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P23989 (BGAL_STRTR) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-galactosidase

Short name=Beta-gal
EC=3.2.1.23
Alternative name(s):
Lactase
Gene names
Name:lacZ
OrganismStreptococcus thermophilus
Taxonomic identifier1308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length1026 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sequence similarities

Belongs to the glycosyl hydrolase 2 family.

Ontologies

Keywords
   Molecular functionGlycosidase
Hydrolase
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentbeta-galactosidase complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionbeta-galactosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

carbohydrate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10261026Beta-galactosidase
PRO_0000057676

Sites

Active site4581Proton donor By similarity
Active site5461Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
P23989 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: B453AFAD68F08C98

FASTA1,026117,046
        10         20         30         40         50         60 
MNMTEKIQTY LNDPKIVSVN TVDAHSDHKY FESLEEFSEG EMKLRQSLNG KWKIHYAQNT 

        70         80         90        100        110        120 
NQVLKDFYKT EFDETDLNFI NVPGHLELQG FGSPQYVNTQ YPWDGKEFLR PPQVPQESNA 

       130        140        150        160        170        180 
VASYVKHFTL NDALKDKKVF ISFQGVATSI FVWVNGNFVG YSEDSFTPSE FEISDYLVEG 

       190        200        210        220        230        240 
DNKLAVAVYR YSTASWLEDQ DFWRLYGIFR DVYLYAIPKV HVQDLFVKGD YDYQTKAGQL 

       250        260        270        280        290        300 
DIDLKTVGDY EDKKIKYVLS DYEGIVTEGD ASVNGDGELS VSLENLKIKP WSAESPKLYD 

       310        320        330        340        350        360 
LILHVLDDDQ VVEVVPVKVG FRRFEIKDKL MLLNGKRIVF KGVNRHEFNA RTGRCITEED 

       370        380        390        400        410        420 
MLWDIKVMKQ HNINAVRTSH YPNQTRWYEL CDEYGLYVID EANLETHGTW QKLGLCEPSW 

       430        440        450        460        470        480 
NIPASEPEWL PACLDRANNM FQRDKNHASV IIWSCGNESY AGKDIADMAD YFRSVDNTRP 

       490        500        510        520        530        540 
VHYEGVAWCR EFDYITDIES RMYAKPADIE EYLTTGKLVD LSSVSDKHFA SGNLTNKPQK 

       550        560        570        580        590        600 
PYISCEYMHT MGNSGGGLQL YTDLEKYPEY QGGFIWDFID QAIYKTLPNG SEFLSYGGDW 

       610        620        630        640        650        660 
HDRPSDYEFC GNGIVFADRT LTPKLQTVKH LYSNIKIAVD EKSVTIKNDN LFEDLSAYTF 

       670        680        690        700        710        720 
LARVYEDGRK VSESEYHFDV KPGEEATFPV NFVVEASNSE QIYEVACVLR EATEWAPKGH 

       730        740        750        760        770        780 
EIVRGQYVVE KISTETPVKA PLNVVEGDFN IGIQGQNFSI LLSRAQNTLV SAKYNGVEFI 

       790        800        810        820        830        840 
EKGPKLSFTR AYTDNDRGAG YPFEMAGWKV AGNYSKVTDT QIQIEDDSVK VTYVHELPGL 

       850        860        870        880        890        900 
SDVEVKVTYQ VDYKGRIFVT ANYDGKAGLP NFPEFGLEFA IGSQFTNLSY YGYGAEESYR 

       910        920        930        940        950        960 
DKLPGAYLGR YETSVEKTFA PYLMPQESGN HYGTREFTVS DDNHNGLKFT ALNKAFEFSA 

       970        980        990       1000       1010       1020 
LRNSTEQIEN ARHQYELQES DATWIKVLAA QMGVGGDDTW GAPVHDEFLL SSADSYQLSF 


MIEPLN 

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References

[1]"Analysis of the lacZ sequences from two Streptococcus thermophilus strains: comparison with the Escherichia coli and Lactobacillus bulgaricus beta-galactosidase sequences."
Schroeder C.J., Robert C., Lenzen G., McKay L.L., Mercenier A.
J. Gen. Microbiol. 137:369-380(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: A054.
[2]"Lactose transport system of Streptococcus thermophilus: a hybrid protein with homology to the melibiose carrier and enzyme III of phosphoenolpyruvate-dependent phosphotransferase systems."
Poolman B., Royer T.J., Mainzer S.E., Schmidt B.F.
J. Bacteriol. 171:244-253(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-108.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M63636 Genomic DNA. Translation: AAA63532.1.
M63636 Genomic DNA. Translation: AAA63533.1.
M23009 Genomic DNA. Translation: AAA26911.1.
PIRA49750.

3D structure databases

ProteinModelPortalP23989.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

CAZyGH2. Glycoside Hydrolase Family 2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKP23989.

Family and domain databases

Gene3D2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
InterProIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSPR00132. GLHYDRLASE2.
SMARTSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBGAL_STRTR
AccessionPrimary (citable) accession number: P23989
Secondary accession number(s): Q6LDR7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 16, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries