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P23975

- SC6A2_HUMAN

UniProt

P23975 - SC6A2_HUMAN

Protein

Sodium-dependent noradrenaline transporter

Gene

SLC6A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.

    GO - Molecular functioni

    1. monoamine transmembrane transporter activity Source: MGI
    2. norepinephrine:sodium symporter activity Source: ProtInc
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. monoamine transport Source: MGI
    2. norepinephrine transport Source: Ensembl
    3. response to drug Source: Ensembl
    4. response to pain Source: Ensembl
    5. synaptic transmission Source: ProtInc
    6. transmembrane transport Source: Reactome
    7. transport Source: ProtInc

    Keywords - Biological processi

    Neurotransmitter transport, Symport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_20506. Na+/Cl- dependent neurotransmitter transporters.

    Protein family/group databases

    TCDBi2.A.22.1.2. the neurotransmitter:sodium symporter (nss) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium-dependent noradrenaline transporter
    Alternative name(s):
    Norepinephrine transporter
    Short name:
    NET
    Solute carrier family 6 member 2
    Gene namesi
    Name:SLC6A2
    Synonyms:NAT1, NET1, SLC6A5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:11048. SLC6A2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. integral component of plasma membrane Source: ProtInc
    3. membrane Source: ProtInc
    4. membrane raft Source: Ensembl
    5. neuron projection Source: Ensembl
    6. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Orthostatic intolerance (OI) [MIM:604715]: Syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti457 – 4571A → P in OI; loss of function. 1 Publication
    VAR_010022

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi604715. phenotype.
    PharmGKBiPA310.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 617617Sodium-dependent noradrenaline transporterPRO_0000214748Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi184 – 1841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP23975.
    PRIDEiP23975.

    PTM databases

    PhosphoSiteiP23975.

    Expressioni

    Gene expression databases

    ArrayExpressiP23975.
    BgeeiP23975.
    CleanExiHS_NAT1.
    HS_NET1.
    HS_SLC6A2.
    HS_SLC6A5.
    GenevestigatoriP23975.

    Organism-specific databases

    HPAiHPA004057.

    Interactioni

    Subunit structurei

    Interacts with PRKCABP.1 Publication

    Protein-protein interaction databases

    BioGridi112421. 3 interactions.
    MINTiMINT-197872.
    STRINGi9606.ENSP00000369237.

    Structurei

    3D structure databases

    ProteinModelPortaliP23975.
    SMRiP23975. Positions 56-594.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6464CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini157 – 23478ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini576 – 61742CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei65 – 8521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei93 – 11220Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei136 – 15621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei235 – 25319Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei262 – 27918Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei315 – 33218Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei344 – 36522Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei398 – 41720Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei444 – 46219Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei478 – 49821Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei519 – 53820Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei557 – 57519Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0733.
    HOGENOMiHOG000116406.
    HOVERGENiHBG071421.
    KOiK05035.
    OMAiAYCITPE.
    OrthoDBiEOG793B71.
    PhylomeDBiP23975.
    TreeFamiTF343812.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    IPR002435. Na/ntran_symport_noradrenaline.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR00176. NANEUSMPORT.
    PR01201. NORTRANSPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P23975-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLLARMNPQV QPENNGADTG PEQPLRARKT AELLVVKERN GVQCLLAPRD    50
    GDAQPRETWG KKIDFLLSVV GFAVDLANVW RFPYLCYKNG GGAFLIPYTL 100
    FLIIAGMPLF YMELALGQYN REGAATVWKI CPFFKGVGYA VILIALYVGF 150
    YYNVIIAWSL YYLFSSFTLN LPWTDCGHTW NSPNCTDPKL LNGSVLGNHT 200
    KYSKYKFTPA AEFYERGVLH LHESSGIHDI GLPQWQLLLC LMVVVIVLYF 250
    SLWKGVKTSG KVVWITATLP YFVLFVLLVH GVTLPGASNG INAYLHIDFY 300
    RLKEATVWID AATQIFFSLG AGFGVLIAFA SYNKFDNNCY RDALLTSSIN 350
    CITSFVSGFA IFSILGYMAH EHKVNIEDVA TEGAGLVFIL YPEAISTLSG 400
    STFWAVVFFV MLLALGLDSS MGGMEAVITG LADDFQVLKR HRKLFTFGVT 450
    FSTFLLALFC ITKGGIYVLT LLDTFAAGTS ILFAVLMEAI GVSWFYGVDR 500
    FSNDIQQMMG FRPGLYWRLC WKFVSPAFLL FVVVVSIINF KPLTYDDYIF 550
    PPWANWVGWG IALSSMVLVP IYVIYKFLST QGSLWERLAY GITPENEHHL 600
    VAQRDIRQFQ LQHWLAI 617
    Length:617
    Mass (Da):69,332
    Last modified:March 1, 1992 - v1
    Checksum:iBDC6DF31316907BB
    GO
    Isoform 2 (identifier: P23975-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         611-617: LQHWLAI → MKTRQGRRRATNSCQISC

