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P23926

- ANR_PSEAE

UniProt

P23926 - ANR_PSEAE

Protein

Transcriptional activator protein anr

Gene

anr

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    Transcriptional activator of anaerobic gene expression.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi21 – 149129cNMPAdd
    BLAST
    DNA bindingi192 – 21120H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: InterPro
    2. transcription regulatory region DNA binding Source: PseudoCAP

    GO - Biological processi

    1. cellular response to decreased oxygen levels Source: PseudoCAP
    2. cyanide biosynthetic process Source: PseudoCAP
    3. positive regulation of oxidoreductase activity Source: PseudoCAP
    4. regulation of arginine catabolic process Source: PseudoCAP
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Iron

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional activator protein anr
    Gene namesi
    Name:anr
    Ordered Locus Names:PA1544
    OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    Taxonomic identifieri208964 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
    ProteomesiUP000002438: Chromosome

    Organism-specific databases

    PseudoCAPiPA1544.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 244244Transcriptional activator protein anrPRO_0000100142Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi208964.PA1544.

    Structurei

    3D structure databases

    ProteinModelPortaliP23926.
    SMRiP23926. Positions 8-230.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini159 – 23274HTH crp-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
    Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000186461.
    KOiK01420.
    OMAiFSANQFR.
    OrthoDBiEOG6RVFWF.
    PhylomeDBiP23926.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    IPR001808. Tscrpt_reg_HTH_Crp.
    IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00325. Crp. 1 hit.
    [Graphical view]
    PRINTSiPR00034. HTHCRP.
    SMARTiSM00100. cNMP. 1 hit.
    SM00419. HTH_CRP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS00042. HTH_CRP_1. 1 hit.
    PS51063. HTH_CRP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23926-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAETIKVRAL PQAHCKDCSL APLCLPLSLT VEDMDSLDEI VKRGRPLKKG    50
    EFLFRQGDPF GSVFAVRSGA LKTFSITDAG EEQITGFHLP SELVGLSGMD 100
    TETYPVSAQA LETTSVCEIP FERLDELSEQ LPQLRRQLMR LMSREIRDDQ 150
    QMMLLLSKKT ADERIATFLV NLSARFRARG FSAQQFRLAM SRNEIGNYLG 200
    LAVETVSRVF TRFQQNGLIS AEGKEVHILD SIELCALAGG QLEG 244
    Length:244
    Mass (Da):27,129
    Last modified:March 1, 1992 - v1
    Checksum:iA57E6C0CFB32600B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58405 Genomic DNA. Translation: CAA41305.1.
    X57736 Genomic DNA. Translation: CAA40906.1.
    M98276 Genomic DNA. Translation: AAA25713.1.
    AE004091 Genomic DNA. Translation: AAG04933.1.
    PIRiS16307.
    RefSeqiNP_250235.1. NC_002516.2.

    Genome annotation databases

    EnsemblBacteriaiAAG04933; AAG04933; PA1544.
    GeneIDi883009.
    KEGGipae:PA1544.
    PATRICi19837422. VBIPseAer58763_1597.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X58405 Genomic DNA. Translation: CAA41305.1 .
    X57736 Genomic DNA. Translation: CAA40906.1 .
    M98276 Genomic DNA. Translation: AAA25713.1 .
    AE004091 Genomic DNA. Translation: AAG04933.1 .
    PIRi S16307.
    RefSeqi NP_250235.1. NC_002516.2.

    3D structure databases

    ProteinModelPortali P23926.
    SMRi P23926. Positions 8-230.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 208964.PA1544.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAG04933 ; AAG04933 ; PA1544 .
    GeneIDi 883009.
    KEGGi pae:PA1544.
    PATRICi 19837422. VBIPseAer58763_1597.

    Organism-specific databases

    PseudoCAPi PA1544.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000186461.
    KOi K01420.
    OMAi FSANQFR.
    OrthoDBi EOG6RVFWF.
    PhylomeDBi P23926.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    IPR001808. Tscrpt_reg_HTH_Crp.
    IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00325. Crp. 1 hit.
    [Graphical view ]
    PRINTSi PR00034. HTHCRP.
    SMARTi SM00100. cNMP. 1 hit.
    SM00419. HTH_CRP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS00042. HTH_CRP_1. 1 hit.
    PS51063. HTH_CRP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and molecular characterization of a transcriptional regulator from Pseudomonas aeruginosa PAO1 exhibiting structural and functional similarity to the FNR protein of Escherichia coli."
      Sawers R.G.
      Mol. Microbiol. 5:1469-1481(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
    2. "Anaerobic growth and cyanide synthesis of Pseudomonas aeruginosa depend on anr, a regulatory gene homologous with fnr of Escherichia coli."
      Zimmermann A., Reimmann C., Galimand M., Haas D.
      Mol. Microbiol. 5:1483-1490(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
    3. "RpoN-independent promoters having a conserved GG-N10-GC motif in Pseudomonas aeruginosa."
      Savioz A., Zimmermann A., Haas D.
      Submitted (JAN-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

    Entry informationi

    Entry nameiANR_PSEAE
    AccessioniPrimary (citable) accession number: P23926
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 1992
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Possesses 4 cysteines which may bind a metal ion (possibly iron).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3