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Protein

Sodium-dependent noradrenaline transporter

Gene

SLC6A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi71Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi73Sodium 2; via carbonyl oxygenBy similarity1
Metal bindingi74Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi78Sodium 2By similarity1
Metal bindingi318Sodium 2By similarity1
Metal bindingi350Sodium 2By similarity1
Metal bindingi415Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi418Sodium 1By similarity1
Metal bindingi419Sodium 1By similarity1

GO - Molecular functioni

GO - Biological processi

  • chemical synaptic transmission Source: ProtInc
  • monoamine transport Source: MGI
  • norepinephrine transport Source: GO_Central
  • response to drug Source: Ensembl
  • response to pain Source: Ensembl
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Neurotransmitter transport, Symport, Transport

Keywords - Ligandi

Metal-binding, Sodium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103546-MONOMER.
ReactomeiR-HSA-442660. Na+/Cl- dependent neurotransmitter transporters.

Protein family/group databases

TCDBi2.A.22.1.2. the neurotransmitter:sodium symporter (nss) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent noradrenaline transporter
Alternative name(s):
Norepinephrine transporter
Short name:
NET
Solute carrier family 6 member 2
Gene namesi
Name:SLC6A2
Synonyms:NAT1, NET1, SLC6A5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:11048. SLC6A2.

Subcellular locationi

  • Cell membrane 1 Publication; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 62CytoplasmicBy similarityAdd BLAST62
Transmembranei63 – 88Helical; Name=1By similarityAdd BLAST26
Topological domaini89 – 92ExtracellularBy similarity4
Transmembranei93 – 116Helical; Name=2By similarityAdd BLAST24
Topological domaini117 – 135CytoplasmicBy similarityAdd BLAST19
Transmembranei136 – 166Helical; Name=3By similarityAdd BLAST31
Topological domaini167 – 233ExtracellularBy similarityAdd BLAST67
Transmembranei234 – 254Helical; Name=4By similarityAdd BLAST21
Topological domaini255 – 257CytoplasmicBy similarity3
Transmembranei258 – 282Helical; Name=5By similarityAdd BLAST25
Topological domaini283 – 306ExtracellularBy similarityAdd BLAST24
Transmembranei307 – 332Helical; Name=6By similarityAdd BLAST26
Topological domaini333 – 338CytoplasmicBy similarity6
Transmembranei339 – 362Helical; Name=7By similarityAdd BLAST24
Topological domaini363 – 402ExtracellularBy similarityAdd BLAST40
Transmembranei403 – 428Helical; Name=8By similarityAdd BLAST26
Topological domaini429 – 443CytoplasmicBy similarityAdd BLAST15
Transmembranei444 – 464Helical; Name=9By similarityAdd BLAST21
Topological domaini465ExtracellularBy similarity1
Transmembranei466 – 492Helical; Name=10By similarityAdd BLAST27
Topological domaini493 – 522CytoplasmicBy similarityAdd BLAST30
Transmembranei523 – 545Helical; Name=11By similarityAdd BLAST23
Topological domaini546 – 548ExtracellularBy similarity3
Transmembranei549 – 569Helical; Name=12By similarityAdd BLAST21
Topological domaini570 – 617CytoplasmicBy similarityAdd BLAST48

GO - Cellular componenti

  • cell surface Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
  • membrane raft Source: Ensembl
  • neuron projection Source: GO_Central
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Orthostatic intolerance (OI)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionSyndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high.
See also OMIM:604715
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010022457A → P in OI; loss of function. 1 PublicationCorresponds to variant rs121918126dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi6530.
MalaCardsiSLC6A2.
MIMi604715. phenotype.
OpenTargetsiENSG00000103546.
PharmGKBiPA310.

Chemistry databases

ChEMBLiCHEMBL222.
DrugBankiDB00321. Amitriptyline.
DB00543. Amoxapine.
DB00182. Amphetamine.
DB00289. Atomoxetine.
DB01156. Bupropion.
DB01114. Chlorphenamine.
DB00215. Citalopram.
DB01242. Clomipramine.
DB00907. Cocaine.
DB04840. Debrisoquin.
DB01151. Desipramine.
DB06700. Desvenlafaxine.
DB06701. Dexmethylphenidate.
DB01576. Dextroamphetamine.
DB00514. Dextromethorphan.
DB00937. Diethylpropion.
DB00988. Dopamine.
DB01142. Doxepin.
DB06262. Droxidopa.
DB00476. Duloxetine.
DB01363. Ephedra.
DB01364. Ephedrine.
DB00696. Ergotamine.
DB01175. Escitalopram.
DB01381. Ginkgo biloba.
DB00226. Guanadrel.
DB01170. Guanethidine.
DB00458. Imipramine.
DB06704. Iobenguane.
DB01221. Ketamine.
DB08918. Levomilnacipran.
DB06707. Levonordefrin.
DB00408. Loxapine.
DB00934. Maprotiline.
DB00579. Mazindol.
DB01577. Methamphetamine.
DB00422. Methylphenidate.
DB06148. Mianserin.
DB04896. Milnacipran.
DB00370. Mirtazapine.
DB01149. Nefazodone.
DB00368. Norepinephrine.
DB00540. Nortriptyline.
DB01173. Orphenadrine.
DB00715. Paroxetine.
DB00454. Pethidine.
DB01579. Phendimetrazine.
DB00830. Phenmetrazine.
DB00191. Phentermine.
DB00344. Protriptyline.
DB00852. Pseudoephedrine.
DB00234. Reboxetine.
DB01105. Sibutramine.
DB06204. Tapentadol.
DB00193. Tramadol.
DB00726. Trimipramine.
DB00285. Venlafaxine.
GuidetoPHARMACOLOGYi926.

Polymorphism and mutation databases

BioMutaiSLC6A2.
DMDMi128616.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002147481 – 617Sodium-dependent noradrenaline transporterAdd BLAST617

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi176 ↔ 185By similarity
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP23975.
PaxDbiP23975.
PeptideAtlasiP23975.
PRIDEiP23975.

PTM databases

iPTMnetiP23975.
PhosphoSitePlusiP23975.

Expressioni

Gene expression databases

BgeeiENSG00000103546.
CleanExiHS_NAT1.
HS_NET1.
HS_SLC6A2.
HS_SLC6A5.
ExpressionAtlasiP23975. baseline and differential.
GenevisibleiP23975. HS.

Interactioni

Subunit structurei

Interacts with PRKCABP.1 Publication

Protein-protein interaction databases

BioGridi112421. 3 interactors.
MINTiMINT-197872.
STRINGi9606.ENSP00000219833.

Chemistry databases

BindingDBiP23975.

Structurei

3D structure databases

ProteinModelPortaliP23975.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiP23975.
KOiK05035.
OMAiPPWANWV.
OrthoDBiEOG091G08PX.
PhylomeDBiP23975.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002435. Na/ntran_symport_noradrenaline.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01201. NORTRANSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P23975-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLARMNPQV QPENNGADTG PEQPLRARKT AELLVVKERN GVQCLLAPRD
60 70 80 90 100
GDAQPRETWG KKIDFLLSVV GFAVDLANVW RFPYLCYKNG GGAFLIPYTL
110 120 130 140 150
FLIIAGMPLF YMELALGQYN REGAATVWKI CPFFKGVGYA VILIALYVGF
160 170 180 190 200
YYNVIIAWSL YYLFSSFTLN LPWTDCGHTW NSPNCTDPKL LNGSVLGNHT
210 220 230 240 250
KYSKYKFTPA AEFYERGVLH LHESSGIHDI GLPQWQLLLC LMVVVIVLYF
260 270 280 290 300
SLWKGVKTSG KVVWITATLP YFVLFVLLVH GVTLPGASNG INAYLHIDFY
310 320 330 340 350
RLKEATVWID AATQIFFSLG AGFGVLIAFA SYNKFDNNCY RDALLTSSIN
360 370 380 390 400
CITSFVSGFA IFSILGYMAH EHKVNIEDVA TEGAGLVFIL YPEAISTLSG
410 420 430 440 450
STFWAVVFFV MLLALGLDSS MGGMEAVITG LADDFQVLKR HRKLFTFGVT
460 470 480 490 500
FSTFLLALFC ITKGGIYVLT LLDTFAAGTS ILFAVLMEAI GVSWFYGVDR
510 520 530 540 550
FSNDIQQMMG FRPGLYWRLC WKFVSPAFLL FVVVVSIINF KPLTYDDYIF
560 570 580 590 600
PPWANWVGWG IALSSMVLVP IYVIYKFLST QGSLWERLAY GITPENEHHL
610
VAQRDIRQFQ LQHWLAI
Length:617
Mass (Da):69,332
Last modified:March 1, 1992 - v1
Checksum:iBDC6DF31316907BB
GO
Isoform 2 (identifier: P23975-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     611-617: LQHWLAI → MKTRQGRRRATNSCQISC

Show »
Length:628
Mass (Da):70,548
Checksum:i4CF79AD92F272587
GO
Isoform 3 (identifier: P23975-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-135: MLLARMNPQV...TVWKICPFFK → MGVQWWSHTQGEVAVGLGLGDSYLTPCPCP

Show »
Length:512
Mass (Da):57,370
Checksum:iB25C836CA8BA912F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0291577N → K.Corresponds to variant rs11568323dbSNPEnsembl.1
Natural variantiVAR_01175669V → I.Corresponds to variant rs1805064dbSNPEnsembl.1
Natural variantiVAR_01175799T → I.Corresponds to variant rs1805065dbSNPEnsembl.1
Natural variantiVAR_011758245V → I.Corresponds to variant rs1805066dbSNPEnsembl.1
Natural variantiVAR_020048283T → R.Corresponds to variant rs45564432dbSNPEnsembl.1
Natural variantiVAR_011759292N → T.Corresponds to variant rs5563dbSNPEnsembl.1
Natural variantiVAR_011760356V → L.Corresponds to variant rs5565dbSNPEnsembl.1
Natural variantiVAR_011761369A → P.Corresponds to variant rs5566dbSNPEnsembl.1
Natural variantiVAR_011762375N → S.Corresponds to variant rs5567dbSNPEnsembl.1
Natural variantiVAR_014800449V → I.Corresponds to variant rs2234910dbSNPEnsembl.1
Natural variantiVAR_010022457A → P in OI; loss of function. 1 PublicationCorresponds to variant rs121918126dbSNPEnsembl.1
Natural variantiVAR_011763463K → R.Corresponds to variant rs5570dbSNPEnsembl.1
Natural variantiVAR_011764478G → S.Corresponds to variant rs1805067dbSNPEnsembl.1
Natural variantiVAR_011765528F → C.Corresponds to variant rs5558dbSNPEnsembl.1
Natural variantiVAR_011766548Y → H.Corresponds to variant rs5559dbSNPEnsembl.1
Natural variantiVAR_021861549I → T.Corresponds to variant rs3743788dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0541191 – 135MLLAR…CPFFK → MGVQWWSHTQGEVAVGLGLG DSYLTPCPCP in isoform 3. 1 PublicationAdd BLAST135
Alternative sequenceiVSP_044479611 – 617LQHWLAI → MKTRQGRRRATNSCQISC in isoform 2. Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65105 mRNA. Translation: AAA59943.1.
X91117
, X91120, X91121, X91122, X91123, X91124, X91125, X91126, X91127, X91118, X91119 Genomic DNA. Translation: CAA62566.1.
X91117
, X91118, X91119, X91120, X91121, X91122, X91123, X91124, X91125, X91126, X91127 Genomic DNA. Translation: CAC39181.1.
AK301811 mRNA. Translation: BAG63260.1.
AK312793 mRNA. Translation: BAG35654.1.
AC136621 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW82831.1.
CH471092 Genomic DNA. Translation: EAW82833.1.
CH471092 Genomic DNA. Translation: EAW82835.1.
CCDSiCCDS10754.1. [P23975-1]
CCDS54011.1. [P23975-2]
CCDS58463.1. [P23975-3]
PIRiS14278.
RefSeqiNP_001034.1. NM_001043.3. [P23975-1]
NP_001165972.1. NM_001172501.1. [P23975-1]
NP_001165973.1. NM_001172502.1. [P23975-3]
NP_001165975.1. NM_001172504.1. [P23975-2]
XP_006721326.1. XM_006721263.2. [P23975-2]
XP_011521597.1. XM_011523295.1. [P23975-2]
UniGeneiHs.78036.

Genome annotation databases

EnsembliENST00000219833; ENSP00000219833; ENSG00000103546. [P23975-2]
ENST00000379906; ENSP00000369237; ENSG00000103546. [P23975-1]
ENST00000567238; ENSP00000457375; ENSG00000103546. [P23975-3]
ENST00000568943; ENSP00000457473; ENSG00000103546. [P23975-1]
GeneIDi6530.
KEGGihsa:6530.
UCSCiuc002eif.4. human. [P23975-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65105 mRNA. Translation: AAA59943.1.
X91117
, X91120, X91121, X91122, X91123, X91124, X91125, X91126, X91127, X91118, X91119 Genomic DNA. Translation: CAA62566.1.
X91117
, X91118, X91119, X91120, X91121, X91122, X91123, X91124, X91125, X91126, X91127 Genomic DNA. Translation: CAC39181.1.
AK301811 mRNA. Translation: BAG63260.1.
AK312793 mRNA. Translation: BAG35654.1.
AC136621 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW82831.1.
CH471092 Genomic DNA. Translation: EAW82833.1.
CH471092 Genomic DNA. Translation: EAW82835.1.
CCDSiCCDS10754.1. [P23975-1]
CCDS54011.1. [P23975-2]
CCDS58463.1. [P23975-3]
PIRiS14278.
RefSeqiNP_001034.1. NM_001043.3. [P23975-1]
NP_001165972.1. NM_001172501.1. [P23975-1]
NP_001165973.1. NM_001172502.1. [P23975-3]
NP_001165975.1. NM_001172504.1. [P23975-2]
XP_006721326.1. XM_006721263.2. [P23975-2]
XP_011521597.1. XM_011523295.1. [P23975-2]
UniGeneiHs.78036.

3D structure databases

ProteinModelPortaliP23975.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112421. 3 interactors.
MINTiMINT-197872.
STRINGi9606.ENSP00000219833.

Chemistry databases

BindingDBiP23975.
ChEMBLiCHEMBL222.
DrugBankiDB00321. Amitriptyline.
DB00543. Amoxapine.
DB00182. Amphetamine.
DB00289. Atomoxetine.
DB01156. Bupropion.
DB01114. Chlorphenamine.
DB00215. Citalopram.
DB01242. Clomipramine.
DB00907. Cocaine.
DB04840. Debrisoquin.
DB01151. Desipramine.
DB06700. Desvenlafaxine.
DB06701. Dexmethylphenidate.
DB01576. Dextroamphetamine.
DB00514. Dextromethorphan.
DB00937. Diethylpropion.
DB00988. Dopamine.
DB01142. Doxepin.
DB06262. Droxidopa.
DB00476. Duloxetine.
DB01363. Ephedra.
DB01364. Ephedrine.
DB00696. Ergotamine.
DB01175. Escitalopram.
DB01381. Ginkgo biloba.
DB00226. Guanadrel.
DB01170. Guanethidine.
DB00458. Imipramine.
DB06704. Iobenguane.
DB01221. Ketamine.
DB08918. Levomilnacipran.
DB06707. Levonordefrin.
DB00408. Loxapine.
DB00934. Maprotiline.
DB00579. Mazindol.
DB01577. Methamphetamine.
DB00422. Methylphenidate.
DB06148. Mianserin.
DB04896. Milnacipran.
DB00370. Mirtazapine.
DB01149. Nefazodone.
DB00368. Norepinephrine.
DB00540. Nortriptyline.
DB01173. Orphenadrine.
DB00715. Paroxetine.
DB00454. Pethidine.
DB01579. Phendimetrazine.
DB00830. Phenmetrazine.
DB00191. Phentermine.
DB00344. Protriptyline.
DB00852. Pseudoephedrine.
DB00234. Reboxetine.
DB01105. Sibutramine.
DB06204. Tapentadol.
DB00193. Tramadol.
DB00726. Trimipramine.
DB00285. Venlafaxine.
GuidetoPHARMACOLOGYi926.

Protein family/group databases

TCDBi2.A.22.1.2. the neurotransmitter:sodium symporter (nss) family.

PTM databases

iPTMnetiP23975.
PhosphoSitePlusiP23975.

Polymorphism and mutation databases

BioMutaiSLC6A2.
DMDMi128616.

Proteomic databases

MaxQBiP23975.
PaxDbiP23975.
PeptideAtlasiP23975.
PRIDEiP23975.

Protocols and materials databases

DNASUi6530.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219833; ENSP00000219833; ENSG00000103546. [P23975-2]
ENST00000379906; ENSP00000369237; ENSG00000103546. [P23975-1]
ENST00000567238; ENSP00000457375; ENSG00000103546. [P23975-3]
ENST00000568943; ENSP00000457473; ENSG00000103546. [P23975-1]
GeneIDi6530.
KEGGihsa:6530.
UCSCiuc002eif.4. human. [P23975-1]

Organism-specific databases

CTDi6530.
DisGeNETi6530.
GeneCardsiSLC6A2.
HGNCiHGNC:11048. SLC6A2.
MalaCardsiSLC6A2.
MIMi163970. gene.
604715. phenotype.
neXtProtiNX_P23975.
OpenTargetsiENSG00000103546.
PharmGKBiPA310.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000118857.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiP23975.
KOiK05035.
OMAiPPWANWV.
OrthoDBiEOG091G08PX.
PhylomeDBiP23975.
TreeFamiTF343812.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103546-MONOMER.
ReactomeiR-HSA-442660. Na+/Cl- dependent neurotransmitter transporters.

Miscellaneous databases

ChiTaRSiSLC6A2. human.
GeneWikiiNorepinephrine_transporter.
GenomeRNAii6530.
PROiP23975.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103546.
CleanExiHS_NAT1.
HS_NET1.
HS_SLC6A2.
HS_SLC6A5.
ExpressionAtlasiP23975. baseline and differential.
GenevisibleiP23975. HS.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002435. Na/ntran_symport_noradrenaline.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01201. NORTRANSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC6A2_HUMAN
AccessioniPrimary (citable) accession number: P23975
Secondary accession number(s): B2R707, B4DX48, Q96KH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 30, 2016
This is version 166 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This protein is the target of psychomotor stimulants such as amphetamines or cocaine.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.