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Protein

Carboxylesterase 1C

Gene

Ces1c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant.

Catalytic activityi

A carboxylic ester + H2O = an alcohol + a carboxylate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei221Acyl-ester intermediatePROSITE-ProRule annotation1
Active sitei342Charge relay systemBy similarity1
Active sitei455Charge relay systemBy similarity1

GO - Molecular functioni

  • carboxylic ester hydrolase activity Source: MGI
  • hydrolase activity, acting on ester bonds Source: MGI

Keywordsi

Molecular functionHydrolase, Serine esterase

Enzyme and pathway databases

ReactomeiR-MMU-211945 Phase I - Functionalization of compounds

Protein family/group databases

ESTHERimouse-Ces1c Carb_B_Chordata
MEROPSiS09.996

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxylesterase 1C (EC:3.1.1.1)
Alternative name(s):
Liver carboxylesterase N
Lung surfactant convertase
PES-N
Gene namesi
Name:Ces1c
Synonyms:Es1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:95420 Ces1c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000000857419 – 554Carboxylesterase 1CAdd BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi87 ↔ 116By similarity
Disulfide bondi273 ↔ 284By similarity
Glycosylationi274N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi304N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi377N-linked (GlcNAc...) asparagine2 Publications1
Modified residuei473PhosphoserineBy similarity1
Glycosylationi478N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP23953
PaxDbiP23953
PeptideAtlasiP23953
PRIDEiP23953

PTM databases

GlyConnecti779
iPTMnetiP23953
PhosphoSitePlusiP23953

Expressioni

Tissue specificityi

Expressed in lung, kidney and liver.1 Publication

Gene expression databases

BgeeiENSMUSG00000057400
CleanExiMM_ES1
ExpressionAtlasiP23953 baseline and differential
GenevisibleiP23953 MM

Interactioni

Protein-protein interaction databases

IntActiP23953, 2 interactors
MINTiP23953
STRINGi10090.ENSMUSP00000034189

Structurei

3D structure databases

ProteinModelPortaliP23953
SMRiP23953
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi551 – 554Prevents secretion from ERSequence analysis4

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
GeneTreeiENSGT00760000118946
HOGENOMiHOG000091866
HOVERGENiHBG008839
InParanoidiP23953
KOiK01044
OMAiMTHELCA
OrthoDBiEOG091G03ZC
TreeFamiTF315470

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23953-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLHALVWAS LAVCPILGHS LLPPVVDTTQ GKVLGKYISL EGFEQPVAVF
60 70 80 90 100
LGVPFAKPPL GSLRFAPPQP AEPWSFVKNA TSYPPMCSQD AGWAKILSDM
110 120 130 140 150
FSTEKEILPL KISEDCLYLN IYSPADLTKS SQLPVMVWIH GGGLVIGGAS
160 170 180 190 200
PYNGLALSAH ENVVVVTIQY RLGIWGLFST GDEHSPGNWA HLDQLAALRW
210 220 230 240 250
VQDNIANFGG NPDSVTIFGE SSGGISVSVL VLSPLGKDLF HRAISESGVV
260 270 280 290 300
INTNVGKKNI QAVNEIIATL SQCNDTSSAA MVQCLRQKTE SELLEISGKL
310 320 330 340 350
VQYNISLSTM IDGVVLPKAP EEILAEKSFN TVPYIVGFNK QEFGWIIPMM
360 370 380 390 400
LQNLLPEGKM NEETASLLLR RFHSELNISE SMIPAVIEQY LRGVDDPAKK
410 420 430 440 450
SELILDMFGD IFFGIPAVLL SRSLRDAGVS TYMYEFRYRP SFVSDKRPQT
460 470 480 490 500
VEGDHGDEIF FVFGAPLLKE GASEEETNLS KMVMKFWANF ARNGNPNGEG
510 520 530 540 550
LPHWPEYDEQ EGYLQIGATT QQAQRLKAEE VAFWTELLAK NPPETDPTEH

TEHK
Length:554
Mass (Da):61,056
Last modified:July 27, 2011 - v4
Checksum:iFBB166E6F9D570CD
GO

Sequence cautioni

The sequence AAA37579 differs from that shown. Sequencing errors.Curated
The sequence AAA37579 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5A → V in AAC04708 (PubMed:9815115).Curated1
Sequence conflicti5A → V in AAH28907 (PubMed:15489334).Curated1
Sequence conflicti96I → L in AAH28907 (PubMed:15489334).Curated1
Sequence conflicti104E → K in AAH28907 (PubMed:15489334).Curated1
Sequence conflicti149A → R in AAA63297 (PubMed:1840565).Curated1
Sequence conflicti149A → R in AAC04708 (PubMed:9815115).Curated1
Sequence conflicti186P → Q in AAC04708 (PubMed:9815115).Curated1
Sequence conflicti186P → Q in AAH28907 (PubMed:15489334).Curated1
Sequence conflicti255V → L in AAH28907 (PubMed:15489334).Curated1
Sequence conflicti310M → V in AAC04708 (PubMed:9815115).Curated1
Sequence conflicti310M → V in AAH28907 (PubMed:15489334).Curated1
Sequence conflicti389Q → K in AAC04708 (PubMed:9815115).Curated1
Sequence conflicti389Q → K in AAH28907 (PubMed:15489334).Curated1
Sequence conflicti398A → V in AAH28907 (PubMed:15489334).Curated1
Sequence conflicti420L → M in AAC04708 (PubMed:9815115).Curated1
Sequence conflicti420L → M in AAH28907 (PubMed:15489334).Curated1
Sequence conflicti432Y → S in AAH28907 (PubMed:15489334).Curated1
Sequence conflicti450T → M in AAC04708 (PubMed:9815115).Curated1
Sequence conflicti450T → M in AAH28907 (PubMed:15489334).Curated1
Sequence conflicti461F → S in AAC04708 (PubMed:9815115).Curated1
Sequence conflicti461F → S in AAH28907 (PubMed:15489334).Curated1
Sequence conflicti510Q → K in AAC04708 (PubMed:9815115).Curated1
Sequence conflicti510Q → K in AAH28907 (PubMed:15489334).Curated1
Sequence conflicti538L → P in AAC04708 (PubMed:9815115).Curated1
Sequence conflicti538L → P in AAH28907 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57960 mRNA Translation: AAA63297.1
AF034435 mRNA Translation: AAC04708.1
AC121985 Genomic DNA No translation available.
AC162949 Genomic DNA No translation available.
BC028907 mRNA Translation: AAH28907.1
M19677 mRNA Translation: AAA37579.1 Sequence problems.
CCDSiCCDS22527.1
PIRiA27686
A39060
RefSeqiNP_031980.2, NM_007954.4
UniGeneiMm.88078

Genome annotation databases

EnsembliENSMUST00000034189; ENSMUSP00000034189; ENSMUSG00000057400
GeneIDi13884
KEGGimmu:13884
UCSCiuc009mul.2 mouse

Similar proteinsi

Entry informationi

Entry nameiEST1C_MOUSE
AccessioniPrimary (citable) accession number: P23953
Secondary accession number(s): E9QQ07
, O54936, P11374, Q8K125
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 152 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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