Carboxylesterase 1C precursor - Mus musculus (Mouse)

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P23953 (EST1C_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 116. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Carboxylesterase 1C
EC=3.1.1.1

Alternative name(s):
Liver carboxylesterase N
Lung surfactant convertase
PES-N

Gene names

Name:	Ces1c
Synonyms:	Es1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	554 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant.
Catalytic activity	A carboxylic ester + H₂O = an alcohol + a carboxylate.
Subcellular location	Endoplasmic reticulum lumen. Note: Microsomal membrane, lumen of endoplasmic reticulum.
Tissue specificity	Expressed in lung, kidney and liver. Ref.2
Sequence similarities	Belongs to the type-B carboxylesterase/lipase family.
Sequence caution	The sequence AAA37579.1 differs from that shown. Reason: Frameshift at several positions. The sequence AAA37579.1 differs from that shown. Reason: Sequencing errors.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Signal
Molecular function	Hydrolase Serine esterase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular space Inferred from direct assay PubMed 2571576 PubMed 4084216. Source: MGI
Molecular_function	carboxylesterase activity Inferred from direct assay PubMed 4084216. Source: MGI methyl indole-3-acetate esterase activity Inferred from electronic annotation. Source: EC methyl jasmonate esterase activity Inferred from electronic annotation. Source: EC methyl salicylate esterase activity Inferred from electronic annotation. Source: EC retinyl-palmitate esterase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 18

By similarity

Chain

19 – 554

536

Carboxylesterase 1C

PRO_0000008574

Regions

Motif

551 – 554

Prevents secretion from ER Potential

Sites

Active site

221

Acyl-ester intermediate By similarity

Active site

342

Charge relay system By similarity

Active site

455

Charge relay system By similarity

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Ref.7

Glycosylation

274

N-linked (GlcNAc...) Ref.7

Glycosylation

304

N-linked (GlcNAc...) Ref.6 Ref.7

Glycosylation

377

N-linked (GlcNAc...) Ref.6 Ref.7

Glycosylation

478

N-linked (GlcNAc...) Potential

Disulfide bond

87 ↔ 116

By similarity

Disulfide bond

273 ↔ 284

By similarity

Experimental info

Sequence conflict

A → V in AAC04708. Ref.2

Sequence conflict

A → V in AAH28907. Ref.4

Sequence conflict

I → L in AAH28907. Ref.4

Sequence conflict

104

E → K in AAH28907. Ref.4

Sequence conflict

149

A → R in AAA63297. Ref.1

Sequence conflict

149

A → R in AAC04708. Ref.2

Sequence conflict

186

P → Q in AAC04708. Ref.2

Sequence conflict

186

P → Q in AAH28907. Ref.4

Sequence conflict

255

V → L in AAH28907. Ref.4

Sequence conflict

310

M → V in AAC04708. Ref.2

Sequence conflict

310

M → V in AAH28907. Ref.4

Sequence conflict

389

Q → K in AAC04708. Ref.2

Sequence conflict

389

Q → K in AAH28907. Ref.4

Sequence conflict

398

A → V in AAH28907. Ref.4

Sequence conflict

420

L → M in AAC04708. Ref.2

Sequence conflict

420

L → M in AAH28907. Ref.4

Sequence conflict

432

Y → S in AAH28907. Ref.4

Sequence conflict

450

T → M in AAC04708. Ref.2

Sequence conflict

450

T → M in AAH28907. Ref.4

Sequence conflict

461

F → S in AAC04708. Ref.2

Sequence conflict

461

F → S in AAH28907. Ref.4

Sequence conflict

510

Q → K in AAC04708. Ref.2

Sequence conflict

510

Q → K in AAH28907. Ref.4

Sequence conflict

538

L → P in AAC04708. Ref.2

Sequence conflict

538

L → P in AAH28907. Ref.4

Sequences

Sequence

Length

Mass (Da)

Tools

P23953 [UniParc].

Last modified July 27, 2011. Version 4.
Checksum: FBB166E6F9D570CD
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FASTA

554

61,056

        10         20         30         40         50         60 
MWLHALVWAS LAVCPILGHS LLPPVVDTTQ GKVLGKYISL EGFEQPVAVF LGVPFAKPPL 

        70         80         90        100        110        120 
GSLRFAPPQP AEPWSFVKNA TSYPPMCSQD AGWAKILSDM FSTEKEILPL KISEDCLYLN 

       130        140        150        160        170        180 
IYSPADLTKS SQLPVMVWIH GGGLVIGGAS PYNGLALSAH ENVVVVTIQY RLGIWGLFST 

       190        200        210        220        230        240 
GDEHSPGNWA HLDQLAALRW VQDNIANFGG NPDSVTIFGE SSGGISVSVL VLSPLGKDLF 

       250        260        270        280        290        300 
HRAISESGVV INTNVGKKNI QAVNEIIATL SQCNDTSSAA MVQCLRQKTE SELLEISGKL 

       310        320        330        340        350        360 
VQYNISLSTM IDGVVLPKAP EEILAEKSFN TVPYIVGFNK QEFGWIIPMM LQNLLPEGKM 

       370        380        390        400        410        420 
NEETASLLLR RFHSELNISE SMIPAVIEQY LRGVDDPAKK SELILDMFGD IFFGIPAVLL 

       430        440        450        460        470        480 
SRSLRDAGVS TYMYEFRYRP SFVSDKRPQT VEGDHGDEIF FVFGAPLLKE GASEEETNLS 

       490        500        510        520        530        540 
KMVMKFWANF ARNGNPNGEG LPHWPEYDEQ EGYLQIGATT QQAQRLKAEE VAFWTELLAK 

       550 
NPPETDPTEH TEHK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a murine cDNA encoding a member of the carboxylesterase multigene family." Ovnic M., Tepperman K., Medda S., Elliott R.W., Stephenson D.A., Grant S.G., Ganschow R.E. Genomics 9:344-354(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J. Tissue: Liver.
[2]	"Molecular cloning, characterization, and differential expression pattern of mouse lung surfactant convertase." Krishnasamy S., Teng A.L., Dhand R., Schultz R.M., Gross N.J. Am. J. Physiol. 275:L969-L975(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, TISSUE SPECIFICITY. Strain: CF-1. Tissue: Lung.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Liver.
[5]	"cDNA cloning of esterase 1, the major esterase activity in mouse plasma." Genetta T.L., D'Eustachio P., Kadner S.S., Finlay T.H. Biochem. Biophys. Res. Commun. 151:1364-1370(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 487-554.
[6]	"Proteome-wide characterization of N-glycosylation events by diagonal chromatography." Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K. J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-304 AND ASN-377, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Plasma.
[7]	"Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides." Bernhard O.K., Kapp E.A., Simpson R.J. J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-79; ASN-274; ASN-304 AND ASN-377, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Plasma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M57960 mRNA. Translation: AAA63297.1. AF034435 mRNA. Translation: AAC04708.1. AC121985 Genomic DNA. No translation available. AC162949 Genomic DNA. No translation available. BC028907 mRNA. Translation: AAH28907.1. M19677 mRNA. Translation: AAA37579.1. Sequence problems.
IPI	IPI00138342.
PIR	A27686. A39060.
RefSeq	NP_031980.2. NM_007954.4.
UniGene	Mm.88078.
3D structure databases
ProteinModelPortal	P23953.
SMR	P23953. Positions 24-540.
ModBase	Search...
Protein family/group databases
MEROPS	S09.996.
PTM databases
PhosphoSite	P23953.
Proteomic databases
PaxDb	P23953.
PRIDE	P23953.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000034189; ENSMUSP00000034189; ENSMUSG00000057400.
GeneID	13884.
KEGG	mmu:13884.
UCSC	uc009mul.2. mouse.
Organism-specific databases
CTD	13884.
MGI	MGI:95420. Ces1c.
Phylogenomic databases
eggNOG	COG2272.
GeneTree	ENSGT00670000097643.
HOGENOM	HOG000091866.
HOVERGEN	HBG008839.
InParanoid	P23953.
KO	K03927.
OMA	NEDEQEW.
OrthoDB	EOG466VM9.
Gene expression databases
ArrayExpress	P23953.
Bgee	P23953.
CleanEx	MM_ES1.
Genevestigator	P23953.
GermOnline	ENSMUSG00000057400. Mus musculus.
Family and domain databases
InterPro	IPR002018. CarbesteraseB. IPR019826. Carboxylesterase_B_AS. IPR019819. Carboxylesterase_B_CS. [Graphical view]
Pfam	PF00135. COesterase. 1 hit. [Graphical view]
PROSITE	PS00122. CARBOXYLESTERASE_B_1. 1 hit. PS00941. CARBOXYLESTERASE_B_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	284812.
SOURCE	Search...

Entry information

Entry name

EST1C_MOUSE

Accession

Primary (citable) accession number: P23953
Secondary accession number(s): E9QQ07

Q8K125

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 116 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents