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P23950

- TISB_MOUSE

UniProt

P23950 - TISB_MOUSE

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Protein

Zinc finger protein 36, C3H1 type-like 1

Gene

Zfp36l1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Probable regulatory protein involved in regulating the response to growth factors.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri114 – 14229C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri152 – 18029C3H1-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. mRNA binding Source: MGI

GO - Biological processi

  1. apoptotic process Source: MGI
  2. cell proliferation Source: MGI
  3. chorio-allantoic fusion Source: MGI
  4. embryonic organ development Source: MGI
  5. heart development Source: MGI
  6. mRNA catabolic process Source: MGI
  7. multicellular organism growth Source: MGI
  8. neural tube development Source: MGI
  9. nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: MGI
  10. proepicardium development Source: MGI
  11. regulation of mRNA stability Source: MGI
  12. regulation of translation Source: MGI
  13. spongiotrophoblast layer development Source: MGI
  14. T cell differentiation in thymus Source: BHF-UCL
  15. vasculogenesis Source: MGI
Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_198695. Butyrate Response Factor 1 (BRF1) destabilizes mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 36, C3H1 type-like 1
Alternative name(s):
Butyrate response factor 1
Protein TIS11B
Gene namesi
Name:Zfp36l1
Synonyms:Brf1, Tis11b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:107946. Zfp36l1.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication
Note: Shuttles between the nucleus and the cytoplasm.

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice lacking both Zfp36l1 and Zfp36l2 during thymopoiesis develop a T-cell acute lymphoblastic leukemia.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Zinc finger protein 36, C3H1 type-like 1PRO_0000089168Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP23950.
PRIDEiP23950.

PTM databases

PhosphoSiteiP23950.

Expressioni

Gene expression databases

BgeeiP23950.
CleanExiMM_ZFP36L1.
ExpressionAtlasiP23950. baseline and differential.
GenevestigatoriP23950.

Interactioni

Protein-protein interaction databases

BioGridi198385. 1 interaction.
STRINGi10090.ENSMUSP00000021552.

Structurei

3D structure databases

ProteinModelPortaliP23950.
SMRiP23950. Positions 112-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi307 – 31610Poly-Ser

Sequence similaritiesi

Contains 2 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri114 – 14229C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri152 – 18029C3H1-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5063.
HOGENOMiHOG000233479.
HOVERGENiHBG008483.
InParanoidiP23950.
OMAiWPSSNPF.
OrthoDBiEOG76QFJP.
PhylomeDBiP23950.
TreeFamiTF315463.

Family and domain databases

Gene3Di4.10.1000.10. 2 hits.
InterProiIPR007635. Tis11B_N.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF04553. Tis11B_N. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23950-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTTLVSATI FDLSEVLCKG NKMLNYSTPS AGGCLLDRKA VGTPAGGGFP
60 70 80 90 100
RRHSVTLPSS KFHQNQLLSS LKGEPAPSLS SRDSRFRDRS FSEGGERLLP
110 120 130 140 150
TQKQPGSGQV NSSRYKTELC RPFEENGACK YGDKCQFAHG IHELRSLTRH
160 170 180 190 200
PKYKTELCRT FHTIGFCPYG PRCHFIHNAE ERRALAGGRD LSADRPRLQH
210 220 230 240 250
SFSFAGFPSA AATAAATGLL DSPTSITPPP ILSADDLLGS PTLPDGTNNP
260 270 280 290 300
FAFSSQELAS LFAPSMGLPG GGSPTTFLFR PMSESPHMFD SPPSPQDSLS
310 320 330
DHEGYLSSSS SSHSGSDSPT LDNSRRLPIF SRLSISDD
Length:338
Mass (Da):36,385
Last modified:March 1, 1992 - v1
Checksum:iA28F2C8BF476496C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M58566 mRNA. Translation: AAA72948.1.
CCDSiCCDS26010.1.
PIRiB39590.
RefSeqiNP_031590.1. NM_007564.5.
UniGeneiMm.235132.

Genome annotation databases

EnsembliENSMUST00000021552; ENSMUSP00000021552; ENSMUSG00000021127.
ENSMUST00000165114; ENSMUSP00000127522; ENSMUSG00000021127.
GeneIDi12192.
KEGGimmu:12192.
UCSCiuc007oal.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M58566 mRNA. Translation: AAA72948.1 .
CCDSi CCDS26010.1.
PIRi B39590.
RefSeqi NP_031590.1. NM_007564.5.
UniGenei Mm.235132.

3D structure databases

ProteinModelPortali P23950.
SMRi P23950. Positions 112-181.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198385. 1 interaction.
STRINGi 10090.ENSMUSP00000021552.

PTM databases

PhosphoSitei P23950.

Proteomic databases

MaxQBi P23950.
PRIDEi P23950.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021552 ; ENSMUSP00000021552 ; ENSMUSG00000021127 .
ENSMUST00000165114 ; ENSMUSP00000127522 ; ENSMUSG00000021127 .
GeneIDi 12192.
KEGGi mmu:12192.
UCSCi uc007oal.1. mouse.

Organism-specific databases

CTDi 677.
MGIi MGI:107946. Zfp36l1.

Phylogenomic databases

eggNOGi COG5063.
HOGENOMi HOG000233479.
HOVERGENi HBG008483.
InParanoidi P23950.
OMAi WPSSNPF.
OrthoDBi EOG76QFJP.
PhylomeDBi P23950.
TreeFami TF315463.

Enzyme and pathway databases

Reactomei REACT_198695. Butyrate Response Factor 1 (BRF1) destabilizes mRNA.

Miscellaneous databases

ChiTaRSi ZFP36L1. mouse.
NextBioi 280591.
PROi P23950.
SOURCEi Search...

Gene expression databases

Bgeei P23950.
CleanExi MM_ZFP36L1.
ExpressionAtlasi P23950. baseline and differential.
Genevestigatori P23950.

Family and domain databases

Gene3Di 4.10.1000.10. 2 hits.
InterProi IPR007635. Tis11B_N.
IPR000571. Znf_CCCH.
[Graphical view ]
Pfami PF04553. Tis11B_N. 1 hit.
PF00642. zf-CCCH. 2 hits.
[Graphical view ]
SMARTi SM00356. ZnF_C3H1. 2 hits.
[Graphical view ]
PROSITEi PS50103. ZF_C3H1. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat."
    Varnum B.C., Ma Q., Chi T., Fletcher B.S., Herschman H.R.
    Mol. Cell. Biol. 11:1754-1758(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling."
    Phillips R.S., Ramos S.B., Blackshear P.J.
    J. Biol. Chem. 277:11606-11613(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  3. "Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia."
    Hodson D.J., Janas M.L., Galloway A., Bell S.E., Andrews S., Li C.M., Pannell R., Siebel C.W., MacDonald H.R., De Keersmaecker K., Ferrando A.A., Grutz G., Turner M.
    Nat. Immunol. 11:717-724(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiTISB_MOUSE
AccessioniPrimary (citable) accession number: P23950
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3