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P23983 (KITH_ILTVT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the herpesviridae thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

TMP biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 364364Thymidine kinase
PRO_0000175081

Regions

Nucleotide binding36 – 438ATP By similarity

Sites

Active site641Proton acceptor Potential
Binding site1081Substrate By similarity
Binding site1571Substrate By similarity
Binding site2011ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P23983 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: C1C04A7342ECCF7E

FASTA36440,215
        10         20         30         40         50         60 
MAVAGAVKTS GGVQFCSEFE NDDSDFRRVV LLYVDGPFGV GKTVTAKTLM QMPNWRGCRL 

        70         80         90        100        110        120 
YLAEPMQAWR QWFGGADMIK EINEIQTLKA SGKLECREAS PVAVAEVQMT IAAPLRIMNH 

       130        140        150        160        170        180 
VIYNYLGSER CYSAAASGPD DVLFLVDRHP LAACLCFPVA QYLSGALEFG DLITLLSGIP 

       190        200        210        220        230        240 
DIPTHSNIVL MDLDICEQAR RIIQRGRPGE TVDWTYLCAL RNSYICLMNT TTYLQRTSYP 

       250        260        270        280        290        300 
ALLKEQEALT SATLLKFKRE CLETATVPEI NPSIDQTLFA ILAFDQQNVH GERLKTVLSF 

       310        320        330        340        350        360 
VVQKLATVLK NLCIFYLPAH GLTPEACALK CLEFAETASS LTTKRAAIAS LIDAVERYNA 


DMGS 

« Hide

References

[1]"Analysis of the nucleotide sequence of DNA from the region of the thymidine kinase gene of infectious laryngotracheitis virus; potential evolutionary relationships between the herpesvirus subfamilies."
Griffin A.M., Boursnell M.E.
J. Gen. Virol. 71:841-850(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D00565 Genomic DNA. Translation: BAA00442.1.
PIRD43675.
RefSeqYP_182352.1. NC_006623.1.

3D structure databases

ProteinModelPortalP23983.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3239035.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKITH_ILTVT
AccessionPrimary (citable) accession number: P23983
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families