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Protein

Beta-galactosidase

Gene

lacZ

Organism
Streptococcus thermophilus
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei458Proton donorBy similarity1
Active sitei546NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

SABIO-RKiP23989

Protein family/group databases

CAZyiGH2 Glycoside Hydrolase Family 2

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Short name:
Beta-gal
Alternative name(s):
Lactase
Gene namesi
Name:lacZ
OrganismiStreptococcus thermophilus
Taxonomic identifieri1308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000576761 – 1026Beta-galactosidaseAdd BLAST1026

Structurei

3D structure databases

ProteinModelPortaliP23989
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.Curated

Phylogenomic databases

eggNOGiENOG4105CNT Bacteria
COG3250 LUCA

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.40.10, 2 hits
2.70.98.10, 1 hit
InterProiView protein in InterPro
IPR004199 B-gal_small/dom_5
IPR036156 Beta-gal/glucu_dom_sf
IPR011013 Gal_mutarotase_sf_dom
IPR008979 Galactose-bd-like_sf
IPR014718 GH-type_carb-bd
IPR006101 Glyco_hydro_2
IPR023232 Glyco_hydro_2_AS
IPR006103 Glyco_hydro_2_cat
IPR023230 Glyco_hydro_2_CS
IPR006102 Glyco_hydro_2_Ig-like
IPR006104 Glyco_hydro_2_N
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
IPR032312 LacZ_4
PfamiView protein in Pfam
PF02929 Bgal_small_N, 1 hit
PF16353 DUF4981, 1 hit
PF00703 Glyco_hydro_2, 1 hit
PF02836 Glyco_hydro_2_C, 1 hit
PF02837 Glyco_hydro_2_N, 1 hit
PRINTSiPR00132 GLHYDRLASE2
SMARTiView protein in SMART
SM01038 Bgal_small_N, 1 hit
SUPFAMiSSF49303 SSF49303, 2 hits
SSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 1 hit
SSF74650 SSF74650, 1 hit
PROSITEiView protein in PROSITE
PS00719 GLYCOSYL_HYDROL_F2_1, 1 hit
PS00608 GLYCOSYL_HYDROL_F2_2, 1 hit

Sequencei

Sequence statusi: Complete.

P23989-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMTEKIQTY LNDPKIVSVN TVDAHSDHKY FESLEEFSEG EMKLRQSLNG
60 70 80 90 100
KWKIHYAQNT NQVLKDFYKT EFDETDLNFI NVPGHLELQG FGSPQYVNTQ
110 120 130 140 150
YPWDGKEFLR PPQVPQESNA VASYVKHFTL NDALKDKKVF ISFQGVATSI
160 170 180 190 200
FVWVNGNFVG YSEDSFTPSE FEISDYLVEG DNKLAVAVYR YSTASWLEDQ
210 220 230 240 250
DFWRLYGIFR DVYLYAIPKV HVQDLFVKGD YDYQTKAGQL DIDLKTVGDY
260 270 280 290 300
EDKKIKYVLS DYEGIVTEGD ASVNGDGELS VSLENLKIKP WSAESPKLYD
310 320 330 340 350
LILHVLDDDQ VVEVVPVKVG FRRFEIKDKL MLLNGKRIVF KGVNRHEFNA
360 370 380 390 400
RTGRCITEED MLWDIKVMKQ HNINAVRTSH YPNQTRWYEL CDEYGLYVID
410 420 430 440 450
EANLETHGTW QKLGLCEPSW NIPASEPEWL PACLDRANNM FQRDKNHASV
460 470 480 490 500
IIWSCGNESY AGKDIADMAD YFRSVDNTRP VHYEGVAWCR EFDYITDIES
510 520 530 540 550
RMYAKPADIE EYLTTGKLVD LSSVSDKHFA SGNLTNKPQK PYISCEYMHT
560 570 580 590 600
MGNSGGGLQL YTDLEKYPEY QGGFIWDFID QAIYKTLPNG SEFLSYGGDW
610 620 630 640 650
HDRPSDYEFC GNGIVFADRT LTPKLQTVKH LYSNIKIAVD EKSVTIKNDN
660 670 680 690 700
LFEDLSAYTF LARVYEDGRK VSESEYHFDV KPGEEATFPV NFVVEASNSE
710 720 730 740 750
QIYEVACVLR EATEWAPKGH EIVRGQYVVE KISTETPVKA PLNVVEGDFN
760 770 780 790 800
IGIQGQNFSI LLSRAQNTLV SAKYNGVEFI EKGPKLSFTR AYTDNDRGAG
810 820 830 840 850
YPFEMAGWKV AGNYSKVTDT QIQIEDDSVK VTYVHELPGL SDVEVKVTYQ
860 870 880 890 900
VDYKGRIFVT ANYDGKAGLP NFPEFGLEFA IGSQFTNLSY YGYGAEESYR
910 920 930 940 950
DKLPGAYLGR YETSVEKTFA PYLMPQESGN HYGTREFTVS DDNHNGLKFT
960 970 980 990 1000
ALNKAFEFSA LRNSTEQIEN ARHQYELQES DATWIKVLAA QMGVGGDDTW
1010 1020
GAPVHDEFLL SSADSYQLSF MIEPLN
Length:1,026
Mass (Da):117,046
Last modified:March 1, 1992 - v1
Checksum:iB453AFAD68F08C98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63636 Genomic DNA Translation: AAA63532.1
M63636 Genomic DNA Translation: AAA63533.1
M23009 Genomic DNA Translation: AAA26911.1
PIRiA49750
RefSeqiWP_011226267.1, NZ_PHHG01000006.1

Genome annotation databases

GeneIDi31940342

Similar proteinsi

Entry informationi

Entry nameiBGAL_STRTR
AccessioniPrimary (citable) accession number: P23989
Secondary accession number(s): Q6LDR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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