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Protein

60S ribosomal protein L24-B

Gene

RPL24B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

Present with 36900 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for eL24 in yeast.Curated

GO - Molecular functioni

  • RNA binding Source: SGD
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-30851-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L24-B1 Publication
Alternative name(s):
L30
Large ribosomal subunit protein eL24-B1 Publication
RP29
YL21
Gene namesi
Name:RPL24B1 Publication
Synonyms:RPL30B
Ordered Locus Names:YGR148C
ORF Names:G6635
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR148C.
SGDiS000003380. RPL24B.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: SGD

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001368951 – 15560S ribosomal protein L24-BAdd BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP24000.
PRIDEiP24000.

PTM databases

iPTMnetiP24000.

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi33396. 114 interactors.
DIPiDIP-4722N.
IntActiP24000. 7 interactors.
MINTiMINT-502170.
STRINGi4932.YGR148C.

Structurei

3D structure databases

ProteinModelPortaliP24000.
SMRiP24000.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000184343.
InParanoidiP24000.
KOiK02896.
OMAiRRHHKKG.
OrthoDBiEOG092C5LTS.

Family and domain databases

CDDicd00472. Ribosomal_L24e_L24. 1 hit.
InterProiView protein in InterPro
IPR000988. Ribosomal_L24e-rel.
IPR023442. Ribosomal_L24e_CS.
PANTHERiPTHR10792. PTHR10792. 1 hit.
PfamiView protein in Pfam
PF01246. Ribosomal_L24e. 1 hit.
PROSITEiView protein in PROSITE
PS01073. RIBOSOMAL_L24E. 1 hit.

Sequencei

Sequence statusi: Complete.

P24000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVEVDSFSG AKIYPGRGTL FVRGDSKIFR FQNSKSASLF KQRKNPRRIA
60 70 80 90 100
WTVLFRKHHK KGITEEVAKK RSRKTVKAQR PITGASLDLI KERRSLKPEV
110 120 130 140 150
RKANREEKLK ANKEKKRAEK AARKAEKAKS AGVQGSKVSK QQAKGAFQKV

AATSR
Length:155
Mass (Da):17,548
Last modified:March 1, 1992 - v1
Checksum:i7EE89CE40D7A657F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34387 Genomic DNA. Translation: AAA34736.1.
X85807 Genomic DNA. Translation: CAA59806.1.
Z72933 Genomic DNA. Translation: CAA97162.1.
AY557819 Genomic DNA. Translation: AAS56145.1.
EF123136 mRNA. Translation: ABM97480.1.
BK006941 Genomic DNA. Translation: DAA08240.1.
PIRiA35925. R6BYY0.
RefSeqiNP_011664.3. NM_001181277.3.

Genome annotation databases

EnsemblFungiiYGR148C; YGR148C; YGR148C.
GeneIDi853051.
KEGGisce:YGR148C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRL24B_YEAST
AccessioniPrimary (citable) accession number: P24000
Secondary accession number(s): A2TBN3, D6VUS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: July 5, 2017
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names