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P23950 (TISB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 36, C3H1 type-like 1
Alternative name(s):
Butyrate response factor 1
Protein TIS11B
Gene names
Name:Zfp36l1
Synonyms:Brf1, Tis11b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable regulatory protein involved in regulating the response to growth factors.

Subcellular location

Cytoplasm. Nucleus. Note: Shuttles between the nucleus and the cytoplasm. Ref.2

Disruption phenotype

Mice lacking both Zfp36l1 and Zfp36l2 during thymopoiesis develop a T-cell acute lymphoblastic leukemia (Ref.3). Ref.3

Sequence similarities

Contains 2 C3H1-type zinc fingers.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Zinc finger protein 36, C3H1 type-like 1
PRO_0000089168

Regions

Zinc finger114 – 14229C3H1-type 1
Zinc finger152 – 18029C3H1-type 2
Compositional bias307 – 31610Poly-Ser

Amino acid modifications

Modified residue541Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P23950 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: A28F2C8BF476496C

FASTA33836,385
        10         20         30         40         50         60 
MTTTLVSATI FDLSEVLCKG NKMLNYSTPS AGGCLLDRKA VGTPAGGGFP RRHSVTLPSS 

        70         80         90        100        110        120 
KFHQNQLLSS LKGEPAPSLS SRDSRFRDRS FSEGGERLLP TQKQPGSGQV NSSRYKTELC 

       130        140        150        160        170        180 
RPFEENGACK YGDKCQFAHG IHELRSLTRH PKYKTELCRT FHTIGFCPYG PRCHFIHNAE 

       190        200        210        220        230        240 
ERRALAGGRD LSADRPRLQH SFSFAGFPSA AATAAATGLL DSPTSITPPP ILSADDLLGS 

       250        260        270        280        290        300 
PTLPDGTNNP FAFSSQELAS LFAPSMGLPG GGSPTTFLFR PMSESPHMFD SPPSPQDSLS 

       310        320        330 
DHEGYLSSSS SSHSGSDSPT LDNSRRLPIF SRLSISDD 

« Hide

References

[1]"The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat."
Varnum B.C., Ma Q., Chi T., Fletcher B.S., Herschman H.R.
Mol. Cell. Biol. 11:1754-1758(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling."
Phillips R.S., Ramos S.B., Blackshear P.J.
J. Biol. Chem. 277:11606-11613(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[3]"Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia."
Hodson D.J., Janas M.L., Galloway A., Bell S.E., Andrews S., Li C.M., Pannell R., Siebel C.W., MacDonald H.R., De Keersmaecker K., Ferrando A.A., Grutz G., Turner M.
Nat. Immunol. 11:717-724(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M58566 mRNA. Translation: AAA72948.1.
PIRB39590.
RefSeqNP_031590.1. NM_007564.5.
UniGeneMm.235132.

3D structure databases

ProteinModelPortalP23950.
SMRP23950. Positions 112-181.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198385. 1 interaction.
STRING10090.ENSMUSP00000021552.

PTM databases

PhosphoSiteP23950.

Proteomic databases

PRIDEP23950.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021552; ENSMUSP00000021552; ENSMUSG00000021127.
ENSMUST00000165114; ENSMUSP00000127522; ENSMUSG00000021127.
GeneID12192.
KEGGmmu:12192.
UCSCuc007oal.1. mouse.

Organism-specific databases

CTD677.
MGIMGI:107946. Zfp36l1.

Phylogenomic databases

eggNOGCOG5063.
HOGENOMHOG000233479.
HOVERGENHBG008483.
InParanoidP23950.
OMAWPSSNPF.
OrthoDBEOG76QFJP.
PhylomeDBP23950.
TreeFamTF315463.

Gene expression databases

ArrayExpressP23950.
BgeeP23950.
CleanExMM_ZFP36L1.
GenevestigatorP23950.

Family and domain databases

Gene3D4.10.1000.10. 2 hits.
InterProIPR007635. Tis11B_N.
IPR000571. Znf_CCCH.
[Graphical view]
PfamPF04553. Tis11B_N. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
PROSITEPS50103. ZF_C3H1. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZFP36L1. mouse.
NextBio280591.
PROP23950.
SOURCESearch...

Entry information

Entry nameTISB_MOUSE
AccessionPrimary (citable) accession number: P23950
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot