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P23975

- SC6A2_HUMAN

UniProt

P23975 - SC6A2_HUMAN

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Protein

Sodium-dependent noradrenaline transporter

Gene
SLC6A2, NAT1, NET1, SLC6A5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.

GO - Molecular functioni

  1. monoamine transmembrane transporter activity Source: MGI
  2. norepinephrine:sodium symporter activity Source: ProtInc
  3. protein binding Source: UniProtKB

GO - Biological processi

  1. monoamine transport Source: MGI
  2. norepinephrine transport Source: Ensembl
  3. response to drug Source: Ensembl
  4. response to pain Source: Ensembl
  5. synaptic transmission Source: ProtInc
  6. transmembrane transport Source: Reactome
  7. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_20506. Na+/Cl- dependent neurotransmitter transporters.

Protein family/group databases

TCDBi2.A.22.1.2. the neurotransmitter:sodium symporter (nss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent noradrenaline transporter
Alternative name(s):
Norepinephrine transporter
Short name:
NET
Solute carrier family 6 member 2
Gene namesi
Name:SLC6A2
Synonyms:NAT1, NET1, SLC6A5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:11048. SLC6A2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6464Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei65 – 8521Helical; Name=1; Reviewed predictionAdd
BLAST
Transmembranei93 – 11220Helical; Name=2; Reviewed predictionAdd
BLAST
Transmembranei136 – 15621Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini157 – 23478Extracellular Reviewed predictionAdd
BLAST
Transmembranei235 – 25319Helical; Name=4; Reviewed predictionAdd
BLAST
Transmembranei262 – 27918Helical; Name=5; Reviewed predictionAdd
BLAST
Transmembranei315 – 33218Helical; Name=6; Reviewed predictionAdd
BLAST
Transmembranei344 – 36522Helical; Name=7; Reviewed predictionAdd
BLAST
Transmembranei398 – 41720Helical; Name=8; Reviewed predictionAdd
BLAST
Transmembranei444 – 46219Helical; Name=9; Reviewed predictionAdd
BLAST
Transmembranei478 – 49821Helical; Name=10; Reviewed predictionAdd
BLAST
Transmembranei519 – 53820Helical; Name=11; Reviewed predictionAdd
BLAST
Transmembranei557 – 57519Helical; Name=12; Reviewed predictionAdd
BLAST
Topological domaini576 – 61742Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. integral component of plasma membrane Source: ProtInc
  3. membrane Source: ProtInc
  4. membrane raft Source: Ensembl
  5. neuron projection Source: Ensembl
  6. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Orthostatic intolerance (OI) [MIM:604715]: Syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti457 – 4571A → P in OI; loss of function. 1 Publication
VAR_010022

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi604715. phenotype.
PharmGKBiPA310.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617Sodium-dependent noradrenaline transporterPRO_0000214748Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi184 – 1841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi192 – 1921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi198 – 1981N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP23975.
PRIDEiP23975.

PTM databases

PhosphoSiteiP23975.

Expressioni

Gene expression databases

ArrayExpressiP23975.
BgeeiP23975.
CleanExiHS_NAT1.
HS_NET1.
HS_SLC6A2.
HS_SLC6A5.
GenevestigatoriP23975.

Organism-specific databases

HPAiHPA004057.

Interactioni

Subunit structurei

Interacts with PRKCABP.1 Publication

Protein-protein interaction databases

BioGridi112421. 3 interactions.
MINTiMINT-197872.
STRINGi9606.ENSP00000369237.

Structurei

3D structure databases

ProteinModelPortaliP23975.
SMRiP23975. Positions 56-594.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0733.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
KOiK05035.
OMAiAYCITPE.
OrthoDBiEOG793B71.
PhylomeDBiP23975.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002435. Na/ntran_symport_noradrenaline.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01201. NORTRANSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P23975-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLLARMNPQV QPENNGADTG PEQPLRARKT AELLVVKERN GVQCLLAPRD    50
GDAQPRETWG KKIDFLLSVV GFAVDLANVW RFPYLCYKNG GGAFLIPYTL 100
FLIIAGMPLF YMELALGQYN REGAATVWKI CPFFKGVGYA VILIALYVGF 150
YYNVIIAWSL YYLFSSFTLN LPWTDCGHTW NSPNCTDPKL LNGSVLGNHT 200
KYSKYKFTPA AEFYERGVLH LHESSGIHDI GLPQWQLLLC LMVVVIVLYF 250
SLWKGVKTSG KVVWITATLP YFVLFVLLVH GVTLPGASNG INAYLHIDFY 300
RLKEATVWID AATQIFFSLG AGFGVLIAFA SYNKFDNNCY RDALLTSSIN 350
CITSFVSGFA IFSILGYMAH EHKVNIEDVA TEGAGLVFIL YPEAISTLSG 400
STFWAVVFFV MLLALGLDSS MGGMEAVITG LADDFQVLKR HRKLFTFGVT 450
FSTFLLALFC ITKGGIYVLT LLDTFAAGTS ILFAVLMEAI GVSWFYGVDR 500
FSNDIQQMMG FRPGLYWRLC WKFVSPAFLL FVVVVSIINF KPLTYDDYIF 550
PPWANWVGWG IALSSMVLVP IYVIYKFLST QGSLWERLAY GITPENEHHL 600
VAQRDIRQFQ LQHWLAI 617
Length:617
Mass (Da):69,332
Last modified:March 1, 1992 - v1
Checksum:iBDC6DF31316907BB
GO
Isoform 2 (identifier: P23975-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     611-617: LQHWLAI → MKTRQGRRRATNSCQISC

Show »
Length:628
Mass (Da):70,548
Checksum:i4CF79AD92F272587
GO
Isoform 3 (identifier: P23975-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: MLLARMNPQV...TVWKICPFFK → MGVQWWSHTQGEVAVGLGLGDSYLTPCPCP

Show »
Length:512
Mass (Da):57,370
Checksum:iB25C836CA8BA912F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71N → K.
Corresponds to variant rs11568323 [ dbSNP | Ensembl ].
VAR_029157
Natural varianti69 – 691V → I.
Corresponds to variant rs1805064 [ dbSNP | Ensembl ].
VAR_011756
Natural varianti99 – 991T → I.
Corresponds to variant rs1805065 [ dbSNP | Ensembl ].
VAR_011757
Natural varianti245 – 2451V → I.
Corresponds to variant rs1805066 [ dbSNP | Ensembl ].
VAR_011758
Natural varianti283 – 2831T → R.
Corresponds to variant rs45564432 [ dbSNP | Ensembl ].
VAR_020048
Natural varianti292 – 2921N → T.
Corresponds to variant rs5563 [ dbSNP | Ensembl ].
VAR_011759
Natural varianti356 – 3561V → L.
Corresponds to variant rs5565 [ dbSNP | Ensembl ].
VAR_011760
Natural varianti369 – 3691A → P.
Corresponds to variant rs5566 [ dbSNP | Ensembl ].
VAR_011761
Natural varianti375 – 3751N → S.
Corresponds to variant rs5567 [ dbSNP | Ensembl ].
VAR_011762
Natural varianti449 – 4491V → I.
Corresponds to variant rs2234910 [ dbSNP | Ensembl ].
VAR_014800
Natural varianti457 – 4571A → P in OI; loss of function. 1 Publication
VAR_010022
Natural varianti463 – 4631K → R.
Corresponds to variant rs5570 [ dbSNP | Ensembl ].
VAR_011763
Natural varianti478 – 4781G → S.
Corresponds to variant rs1805067 [ dbSNP | Ensembl ].
VAR_011764
Natural varianti528 – 5281F → C.
Corresponds to variant rs5558 [ dbSNP | Ensembl ].
VAR_011765
Natural varianti548 – 5481Y → H.
Corresponds to variant rs5559 [ dbSNP | Ensembl ].
VAR_011766
Natural varianti549 – 5491I → T.
Corresponds to variant rs3743788 [ dbSNP | Ensembl ].
VAR_021861

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 135135MLLAR…CPFFK → MGVQWWSHTQGEVAVGLGLG DSYLTPCPCP in isoform 3. VSP_054119Add
BLAST
Alternative sequencei611 – 6177LQHWLAI → MKTRQGRRRATNSCQISC in isoform 2. VSP_044479

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M65105 mRNA. Translation: AAA59943.1.
X91117
, X91120, X91121, X91122, X91123, X91124, X91125, X91126, X91127, X91118, X91119 Genomic DNA. Translation: CAA62566.1.
X91117
, X91118, X91119, X91120, X91121, X91122, X91123, X91124, X91125, X91126, X91127 Genomic DNA. Translation: CAC39181.1.
AK301811 mRNA. Translation: BAG63260.1.
AK312793 mRNA. Translation: BAG35654.1.
AC136621 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW82831.1.
CH471092 Genomic DNA. Translation: EAW82833.1.
CH471092 Genomic DNA. Translation: EAW82835.1.
CCDSiCCDS10754.1. [P23975-1]
CCDS54011.1. [P23975-2]
CCDS58463.1. [P23975-3]
PIRiS14278.
RefSeqiNP_001034.1. NM_001043.3. [P23975-1]
NP_001165972.1. NM_001172501.1. [P23975-1]
NP_001165973.1. NM_001172502.1. [P23975-3]
NP_001165975.1. NM_001172504.1. [P23975-2]
XP_006721326.1. XM_006721263.1. [P23975-2]
UniGeneiHs.78036.

Genome annotation databases

EnsembliENST00000219833; ENSP00000219833; ENSG00000103546. [P23975-2]
ENST00000379906; ENSP00000369237; ENSG00000103546. [P23975-1]
ENST00000567238; ENSP00000457375; ENSG00000103546.
ENST00000568943; ENSP00000457473; ENSG00000103546. [P23975-1]
GeneIDi6530.
KEGGihsa:6530.
UCSCiuc002eif.3. human. [P23975-1]
uc002eii.3. human.
uc021tio.1. human. [P23975-2]

Polymorphism databases

DMDMi128616.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M65105 mRNA. Translation: AAA59943.1 .
X91117
, X91120 , X91121 , X91122 , X91123 , X91124 , X91125 , X91126 , X91127 , X91118 , X91119 Genomic DNA. Translation: CAA62566.1 .
X91117
, X91118 , X91119 , X91120 , X91121 , X91122 , X91123 , X91124 , X91125 , X91126 , X91127 Genomic DNA. Translation: CAC39181.1 .
AK301811 mRNA. Translation: BAG63260.1 .
AK312793 mRNA. Translation: BAG35654.1 .
AC136621 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW82831.1 .
CH471092 Genomic DNA. Translation: EAW82833.1 .
CH471092 Genomic DNA. Translation: EAW82835.1 .
CCDSi CCDS10754.1. [P23975-1 ]
CCDS54011.1. [P23975-2 ]
CCDS58463.1. [P23975-3 ]
PIRi S14278.
RefSeqi NP_001034.1. NM_001043.3. [P23975-1 ]
NP_001165972.1. NM_001172501.1. [P23975-1 ]
NP_001165973.1. NM_001172502.1. [P23975-3 ]
NP_001165975.1. NM_001172504.1. [P23975-2 ]
XP_006721326.1. XM_006721263.1. [P23975-2 ]
UniGenei Hs.78036.

3D structure databases

ProteinModelPortali P23975.
SMRi P23975. Positions 56-594.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112421. 3 interactions.
MINTi MINT-197872.
STRINGi 9606.ENSP00000369237.

Chemistry

BindingDBi P23975.
ChEMBLi CHEMBL2363064.
DrugBanki DB04836. Amineptine.
DB00321. Amitriptyline.
DB00543. Amoxapine.
DB00289. Atomoxetine.
DB00217. Bethanidine.
DB01156. Bupropion.
DB01242. Clomipramine.
DB00907. Cocaine.
DB04840. Debrisoquin.
DB01151. Desipramine.
DB00937. Diethylpropion.
DB01142. Doxepin.
DB00476. Duloxetine.
DB00696. Ergotamine.
DB00226. Guanadrel Sulfate.
DB01170. Guanethidine.
DB00458. Imipramine.
DB00934. Maprotiline.
DB00579. Mazindol.
DB00422. Methylphenidate.
DB04896. Milnacipran.
DB01149. Nefazodone.
DB00368. Norepinephrine.
DB00540. Nortriptyline.
DB00715. Paroxetine.
DB00830. Phenmetrazine.
DB00191. Phentermine.
DB00344. Protriptyline.
DB00234. Reboxetine.
DB01105. Sibutramine.
DB00193. Tramadol.
DB00656. Trazodone.
DB00726. Trimipramine.
DB00285. Venlafaxine.
GuidetoPHARMACOLOGYi 926.

Protein family/group databases

TCDBi 2.A.22.1.2. the neurotransmitter:sodium symporter (nss) family.

PTM databases

PhosphoSitei P23975.

Polymorphism databases

DMDMi 128616.

Proteomic databases

PaxDbi P23975.
PRIDEi P23975.

Protocols and materials databases

DNASUi 6530.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000219833 ; ENSP00000219833 ; ENSG00000103546 . [P23975-2 ]
ENST00000379906 ; ENSP00000369237 ; ENSG00000103546 . [P23975-1 ]
ENST00000567238 ; ENSP00000457375 ; ENSG00000103546 .
ENST00000568943 ; ENSP00000457473 ; ENSG00000103546 . [P23975-1 ]
GeneIDi 6530.
KEGGi hsa:6530.
UCSCi uc002eif.3. human. [P23975-1 ]
uc002eii.3. human.
uc021tio.1. human. [P23975-2 ]

Organism-specific databases

CTDi 6530.
GeneCardsi GC16P055745.
HGNCi HGNC:11048. SLC6A2.
HPAi HPA004057.
MIMi 163970. gene.
604715. phenotype.
neXtProti NX_P23975.
PharmGKBi PA310.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0733.
HOGENOMi HOG000116406.
HOVERGENi HBG071421.
KOi K05035.
OMAi AYCITPE.
OrthoDBi EOG793B71.
PhylomeDBi P23975.
TreeFami TF343812.

Enzyme and pathway databases

Reactomei REACT_20506. Na+/Cl- dependent neurotransmitter transporters.

Miscellaneous databases

GeneWikii Norepinephrine_transporter.
GenomeRNAii 6530.
NextBioi 25407.
PROi P23975.
SOURCEi Search...

Gene expression databases

ArrayExpressi P23975.
Bgeei P23975.
CleanExi HS_NAT1.
HS_NET1.
HS_SLC6A2.
HS_SLC6A5.
Genevestigatori P23975.

Family and domain databases

InterProi IPR000175. Na/ntran_symport.
IPR002435. Na/ntran_symport_noradrenaline.
[Graphical view ]
PANTHERi PTHR11616. PTHR11616. 1 hit.
Pfami PF00209. SNF. 1 hit.
[Graphical view ]
PRINTSi PR00176. NANEUSMPORT.
PR01201. NORTRANSPORT.
PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter."
    Pacholczyk T., Blakely R.D., Amara S.G.
    Nature 350:350-354(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Molecular cloning and organization of the coding region of the human norepinephrine transporter gene."
    Poerzgen P., Boenisch H., Bruss M.
    Biochem. Biophys. Res. Commun. 215:1145-1150(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Lung.
  3. "The human noradrenaline transporter gene contains multiple polyadenylation sites and two alternatively spliced C-terminal exons."
    Porzgen P., Bonisch H., Hammermann R., Bruss M.
    Biochim. Biophys. Acta 1398:365-370(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2), ALTERNATIVE SPLICING.
    Tissue: Lung.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Testis.
  5. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1."
    Torres G.E., Yao W.-D., Mohn A.R., Quan H., Kim K.-M., Levey A.I., Staudinger J., Caron M.G.
    Neuron 30:121-134(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PRKCABP.
  8. "Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency."
    Shannon J.R., Flattem N.L., Jordan J., Jacob G., Black B.K., Biaggioni I., Blakely R.D., Robertson D.
    N. Engl. J. Med. 342:541-549(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT OI PRO-457.

Entry informationi

Entry nameiSC6A2_HUMAN
AccessioniPrimary (citable) accession number: P23975
Secondary accession number(s): B2R707, B4DX48, Q96KH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: September 3, 2014
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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