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Protein

Endothelin-2

Gene

Edn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Vasoconstrictor.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei67 – 682Cleavage; by KELBy similarity

GO - Biological processi

  • negative regulation of hormone secretion Source: RGD
  • ovarian follicle rupture Source: RGD
  • positive regulation of hormone secretion Source: RGD
  • positive regulation of smooth muscle contraction Source: RGD
  • protein kinase C-activating G-protein coupled receptor signaling pathway Source: RGD
  • regulation of vasoconstriction Source: InterPro
  • vasoconstriction Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive, Vasoconstrictor

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-2
Short name:
ET-2
Alternative name(s):
Preproendothelin-2
Short name:
PPET2
Vasoactive intestinal contractor
Short name:
VIC
Gene namesi
Name:Edn2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2533. Edn2.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Propeptidei23 – 4422PRO_0000008105Add
BLAST
Peptidei47 – 6721Endothelin-2PRO_0000008106Add
BLAST
Propeptidei68 – 176109PRO_0000008107Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 61By similarity
Disulfide bondi49 ↔ 57By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Expressioni

Gene expression databases

GenevisibleiP23943. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012569.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 10916Endothelin-likeAdd
BLAST

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG43933.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP23943.
KOiK16367.
PhylomeDBiP23943.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
IPR015658. ET-2.
[Graphical view]
PANTHERiPTHR13874:SF8. PTHR13874:SF8. 1 hit.
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSPAWCSIA LALLLALHEG KGQAAATMEQ PASAPKGRGP HLRFRRCSCN
60 70 80 90 100
SWLDKECVYF CHLDIIWVNT AGQTAPYGLG NPPQRRRRSL PKRCECSSAG
110 120 130 140 150
DSACATFCHR RPWPEAEVTS SSQGPAAVLE TSKTWTAAGD LLQKLRDISA
160 170
AKLQFVRLRP ELTREAIPAH SRRRKR
Length:176
Mass (Da):19,478
Last modified:November 1, 1997 - v2
Checksum:i9CAE30134EB1E73F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64949
, U59510, U64946, U64947, U64948 Genomic DNA. Translation: AAB39213.1.
M65200 Genomic DNA. Translation: AAA42338.1.
PIRiB39070.
RefSeqiNP_036681.1. NM_012549.2.
UniGeneiRn.10642.

Genome annotation databases

GeneIDi24324.
KEGGirno:24324.
UCSCiRGD:2533. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64949
, U59510, U64946, U64947, U64948 Genomic DNA. Translation: AAB39213.1.
M65200 Genomic DNA. Translation: AAA42338.1.
PIRiB39070.
RefSeqiNP_036681.1. NM_012549.2.
UniGeneiRn.10642.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012569.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24324.
KEGGirno:24324.
UCSCiRGD:2533. rat.

Organism-specific databases

CTDi1907.
RGDi2533. Edn2.

Phylogenomic databases

eggNOGiNOG43933.
HOGENOMiHOG000231110.
HOVERGENiHBG051441.
InParanoidiP23943.
KOiK16367.
PhylomeDBiP23943.

Miscellaneous databases

NextBioi602987.
PROiP23943.

Gene expression databases

GenevisibleiP23943. RN.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
IPR015658. ET-2.
[Graphical view]
PANTHERiPTHR13874:SF8. PTHR13874:SF8. 1 hit.
PfamiPF00322. Endothelin. 1 hit.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 2 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure and organization of the rat endothelin-2 gene."
    Deng A.Y.
    Mamm. Genome 8:157-157(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "cDNA cloning and chromosomal assignment of the endothelin 2 gene: vasoactive intestinal contractor peptide is rat endothelin 2."
    Bloch K.D., Hong C.C., Eddy R.L. Jr., Shows T.B., Quertermous T.
    Genomics 10:236-242(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-71.

Entry informationi

Entry nameiEDN2_RAT
AccessioniPrimary (citable) accession number: P23943
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: November 1, 1997
Last modified: June 24, 2015
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.