SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P23983

- KITH_ILTVT

UniProt

P23983 - KITH_ILTVT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Thymidine kinase
Gene
TK
Organism
Infectious laryngotracheitis virus (strain Thorne V882) (ILTV) (Gallid herpesvirus 1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome By similarity.

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641Proton acceptor Reviewed prediction
Binding sitei108 – 1081Substrate By similarity
Binding sitei157 – 1571Substrate By similarity
Binding sitei201 – 2011ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 438ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. thymidine kinase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
  2. TMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
OrganismiInfectious laryngotracheitis virus (strain Thorne V882) (ILTV) (Gallid herpesvirus 1)
Taxonomic identifieri10344 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeIltovirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Thymidine kinase
PRO_0000175081Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP23983.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00693. Herpes_TK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

P23983-1 [UniParc]FASTAAdd to Basket

« Hide

MAVAGAVKTS GGVQFCSEFE NDDSDFRRVV LLYVDGPFGV GKTVTAKTLM    50
QMPNWRGCRL YLAEPMQAWR QWFGGADMIK EINEIQTLKA SGKLECREAS 100
PVAVAEVQMT IAAPLRIMNH VIYNYLGSER CYSAAASGPD DVLFLVDRHP 150
LAACLCFPVA QYLSGALEFG DLITLLSGIP DIPTHSNIVL MDLDICEQAR 200
RIIQRGRPGE TVDWTYLCAL RNSYICLMNT TTYLQRTSYP ALLKEQEALT 250
SATLLKFKRE CLETATVPEI NPSIDQTLFA ILAFDQQNVH GERLKTVLSF 300
VVQKLATVLK NLCIFYLPAH GLTPEACALK CLEFAETASS LTTKRAAIAS 350
LIDAVERYNA DMGS 364
Length:364
Mass (Da):40,215
Last modified:March 1, 1992 - v1
Checksum:iC1C04A7342ECCF7E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00565 Genomic DNA. Translation: BAA00442.1.
PIRiD43675.
RefSeqiYP_182352.1. NC_006623.1.

Genome annotation databases

GeneIDi3239035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D00565 Genomic DNA. Translation: BAA00442.1 .
PIRi D43675.
RefSeqi YP_182352.1. NC_006623.1.

3D structure databases

ProteinModelPortali P23983.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3239035.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR001889. Herpes_TK.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00693. Herpes_TK. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Analysis of the nucleotide sequence of DNA from the region of the thymidine kinase gene of infectious laryngotracheitis virus; potential evolutionary relationships between the herpesvirus subfamilies."
    Griffin A.M., Boursnell M.E.
    J. Gen. Virol. 71:841-850(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiKITH_ILTVT
AccessioniPrimary (citable) accession number: P23983
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi