ID FSHR_HUMAN STANDARD; PRT; 695 AA. AC P23945; DT 01-MAR-1992 (Rel. 21, Created) DT 01-JUN-1994 (Rel. 29, Last sequence update) DT 15-JUL-1998 (Rel. 36, Last annotation update) DE FOLLICLE STIMULATING HORMONE RECEPTOR PRECURSOR (FSH-R) (FOLLITROPIN DE RECEPTOR). GN FSHR. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=OVARY; RX MEDLINE; 91222171. RA Minegish T., Nakamura K., Takakura Y., Ibuki Y., Igarashi M.; RT "Cloning and sequencing of human FSH receptor cDNA."; RL Biochem. Biophys. Res. Commun. 175:1125-1130(1991). RN [2] RP SEQUENCE FROM N.A. RC TISSUE=TESTIS; RX MEDLINE; 93246012. RA Kelton C.A., Cheng S.V., Nugent N.P., Schweickhardt R.L., RA Rosenthal J.L., Overton S.A., Wands G.D., Kuzeja J.B., Luchette C.A., RA Chappel S.C.; RT "The cloning of the human follicle stimulating hormone receptor and RT its expression in COS-7, CHO, and Y-1 cells."; RL Mol. Cell. Endocrinol. 89:141-151(1992). RN [3] RP SEQUENCE FROM N.A. RA Tilly L.T., Aihara T., Nishimori K., Jai X.-C., Billig H., RA Kowalski K.I., Perlas E.A., Hsueh A.J.; RL Submitted (XXX-1992) to the EMBL/GenBank/DDBJ databases. RN [4] RP SEQUENCE OF 1-342 FROM N.A. RC TISSUE=TESTIS; RX MEDLINE; 93075197. RA Gromoll J., Gudermann T., Nieschlag E.; RT "Molecular cloning of a truncated isoform of the human follicle RT stimulating hormone receptor."; RL Biochem. Biophys. Res. Commun. 188:1077-1083(1992). RN [5] RP SEQUENCE OF 1-51 FROM N.A. RX MEDLINE; 95011044. RA Gromoll J., Dankbar B., Gudermann T.; RT "Characterization of the 5' flanking region of the human follicle- RT stimulating hormone receptor gene."; RL Mol. Cell. Endocrinol. 102:93-102(1994). RN [6] RP 3D-STRUCTURE MODELING OF 49-228. RX MEDLINE; 96363672. RA Jiang X., Dreano M., Buckler D.R., Cheng S., Ythier A., Wu H., RA Hendrickson W.A., el Tayar N.; RT "Structural predictions for the ligand-binding region of glycoprotein RT hormone receptors and the nature of hormone-receptor interactions."; RL Structure 3:1341-1353(1995). CC -!- FUNCTION: RECEPTOR FOR FOLLICLE STIMULATING HORMONE. THE ACTIVITY CC OF THIS RECEPTOR IS MEDIATED BY G PROTEINS WHICH ACTIVATE CC ADENYLATE CYCLASE. CC -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN. CC -!- ALTERNATIVE PRODUCTS: A SHORT FORM OF THE TESTICULAR PROTEIN IS CC PRODUCED BY ALTERNATIVE SPLICING OF THE SAME GENE. THE SEQUENCE CC SHOWN HERE IS THAT OF THE LONG TESTICULAR PROTEIN. CC -!- TISSUE SPECIFICITY: SERTOLI CELLS AND OVARIAN GRANULOSA CELLS. CC -!