    Show »
    Length:628
    Mass (Da):70,548
    Checksum:i4CF79AD92F272587
    GO
    Isoform 3 (identifier: P23975-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-135: MLLARMNPQV...TVWKICPFFK → MGVQWWSHTQGEVAVGLGLGDSYLTPCPCP

    Show »
    Length:512
    Mass (Da):57,370
    Checksum:iB25C836CA8BA912F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti7 – 71N → K.
    Corresponds to variant rs11568323 [ dbSNP | Ensembl ].
    VAR_029157
    Natural varianti69 – 691V → I.
    Corresponds to variant rs1805064 [ dbSNP | Ensembl ].
    VAR_011756
    Natural varianti99 – 991T → I.
    Corresponds to variant rs1805065 [ dbSNP | Ensembl ].
    VAR_011757
    Natural varianti245 – 2451V → I.
    Corresponds to variant rs1805066 [ dbSNP | Ensembl ].
    VAR_011758
    Natural varianti283 – 2831T → R.
    Corresponds to variant rs45564432 [ dbSNP | Ensembl ].
    VAR_020048
    Natural varianti292 – 2921N → T.
    Corresponds to variant rs5563 [ dbSNP | Ensembl ].
    VAR_011759
    Natural varianti356 – 3561V → L.
    Corresponds to variant rs5565 [ dbSNP | Ensembl ].
    VAR_011760
    Natural varianti369 – 3691A → P.
    Corresponds to variant rs5566 [ dbSNP | Ensembl ].
    VAR_011761
    Natural varianti375 – 3751N → S.
    Corresponds to variant rs5567 [ dbSNP | Ensembl ].
    VAR_011762
    Natural varianti449 – 4491V → I.
    Corresponds to variant rs2234910 [ dbSNP | Ensembl ].
    VAR_014800
    Natural varianti457 – 4571A → P in OI; loss of function. 1 Publication
    VAR_010022
    Natural varianti463 – 4631K → R.
    Corresponds to variant rs5570 [ dbSNP | Ensembl ].
    VAR_011763
    Natural varianti478 – 4781G → S.
    Corresponds to variant rs1805067 [ dbSNP | Ensembl ].
    VAR_011764
    Natural varianti528 – 5281F → C.
    Corresponds to variant rs5558 [ dbSNP | Ensembl ].
    VAR_011765
    Natural varianti548 – 5481Y → H.
    Corresponds to variant rs5559 [ dbSNP | Ensembl ].
    VAR_011766
    Natural varianti549 – 5491I → T.
    Corresponds to variant rs3743788 [ dbSNP | Ensembl ].
    VAR_021861

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 135135MLLAR…CPFFK → MGVQWWSHTQGEVAVGLGLG DSYLTPCPCP in isoform 3. 1 PublicationVSP_054119Add
    BLAST
    Alternative sequencei611 – 6177LQHWLAI → MKTRQGRRRATNSCQISC in isoform 2. CuratedVSP_044479

