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Protein

Thymidine kinase

Gene

TK

Organism
Infectious laryngotracheitis virus (strain Thorne V882) (ILTV) (Gallid herpesvirus 1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.By similarity

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641Proton acceptorSequence Analysis
Binding sitei108 – 1081SubstrateBy similarity
Binding sitei157 – 1571SubstrateBy similarity
Binding sitei201 – 2011ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 438ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
OrganismiInfectious laryngotracheitis virus (strain Thorne V882) (ILTV) (Gallid herpesvirus 1)
Taxonomic identifieri10344 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeIltovirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Thymidine kinasePRO_0000175081Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP23983.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P23983-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVAGAVKTS GGVQFCSEFE NDDSDFRRVV LLYVDGPFGV GKTVTAKTLM
60 70 80 90 100
QMPNWRGCRL YLAEPMQAWR QWFGGADMIK EINEIQTLKA SGKLECREAS
110 120 130 140 150
PVAVAEVQMT IAAPLRIMNH VIYNYLGSER CYSAAASGPD DVLFLVDRHP
160 170 180 190 200
LAACLCFPVA QYLSGALEFG DLITLLSGIP DIPTHSNIVL MDLDICEQAR
210 220 230 240 250
RIIQRGRPGE TVDWTYLCAL RNSYICLMNT TTYLQRTSYP ALLKEQEALT
260 270 280 290 300
SATLLKFKRE CLETATVPEI NPSIDQTLFA ILAFDQQNVH GERLKTVLSF
310 320 330 340 350
VVQKLATVLK NLCIFYLPAH GLTPEACALK CLEFAETASS LTTKRAAIAS
360
LIDAVERYNA DMGS
Length:364
Mass (Da):40,215
Last modified:March 1, 1992 - v1
Checksum:iC1C04A7342ECCF7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00565 Genomic DNA. Translation: BAA00442.1.
PIRiD43675.
RefSeqiYP_182352.1. NC_006623.1.

Genome annotation databases

GeneIDi3239035.
KEGGivg:3239035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00565 Genomic DNA. Translation: BAA00442.1.
PIRiD43675.
RefSeqiYP_182352.1. NC_006623.1.

3D structure databases

ProteinModelPortaliP23983.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3239035.
KEGGivg:3239035.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Analysis of the nucleotide sequence of DNA from the region of the thymidine kinase gene of infectious laryngotracheitis virus; potential evolutionary relationships between the herpesvirus subfamilies."
    Griffin A.M., Boursnell M.E.
    J. Gen. Virol. 71:841-850(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiKITH_ILTVT
AccessioniPrimary (citable) accession number: P23983
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: April 1, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.