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Protein

Alpha-1D adrenergic receptor

Gene

Adra1d

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

GO - Molecular functioni

  • alpha1-adrenergic receptor activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1D adrenergic receptor
Alternative name(s):
Alpha-1A adrenergic receptor
Alpha-1D adrenoreceptor
Short name:
Alpha-1D adrenoceptor
RA42
Gene namesi
Name:Adra1d
Synonyms:Adra1a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi62064. Adra1d.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 90ExtracellularBy similarityAdd BLAST90
Transmembranei91 – 115Helical; Name=1By similarityAdd BLAST25
Topological domaini116 – 127CytoplasmicBy similarityAdd BLAST12
Transmembranei128 – 153Helical; Name=2By similarityAdd BLAST26
Topological domaini154 – 163ExtracellularBy similarity10
Transmembranei164 – 186Helical; Name=3By similarityAdd BLAST23
Topological domaini187 – 207CytoplasmicBy similarityAdd BLAST21
Transmembranei208 – 232Helical; Name=4By similarityAdd BLAST25
Topological domaini233 – 245ExtracellularBy similarityAdd BLAST13
Transmembranei246 – 269Helical; Name=5By similarityAdd BLAST24
Topological domaini270 – 342CytoplasmicBy similarityAdd BLAST73
Transmembranei343 – 367Helical; Name=6By similarityAdd BLAST25
Topological domaini368 – 374ExtracellularBy similarity7
Transmembranei375 – 399Helical; Name=7By similarityAdd BLAST25
Topological domaini400 – 561CytoplasmicBy similarityAdd BLAST162

GO - Cellular componenti

  • cytosol Source: RGD
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL326.
GuidetoPHARMACOLOGYi24.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690771 – 561Alpha-1D adrenergic receptorAdd BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi60N-linked (GlcNAc...)Sequence analysis1
Glycosylationi76N-linked (GlcNAc...)Sequence analysis1
Lipidationi413S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP23944.

PTM databases

PhosphoSitePlusiP23944.

Expressioni

Tissue specificityi

Vas deferens, hippocampus, cerebral cortex, aorta, brain stem, heart and spleen.

Interactioni

Subunit structurei

Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028877.

Chemistry databases

BindingDBiP23944.

Structurei

3D structure databases

ProteinModelPortaliP23944.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 57Gly-richAdd BLAST37
Compositional biasi416 – 421Poly-Arg6

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239244.
HOVERGENiHBG106962.
InParanoidiP23944.
KOiK04137.
PhylomeDBiP23944.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000363. ADRA1D_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF14. PTHR24248:SF14. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00240. ADRENRGCA1DR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23944-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFRDILSVT FEGPRSSSST GGSGAGGGAG TVGPEGGAVG GVPGATGGGA
60 70 80 90 100
VVGTGSGEDN QSSTGEPGAA ASGEVNGSAA VGGLVVSAQG VGVGVFLAAF
110 120 130 140 150
ILTAVAGNLL VILSVACNRH LQTVTNYFIV NLAVADLLLS AAVLPFSATM
160 170 180 190 200
EVLGFWAFGR TFCDVWAAVD VLCCTASILS LCTISVDRYV GVRHSLKYPA
210 220 230 240 250
IMTERKAAAI LALLWAVALV VSVGPLLGWK EPVPPDERFC GITEEVGYAI
260 270 280 290 300
FSSVCSFYLP MAVIVVMYCR VYVVARSTTR SLEAGIKREP GKASEVVLRI
310 320 330 340 350
HCRGAATSAK GYPGTQSSKG HTLRSSLSVR LLKFSREKKA AKTLAIVVGV
360 370 380 390 400
FVLCWFPFFF VLPLGSLFPQ LKPSEGVFKV IFWLGYFNSC VNPLIYPCSS
410 420 430 440 450
REFKRAFLRL LRCQCRRRRR RLWAVYGHHW RASTGDARSD CAPSPRIAPP
460 470 480 490 500
GAPLALTAHP GAGSADTPET QDSVSSSRKP ASALREWRLL GPLQRPTTQL
510 520 530 540 550
RAKVSSLSHK IRSGARRAET ACALRSEVEA VSLNVPQDGA EAVICQAYEP
560
GDYSNLRETD I
Length:561
Mass (Da):59,354
Last modified:November 1, 1995 - v2
Checksum:iB6537DCAD4F7BE27
GO

Sequence cautioni

The sequence AAA63477 differs from that shown. Reason: Frameshift at positions 424 and 483.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60654 mRNA. Translation: AAA63477.1. Frameshift.
L31771 mRNA. Translation: AAB59704.1.
AF071014 Genomic DNA. Translation: AAC25396.1.
PIRiA38731.
RefSeqiNP_077809.1. NM_024483.1.
UniGeneiRn.11314.

Genome annotation databases

GeneIDi29413.
KEGGirno:29413.
UCSCiRGD:62064. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60654 mRNA. Translation: AAA63477.1. Frameshift.
L31771 mRNA. Translation: AAB59704.1.
AF071014 Genomic DNA. Translation: AAC25396.1.
PIRiA38731.
RefSeqiNP_077809.1. NM_024483.1.
UniGeneiRn.11314.

3D structure databases

ProteinModelPortaliP23944.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028877.

Chemistry databases

BindingDBiP23944.
ChEMBLiCHEMBL326.
GuidetoPHARMACOLOGYi24.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP23944.

Proteomic databases

PaxDbiP23944.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29413.
KEGGirno:29413.
UCSCiRGD:62064. rat.

Organism-specific databases

CTDi146.
RGDi62064. Adra1d.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239244.
HOVERGENiHBG106962.
InParanoidiP23944.
KOiK04137.
PhylomeDBiP23944.

Miscellaneous databases

PROiP23944.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000363. ADRA1D_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF14. PTHR24248:SF14. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00240. ADRENRGCA1DR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADA1D_RAT
AccessioniPrimary (citable) accession number: P23944
Secondary accession number(s): Q71UM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.