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P23909

- MUTS_ECOLI

UniProt

P23909 - MUTS_ECOLI

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Protein
DNA mismatch repair protein MutS
Gene
mutS, fdv, b2733, JW2703
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi614 – 6218ATP Reviewed prediction

GO - Molecular functioni

  1. ADP binding Source: EcoliWiki
  2. ATP binding Source: EcoliWiki
  3. ATPase activity Source: EcoliWiki
  4. DNA binding, bending Source: EcoliWiki
  5. DNA-dependent ATPase activity Source: RefGenome
  6. adenine/cytosine mispair binding Source: EcoliWiki
  7. damaged DNA binding Source: RefGenome
  8. identical protein binding Source: IntAct
  9. mismatched DNA binding Source: EcoliWiki
Complete GO annotation...

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. cellular response to DNA damage stimulus Source: EcoliWiki
  3. mismatch repair Source: EcoliWiki
  4. regulation of DNA recombination Source: EcoliWiki
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG10625-MONOMER.
ECOL316407:JW2703-MONOMER.
MetaCyc:EG10625-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutS
Gene namesi
Name:mutS
Synonyms:fdv
Ordered Locus Names:b2733, JW2703
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG10625. mutS.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: EcoCyc
  2. mismatch repair complex Source: EcoliWiki
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 853853DNA mismatch repair protein MutSUniRule annotation
PRO_0000115094Add
BLAST

Proteomic databases

PaxDbiP23909.
PRIDEiP23909.

2D gel databases

SWISS-2DPAGEP23909.

Expressioni

Gene expression databases

GenevestigatoriP23909.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-554920,EBI-554920

Protein-protein interaction databases

DIPiDIP-10287N.
IntActiP23909. 10 interactions.
MINTiMINT-1264156.
STRINGi511145.b2733.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 93
Helixi12 – 2312
Beta strandi27 – 337
Beta strandi36 – 405
Helixi41 – 5111
Beta strandi56 – 583
Beta strandi61 – 633
Beta strandi66 – 727
Helixi73 – 753
Helixi76 – 8510
Beta strandi90 – 956
Helixi99 – 1013
Beta strandi103 – 1053
Beta strandi108 – 1147
Turni116 – 1183
Helixi122 – 1243
Beta strandi133 – 1386
Beta strandi143 – 1486
Turni150 – 1523
Beta strandi155 – 1584
Helixi163 – 17311
Beta strandi176 – 1816
Helixi187 – 1893
Turni190 – 1923
Beta strandi194 – 1996
Helixi201 – 2044
Helixi206 – 21712
Beta strandi220 – 2223
Helixi223 – 2253
Helixi231 – 24818
Beta strandi258 – 2603
Helixi263 – 2653
Helixi271 – 2766
Beta strandi279 – 2813
Beta strandi287 – 2904
Helixi291 – 2955
Helixi301 – 31212
Helixi318 – 33013
Helixi332 – 3343
Helixi335 – 3439
Helixi348 – 3569
Helixi362 – 37211
Helixi375 – 3839
Helixi388 – 39710
Helixi401 – 41010
Beta strandi419 – 4224
Helixi431 – 45828
Beta strandi464 – 4685
Turni469 – 4713
Beta strandi472 – 4787
Helixi479 – 4824
Beta strandi490 – 4945
Beta strandi496 – 5027
Helixi504 – 53532
Helixi536 – 5383
Helixi539 – 56426
Beta strandi570 – 5723
Beta strandi574 – 5763
Beta strandi578 – 5836
Helixi588 – 5914
Beta strandi592 – 5943
Beta strandi599 – 6035
Beta strandi605 – 6073
Beta strandi609 – 6135
Helixi620 – 63415
Turni635 – 6373
Beta strandi640 – 6478
Beta strandi652 – 6576
Helixi671 – 68313
Beta strandi688 – 6947
Beta strandi699 – 7024
Helixi703 – 71715
Beta strandi722 – 7265
Helixi730 – 7345
Helixi735 – 7384
Beta strandi742 – 75211
Beta strandi755 – 76511
Helixi772 – 7787
Helixi783 – 79715
Helixi826 – 8316
Turni834 – 8363
Helixi839 – 85214

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E3MX-ray2.20A/B1-800[»]
1NG9X-ray2.60A/B1-800[»]
1OH5X-ray2.90A/B1-800[»]
1OH6X-ray2.40A/B1-800[»]
1OH7X-ray2.50A/B1-800[»]
1OH8X-ray2.90A/B1-800[»]
1W7AX-ray2.27A/B1-800[»]
1WB9X-ray2.10A/B1-800[»]
1WBBX-ray2.50A/B1-800[»]
1WBDX-ray2.40A/B1-800[»]
2OK2X-ray2.00A/B820-853[»]
2WTUX-ray3.40A/B1-800[»]
3K0SX-ray2.20A/B2-800[»]
3ZLJX-ray3.10A/B1-800[»]
C/D801-853[»]
ProteinModelPortaliP23909.

