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Protein

Thymidylate kinase

Gene

DTYMK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of dTMP to dTDP.

Catalytic activityi

ATP + dTMP = ADP + dTDP.

Pathwayi: dTTP biosynthesis

This protein is involved in the pathway dTTP biosynthesis, which is part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the pathway dTTP biosynthesis and in Pyrimidine metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20ATPCurated8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS11626-MONOMER
BRENDAi2.7.4.9 2681
ReactomeiR-HSA-499943 Interconversion of nucleotide di- and triphosphates
SABIO-RKP23919
UniPathwayiUPA00575

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinase (EC:2.7.4.9)
Alternative name(s):
dTMP kinase
Gene namesi
Name:DTYMK
Synonyms:CDC8, TMPK, TYMK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000168393.12
HGNCiHGNC:3061 DTYMK
MIMi188345 gene
neXtProtiNX_P23919

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi1841
OpenTargetsiENSG00000168393
PharmGKBiPA150

Chemistry databases

ChEMBLiCHEMBL4388
DrugBankiDB03666 3'-Azido-3'-Deoxythymidine-5'-Monophosphate
DB03845 P1-(5'-Adenosyl)P5-(5'-(3'azido-3'-Deoxythymidyl))Pentaphosphate
DB03280 P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate
DB04395 Phosphoaminophosphonic Acid-Adenylate Ester
DB01643 Thymidine-5'-Phosphate

Polymorphism and mutation databases

BioMutaiDTYMK
DMDMi56405325

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001552102 – 212Thymidylate kinaseAdd BLAST211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei169N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP23919
PaxDbiP23919
PeptideAtlasiP23919
PRIDEiP23919

PTM databases

iPTMnetiP23919
PhosphoSitePlusiP23919
SwissPalmiP23919

Expressioni

Gene expression databases

BgeeiENSG00000168393
CleanExiHS_DTYMK
ExpressionAtlasiP23919 baseline and differential
GenevisibleiP23919 HS

Organism-specific databases

HPAiHPA042593
HPA042719

Interactioni

Protein-protein interaction databases

BioGridi108174, 9 interactors
IntActiP23919, 3 interactors
MINTiP23919
STRINGi9606.ENSP00000304802

Chemistry databases

BindingDBiP23919

Structurei

Secondary structure

1212
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 14Combined sources7
Helixi19 – 32Combined sources14
Beta strandi37 – 43Combined sources7
Helixi48 – 57Combined sources10
Helixi65 – 77Combined sources13
Helixi80 – 88Combined sources9
Beta strandi92 – 97Combined sources6
Helixi99 – 107Combined sources9
Helixi114 – 118Combined sources5
Helixi119 – 121Combined sources3
Beta strandi124 – 126Combined sources3
Beta strandi128 – 134Combined sources7
Helixi137 – 142Combined sources6
Helixi149 – 151Combined sources3
Helixi154 – 167Combined sources14
Beta strandi171 – 173Combined sources3
Beta strandi175 – 179Combined sources5
Helixi184 – 201Combined sources18
Helixi202 – 204Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E2DX-ray1.65A1-212[»]
1E2EX-ray2.00A1-212[»]
1E2FX-ray1.60A1-212[»]
1E2GX-ray1.70A1-212[»]
1E2QX-ray1.70A1-212[»]
1E98X-ray1.90A1-212[»]
1E99X-ray1.80A1-212[»]
1E9AX-ray1.60A1-212[»]
1E9BX-ray1.70A1-212[»]
1E9CX-ray1.60A1-212[»]
1E9DX-ray1.70A1-212[»]
1E9EX-ray1.60A1-212[»]
1E9FX-ray1.90A1-144[»]
A149-212[»]
1NMXX-ray1.70A1-212[»]
1NMYX-ray1.60A4-212[»]
1NMZX-ray1.75A1-212[»]
1NN0X-ray1.60A1-212[»]
1NN1X-ray1.90A1-212[»]
1NN3X-ray1.55A1-212[»]
1NN5X-ray1.50A1-212[»]
2XX3X-ray2.00A1-212[»]
ProteinModelPortaliP23919
SMRiP23919
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23919

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.Curated

Phylogenomic databases

eggNOGiKOG3327 Eukaryota
COG0125 LUCA
GeneTreeiENSGT00390000017546
HOGENOMiHOG000229079
HOVERGENiHBG051418
InParanoidiP23919
KOiK00943
OMAiTPIGQMI
OrthoDBiEOG091G0M12
PhylomeDBiP23919
TreeFamiTF324638

Family and domain databases

HAMAPiMF_00165 Thymidylate_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR018095 Thymidylate_kin_CS
IPR018094 Thymidylate_kinase
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00041 DTMP_kinase, 1 hit
PROSITEiView protein in PROSITE
PS01331 THYMIDYLATE_KINASE, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P23919-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAARRGALIV LEGVDRAGKS TQSRKLVEAL CAAGHRAELL RFPERSTEIG
60 70 80 90 100
KLLSSYLQKK SDVEDHSVHL LFSANRWEQV PLIKEKLSQG VTLVVDRYAF
110 120 130 140 150
SGVAFTGAKE NFSLDWCKQP DVGLPKPDLV LFLQLQLADA AKRGAFGHER
160 170 180 190 200
YENGAFQERA LRCFHQLMKD TTLNWKMVDA SKSIEAVHED IRVLSEDAIR
210
TATEKPLGEL WK
Length:212
Mass (Da):23,819
Last modified:December 7, 2004 - v4
Checksum:iA52876625B3621B1
GO
Isoform 2 (identifier: P23919-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-134: Missing.

Note: No experimental confirmation available.
Show »
Length:188
Mass (Da):21,064
Checksum:i38FE4F99F6DDA886
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3A → P in CAG46783 (Ref. 3) Curated1
Sequence conflicti31 – 37CAAGHRA → SRGPPP in CAA38528 (PubMed:2017365).Curated7
Sequence conflicti58Q → K in AAA21719 (PubMed:8024690).Curated1
Sequence conflicti68V → A in CAG46783 (Ref. 3) Curated1
Sequence conflicti183 – 184SI → RL in CAA38528 (PubMed:2017365).Curated2
Sequence conflicti190 – 191DI → EL (PubMed:2017365).Curated2
Sequence conflicti190 – 191DI → EL (PubMed:8024690).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054164111 – 134Missing in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54729 mRNA Translation: CAA38528.1
L16991 mRNA Translation: AAA21719.1
CR541986 mRNA Translation: CAG46783.1
BC001827 mRNA Translation: AAH01827.1
BC171902 mRNA Translation: AAI71902.1
CCDSiCCDS2552.1 [P23919-1]
PIRiS26845
RefSeqiNP_001158503.1, NM_001165031.1 [P23919-2]
NP_001307832.1, NM_001320903.1
NP_036277.2, NM_012145.3 [P23919-1]
UniGeneiHs.471873

Genome annotation databases

EnsembliENST00000305784; ENSP00000304802; ENSG00000168393 [P23919-1]
GeneIDi1841
KEGGihsa:1841

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKTHY_HUMAN
AccessioniPrimary (citable) accession number: P23919
Secondary accession number(s): B7ZW70, Q6FGX1, Q9BUX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: December 7, 2004
Last modified: March 28, 2018
This is version 171 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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