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Protein

60S ribosomal protein L24-B

Gene

RPL24B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

Present with 36900 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for eL24 in yeast.Curated

GO - Molecular functioni

  • RNA binding Source: SGD
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-30851-MONOMER
ReactomeiR-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SCE-72689 Formation of a pool of free 40S subunits
R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L24-B1 Publication
Alternative name(s):
L30
Large ribosomal subunit protein eL24-B1 Publication
RP29
YL21
Gene namesi
Name:RPL24B1 Publication
Synonyms:RPL30B
Ordered Locus Names:YGR148C
ORF Names:G6635
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGR148C
SGDiS000003380 RPL24B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001368951 – 15560S ribosomal protein L24-BAdd BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei7PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP24000
PaxDbiP24000
PRIDEiP24000

PTM databases

iPTMnetiP24000

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi33396, 116 interactors
DIPiDIP-4722N
IntActiP24000, 8 interactors
MINTiP24000
STRINGi4932.YGR148C

Structurei

3D structure databases

ProteinModelPortaliP24000
SMRiP24000
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000074809
HOGENOMiHOG000184343
InParanoidiP24000
KOiK02896
OMAiFHQRKNP
OrthoDBiEOG092C5LTS

Family and domain databases

CDDicd00472 Ribosomal_L24e_L24, 1 hit
Gene3Di2.30.170.20, 1 hit
InterProiView protein in InterPro
IPR038630 L24e/L24_sf
IPR000988 Ribosomal_L24e-rel
IPR023442 Ribosomal_L24e_CS
PANTHERiPTHR10792 PTHR10792, 1 hit
PfamiView protein in Pfam
PF01246 Ribosomal_L24e, 1 hit
PROSITEiView protein in PROSITE
PS01073 RIBOSOMAL_L24E, 1 hit

Sequencei

Sequence statusi: Complete.

P24000-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVEVDSFSG AKIYPGRGTL FVRGDSKIFR FQNSKSASLF KQRKNPRRIA
60 70 80 90 100
WTVLFRKHHK KGITEEVAKK RSRKTVKAQR PITGASLDLI KERRSLKPEV
110 120 130 140 150
RKANREEKLK ANKEKKRAEK AARKAEKAKS AGVQGSKVSK QQAKGAFQKV

AATSR
Length:155
Mass (Da):17,548
Last modified:March 1, 1992 - v1
Checksum:i7EE89CE40D7A657F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34387 Genomic DNA Translation: AAA34736.1
X85807 Genomic DNA Translation: CAA59806.1
Z72933 Genomic DNA Translation: CAA97162.1
AY557819 Genomic DNA Translation: AAS56145.1
EF123136 mRNA Translation: ABM97480.1
BK006941 Genomic DNA Translation: DAA08240.1
PIRiA35925 R6BYY0
RefSeqiNP_011664.3, NM_001181277.3

Genome annotation databases

EnsemblFungiiYGR148C; YGR148C; YGR148C
GeneIDi853051
KEGGisce:YGR148C

Similar proteinsi

Entry informationi

Entry nameiRL24B_YEAST
AccessioniPrimary (citable) accession number: P24000
Secondary accession number(s): A2TBN3, D6VUS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: April 25, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health