Miscellaneous databases

EvolutionaryTraceiP23909.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0249.
HOGENOMiHOG000221407.
KOiK03555.
OMAiSIAFMHA.
OrthoDBiEOG6Q5NPV.
PhylomeDBiP23909.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00096. MutS.
InterProiIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsiTIGR01070. mutS1. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23909-1 [UniParc]FASTAAdd to Basket

« Hide

MSAIENFDAH TPMMQQYLRL KAQHPEILLF YRMGDFYELF YDDAKRASQL    50
LDISLTKRGA SAGEPIPMAG IPYHAVENYL AKLVNQGESV AICEQIGDPA 100
TSKGPVERKV VRIVTPGTIS DEALLQERQD NLLAAIWQDS KGFGYATLDI 150
SSGRFRLSEP ADRETMAAEL QRTNPAELLY AEDFAEMSLI EGRRGLRRRP 200
LWEFEIDTAR QQLNLQFGTR DLVGFGVENA PRGLCAAGCL LQYAKDTQRT 250
TLPHIRSITM EREQDSIIMD AATRRNLEIT QNLAGGAENT LASVLDCTVT 300
PMGSRMLKRW LHMPVRDTRV LLERQQTIGA LQDFTAGLQP VLRQVGDLER 350
ILARLALRTA RPRDLARMRH AFQQLPELRA QLETVDSAPV QALREKMGEF 400
AELRDLLERA IIDTPPVLVR DGGVIASGYN EELDEWRALA DGATDYLERL 450
EVRERERTGL DTLKVGFNAV HGYYIQISRG QSHLAPINYM RRQTLKNAER 500
YIIPELKEYE DKVLTSKGKA LALEKQLYEE LFDLLLPHLE ALQQSASALA 550
ELDVLVNLAE RAYTLNYTCP TFIDKPGIRI TEGRHPVVEQ VLNEPFIANP 600
LNLSPQRRML IITGPNMGGK STYMRQTALI ALMAYIGSYV PAQKVEIGPI 650
DRIFTRVGAA DDLASGRSTF MVEMTETANI LHNATEYSLV LMDEIGRGTS 700
TYDGLSLAWA CAENLANKIK ALTLFATHYF ELTQLPEKME GVANVHLDAL 750
EHGDTIAFMH SVQDGAASKS YGLAVAALAG VPKEVIKRAR QKLRELESIS 800
PNAAATQVDG TQMSLLSVPE ETSPAVEALE NLDPDSLTPR QALEWIYRLK 850
SLV 853
Length:853
Mass (Da):95,247
Last modified:March 1, 1992 - v1
Checksum:i5A1F295362671D55
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64730 Genomic DNA. Translation: AAA24188.1.
U29579 Genomic DNA. Translation: AAA69243.1.
U00096 Genomic DNA. Translation: AAC75775.1.
AP009048 Genomic DNA. Translation: BAE76810.1.
AF004287 Genomic DNA. Translation: AAD01197.1.
AF001987 Genomic DNA. Translation: AAD00921.1.
AF001988 Genomic DNA. Translation: AAD00922.1.
AF001989 Genomic DNA. Translation: AAD00923.1.
AF001990 Genomic DNA. Translation: AAD00924.1.
AF001991 Genomic DNA. Translation: AAD00925.1.
AF001992 Genomic DNA. Translation: AAD00926.1.
AF001993 Genomic DNA. Translation: AAD00927.1.
AF001994 Genomic DNA. Translation: AAD00928.1.
AF001995 Genomic DNA. Translation: AAD00929.1.
AF001996 Genomic DNA. Translation: AAD00930.1.
AF001997 Genomic DNA. Translation: AAD00931.1.
AF001998 Genomic DNA. Translation: AAD00932.1.
AF001999 Genomic DNA. Translation: AAD00933.1.
AF002000 Genomic DNA. Translation: AAD00934.1.
AF002001 Genomic DNA. Translation: AAD00935.1.
AF002002 Genomic DNA. Translation: AAD00936.1.
AF002003 Genomic DNA. Translation: AAD00937.1.
AF002004 Genomic DNA. Translation: AAD00938.1.
AF002005 Genomic DNA. Translation: AAD00939.1.
AF002006 Genomic DNA. Translation: AAD00940.1.
AF002007 Genomic DNA. Translation: AAD00941.1.
AF002008 Genomic DNA. Translation: AAD00942.1.
AF002009 Genomic DNA. Translation: AAD00943.1.
AF002010 Genomic DNA. Translation: AAD00944.1.
PIRiI54964.
RefSeqiNP_417213.1. NC_000913.3.
YP_490942.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC75775; AAC75775; b2733.
BAE76810; BAE76810; BAE76810.
GeneIDi12932427.
947206.
KEGGiecj:Y75_p2671.
eco:b2733.
PATRICi32120868. VBIEscCol129921_2826.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64730 Genomic DNA. Translation: AAA24188.1 .
U29579 Genomic DNA. Translation: AAA69243.1 .
U00096 Genomic DNA. Translation: AAC75775.1 .
AP009048 Genomic DNA. Translation: BAE76810.1 .
AF004287 Genomic DNA. Translation: AAD01197.1 .
AF001987 Genomic DNA. Translation: AAD00921.1 .
AF001988 Genomic DNA. Translation: AAD00922.1 .
AF001989 Genomic DNA. Translation: AAD00923.1 .
AF001990 Genomic DNA. Translation: AAD00924.1 .
AF001991 Genomic DNA. Translation: AAD00925.1 .
AF001992 Genomic DNA. Translation: AAD00926.1 .
AF001993 Genomic DNA. Translation: AAD00927.1 .
AF001994 Genomic DNA. Translation: AAD00928.1 .
AF001995 Genomic DNA. Translation: AAD00929.1 .
AF001996 Genomic DNA. Translation: AAD00930.1 .
AF001997 Genomic DNA. Translation: AAD00931.1 .
AF001998 Genomic DNA. Translation: AAD00932.1 .
AF001999 Genomic DNA. Translation: AAD00933.1 .
AF002000 Genomic DNA. Translation: AAD00934.1 .
AF002001 Genomic DNA. Translation: AAD00935.1 .
AF002002 Genomic DNA. Translation: AAD00936.1 .
AF002003 Genomic DNA. Translation: AAD00937.1 .
AF002004 Genomic DNA. Translation: AAD00938.1 .
AF002005 Genomic DNA. Translation: AAD00939.1 .
AF002006 Genomic DNA. Translation: AAD00940.1 .
AF002007 Genomic DNA. Translation: AAD00941.1 .
AF002008 Genomic DNA. Translation: AAD00942.1 .
AF002009 Genomic DNA. Translation: AAD00943.1 .
AF002010 Genomic DNA. Translation: AAD00944.1 .
PIRi I54964.
RefSeqi NP_417213.1. NC_000913.3.
YP_490942.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1E3M X-ray 2.20 A/B 1-800 [» ]
1NG9 X-ray 2.60 A/B 1-800 [» ]
1OH5 X-ray 2.90 A/B 1-800 [» ]
1OH6 X-ray 2.40 A/B 1-800 [» ]
1OH7 X-ray 2.50 A/B 1-800 [» ]
1OH8 X-ray 2.90 A/B 1-800 [» ]
1W7A X-ray 2.27 A/B 1-800 [» ]
1WB9 X-ray 2.10 A/B 1-800 [» ]
1WBB X-ray 2.50 A/B 1-800 [» ]
1WBD X-ray 2.40 A/B 1-800 [» ]
2OK2 X-ray 2.00 A/B 820-853 [» ]
2WTU X-ray 3.40 A/B 1-800 [» ]
3K0S X-ray 2.20 A/B 2-800 [» ]
3ZLJ X-ray 3.10 A/B 1-800 [» ]
C/D 801-853 [» ]
ProteinModelPortali P23909.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-10287N.
IntActi P23909. 10 interactions.
MINTi MINT-1264156.
STRINGi 511145.b2733.