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M65105 mRNA. Translation: AAA59943.1.
    X91117
    , X91120, X91121, X91122, X91123, X91124, X91125, X91126, X91127, X91118, X91119 Genomic DNA. Translation: CAA62566.1.
    X91117
    , X91118, X91119, X91120, X91121, X91122, X91123, X91124, X91125, X91126, X91127 Genomic DNA. Translation: CAC39181.1.
    AK301811 mRNA. Translation: BAG63260.1.
    AK312793 mRNA. Translation: BAG35654.1.
    AC136621 Genomic DNA. No translation available.
    CH471092 Genomic DNA. Translation: EAW82831.1.
    CH471092 Genomic DNA. Translation: EAW82833.1.
    CH471092 Genomic DNA. Translation: EAW82835.1.
    CCDSiCCDS10754.1. [P23975-1]
    CCDS54011.1. [P23975-2]
    CCDS58463.1. [P23975-3]
    PIRiS14278.
    RefSeqiNP_001034.1. NM_001043.3. [P23975-1]
    NP_001165972.1. NM_001172501.1. [P23975-1]
    NP_001165973.1. NM_001172502.1. [P23975-3]
    NP_001165975.1. NM_001172504.1. [P23975-2]
    XP_006721326.1. XM_006721263.1. [P23975-2]
    UniGeneiHs.78036.

    Genome annotation databases

    EnsembliENST00000219833; ENSP00000219833; ENSG00000103546. [P23975-2]
    ENST00000379906; ENSP00000369237; ENSG00000103546. [P23975-1]
    ENST00000567238; ENSP00000457375; ENSG00000103546. [P23975-3]
    ENST00000568943; ENSP00000457473; ENSG00000103546. [P23975-1]
    GeneIDi6530.
    KEGGihsa:6530.
    UCSCiuc002eif.3. human. [P23975-1]
    uc002eii.3. human.
    uc021tio.1. human. [P23975-2]

    Polymorphism databases

    DMDMi128616.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M65105 mRNA. Translation: AAA59943.1 .
    X91117
    , X91120 , X91121 , X91122 , X91123 , X91124 , X91125 , X91126 , X91127 , X91118 , X91119 Genomic DNA. Translation: CAA62566.1 .
    X91117
    , X91118 , X91119 , X91120 , X91121 , X91122 , X91123 , X91124 , X91125 , X91126 , X91127 Genomic DNA. Translation: CAC39181.1 .
    AK301811 mRNA. Translation: BAG63260.1 .
    AK312793 mRNA. Translation: BAG35654.1 .
    AC136621 Genomic DNA. No translation available.
    CH471092 Genomic DNA. Translation: EAW82831.1 .
    CH471092 Genomic DNA. Translation: EAW82833.1 .
    CH471092 Genomic DNA. Translation: EAW82835.1 .
    CCDSi CCDS10754.1. [P23975-1 ]
    CCDS54011.1. [P23975-2 ]
    CCDS58463.1. [P23975-3 ]
    PIRi S14278.
    RefSeqi NP_001034.1. NM_001043.3. [P23975-1 ]
    NP_001165972.1. NM_001172501.1. [P23975-1 ]
    NP_001165973.1. NM_001172502.1. [P23975-3 ]
    NP_001165975.1. NM_001172504.1. [P23975-2 ]
    XP_006721326.1. XM_006721263.1. [P23975-2 ]
    UniGenei Hs.78036.

    3D structure databases

    ProteinModelPortali P23975.
    SMRi P23975. Positions 56-594.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112421. 3 interactions.
    MINTi MINT-197872.
    STRINGi 9606.ENSP00000369237.

    Chemistry

    BindingDBi P23975.
    ChEMBLi CHEMBL2363064.
    DrugBanki DB04836. Amineptine.
    DB00321. Amitriptyline.
    DB00543. Amoxapine.
    DB00289. Atomoxetine.
    DB00217. Bethanidine.
    DB01156. Bupropion.
    DB01242. Clomipramine.
    DB00907. Cocaine.
    DB04840. Debrisoquin.
    DB01151. Desipramine.
    DB00937. Diethylpropion.
    DB01142. Doxepin.
    DB00476. Duloxetine.
    DB00696. Ergotamine.
    DB00226. Guanadrel Sulfate.
    DB01170. Guanethidine.
    DB00458. Imipramine.
    DB00934. Maprotiline.
    DB00579. Mazindol.
    DB00422. Methylphenidate.
    DB04896. Milnacipran.
    DB01149. Nefazodone.
    DB00368. Norepinephrine.
    DB00540. Nortriptyline.
    DB00715. Paroxetine.
    DB00830. Phenmetrazine.
    DB00191. Phentermine.
    DB00344. Protriptyline.
    DB00234. Reboxetine.
    DB01105. Sibutramine.
    DB00193. Tramadol.
    DB00656. Trazodone.
    DB00726. Trimipramine.
    DB00285. Venlafaxine.
    GuidetoPHARMACOLOGYi 926.

