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P23983

- KITH_ILTVT

UniProt

P23983 - KITH_ILTVT

Protein

Thymidine kinase

Gene

TK

Organism
Infectious laryngotracheitis virus (strain Thorne V882) (ILTV) (Gallid herpesvirus 1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.By similarity

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei64 – 641Proton acceptorSequence Analysis
    Binding sitei108 – 1081SubstrateBy similarity
    Binding sitei157 – 1571SubstrateBy similarity
    Binding sitei201 – 2011ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi36 – 438ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW
    2. TMP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:TK
    OrganismiInfectious laryngotracheitis virus (strain Thorne V882) (ILTV) (Gallid herpesvirus 1)
    Taxonomic identifieri10344 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeIltovirus
    Virus hostiGallus gallus (Chicken) [TaxID: 9031]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 364364Thymidine kinasePRO_0000175081Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP23983.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR001889. Herpes_TK.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00693. Herpes_TK. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P23983-1 [UniParc]FASTAAdd to Basket

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    MAVAGAVKTS GGVQFCSEFE NDDSDFRRVV LLYVDGPFGV GKTVTAKTLM    50
    QMPNWRGCRL YLAEPMQAWR QWFGGADMIK EINEIQTLKA SGKLECREAS 100
    PVAVAEVQMT IAAPLRIMNH VIYNYLGSER CYSAAASGPD DVLFLVDRHP 150
    LAACLCFPVA QYLSGALEFG DLITLLSGIP DIPTHSNIVL MDLDICEQAR 200
    RIIQRGRPGE TVDWTYLCAL RNSYICLMNT TTYLQRTSYP ALLKEQEALT 250
    SATLLKFKRE CLETATVPEI NPSIDQTLFA ILAFDQQNVH GERLKTVLSF 300
    VVQKLATVLK NLCIFYLPAH GLTPEACALK CLEFAETASS LTTKRAAIAS 350
    LIDAVERYNA DMGS 364
    Length:364
    Mass (Da):40,215
    Last modified:March 1, 1992 - v1
    Checksum:iC1C04A7342ECCF7E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00565 Genomic DNA. Translation: BAA00442.1.
    PIRiD43675.
    RefSeqiYP_182352.1. NC_006623.1.

    Genome annotation databases

    GeneIDi3239035.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00565 Genomic DNA. Translation: BAA00442.1 .
    PIRi D43675.
    RefSeqi YP_182352.1. NC_006623.1.

    3D structure databases

    ProteinModelPortali P23983.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3239035.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR001889. Herpes_TK.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00693. Herpes_TK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the nucleotide sequence of DNA from the region of the thymidine kinase gene of infectious laryngotracheitis virus; potential evolutionary relationships between the herpesvirus subfamilies."
      Griffin A.M., Boursnell M.E.
      J. Gen. Virol. 71:841-850(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiKITH_ILTVT
    AccessioniPrimary (citable) accession number: P23983
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3