P23943 (EDN2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Endothelin-2
Short name=ET-2

Alternative name(s):
Preproendothelin-2
Short name=PPET2
Vasoactive intestinal contractor
Short name=VIC

Gene names

Name:

Edn2

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	176 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Vasoconstrictor.
Subcellular location	Secreted.
Sequence similarities	Belongs to the endothelin/sarafotoxin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Vasoactive Vasoconstrictor
PTM	Cleavage on pair of basic residues Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of hormone secretion Inferred from direct assay PubMed 1533364. Source: RGD ovarian follicle rupture Inferred from direct assay PubMed 16410304. Source: RGD positive regulation of hormone secretion Inferred from direct assay PubMed 1533364. Source: RGD positive regulation of smooth muscle contraction Inferred from direct assay PubMed 12396026. Source: RGD protein kinase C-activating G-protein coupled receptor signaling pathway Inferred from mutant phenotype PubMed 1533364. Source: RGD regulation of blood pressure Inferred from genetic interaction PubMed 8201007. Source: RGD regulation of vasoconstriction Inferred from electronic annotation. Source: InterPro vasoconstriction Traceable author statement PubMed 8201007. Source: RGD
Cellular_component	extracellular space Inferred from direct assay PubMed 1860178. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Propeptide	23 – 44	22			PRO_0000008105
	Peptide	47 – 67	21	Endothelin-2		PRO_0000008106
	Propeptide	68 – 176	109			PRO_0000008107
Regions
	Region	94 – 109	16	Endothelin-like
Sites
	Site	67 – 68	2	Cleavage; by KEL By similarity
Amino acid modifications
	Disulfide bond	47 ↔ 61		By similarity
	Disulfide bond	49 ↔ 57		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P23943 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: 9CAE30134EB1E73F	FASTA	176	19,478
	10 20 30 40 50 60 MVSPAWCSIA LALLLALHEG KGQAAATMEQ PASAPKGRGP HLRFRRCSCN SWLDKECVYF 70 80 90 100 110 120 CHLDIIWVNT AGQTAPYGLG NPPQRRRRSL PKRCECSSAG DSACATFCHR RPWPEAEVTS 130 140 150 160 170 SSQGPAAVLE TSKTWTAAGD LLQKLRDISA AKLQFVRLRP ELTREAIPAH SRRRKR

References

[1]	"Structure and organization of the rat endothelin-2 gene." Deng A.Y. Mamm. Genome 8:157-157(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"cDNA cloning and chromosomal assignment of the endothelin 2 gene: vasoactive intestinal contractor peptide is rat endothelin 2." Bloch K.D., Hong C.C., Eddy R.L. Jr., Shows T.B., Quertermous T. Genomics 10:236-242(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-71.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U64949 , U59510, U64946, U64947, U64948 Genomic DNA. Translation: AAB39213.1. M65200 Genomic DNA. Translation: AAA42338.1.
IPI	IPI00215502.
PIR	B39070.
RefSeq	NP_036681.1. NM_012549.2.
UniGene	Rn.10642.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000012569.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	24324.
KEGG	rno:24324.
UCSC	RGD:2533. rat.
Organism-specific databases
CTD	1907.
RGD	2533. Edn2.
Phylogenomic databases
eggNOG	NOG43933.
HOGENOM	HOG000231110.
HOVERGEN	HBG051441.
InParanoid	P23943.
KO	K16367.
OrthoDB	EOG4WH8N0.
Gene expression databases
Genevestigator	P23943.
GermOnline	ENSRNOG00000009390. Rattus norvegicus.
Family and domain databases
InterPro	IPR020475. Bibrotoxin/Sarafotoxin-D. IPR019764. Endothelin_toxin_CS. IPR001928. Endothln-like_toxin. IPR015658. ET-2. [Graphical view]
PANTHER	PTHR13874:SF4. PTHR13874:SF4. 1 hit.
Pfam	PF00322. Endothelin. 1 hit. [Graphical view]
PRINTS	PR00365. ENDOTHELIN.
SMART	SM00272. END. 2 hits. [Graphical view]
PROSITE	PS00270. ENDOTHELIN. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	602987.

Entry information

Entry name

EDN2_RAT

Accession

Primary (citable) accession number: P23943

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 1992
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program