    Protein family/group databases

    TCDBi 2.A.22.1.2. the neurotransmitter:sodium symporter (nss) family.

    PTM databases

    PhosphoSitei P23975.

    Polymorphism databases

    DMDMi 128616.

    Proteomic databases

    PaxDbi P23975.
    PRIDEi P23975.

    Protocols and materials databases

    DNASUi 6530.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000219833 ; ENSP00000219833 ; ENSG00000103546 . [P23975-2 ]
    ENST00000379906 ; ENSP00000369237 ; ENSG00000103546 . [P23975-1 ]
    ENST00000567238 ; ENSP00000457375 ; ENSG00000103546 . [P23975-3 ]
    ENST00000568943 ; ENSP00000457473 ; ENSG00000103546 . [P23975-1 ]
    GeneIDi 6530.
    KEGGi hsa:6530.
    UCSCi uc002eif.3. human. [P23975-1 ]
    uc002eii.3. human.
    uc021tio.1. human. [P23975-2 ]

    Organism-specific databases

    CTDi 6530.
    GeneCardsi GC16P055745.
    HGNCi HGNC:11048. SLC6A2.
    HPAi HPA004057.
    MIMi 163970. gene.
    604715. phenotype.
    neXtProti NX_P23975.
    PharmGKBi PA310.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0733.
    HOGENOMi HOG000116406.
    HOVERGENi HBG071421.
    KOi K05035.
    OMAi AYCITPE.
    OrthoDBi EOG793B71.
    PhylomeDBi P23975.
    TreeFami TF343812.

    Enzyme and pathway databases

    Reactomei REACT_20506. Na+/Cl- dependent neurotransmitter transporters.

    Miscellaneous databases

    GeneWikii Norepinephrine_transporter.
    GenomeRNAii 6530.
    NextBioi 25407.
    PROi P23975.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P23975.
    Bgeei P23975.
    CleanExi HS_NAT1.
    HS_NET1.
    HS_SLC6A2.
    HS_SLC6A5.
    Genevestigatori P23975.

    Family and domain databases

    InterProi IPR000175. Na/ntran_symport.
    IPR002435. Na/ntran_symport_noradrenaline.
    [Graphical view ]
    PANTHERi PTHR11616. PTHR11616. 1 hit.
    Pfami PF00209. SNF. 1 hit.
    [Graphical view ]
    PRINTSi PR00176. NANEUSMPORT.
    PR01201. NORTRANSPORT.
    PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter."
      Pacholczyk T., Blakely R.D., Amara S.G.
      Nature 350:350-354(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Molecular cloning and organization of the coding region of the human norepinephrine transporter gene."
      Poerzgen P., Boenisch H., Bruss M.
      Biochem. Biophys. Res. Commun. 215:1145-1150(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Lung.
    3. "The human noradrenaline transporter gene contains multiple polyadenylation sites and two alternatively spliced C-terminal exons."
      Porzgen P., Bonisch H., Hammermann R., Bruss M.
      Biochim. Biophys. Acta 1398:365-370(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2), ALTERNATIVE SPLICING.
      Tissue: Lung.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Testis.
    5. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1."
      Torres G.E., Yao W.-D., Mohn A.R., Quan H., Kim K.-M., Levey A.I., Staudinger J., Caron M.G.
      Neuron 30:121-134(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PRKCABP.
    8. "Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency."
      Shannon J.R., Flattem N.L., Jordan J., Jacob G., Black B.K., Biaggioni I., Blakely R.D., Robertson D.
      N. Engl. J. Med. 342:541-549(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT OI PRO-457.

    Entry informationi

    Entry nameiSC6A2_HUMAN
    AccessioniPrimary (citable) accession number: P23975
    Secondary accession number(s): B2R707, B4DX48, Q96KH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 144 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3