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Protein

Transcriptional activator protein anr

Gene

anr

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein predictedi

Functioni

Transcriptional activator of anaerobic gene expression.

Miscellaneous

Possesses 4 cysteines which may bind a metal ion (possibly iron).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 149cNMPAdd BLAST129
DNA bindingi192 – 211H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • cellular response to decreased oxygen levels Source: PseudoCAP
  • cyanide biosynthetic process Source: PseudoCAP
  • negative regulation of phospholipase C activity Source: PseudoCAP
  • positive regulation of oxidoreductase activity Source: PseudoCAP
  • regulation of arginine catabolic process Source: PseudoCAP
  • regulation of transcription, DNA-templated Source: PseudoCAP
  • response to decreased oxygen levels Source: PseudoCAP
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandIron

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator protein anr
Gene namesi
Name:anr
Ordered Locus Names:PA1544
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA1544.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001001421 – 244Transcriptional activator protein anrAdd BLAST244

Proteomic databases

PaxDbiP23926.
PRIDEiP23926.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA1544.

Structurei

3D structure databases

ProteinModelPortaliP23926.
SMRiP23926.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini159 – 232HTH crp-typePROSITE-ProRule annotationAdd BLAST74

Phylogenomic databases

eggNOGiENOG4105DS0. Bacteria.
COG0664. LUCA.
HOGENOMiHOG000186461.
InParanoidiP23926.
KOiK01420.
OMAiTLPMSKK.
PhylomeDBiP23926.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiView protein in InterPro
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP.
IPR014710. RmlC-like_jellyroll.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
PRINTSiPR00034. HTHCRP.
SMARTiView protein in SMART
SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51206. SSF51206. 1 hit.
PROSITEiView protein in PROSITE
PS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P23926-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETIKVRAL PQAHCKDCSL APLCLPLSLT VEDMDSLDEI VKRGRPLKKG
60 70 80 90 100
EFLFRQGDPF GSVFAVRSGA LKTFSITDAG EEQITGFHLP SELVGLSGMD
110 120 130 140 150
TETYPVSAQA LETTSVCEIP FERLDELSEQ LPQLRRQLMR LMSREIRDDQ
160 170 180 190 200
QMMLLLSKKT ADERIATFLV NLSARFRARG FSAQQFRLAM SRNEIGNYLG
210 220 230 240
LAVETVSRVF TRFQQNGLIS AEGKEVHILD SIELCALAGG QLEG
Length:244
Mass (Da):27,129
Last modified:March 1, 1992 - v1
Checksum:iA57E6C0CFB32600B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58405 Genomic DNA. Translation: CAA41305.1.
X57736 Genomic DNA. Translation: CAA40906.1.
M98276 Genomic DNA. Translation: AAA25713.1.
AE004091 Genomic DNA. Translation: AAG04933.1.
PIRiS16307.
RefSeqiNP_250235.1. NC_002516.2.
WP_003087262.1. NC_002516.2.

Genome annotation databases

EnsemblBacteriaiAAG04933; AAG04933; PA1544.
GeneIDi883009.
KEGGipae:PA1544.
PATRICifig|208964.12.peg.1597.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiANR_PSEAE
AccessioniPrimary (citable) accession number: P23926
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: July 5, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome