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P23950

- TISB_MOUSE

UniProt

P23950 - TISB_MOUSE

Protein

Zinc finger protein 36, C3H1 type-like 1

Gene

Zfp36l1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    Probable regulatory protein involved in regulating the response to growth factors.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri114 – 14229C3H1-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri152 – 18029C3H1-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. mRNA binding Source: MGI

    GO - Biological processi

    1. mRNA catabolic process Source: MGI
    2. nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: MGI
    3. regulation of mRNA stability Source: MGI
    4. regulation of translation Source: MGI
    5. T cell differentiation in thymus Source: BHF-UCL
    6. vasculogenesis Source: MGI

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_198695. Butyrate Response Factor 1 (BRF1) destabilizes mRNA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 36, C3H1 type-like 1
    Alternative name(s):
    Butyrate response factor 1
    Protein TIS11B
    Gene namesi
    Name:Zfp36l1
    Synonyms:Brf1, Tis11b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:107946. Zfp36l1.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication
    Note: Shuttles between the nucleus and the cytoplasm.

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytosol Source: MGI
    3. nucleus Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Mice lacking both Zfp36l1 and Zfp36l2 during thymopoiesis develop a T-cell acute lymphoblastic leukemia.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 338338Zinc finger protein 36, C3H1 type-like 1PRO_0000089168Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei54 – 541PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP23950.
    PRIDEiP23950.

    PTM databases

    PhosphoSiteiP23950.

    Expressioni

    Gene expression databases

    ArrayExpressiP23950.
    BgeeiP23950.
    CleanExiMM_ZFP36L1.
    GenevestigatoriP23950.

    Interactioni

    Protein-protein interaction databases

    BioGridi198385. 1 interaction.
    STRINGi10090.ENSMUSP00000021552.

    Structurei

    3D structure databases

    ProteinModelPortaliP23950.
    SMRiP23950. Positions 112-181.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi307 – 31610Poly-Ser

    Sequence similaritiesi

    Contains 2 C3H1-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri114 – 14229C3H1-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri152 – 18029C3H1-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5063.
    HOGENOMiHOG000233479.
    HOVERGENiHBG008483.
    InParanoidiP23950.
    OMAiWPSSNPF.
    OrthoDBiEOG76QFJP.
    PhylomeDBiP23950.
    TreeFamiTF315463.

    Family and domain databases

    Gene3Di4.10.1000.10. 2 hits.
    InterProiIPR007635. Tis11B_N.
    IPR000571. Znf_CCCH.
    [Graphical view]
    PfamiPF04553. Tis11B_N. 1 hit.
    PF00642. zf-CCCH. 2 hits.
    [Graphical view]
    SMARTiSM00356. ZnF_C3H1. 2 hits.
    [Graphical view]
    PROSITEiPS50103. ZF_C3H1. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23950-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTTLVSATI FDLSEVLCKG NKMLNYSTPS AGGCLLDRKA VGTPAGGGFP    50
    RRHSVTLPSS KFHQNQLLSS LKGEPAPSLS SRDSRFRDRS FSEGGERLLP 100
    TQKQPGSGQV NSSRYKTELC RPFEENGACK YGDKCQFAHG IHELRSLTRH 150
    PKYKTELCRT FHTIGFCPYG PRCHFIHNAE ERRALAGGRD LSADRPRLQH 200
    SFSFAGFPSA AATAAATGLL DSPTSITPPP ILSADDLLGS PTLPDGTNNP 250
    FAFSSQELAS LFAPSMGLPG GGSPTTFLFR PMSESPHMFD SPPSPQDSLS 300
    DHEGYLSSSS SSHSGSDSPT LDNSRRLPIF SRLSISDD 338
    Length:338
    Mass (Da):36,385
    Last modified:March 1, 1992 - v1
    Checksum:iA28F2C8BF476496C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M58566 mRNA. Translation: AAA72948.1.
    CCDSiCCDS26010.1.
    PIRiB39590.
    RefSeqiNP_031590.1. NM_007564.5.
    UniGeneiMm.235132.

    Genome annotation databases

    EnsembliENSMUST00000021552; ENSMUSP00000021552; ENSMUSG00000021127.
    ENSMUST00000165114; ENSMUSP00000127522; ENSMUSG00000021127.
    GeneIDi12192.
    KEGGimmu:12192.
    UCSCiuc007oal.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M58566 mRNA. Translation: AAA72948.1 .
    CCDSi CCDS26010.1.
    PIRi B39590.
    RefSeqi NP_031590.1. NM_007564.5.
    UniGenei Mm.235132.

    3D structure databases

    ProteinModelPortali P23950.
    SMRi P23950. Positions 112-181.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198385. 1 interaction.
    STRINGi 10090.ENSMUSP00000021552.

    PTM databases

    PhosphoSitei P23950.

    Proteomic databases

    MaxQBi P23950.
    PRIDEi P23950.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021552 ; ENSMUSP00000021552 ; ENSMUSG00000021127 .
    ENSMUST00000165114 ; ENSMUSP00000127522 ; ENSMUSG00000021127 .
    GeneIDi 12192.
    KEGGi mmu:12192.
    UCSCi uc007oal.1. mouse.

    Organism-specific databases

    CTDi 677.
    MGIi MGI:107946. Zfp36l1.

    Phylogenomic databases

    eggNOGi COG5063.
    HOGENOMi HOG000233479.
    HOVERGENi HBG008483.
    InParanoidi P23950.
    OMAi WPSSNPF.
    OrthoDBi EOG76QFJP.
    PhylomeDBi P23950.
    TreeFami TF315463.

    Enzyme and pathway databases

    Reactomei REACT_198695. Butyrate Response Factor 1 (BRF1) destabilizes mRNA.

    Miscellaneous databases

    ChiTaRSi ZFP36L1. mouse.
    NextBioi 280591.
    PROi P23950.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P23950.
    Bgeei P23950.
    CleanExi MM_ZFP36L1.
    Genevestigatori P23950.

    Family and domain databases

    Gene3Di 4.10.1000.10. 2 hits.
    InterProi IPR007635. Tis11B_N.
    IPR000571. Znf_CCCH.
    [Graphical view ]
    Pfami PF04553. Tis11B_N. 1 hit.
    PF00642. zf-CCCH. 2 hits.
    [Graphical view ]
    SMARTi SM00356. ZnF_C3H1. 2 hits.
    [Graphical view ]
    PROSITEi PS50103. ZF_C3H1. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat."
      Varnum B.C., Ma Q., Chi T., Fletcher B.S., Herschman H.R.
      Mol. Cell. Biol. 11:1754-1758(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling."
      Phillips R.S., Ramos S.B., Blackshear P.J.
      J. Biol. Chem. 277:11606-11613(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    3. "Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia."
      Hodson D.J., Janas M.L., Galloway A., Bell S.E., Andrews S., Li C.M., Pannell R., Siebel C.W., MacDonald H.R., De Keersmaecker K., Ferrando A.A., Grutz G., Turner M.
      Nat. Immunol. 11:717-724(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiTISB_MOUSE
    AccessioniPrimary (citable) accession number: P23950
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3