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Protein

Zinc finger protein 36, C3H1 type-like 1

Gene

Zfp36l1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probable regulatory protein involved in regulating the response to growth factors.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri114 – 14229C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri152 – 18029C3H1-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. mRNA binding Source: MGI
  4. poly(A) RNA binding Source: MGI

GO - Biological processi

  1. apoptotic process Source: MGI
  2. cell proliferation Source: MGI
  3. chorio-allantoic fusion Source: MGI
  4. embryonic organ development Source: MGI
  5. heart development Source: MGI
  6. mRNA catabolic process Source: MGI
  7. multicellular organism growth Source: MGI
  8. neural tube development Source: MGI
  9. nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: MGI
  10. proepicardium development Source: MGI
  11. regulation of mRNA stability Source: MGI
  12. regulation of translation Source: MGI
  13. spongiotrophoblast layer development Source: MGI
  14. T cell differentiation in thymus Source: BHF-UCL
  15. vasculogenesis Source: MGI
Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_288807. Butyrate Response Factor 1 (BRF1) destabilizes mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 36, C3H1 type-like 1
Alternative name(s):
Butyrate response factor 1
Protein TIS11B
Gene namesi
Name:Zfp36l1
Synonyms:Brf1, Tis11b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:107946. Zfp36l1.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication
Note: Shuttles between the nucleus and the cytoplasm.

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice lacking both Zfp36l1 and Zfp36l2 during thymopoiesis develop a T-cell acute lymphoblastic leukemia.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Zinc finger protein 36, C3H1 type-like 1PRO_0000089168Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541PhosphoserineBy similarity
Modified residuei318 – 3181PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP23950.
PRIDEiP23950.

PTM databases

PhosphoSiteiP23950.

Expressioni

Gene expression databases

BgeeiP23950.
CleanExiMM_ZFP36L1.
ExpressionAtlasiP23950. baseline and differential.
GenevestigatoriP23950.

Interactioni

Protein-protein interaction databases

BioGridi198385. 1 interaction.
STRINGi10090.ENSMUSP00000021552.

Structurei

3D structure databases

ProteinModelPortaliP23950.
SMRiP23950. Positions 112-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi307 – 31610Poly-Ser

Sequence similaritiesi

Contains 2 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri114 – 14229C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri152 – 18029C3H1-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5063.
HOGENOMiHOG000233479.
HOVERGENiHBG008483.
InParanoidiP23950.
KOiK18753.
OMAiLQHSYSF.
OrthoDBiEOG76QFJP.
PhylomeDBiP23950.
TreeFamiTF315463.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiIPR007635. Tis11B_N.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF04553. Tis11B_N. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23950-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTLVSATI FDLSEVLCKG NKMLNYSTPS AGGCLLDRKA VGTPAGGGFP
60 70 80 90 100
RRHSVTLPSS KFHQNQLLSS LKGEPAPSLS SRDSRFRDRS FSEGGERLLP
110 120 130 140 150
TQKQPGSGQV NSSRYKTELC RPFEENGACK YGDKCQFAHG IHELRSLTRH
160 170 180 190 200
PKYKTELCRT FHTIGFCPYG PRCHFIHNAE ERRALAGGRD LSADRPRLQH
210 220 230 240 250
SFSFAGFPSA AATAAATGLL DSPTSITPPP ILSADDLLGS PTLPDGTNNP
260 270 280 290 300
FAFSSQELAS LFAPSMGLPG GGSPTTFLFR PMSESPHMFD SPPSPQDSLS
310 320 330
DHEGYLSSSS SSHSGSDSPT LDNSRRLPIF SRLSISDD
Length:338
Mass (Da):36,385
Last modified:February 29, 1992 - v1
Checksum:iA28F2C8BF476496C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58566 mRNA. Translation: AAA72948.1.
CCDSiCCDS26010.1.
PIRiB39590.
RefSeqiNP_031590.1. NM_007564.5.
UniGeneiMm.235132.

Genome annotation databases

EnsembliENSMUST00000021552; ENSMUSP00000021552; ENSMUSG00000021127.
ENSMUST00000165114; ENSMUSP00000127522; ENSMUSG00000021127.
GeneIDi12192.
KEGGimmu:12192.
UCSCiuc007oal.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58566 mRNA. Translation: AAA72948.1.
CCDSiCCDS26010.1.
PIRiB39590.
RefSeqiNP_031590.1. NM_007564.5.
UniGeneiMm.235132.

3D structure databases

ProteinModelPortaliP23950.
SMRiP23950. Positions 112-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198385. 1 interaction.
STRINGi10090.ENSMUSP00000021552.

PTM databases

PhosphoSiteiP23950.

Proteomic databases

MaxQBiP23950.
PRIDEiP23950.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021552; ENSMUSP00000021552; ENSMUSG00000021127.
ENSMUST00000165114; ENSMUSP00000127522; ENSMUSG00000021127.
GeneIDi12192.
KEGGimmu:12192.
UCSCiuc007oal.1. mouse.

Organism-specific databases

CTDi677.
MGIiMGI:107946. Zfp36l1.

Phylogenomic databases

eggNOGiCOG5063.
HOGENOMiHOG000233479.
HOVERGENiHBG008483.
InParanoidiP23950.
KOiK18753.
OMAiLQHSYSF.
OrthoDBiEOG76QFJP.
PhylomeDBiP23950.
TreeFamiTF315463.

Enzyme and pathway databases

ReactomeiREACT_288807. Butyrate Response Factor 1 (BRF1) destabilizes mRNA.

Miscellaneous databases

ChiTaRSiZfp36l1. mouse.
NextBioi280591.
PROiP23950.
SOURCEiSearch...

Gene expression databases

BgeeiP23950.
CleanExiMM_ZFP36L1.
ExpressionAtlasiP23950. baseline and differential.
GenevestigatoriP23950.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiIPR007635. Tis11B_N.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF04553. Tis11B_N. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat."
    Varnum B.C., Ma Q., Chi T., Fletcher B.S., Herschman H.R.
    Mol. Cell. Biol. 11:1754-1758(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling."
    Phillips R.S., Ramos S.B., Blackshear P.J.
    J. Biol. Chem. 277:11606-11613(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  3. "Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia."
    Hodson D.J., Janas M.L., Galloway A., Bell S.E., Andrews S., Li C.M., Pannell R., Siebel C.W., MacDonald H.R., De Keersmaecker K., Ferrando A.A., Grutz G., Turner M.
    Nat. Immunol. 11:717-724(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiTISB_MOUSE
AccessioniPrimary (citable) accession number: P23950
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 29, 1992
Last sequence update: February 29, 1992
Last modified: March 31, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.