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Protein

Alcohol dehydrogenase 1

Gene

ADH1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+Note: Binds 2 Zn2+ ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi47Zinc 1; catalytic1
Metal bindingi68Zinc 1; catalytic1
Metal bindingi98Zinc 21
Metal bindingi101Zinc 21
Metal bindingi104Zinc 21
Metal bindingi112Zinc 21
Metal bindingi176Zinc 1; catalytic1
Binding sitei225NADBy similarity1
Binding sitei230NADBy similarity1
Binding sitei371NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi201 – 206NADBy similarity6
Nucleotide bindingi294 – 296NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Short name:
ADH-1
Alternative name(s):
Alcohol dehydrogenase I
Gene namesi
Name:ADH1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001606722 – 376Alcohol dehydrogenase 1Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP23991
PRIDEiP23991

PTM databases

iPTMnetiP23991

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019979

Structurei

3D structure databases

ProteinModelPortaliP23991
SMRiP23991
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022 Eukaryota
COG1062 LUCA
HOGENOMiHOG000294674
HOVERGENiHBG000195
InParanoidiP23991
KOiK13951
PhylomeDBiP23991

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 2 hits
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23991-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTVGKVIKC KAAVLWEANK PFSLEEVEVA PPKAHEVRIK IVATGICRSD
60 70 80 90 100
DHVVTGALAM PFPIILGHEA AGVIESVGEK VTSLKPGDAV IPLFVPQCGE
110 120 130 140 150
CRSCLSTKGN LCIKNDLSSS PTGLMADGTT RFTCKGKAIH HFVGTSTFTE
160 170 180 190 200
YTVVHETAAA KIDSAAPLEK VCLIGCGFST GYGAVLQTAK VEAGSTCAVF
210 220 230 240 250
GLGGVGLSVV MGCKAAGASR IIAVDINKDK FAKAKELGAT ECINPKDFKK
260 270 280 290 300
PIHEVLTEMT GQGVDYSFEV IGRIETMTAA LASCHNNYGV SVIVGVPPAA
310 320 330 340 350
QKISFDPMLI FSGRTWKGSV FGGWKSKDAV PKLVADYMKK KFVLDPLITH
360 370
TLPFTKINEG FDLLRTGKSI RSVLVL
Length:376
Mass (Da):39,808
Last modified:January 23, 2007 - v2
Checksum:iCCD03989E53273DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54612 mRNA Translation: CAA38433.1 Sequence problems.
PIRiS13851 DECHA1
RefSeqiNP_001292112.1, NM_001305183.1
UniGeneiGga.3415
Gga.4115

Genome annotation databases

GeneIDi771920
KEGGigga:771920

Similar proteinsi

Entry informationi

Entry nameiADH1_CHICK
AccessioniPrimary (citable) accession number: P23991
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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