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P23989

- BGAL_STRTR

UniProt

P23989 - BGAL_STRTR

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Protein

Beta-galactosidase

Gene

lacZ

Organism
Streptococcus thermophilus
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei458 – 4581Proton donorBy similarity
Active sitei546 – 5461NucleophileBy similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

SABIO-RKP23989.

Protein family/group databases

CAZyiGH2. Glycoside Hydrolase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidase (EC:3.2.1.23)
Short name:
Beta-gal
Alternative name(s):
Lactase
Gene namesi
Name:lacZ
OrganismiStreptococcus thermophilus
Taxonomic identifieri1308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

GO - Cellular componenti

  1. beta-galactosidase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10261026Beta-galactosidasePRO_0000057676Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP23989.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.Curated

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SMARTiSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23989-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNMTEKIQTY LNDPKIVSVN TVDAHSDHKY FESLEEFSEG EMKLRQSLNG
60 70 80 90 100
KWKIHYAQNT NQVLKDFYKT EFDETDLNFI NVPGHLELQG FGSPQYVNTQ
110 120 130 140 150
YPWDGKEFLR PPQVPQESNA VASYVKHFTL NDALKDKKVF ISFQGVATSI
160 170 180 190 200
FVWVNGNFVG YSEDSFTPSE FEISDYLVEG DNKLAVAVYR YSTASWLEDQ
210 220 230 240 250
DFWRLYGIFR DVYLYAIPKV HVQDLFVKGD YDYQTKAGQL DIDLKTVGDY
260 270 280 290 300
EDKKIKYVLS DYEGIVTEGD ASVNGDGELS VSLENLKIKP WSAESPKLYD
310 320 330 340 350
LILHVLDDDQ VVEVVPVKVG FRRFEIKDKL MLLNGKRIVF KGVNRHEFNA
360 370 380 390 400
RTGRCITEED MLWDIKVMKQ HNINAVRTSH YPNQTRWYEL CDEYGLYVID
410 420 430 440 450
EANLETHGTW QKLGLCEPSW NIPASEPEWL PACLDRANNM FQRDKNHASV
460 470 480 490 500
IIWSCGNESY AGKDIADMAD YFRSVDNTRP VHYEGVAWCR EFDYITDIES
510 520 530 540 550
RMYAKPADIE EYLTTGKLVD LSSVSDKHFA SGNLTNKPQK PYISCEYMHT
560 570 580 590 600
MGNSGGGLQL YTDLEKYPEY QGGFIWDFID QAIYKTLPNG SEFLSYGGDW
610 620 630 640 650
HDRPSDYEFC GNGIVFADRT LTPKLQTVKH LYSNIKIAVD EKSVTIKNDN
660 670 680 690 700
LFEDLSAYTF LARVYEDGRK VSESEYHFDV KPGEEATFPV NFVVEASNSE
710 720 730 740 750
QIYEVACVLR EATEWAPKGH EIVRGQYVVE KISTETPVKA PLNVVEGDFN
760 770 780 790 800
IGIQGQNFSI LLSRAQNTLV SAKYNGVEFI EKGPKLSFTR AYTDNDRGAG
810 820 830 840 850
YPFEMAGWKV AGNYSKVTDT QIQIEDDSVK VTYVHELPGL SDVEVKVTYQ
860 870 880 890 900
VDYKGRIFVT ANYDGKAGLP NFPEFGLEFA IGSQFTNLSY YGYGAEESYR
910 920 930 940 950
DKLPGAYLGR YETSVEKTFA PYLMPQESGN HYGTREFTVS DDNHNGLKFT
960 970 980 990 1000
ALNKAFEFSA LRNSTEQIEN ARHQYELQES DATWIKVLAA QMGVGGDDTW
1010 1020
GAPVHDEFLL SSADSYQLSF MIEPLN
Length:1,026
Mass (Da):117,046
Last modified:March 1, 1992 - v1
Checksum:iB453AFAD68F08C98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63636 Genomic DNA. Translation: AAA63532.1.
M63636 Genomic DNA. Translation: AAA63533.1.
M23009 Genomic DNA. Translation: AAA26911.1.
PIRiA49750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63636 Genomic DNA. Translation: AAA63532.1 .
M63636 Genomic DNA. Translation: AAA63533.1 .
M23009 Genomic DNA. Translation: AAA26911.1 .
PIRi A49750.

3D structure databases

ProteinModelPortali P23989.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH2. Glycoside Hydrolase Family 2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

SABIO-RK P23989.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view ]
PRINTSi PR00132. GLHYDRLASE2.
SMARTi SM01038. Bgal_small_N. 1 hit.
[Graphical view ]
SUPFAMi SSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the lacZ sequences from two Streptococcus thermophilus strains: comparison with the Escherichia coli and Lactobacillus bulgaricus beta-galactosidase sequences."
    Schroeder C.J., Robert C., Lenzen G., McKay L.L., Mercenier A.
    J. Gen. Microbiol. 137:369-380(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A054.
  2. "Lactose transport system of Streptococcus thermophilus: a hybrid protein with homology to the melibiose carrier and enzyme III of phosphoenolpyruvate-dependent phosphotransferase systems."
    Poolman B., Royer T.J., Mainzer S.E., Schmidt B.F.
    J. Bacteriol. 171:244-253(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-108.

Entry informationi

Entry nameiBGAL_STRTR
AccessioniPrimary (citable) accession number: P23989
Secondary accession number(s): Q6LDR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 1, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3