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P23944 (ADA1D_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-1D adrenergic receptor
Alternative name(s):
Alpha-1A adrenergic receptor
Alpha-1D adrenoreceptor
Short name=Alpha-1D adrenoceptor
RA42
Gene names
Name:Adra1d
Synonyms:Adra1a
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length561 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Vas deferens, hippocampus, cerebral cortex, aorta, brain stem, heart and spleen.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.

Sequence caution

The sequence AAA63477.1 differs from that shown. Reason: Frameshift at positions 424 and 483.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 561561Alpha-1D adrenergic receptor
PRO_0000069077

Regions

Topological domain1 – 9090Extracellular By similarity
Transmembrane91 – 11525Helical; Name=1; By similarity
Topological domain116 – 12712Cytoplasmic By similarity
Transmembrane128 – 15326Helical; Name=2; By similarity
Topological domain154 – 16310Extracellular By similarity
Transmembrane164 – 18623Helical; Name=3; By similarity
Topological domain187 – 20721Cytoplasmic By similarity
Transmembrane208 – 23225Helical; Name=4; By similarity
Topological domain233 – 24513Extracellular By similarity
Transmembrane246 – 26924Helical; Name=5; By similarity
Topological domain270 – 34273Cytoplasmic By similarity
Transmembrane343 – 36725Helical; Name=6; By similarity
Topological domain368 – 3747Extracellular By similarity
Transmembrane375 – 39925Helical; Name=7; By similarity
Topological domain400 – 561162Cytoplasmic By similarity
Compositional bias21 – 5737Gly-rich
Compositional bias416 – 4216Poly-Arg

Amino acid modifications

Lipidation4131S-palmitoyl cysteine Potential
Glycosylation601N-linked (GlcNAc...) Potential
Glycosylation761N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P23944 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: B6537DCAD4F7BE27

FASTA56159,354
        10         20         30         40         50         60 
MTFRDILSVT FEGPRSSSST GGSGAGGGAG TVGPEGGAVG GVPGATGGGA VVGTGSGEDN 

        70         80         90        100        110        120 
QSSTGEPGAA ASGEVNGSAA VGGLVVSAQG VGVGVFLAAF ILTAVAGNLL VILSVACNRH 

       130        140        150        160        170        180 
LQTVTNYFIV NLAVADLLLS AAVLPFSATM EVLGFWAFGR TFCDVWAAVD VLCCTASILS 

       190        200        210        220        230        240 
LCTISVDRYV GVRHSLKYPA IMTERKAAAI LALLWAVALV VSVGPLLGWK EPVPPDERFC 

       250        260        270        280        290        300 
GITEEVGYAI FSSVCSFYLP MAVIVVMYCR VYVVARSTTR SLEAGIKREP GKASEVVLRI 

       310        320        330        340        350        360 
HCRGAATSAK GYPGTQSSKG HTLRSSLSVR LLKFSREKKA AKTLAIVVGV FVLCWFPFFF 

       370        380        390        400        410        420 
VLPLGSLFPQ LKPSEGVFKV IFWLGYFNSC VNPLIYPCSS REFKRAFLRL LRCQCRRRRR 

       430        440        450        460        470        480 
RLWAVYGHHW RASTGDARSD CAPSPRIAPP GAPLALTAHP GAGSADTPET QDSVSSSRKP 

       490        500        510        520        530        540 
ASALREWRLL GPLQRPTTQL RAKVSSLSHK IRSGARRAET ACALRSEVEA VSLNVPQDGA 

       550        560 
EAVICQAYEP GDYSNLRETD I

« Hide

References

[1]"Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5."
Lomasney J.W., Cotecchia S., Lorenz W., Leung W.-Y., Schwinn D.A., Yang-Feng T.L., Brownstein M., Lefkowitz R.J., Caron M.G.
J. Biol. Chem. 266:6365-6369(1991) [PubMed: 1706716] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Sprague-Dawley.
Tissue: Brain cortex.
[2]"Solution-phase library screening for the identification of rare clones: isolation of an alpha 1D-adrenergic receptor cDNA."
Perez D.M., Piascik M.T., Graham R.M.
Mol. Pharmacol. 40:876-883(1991) [PubMed: 1661838] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Hippocampus.
[3]"Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues."
Schwinn D.A., Johnston G.I., Page S.O., Mosley M.J., Wilson K.H., Worman N.P., Campbell S., Fidock M.D., Furness L.M., Parry-Smith D.J., Peter B., Bailey D.S.
J. Pharmacol. Exp. Ther. 272:134-142(1995) [PubMed: 7815325] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Platelet-derived growth factor-BB inhibits rat alpha1D-adrenergic receptor gene expression in vascular smooth muscle cells by inducing AP-2-like protein binding to alpha1D proximal promoter region."
Xin X., Yang N., Faber J.E.
Mol. Pharmacol. 56:1152-1161(1999) [PubMed: 10570042] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-62.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M60654 mRNA. Translation: AAA63477.1. Frameshift.
L31771 mRNA. Translation: AAB59704.1.
AF071014 Genomic DNA. Translation: AAC25396.1.
IPIIPI00215504.
PIRA38731.
RefSeqNP_077809.1. NM_024483.1.
UniGeneRn.11314.

3D structure databases

ProteinModelPortalP23944.
ModBaseSearch...

Protein-protein interaction databases

STRINGP23944.

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID29413.
KEGGrno:29413.
UCSCNM_024483. rat.

Organism-specific databases

CTD146.
RGD62064. Adra1d.

Phylogenomic databases

eggNOGroNOG05337.
GeneTreeENSGT00600000084087.
HOVERGENHBG106962.
InParanoidP23944.
OrthoDBEOG480HWT.

Gene expression databases

ArrayExpressP23944.
GenevestigatorP23944.
GermOnlineENSRNOG00000021256. Rattus norvegicus.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR000363. Adren_rcpt_A1A.
IPR002233. Adrnrgc_rcpt.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
KOK04137.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01103. ADRENERGICR.
PR00240. ADRENRGCA1DR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio609084.

Entry information

Entry nameADA1D_RAT
AccessionPrimary (citable) accession number: P23944
Secondary accession number(s): Q71UM4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1995
Last modified: November 16, 2011
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

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