Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot P23991 (ADH1_CHICK)

Last modified June 16, 2009. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Alcohol dehydrogenase 1
      Short name=ADH-1
    EC=1.1.1.1
Alternative name(s):
    Alcohol dehydrogenase I
Gene names
Name: ADH1
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Hide | Top

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Catalytic activity

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit.

Subunit structure

Homodimer.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily.

Hide | Top

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
   PTMAcetylation
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionalcohol dehydrogenase activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 376375Alcohol dehydrogenase 1
PRO_0000160672

Regions

Nucleotide binding201 – 2066NAD By similarity
Nucleotide binding294 – 2963NAD By similarity

Sites

Metal binding471Zinc 1; catalytic
Metal binding681Zinc 1; catalytic
Metal binding981Zinc 2
Metal binding1011Zinc 2
Metal binding1041Zinc 2
Metal binding1121Zinc 2
Metal binding1761Zinc 1; catalytic
Binding site2251NAD By similarity
Binding site2301NAD By similarity
Binding site3711NAD By similarity

Amino acid modifications

Modified residue21N-acetylserine Ref.2

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
P23991-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: CCD03989E53273DE

FASTA37639,808
        10         20         30         40         50         60 
MSTVGKVIKC KAAVLWEANK PFSLEEVEVA PPKAHEVRIK IVATGICRSD DHVVTGALAM 

        70         80         90        100        110        120 
PFPIILGHEA AGVIESVGEK VTSLKPGDAV IPLFVPQCGE CRSCLSTKGN LCIKNDLSSS 

       130        140        150        160        170        180 
PTGLMADGTT RFTCKGKAIH HFVGTSTFTE YTVVHETAAA KIDSAAPLEK VCLIGCGFST 

       190        200        210        220        230        240 
GYGAVLQTAK VEAGSTCAVF GLGGVGLSVV MGCKAAGASR IIAVDINKDK FAKAKELGAT 

       250        260        270        280        290        300 
ECINPKDFKK PIHEVLTEMT GQGVDYSFEV IGRIETMTAA LASCHNNYGV SVIVGVPPAA 

       310        320        330        340        350        360 
QKISFDPMLI FSGRTWKGSV FGGWKSKDAV PKLVADYMKK KFVLDPLITH TLPFTKINEG 

       370 
FDLLRTGKSI RSVLVL

« Hide

Hide | Top

References

[1]"Avian alcohol dehydrogenase: the chicken liver enzyme. Primary structure, cDNA-cloning, and relationships to other alcohol dehydrogenases."
Estonius M., Karlsson C., Fox E.A., Hoeoeg J.-O., Holmquist B., Vallee B.L., Davidson W.S., Joernvall H.
Eur. J. Biochem. 194:593-602(1990) [PubMed: 2269284] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Fast atom bombardment mass spectrometry and chemical analysis in determinations of acyl-blocked protein structures."
Egestad B., Estonius M., Danielsson O., Persson B., Cederlund E., Kaiser R., Holmquist B., Vallee B., Pares X., Jefferey J., Joernvall H.
FEBS Lett. 269:194-196(1990) [PubMed: 2387402] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-17 AND 360-376.

Hide | Top

Cross-references

Sequence databases

X54612 mRNA. Translation: CAA38433.1. Sequence problems.
IPIIPI00599701.
PIRDECHA1. S13851.
UniGeneGga.4115

3D structure databases

HSSPHSSP built from PDB template 1HEU based on UniProtKB P00327.
SMRP23991. Positions 2-376.
ModBaseSearch...

Genome annotation databases

EnsemblENSGALG00000012250. Gallus gallus. [Contig view]

Phylogenomic databases

HOVERGENP23991.

Enzyme and pathway databases

BRENDA1.1.1.1. 4.

Family and domain databases

InterProIPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn.
IPR013149. ADH_Zn-bd.
IPR002328. ADH_Zn_CS.
[Graphical view]
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry nameADH1_CHICK
AccessionPrimary (citable) accession number: P23991
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: June 16, 2009
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Hide | Top

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents