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Protein

Beta-lactamase OXY-2

Gene

bla

Organism
Klebsiella oxytoca
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes broad-spectrum beta-lactam antibiotics. Active against all third-generation cephalosporins but ceftazidime.

Miscellaneous

In strain KH11 OXY-2 is known as OXY-2a.

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei72Acyl-ester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-lactamase OXY-2 (EC:3.5.2.6)
Alternative name(s):
Penicillinase
Gene namesi
Name:bla
OrganismiKlebsiella oxytoca
Taxonomic identifieri571 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 272 PublicationsAdd BLAST27
ChainiPRO_000001699828 – 290Beta-lactamase OXY-2Add BLAST263

Proteomic databases

PRIDEiP23954

Structurei

3D structure databases

ProteinModelPortaliP23954
SMRiP23954
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni236 – 238Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the class-A beta-lactamase family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR000871 Beta-lactam_class-A
IPR023650 Beta-lactam_class-A_AS
PRINTSiPR00118 BLACTAMASEA
SUPFAMiSSF56601 SSF56601, 1 hit
PROSITEiView protein in PROSITE
PS00146 BETA_LACTAMASE_A, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23954-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKSSWRKIA MLAAAVPLLL ASGALWASTD AIHQKLTDLE KRSGGRLGVA
60 70 80 90 100
LINTADNSQI LYRGDERFAM CSTSKVMAAA AVLKQSESNK EVVNKRLEIN
110 120 130 140 150
AADLVVWSPI TEKHLQSGMT LAELSAATLQ YSDNTAMNLI IGYLGGPEKV
160 170 180 190 200
TAFARSIGDA TFRLDRTEPT LNTAIPGDER DTSTPLAMAE SLRKLTLGDA
210 220 230 240 250
LGEQQRAQLV TWLKGNTTGG QSIRAGLPES WVVGDKTGAG DYGTTNDIAV
260 270 280 290
IWPEDHAPLV LVTYFTQPQQ DAKNRKEVLA AAAKIVTEGL
Length:290
Mass (Da):31,136
Last modified:October 1, 1996 - v2
Checksum:i134C4BC24E9999E7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti15Missing in strain: KH11 and SB23. 1
Natural varianti199D → N in strain: D488 and HB60. 1
Natural varianti225A → V in strain: D488. 1
Natural varianti255D → N in strain: D488. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49084 Genomic DNA Translation: CAA88908.1
D84548 Genomic DNA Translation: BAA12695.1
Y17714 Genomic DNA Translation: CAB42614.1
RefSeqiWP_004099854.1, NZ_KQ088007.1
WP_017146441.1, NZ_FLAE01000001.1

Similar proteinsi

Entry informationi

Entry nameiBLO2_KLEOX
AccessioniPrimary (citable) accession number: P23954
Secondary accession number(s): P71418
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 73 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

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