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Protein

Alpha-crystallin B chain

Gene

Cryab

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83Zinc 1By similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi111Zinc 1By similarity1
Metal bindingi119Zinc 1By similarity1

GO - Molecular functioni

GO - Biological processi

  • apoptotic process involved in morphogenesis Source: MGI
  • camera-type eye development Source: MGI
  • cellular response to gamma radiation Source: MGI
  • lens development in camera-type eye Source: MGI
  • microtubule polymerization or depolymerization Source: Ensembl
  • multicellular organism aging Source: Ensembl
  • muscle organ development Source: MGI
  • negative regulation of amyloid fibril formation Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of cell growth Source: Ensembl
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • negative regulation of gene expression Source: MGI
  • negative regulation of intracellular transport Source: MGI
  • negative regulation of protein homooligomerization Source: MGI
  • negative regulation of reactive oxygen species metabolic process Source: Ensembl
  • protein folding Source: Ensembl
  • protein homooligomerization Source: MGI
  • protein stabilization Source: MGI
  • regulation of cell death Source: MGI
  • response to estradiol Source: Ensembl
  • response to hydrogen peroxide Source: MGI
  • response to hypoxia Source: MGI
  • stress-activated MAPK cascade Source: Ensembl
  • tubulin complex assembly Source: MGI

Keywordsi

Molecular functionChaperone, Eye lens protein
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-3371571 HSF1-dependent transactivation

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-crystallin B chain
Alternative name(s):
Alpha(B)-crystallin
P23
Gene namesi
Name:Cryab
Synonyms:Crya2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:88516 Cryab

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001259101 – 175Alpha-crystallin B chainAdd BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarityCurated1
Modified residuei19PhosphoserineCombined sources1
Modified residuei22Omega-N-methylated arginineBy similarity1
Modified residuei45PhosphoserineBy similarity1
Modified residuei50Omega-N-methylated arginineBy similarity1
Modified residuei59PhosphoserineCombined sources1
Modified residuei92N6-acetyllysineBy similarity1
Modified residuei166N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP23927
PeptideAtlasiP23927
PRIDEiP23927
TopDownProteomicsiP23927

2D gel databases

SWISS-2DPAGEiP23927

PTM databases

iPTMnetiP23927
PhosphoSitePlusiP23927

Expressioni

Tissue specificityi

Lens as well as other tissues.

Gene expression databases

BgeeiENSMUSG00000032060
CleanExiMM_CRYAB
ExpressionAtlasiP23927 baseline and differential
GenevisibleiP23927 MM

Interactioni

Subunit structurei

Heteropolymer composed of three CRYAA and one CRYAB subunits. Aggregates with homologous proteins, including the small heat shock protein HSPB1, to form large heteromeric complexes. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens (By similarity). Interacts with HSPBAP1 (PubMed:10751411). Interacts with TTN/titin. Interacts with TMEM109. Interacts with DES; binds rapidly during early stages of DES filament assembly and a reduced binding seen in the later stages (By similarity).By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198909, 9 interactors
DIPiDIP-31060N
IntActiP23927, 14 interactors
MINTiP23927
STRINGi10090.ENSMUSP00000034562

Structurei

3D structure databases

ProteinModelPortaliP23927
SMRiP23927
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 164sHSPPROSITE-ProRule annotationAdd BLAST109

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
GeneTreeiENSGT00760000119238
HOGENOMiHOG000233954
HOVERGENiHBG054766
InParanoidiP23927
KOiK09542
OMAiTAPMKKL
OrthoDBiEOG091G0USC
PhylomeDBiP23927
TreeFamiTF105049

Family and domain databases

CDDicd06498 ACD_alphaB-crystallin_HspB5, 1 hit
Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR037882 ACD_alphaB-crystallin
IPR001436 Alpha-crystallin/HSP
IPR003090 Alpha-crystallin_N
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00525 Crystallin, 1 hit
PF00011 HSP20, 1 hit
PIRSFiPIRSF036514 Sm_HSP_B1, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequencei

Sequence statusi: Complete.

P23927-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIAIHHPWI RRPFFPFHSP SRLFDQFFGE HLLESDLFST ATSLSPFYLR
60 70 80 90 100
PPSFLRAPSW IDTGLSEMRL EKDRFSVNLD VKHFSPEELK VKVLGDVIEV
110 120 130 140 150
HGKHEERQDE HGFISREFHR KYRIPADVDP LTITSSLSSD GVLTVNGPRK
160 170
QVSGPERTIP ITREEKPAVA AAPKK
Length:175
Mass (Da):20,069
Last modified:July 15, 1999 - v2
Checksum:i46702976C008EFD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63170 mRNA Translation: AAA37472.1
M73741 Genomic DNA Translation: AAA67045.1
BC010768 mRNA Translation: AAH10768.1
M25770 Genomic DNA Translation: AAA37133.1
CCDSiCCDS23172.1
PIRiA39608
RefSeqiNP_001276711.1, NM_001289782.1
NP_001276713.1, NM_001289784.1
NP_001276714.1, NM_001289785.1
NP_034094.1, NM_009964.3
XP_006510033.1, XM_006509970.3
UniGeneiMm.178

Genome annotation databases

EnsembliENSMUST00000034562; ENSMUSP00000034562; ENSMUSG00000032060
ENSMUST00000214962; ENSMUSP00000149759; ENSMUSG00000032060
ENSMUST00000216755; ENSMUSP00000150669; ENSMUSG00000032060
ENSMUST00000217475; ENSMUSP00000149803; ENSMUSG00000032060
GeneIDi12955
KEGGimmu:12955
UCSCiuc009pkl.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCRYAB_MOUSE
AccessioniPrimary (citable) accession number: P23927
Secondary accession number(s): Q64325
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: July 15, 1999
Last modified: May 23, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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