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P23943

- EDN2_RAT

UniProt

P23943 - EDN2_RAT

Protein

Endothelin-2

Gene

Edn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Vasoconstrictor.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei67 – 682Cleavage; by KELBy similarity

    GO - Biological processi

    1. negative regulation of hormone secretion Source: RGD
    2. ovarian follicle rupture Source: RGD
    3. positive regulation of hormone secretion Source: RGD
    4. positive regulation of smooth muscle contraction Source: RGD
    5. protein kinase C-activating G-protein coupled receptor signaling pathway Source: RGD
    6. regulation of blood pressure Source: RGD
    7. regulation of vasoconstriction Source: InterPro
    8. vasoconstriction Source: RGD

    Keywords - Molecular functioni

    Vasoactive, Vasoconstrictor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endothelin-2
    Short name:
    ET-2
    Alternative name(s):
    Preproendothelin-2
    Short name:
    PPET2
    Vasoactive intestinal contractor
    Short name:
    VIC
    Gene namesi
    Name:Edn2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2533. Edn2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Propeptidei23 – 4422PRO_0000008105Add
    BLAST
    Peptidei47 – 6721Endothelin-2PRO_0000008106Add
    BLAST
    Propeptidei68 – 176109PRO_0000008107Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi47 ↔ 61By similarity
    Disulfide bondi49 ↔ 57By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond

    Expressioni

    Gene expression databases

    GenevestigatoriP23943.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000012569.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 10916Endothelin-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the endothelin/sarafotoxin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG43933.
    HOGENOMiHOG000231110.
    HOVERGENiHBG051441.
    InParanoidiP23943.
    KOiK16367.
    PhylomeDBiP23943.

    Family and domain databases

    InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    IPR015658. ET-2.
    [Graphical view]
    PANTHERiPTHR13874:SF8. PTHR13874:SF8. 1 hit.
    PfamiPF00322. Endothelin. 1 hit.
    [Graphical view]
    PRINTSiPR00365. ENDOTHELIN.
    SMARTiSM00272. END. 2 hits.
    [Graphical view]
    PROSITEiPS00270. ENDOTHELIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P23943-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSPAWCSIA LALLLALHEG KGQAAATMEQ PASAPKGRGP HLRFRRCSCN    50
    SWLDKECVYF CHLDIIWVNT AGQTAPYGLG NPPQRRRRSL PKRCECSSAG 100
    DSACATFCHR RPWPEAEVTS SSQGPAAVLE TSKTWTAAGD LLQKLRDISA 150
    AKLQFVRLRP ELTREAIPAH SRRRKR 176
    Length:176
    Mass (Da):19,478
    Last modified:November 1, 1997 - v2
    Checksum:i9CAE30134EB1E73F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U64949
    , U59510, U64946, U64947, U64948 Genomic DNA. Translation: AAB39213.1.
    M65200 Genomic DNA. Translation: AAA42338.1.
    PIRiB39070.
    RefSeqiNP_036681.1. NM_012549.2.
    UniGeneiRn.10642.

    Genome annotation databases

    GeneIDi24324.
    KEGGirno:24324.
    UCSCiRGD:2533. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U64949
    , U59510 , U64946 , U64947 , U64948 Genomic DNA. Translation: AAB39213.1 .
    M65200 Genomic DNA. Translation: AAA42338.1 .
    PIRi B39070.
    RefSeqi NP_036681.1. NM_012549.2.
    UniGenei Rn.10642.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000012569.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 24324.
    KEGGi rno:24324.
    UCSCi RGD:2533. rat.

    Organism-specific databases

    CTDi 1907.
    RGDi 2533. Edn2.

    Phylogenomic databases

    eggNOGi NOG43933.
    HOGENOMi HOG000231110.
    HOVERGENi HBG051441.
    InParanoidi P23943.
    KOi K16367.
    PhylomeDBi P23943.

    Miscellaneous databases

    NextBioi 602987.
    PROi P23943.

    Gene expression databases

    Genevestigatori P23943.

    Family and domain databases

    InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
    IPR019764. Endothelin_toxin_CS.
    IPR001928. Endothln-like_toxin.
    IPR015658. ET-2.
    [Graphical view ]
    PANTHERi PTHR13874:SF8. PTHR13874:SF8. 1 hit.
    Pfami PF00322. Endothelin. 1 hit.
    [Graphical view ]
    PRINTSi PR00365. ENDOTHELIN.
    SMARTi SM00272. END. 2 hits.
    [Graphical view ]
    PROSITEi PS00270. ENDOTHELIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and organization of the rat endothelin-2 gene."
      Deng A.Y.
      Mamm. Genome 8:157-157(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "cDNA cloning and chromosomal assignment of the endothelin 2 gene: vasoactive intestinal contractor peptide is rat endothelin 2."
      Bloch K.D., Hong C.C., Eddy R.L. Jr., Shows T.B., Quertermous T.
      Genomics 10:236-242(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-71.

    Entry informationi

    Entry nameiEDN2_RAT
    AccessioniPrimary (citable) accession number: P23943
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3