00000008517. [P24001-2]
ENST00000526464; ENSP00000450364; ENSG00000008517. [P24001-2]
ENST00000528163; ENSP00000432850; ENSG00000008517. [P24001-2]
ENST00000529550; ENSP00000437020; ENSG00000008517. [P24001-2]
ENST00000530538; ENSP00000436929; ENSG00000008517. [P24001-2]
ENST00000530890; ENSP00000433747; ENSG00000008517. [P24001-5]
ENST00000531965; ENSP00000433177; ENSG00000008517. [P24001-3]
ENST00000533097; ENSP00000432917; ENSG00000008517. [P24001-2]
ENST00000534507; ENSP00000431775; ENSG00000008517. [P24001-1]
ENST00000548246; ENSP00000447979; ENSG00000008517. [P24001-7]
ENST00000548476; ENSP00000449483; ENSG00000008517. [P24001-1]
ENST00000548652; ENSP00000446624; ENSG00000008517. [P24001-6]
ENST00000549213; ENSP00000447812; ENSG00000008517. [P24001-4]
ENST00000551122; ENSP00000447496; ENSG00000008517. [P24001-4]
ENST00000552356; ENSP00000446978; ENSG00000008517. [P24001-5]
ENST00000552664; ENSP00000448683; ENSG00000008517. [P24001-2]
GeneIDi9235.
KEGGihsa:9235.
UCSCiuc002ctk.4. human. [P24001-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59807 mRNA. Translation: AAA36367.2.
AY495331 mRNA. Translation: AAS80143.1.
AY495332 mRNA. Translation: AAS80144.1.
AY495333 mRNA. Translation: AAS80145.1.
AY495334 Genomic DNA. Translation: AAS80146.1.
AY495334 Genomic DNA. Translation: AAS80147.1.
AY495334 Genomic DNA. Translation: AAS80148.1.
EU339107 mRNA. Translation: ACA50721.1.
AK296143 mRNA. Translation: BAG58883.1.
BM825040 mRNA. No translation available.
AC108134 Genomic DNA. No translation available.
CH471112 Genomic DNA. Translation: EAW85405.1.
CH471112 Genomic DNA. Translation: EAW85406.1.
CH471112 Genomic DNA. Translation: EAW85407.1.
CH471112 Genomic DNA. Translation: EAW85408.1.
CH471112 Genomic DNA. Translation: EAW85409.1.
CH471112 Genomic DNA. Translation: EAW85410.1.
BC009401 mRNA. Translation: AAH09401.1.
BC018782 mRNA. Translation: AAH18782.1.
BC105602 mRNA. Translation: AAI05603.1.
CCDSiCCDS32377.1. [P24001-2]
CCDS32378.1. [P24001-4]
CCDS32379.1. [P24001-6]
CCDS45394.1. [P24001-5]
CCDS76811.1. [P24001-1]
PIRiI56140.
RefSeqiNP_001012649.1. NM_001012631.1. [P24001-2]
NP_001012650.1. NM_001012632.1. [P24001-2]
NP_001012651.1. NM_001012633.1. [P24001-4]
NP_001012652.1. NM_001012634.1. [P24001-5]
NP_001012653.1. NM_001012635.1. [P24001-5]
NP_001012654.1. NM_001012636.1. [P24001-6]
NP_001012736.1. NM_001012718.1. [P24001-2]
NP_001295007.1. NM_001308078.1. [P24001-1]
NP_004212.4. NM_004221.4. [P24001-2]
UniGeneiHs.943.

3D structure databases

ProteinModelPortaliP24001.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114664. 14 interactors.
DIPiDIP-61119N.
IntActiP24001. 3 interactors.

PTM databases

iPTMnetiP24001.
PhosphoSitePlusiP24001.
SwissPalmiP24001.

Polymorphism and mutation databases

BioMutaiIL32.
DMDMi119364597.

Proteomic databases

MaxQBiP24001.
PeptideAtlasiP24001.
PRIDEiP24001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000008180; ENSP00000008180; ENSG00000008517. [P24001-5]
ENST00000325568; ENSP00000324742; ENSG00000008517. [P24001-2]
ENST00000382213; ENSP00000371648; ENSG00000008517. [P24001-6]
ENST00000396887; ENSP00000380096; ENSG00000008517. [P24001-4]
ENST00000396890; ENSP00000380099; ENSG00000008517. [P24001-1]
ENST00000440815; ENSP00000405063; ENSG00000008517. [P24001-2]
ENST00000444393; ENSP00000411958; ENSG00000008517. [P24001-2]
ENST00000525643; ENSP00000432218; ENSG00000008517. [P24001-2]
ENST00000526464; ENSP00000450364; ENSG00000008517. [P24001-2]
ENST00000528163; ENSP00000432850; ENSG00000008517. [P24001-2]
ENST00000529550; ENSP00000437020; ENSG00000008517. [P24001-2]
ENST00000530538; ENSP00000436929; ENSG00000008517. [P24001-2]
ENST00000530890; ENSP00000433747; ENSG00000008517. [P24001-5]
ENST00000531965; ENSP00000433177; ENSG00000008517. [P24001-3]
ENST00000533097; ENSP00000432917; ENSG00000008517. [P24001-2]
ENST00000534507; ENSP00000431775; ENSG00000008517. [P24001-1]
ENST00000548246; ENSP00000447979; ENSG00000008517. [P24001-7]
ENST00000548476; ENSP00000449483; ENSG00000008517. [P24001-1]
ENST00000548652; ENSP00000446624; ENSG00000008517. [P24001-6]
ENST00000549213; ENSP00000447812; ENSG00000008517. [P24001-4]
ENST00000551122; ENSP00000447496; ENSG00000008517. [P24001-4]
ENST00000552356; ENSP00000446978; ENSG00000008517. [P24001-5]
ENST00000552664; ENSP00000448683; ENSG00000008517. [P24001-2]
GeneIDi9235.
KEGGihsa:9235.
UCSCiuc002ctk.4. human. [P24001-1]

Organism-specific databases

CTDi9235.
DisGeNETi9235.
GeneCardsiIL32.
HGNCiHGNC:16830. IL32.
HPAiCAB030029.
HPA029397.
MIMi606001. gene.
neXtProtiNX_P24001.
OpenTargetsiENSG00000008517.
PharmGKBiPA128395754.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000000661.
HOGENOMiHOG000293381.
HOVERGENiHBG081790.
InParanoidiP24001.
OMAiELERFCC.
OrthoDBiEOG091G14OI.
PhylomeDBiP24001.
TreeFamiTF341753.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000008517-MONOMER.
ReactomeiR-HSA-449147. Signaling by Interleukins.

Miscellaneous databases

ChiTaRSiIL32. human.
GenomeRNAii9235.
PROiP24001.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000008517.
CleanExiHS_IL32.
ExpressionAtlasiP24001. baseline and differential.
GenevisibleiP24001. HS.

Family and domain databases

InterProiIPR028067. IL-32.
[Graphical view]
PfamiPF15225. IL32. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL32_HUMAN
AccessioniPrimary (citable) accession number: P24001
Secondary accession number(s): A6NNM0
, A8MPX0, B4DJM1, B8Q191, D3DUB0, D3DUB2, Q5VFH7, Q5VFH8, Q8WV38, Q96GK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: December 12, 2006
Last modified: November 2, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.