2D gel databases

SWISS-2DPAGE P23909.

Proteomic databases

PaxDbi P23909.
PRIDEi P23909.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC75775 ; AAC75775 ; b2733 .
BAE76810 ; BAE76810 ; BAE76810 .
GeneIDi 12932427.
947206.
KEGGi ecj:Y75_p2671.
eco:b2733.
PATRICi 32120868. VBIEscCol129921_2826.

Organism-specific databases

EchoBASEi EB0620.
EcoGenei EG10625. mutS.

Phylogenomic databases

eggNOGi COG0249.
HOGENOMi HOG000221407.
KOi K03555.
OMAi SIAFMHA.
OrthoDBi EOG6Q5NPV.
PhylomeDBi P23909.

Enzyme and pathway databases

BioCyci EcoCyc:EG10625-MONOMER.
ECOL316407:JW2703-MONOMER.
MetaCyc:EG10625-MONOMER.

Miscellaneous databases

EvolutionaryTracei P23909.
PROi P23909.

Gene expression databases

Genevestigatori P23909.

Family and domain databases

Gene3Di 3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00096. MutS.
InterProi IPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view ]
SMARTi SM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view ]
SUPFAMi SSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsi TIGR01070. mutS1. 1 hit.
PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Escherichia coli fdv gene probably encodes mutS and is located at minute 58.8 adjacent to the hyc-hyp gene cluster."
    Schlensog V., Boeck A.
    J. Bacteriol. 173:7414-7415(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. Denamur E.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 602-731.
    Strain: Various strains.
  5. "Escherichia coli proteome analysis using the gene-protein database."
    VanBogelen R.A., Abshire K.Z., Moldover B., Olson E.R., Neidhardt F.C.
    Electrophoresis 18:1243-1251(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY 2D-GEL.

Entry informationi

Entry nameiMUTS_ECOLI
AccessioniPrimary (citable) accession number: P23909
Secondary accession number(s): P71279, Q2MA96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: June 11, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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