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P23943 (EDN2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Endothelin-2

Short name=ET-2
Alternative name(s):
Preproendothelin-2
Short name=PPET2
Vasoactive intestinal contractor
Short name=VIC
Gene names
Name:Edn2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length176 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Vasoconstrictor.

Subcellular location

Secreted.

Sequence similarities

Belongs to the endothelin/sarafotoxin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Propeptide23 – 4422
PRO_0000008105
Peptide47 – 6721Endothelin-2
PRO_0000008106
Propeptide68 – 176109
PRO_0000008107

Regions

Region94 – 10916Endothelin-like

Sites

Site67 – 682Cleavage; by KEL By similarity

Amino acid modifications

Disulfide bond47 ↔ 61 By similarity
Disulfide bond49 ↔ 57 By similarity

Sequences

Sequence LengthMass (Da)Tools
P23943 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 9CAE30134EB1E73F

FASTA17619,478
        10         20         30         40         50         60 
MVSPAWCSIA LALLLALHEG KGQAAATMEQ PASAPKGRGP HLRFRRCSCN SWLDKECVYF 

        70         80         90        100        110        120 
CHLDIIWVNT AGQTAPYGLG NPPQRRRRSL PKRCECSSAG DSACATFCHR RPWPEAEVTS 

       130        140        150        160        170 
SSQGPAAVLE TSKTWTAAGD LLQKLRDISA AKLQFVRLRP ELTREAIPAH SRRRKR 

« Hide

References

[1]"Structure and organization of the rat endothelin-2 gene."
Deng A.Y.
Mamm. Genome 8:157-157(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"cDNA cloning and chromosomal assignment of the endothelin 2 gene: vasoactive intestinal contractor peptide is rat endothelin 2."
Bloch K.D., Hong C.C., Eddy R.L. Jr., Shows T.B., Quertermous T.
Genomics 10:236-242(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-71.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U64949 expand/collapse EMBL AC list , U59510, U64946, U64947, U64948 Genomic DNA. Translation: AAB39213.1.
M65200 Genomic DNA. Translation: AAA42338.1.
PIRB39070.
RefSeqNP_036681.1. NM_012549.2.
UniGeneRn.10642.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000012569.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID24324.
KEGGrno:24324.
UCSCRGD:2533. rat.

Organism-specific databases

CTD1907.
RGD2533. Edn2.

Phylogenomic databases

eggNOGNOG43933.
HOGENOMHOG000231110.
HOVERGENHBG051441.
InParanoidP23943.
KOK16367.
PhylomeDBP23943.

Gene expression databases

GenevestigatorP23943.

Family and domain databases

InterProIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
IPR015658. ET-2.
[Graphical view]
PANTHERPTHR13874:SF8. PTHR13874:SF8. 1 hit.
PfamPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSPR00365. ENDOTHELIN.
SMARTSM00272. END. 2 hits.
[Graphical view]
PROSITEPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio602987.
PROP23943.

Entry information

Entry nameEDN2_RAT
AccessionPrimary (citable) accession number: P23943
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families