- SIMILARITY: HIGHLY SIMILAR TO LSH AND TSH RECEPTORS. CC -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M65085; AAA52477.1; -. DR EMBL; S59900; AAB26480.1; -. DR EMBL; M95489; AAA52478.1; -. DR EMBL; X68044; CAA48179.1; -. DR EMBL; S73199; AAB32071.1; -. DR PIR; JN0122; JN0122. DR PDB; 1XUN; 15-MAY-97. DR GCRDB; GCR_0071; -. DR GCRDB; GCR_0404; -. DR GCRDB; GCR_0588; -. DR GCRDB; GCR_0690; -. DR MIM; 136435; -. DR INTERPRO; IPR000276; -. DR INTERPRO; IPR000372; -. DR INTERPRO; IPR001611; -. DR INTERPRO; IPR002131; -. DR INTERPRO; IPR002272; -. DR PFAM; PF00001; 7tm_1; 1. DR PFAM; PF00560; LRR; 4. DR PFAM; PF01462; LRRNT; 1. DR PRINTS; PR00373; GLYCHORMONER. DR PRINTS; PR01143; FSHRECEPTOR. DR PROSITE; PS00237; G_PROTEIN_RECEPTOR; 1. KW G-protein coupled receptor; Transmembrane; Glycoprotein; Signal; KW Phosphorylation; Repeat; Leucine-repeat; Alternative splicing; KW 3D-structure. FT SIGNAL 1 17 POTENTIAL. FT CHAIN 18 695 FOLLICLE STIMULATING HORMONE RECEPTOR. FT DOMAIN 18 366 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 367 387 1 (POTENTIAL). FT DOMAIN 388 398 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 399 421 2 (POTENTIAL). FT DOMAIN 422 443 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 444 465 3 (POTENTIAL). FT DOMAIN 466 485 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 486 508 4 (POTENTIAL). FT DOMAIN 509 528 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 529 550 5 (POTENTIAL). FT DOMAIN 551 573 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 574 597 6 (POTENTIAL). FT DOMAIN 598 608 EXTRACELLULAR (POTENTIAL). FT TRANSMEM 609 630 7 (POTENTIAL). FT DOMAIN 631 695 CYTOPLASMIC (POTENTIAL). FT CARBOHYD 191 191 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 199 199 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 293 293 N-LINKED (GLCNAC...) (POTENTIAL). FT CARBOHYD 318 318 N-LINKED (GLCNAC...) (POTENTIAL). FT DISULFID 442 517 BY SIMILARITY. FT VARSPLIC 224 285 MISSING (IN SHORT TESTICULAR ISOFORM). FT VARSPLIC 342 695 MISSING (IN SHORT TESTICULAR ISOFORM). FT CONFLICT 13 13 S -> R (IN REF. 4). FT CONFLICT 112 112 N -> T (IN REF. 1). FT CONFLICT 197 198 EL -> AV (IN REF. 1). FT CONFLICT 295 295 S -> P (IN REF. 4). FT CONFLICT 307 307 T -> A (IN REF. 1). FT CONFLICT 680 680 N -> S (IN REF. 1). SQ SEQUENCE 695 AA; 78294 MW; 723B8E71F76D2CD5 CRC64; MALLLVSLLA FLSLGSGCHH RICHCSNRVF LCQESKVTEI PSDLPRNAIE LRFVLTKLRV IQKGAFSGFG DLEKIEISQN DVLEVIEADV FSNLPKLHEI RIEKANNLLY INPEAFQNLP NLQYLLISNT GIKHLPDVHK IHSLQKVLLD IQDNINIHTI ERNSFVGLSF ESVILWLNKN GIQEIHNCAF NGTQLDELNL SDNNNLEELP NDVFHGASGP VILDISRTRI HSLPSYGLEN LKKLRARSTY NLKKLPTLEK LVALMEASLT YPSHCCAFAN WRRQISELHP ICNKSILRQE VDYMTQTRGQ RSSLAEDNES SYSRGFDMTY TEFDYDLCNE VVDVTCSPKP DAFNPCEDIM GYNILRVLIW FISILAITGN IIVLVILTTS QYKLTVPRFL MCNLAFADLC IGIYLLLIAS VDIHTKSQYH NYAIDWQTGA GCDAAGFFTV FASELSVYTL TAITLERWHT ITHAMQLDCK VQLRHAASVM VMGWIFAFAA ALFPIFGISS YMKVSICLPM DIDSPLSQLY VMSLLVLNVL AFVVICGCYI HIYLTVRNPN IVSSSSDTRI AKRMAMLIFT DFLCMAPISF FAISASLKVP LITVSKAKIL LVLFHPINSC ANPFLYAIFT KNFRRDFFIL LSKCGCYEMQ AQIYRTETSS TVHNTHPRNG HCSSAPRVTN GSTYILVPLS HLAQN //