ID   FSHR_HUMAN     STANDARD;      PRT;   695 AA.
AC   P23945;
DT   01-MAR-1992 (REL. 21, CREATED)
DT   01-JUN-1994 (REL. 29, LAST SEQUENCE UPDATE)
DT   01-FEB-1996 (REL. 33, LAST ANNOTATION UPDATE)
DE   FOLLICLE STIMULATING HORMONE RECEPTOR PRECURSOR (FSH-R) (FOLLITROPIN
DE   RECEPTOR).
GN   FSHR.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=OVARY;
RX   MEDLINE; 91222171.
RA   MINEGISH T., NAKAMURA K., TAKAKURA Y., IBUKI Y., IGARASHI M.;
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 175:1125-1130(1991).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   TISSUE=TESTIS;
RX   MEDLINE; 93246012.
RA   KELTON C.A., CHENG S.V., NUGENT N.P., SCHWEICKHARDT R.L.,
RA   ROSENTHAL J.L., OVERTON S.A., WANDS G.D., KUZEJA J.B., LUCHETTE C.A.,
RA   CHAPPEL S.C.;
RL   MOL. CELL. ENDOCRINOL. 89:141-151(1992).
RN   [3]
RP   SEQUENCE FROM N.A.
RA   TILLY L.T., AIHARA T., NISHIMORI K., JAI X.-C., BILLIG H.,
RA   KOWALSKI K.I., PERLAS E.A., HSUEH A.J.;
RL   SUBMITTED (XXX-1992) TO EMBL/GENBANK/DDBJ DATA BANKS.
RN   [4]
RP   SEQUENCE OF 1-342 FROM N.A.
RC   TISSUE=TESTIS;
RX   MEDLINE; 93075197.
RA   GROMOLL J., GUDERMANN T., NIESCHLAG E.;
RL   BIOCHEM. BIOPHYS. RES. COMMUN. 188:1077-1083(1992).
CC   -!- FUNCTION: RECEPTOR FOR FOLLICLE STIMULATING HORMONE. THE ACTIVITY
CC       OF THIS RECEPTOR IS MEDIATED BY G PROTEINS WHICH ACTIVATE
CC       ADENYLATE CYCLASE.
CC   -!- SUBCELLULAR LOCATION: INTEGRAL MEMBRANE PROTEIN.
CC   -!- TISSUE SPECIFICITY: SERTOLI CELLS AND OVARIAN GRANULOSA CELLS.
CC   -!- ALTERNATIVE PRODUCTS: A SHORT FORM OF THE TESTICULAR PROTEIN IS
CC       PRODUCED BY ALTERNATIVE SPLICING OF THE SAME GENE. THE SEQUENCE
CC       SHOWN HERE IS THAT OF THE LONG TESTICULAR PROTEIN.
CC   -!- SIMILARITY: HIGHLY SIMILAR TO LSH AND TSH RECEPTORS.
CC   -!- SIMILARITY: BELONGS TO FAMILY 1 OF G-PROTEIN COUPLED RECEPTORS.
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DR   EMBL; M65085; G182771; -.
DR   EMBL; S59900; G300073; -.
DR   EMBL; M95489; G182773; -.
DR   EMBL; X68044; G31474; -.
DR   PIR; JN0122; JN0122.
DR   GCRDB; GCR_0071; -.
DR   GCRDB; GCR_0404; -.
DR   GCRDB; GCR_0690; -.
DR   MIM; 136435; 11TH EDITION.
DR   PROSITE; PS00237; G_PROTEIN_RECEPTOR.
KW   G-PROTEIN COUPLED RECEPTOR; TRANSMEMBRANE; GLYCOPROTEIN; SIGNAL;
KW   PHOSPHORYLATION; REPEAT; LEUCINE-REPEAT; ALTERNATIVE SPLICING.
FT   SIGNAL        1     17       POTENTIAL.
FT   CHAIN        18    695       FOLLICLE STIMULATING HORMONE RECEPTOR.
FT   DOMAIN       18    366       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    367    387       1 (POTENTIAL).
FT   DOMAIN      388    398       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    399    421       2 (POTENTIAL).
FT   DOMAIN      422    443       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    444    465       3 (POTENTIAL).
FT   DOMAIN      466    485       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    486    508       4 (POTENTIAL).
FT   DOMAIN      509    528       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    529    550       5 (POTENTIAL).
FT   DOMAIN      551    573       CYTOPLASMIC (POTENTIAL).
FT   TRANSMEM    574    597       6 (POTENTIAL).
FT   DOMAIN      598    608       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    609    630       7 (POTENTIAL).
FT   DOMAIN      631    695       CYTOPLASMIC (POTENTIAL).
FT   CARBOHYD    191    191       POTENTIAL.
FT   CARBOHYD    199    199       POTENTIAL.
FT   CARBOHYD    293    293       POTENTIAL.
FT   CARBOHYD    318    318       POTENTIAL.
FT   DISULFID    442    517       BY SIMILARITY.
FT   VARSPLIC    224    285       MISSING (IN SHORT TESTICULAR FORM).
FT   VARSPLIC    342    695       MISSING (IN SHORT TESTICULAR FORM).
FT   CONFLICT     13     13       S -> R (IN REF. 4).
FT   CONFLICT    112    112       N -> T (IN REF. 1).
FT   CONFLICT    197    198       EL -> AV (IN REF. 1).
FT   CONFLICT    295    295       S -> P (IN REF. 4).
FT   CONFLICT    307    307       T -> A (IN REF. 1).
FT   CONFLICT    680    680       N -> S (IN REF. 1).
SQ   SEQUENCE   695 AA;  78294 MW;  7032FA16 CRC32;
     MALLLVSLLA FLSLGSGCHH RICHCSNRVF LCQESKVTEI PSDLPRNAIE LRFVLTKLRV
     IQKGAFSGFG DLEKIEISQN DVLEVIEADV FSNLPKLHEI RIEKANNLLY INPEAFQNLP
     NLQYLLISNT GIKHLPDVHK IHSLQKVLLD IQDNINIHTI ERNSFVGLSF ESVILWLNKN
     GIQEIHNCAF NGTQLDELNL SDNNNLEELP NDVFHGASGP VILDISRTRI HSLPSYGLEN
     LKKLRARSTY NLKKLPTLEK LVALMEASLT YPSHCCAFAN WRRQISELHP ICNKSILRQE
     VDYMTQTRGQ RSSLAEDNES SYSRGFDMTY TEFDYDLCNE VVDVTCSPKP DAFNPCEDIM
     GYNILRVLIW FISILAITGN IIVLVILTTS QYKLTVPRFL MCNLAFADLC IGIYLLLIAS
     VDIHTKSQYH NYAIDWQTGA GCDAAGFFTV FASELSVYTL TAITLERWHT ITHAMQLDCK
     VQLRHAASVM VMGWIFAFAA ALFPIFGISS YMKVSICLPM DIDSPLSQLY VMSLLVLNVL
     AFVVICGCYI HIYLTVRNPN IVSSSSDTRI AKRMAMLIFT DFLCMAPISF FAISASLKVP
     LITVSKAKIL LVLFHPINSC ANPFLYAIFT KNFRRDFFIL LSKCGCYEMQ AQIYRTETSS
     TVHNTHPRNG HCSSAPRVTN GSTYILVPLS HLAQN
//