Skip Header

Contribute Send feedback
Read comments (?) or add your own

P23909 (MUTS_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA mismatch repair protein MutS
Gene names
Name:mutS
Synonyms:fdv
Ordered Locus Names:b2733, JW2703
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length853 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. HAMAP-Rule MF_00096

Sequence similarities

Belongs to the DNA mismatch repair MutS family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 853853DNA mismatch repair protein MutS HAMAP-Rule MF_00096
PRO_0000115094

Regions

Nucleotide binding614 – 6218ATP Potential

Secondary structure

1 ..................................................................................................................................................... 853
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P23909 [UniParc].

Last modified March 1, 1992. Version 1.
Checksum: 5A1F295362671D55

FASTA85395,247
        10         20         30         40         50         60 
MSAIENFDAH TPMMQQYLRL KAQHPEILLF YRMGDFYELF YDDAKRASQL LDISLTKRGA 

        70         80         90        100        110        120 
SAGEPIPMAG IPYHAVENYL AKLVNQGESV AICEQIGDPA TSKGPVERKV VRIVTPGTIS 

       130        140        150        160        170        180 
DEALLQERQD NLLAAIWQDS KGFGYATLDI SSGRFRLSEP ADRETMAAEL QRTNPAELLY 

       190        200        210        220        230        240 
AEDFAEMSLI EGRRGLRRRP LWEFEIDTAR QQLNLQFGTR DLVGFGVENA PRGLCAAGCL 

       250        260        270        280        290        300 
LQYAKDTQRT TLPHIRSITM EREQDSIIMD AATRRNLEIT QNLAGGAENT LASVLDCTVT 

       310        320        330        340        350        360 
PMGSRMLKRW LHMPVRDTRV LLERQQTIGA LQDFTAGLQP VLRQVGDLER ILARLALRTA 

       370        380        390        400        410        420 
RPRDLARMRH AFQQLPELRA QLETVDSAPV QALREKMGEF AELRDLLERA IIDTPPVLVR 

       430        440        450        460        470        480 
DGGVIASGYN EELDEWRALA DGATDYLERL EVRERERTGL DTLKVGFNAV HGYYIQISRG 

       490        500        510        520        530        540 
QSHLAPINYM RRQTLKNAER YIIPELKEYE DKVLTSKGKA LALEKQLYEE LFDLLLPHLE 

       550        560        570        580        590        600 
ALQQSASALA ELDVLVNLAE RAYTLNYTCP TFIDKPGIRI TEGRHPVVEQ VLNEPFIANP 

       610        620        630        640        650        660 
LNLSPQRRML IITGPNMGGK STYMRQTALI ALMAYIGSYV PAQKVEIGPI DRIFTRVGAA 

       670        680        690        700        710        720 
DDLASGRSTF MVEMTETANI LHNATEYSLV LMDEIGRGTS TYDGLSLAWA CAENLANKIK 

       730        740        750        760        770        780 
ALTLFATHYF ELTQLPEKME GVANVHLDAL EHGDTIAFMH SVQDGAASKS YGLAVAALAG 

       790        800        810        820        830        840 
VPKEVIKRAR QKLRELESIS PNAAATQVDG TQMSLLSVPE ETSPAVEALE NLDPDSLTPR 

       850 
QALEWIYRLK SLV

« Hide

References

« Hide 'large scale' references
[1]"The Escherichia coli fdv gene probably encodes mutS and is located at minute 58.8 adjacent to the hyc-hyp gene cluster."
Schlensog V., Boeck A.
J. Bacteriol. 173:7414-7415(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]Denamur E.
Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 602-731.
Strain: Various strains.
[5]"Escherichia coli proteome analysis using the gene-protein database."
VanBogelen R.A., Abshire K.Z., Moldover B., Olson E.R., Neidhardt F.C.
Electrophoresis 18:1243-1251(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY 2D-GEL.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M64730 Genomic DNA. Translation: AAA24188.1.
U29579 Genomic DNA. Translation: AAA69243.1.
U00096 Genomic DNA. Translation: AAC75775.1.
AP009048 Genomic DNA. Translation: BAE76810.1.
AF004287 Genomic DNA. Translation: AAD01197.1.
AF001987 Genomic DNA. Translation: AAD00921.1.
AF001988 Genomic DNA. Translation: AAD00922.1.
AF001989 Genomic DNA. Translation: AAD00923.1.
AF001990 Genomic DNA. Translation: AAD00924.1.
AF001991 Genomic DNA. Translation: AAD00925.1.
AF001992 Genomic DNA. Translation: AAD00926.1.
AF001993 Genomic DNA. Translation: AAD00927.1.
AF001994 Genomic DNA. Translation: AAD00928.1.
AF001995 Genomic DNA. Translation: AAD00929.1.
AF001996 Genomic DNA. Translation: AAD00930.1.
AF001997 Genomic DNA. Translation: AAD00931.1.
AF001998 Genomic DNA. Translation: AAD00932.1.
AF001999 Genomic DNA. Translation: AAD00933.1.
AF002000 Genomic DNA. Translation: AAD00934.1.
AF002001 Genomic DNA. Translation: AAD00935.1.
AF002002 Genomic DNA. Translation: AAD00936.1.
AF002003 Genomic DNA. Translation: AAD00937.1.
AF002004 Genomic DNA. Translation: AAD00938.1.
AF002005 Genomic DNA. Translation: AAD00939.1.
AF002006 Genomic DNA. Translation: AAD00940.1.
AF002007 Genomic DNA. Translation: AAD00941.1.
AF002008 Genomic DNA. Translation: AAD00942.1.
AF002009 Genomic DNA. Translation: AAD00943.1.
AF002010 Genomic DNA. Translation: AAD00944.1.
PIRI54964.
RefSeqNP_417213.1. NC_000913.2.
YP_490942.1. NC_007779.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1E3MX-ray2.20A/B1-800[»]
1NG9X-ray2.60A/B1-800[»]
1OH5X-ray2.90A/B1-800[»]
1OH6X-ray2.40A/B1-800[»]
1OH7X-ray2.50A/B1-800[»]
1OH8X-ray2.90A/B1-800[»]
1W7AX-ray2.27A/B1-800[»]
1WB9X-ray2.10A/B1-800[»]
1WBBX-ray2.50A/B1-800[»]
1WBDX-ray2.40A/B1-800[»]
2OK2X-ray2.00A/B820-853[»]
2WTUX-ray3.40A/B1-800[»]
3K0SX-ray2.20A/B2-800[»]
ProteinModelPortalP23909.
SMRP23909. Positions 2-800, 820-853.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-10287N.
IntActP23909. 10 interactions.
MINTMINT-1264156.
STRING511145.b2733.

2D gel databases

SWISS-2DPAGEP23909.

Proteomic databases

PaxDbP23909.
PRIDEP23909.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC75775; AAC75775; b2733.
BAE76810; BAE76810; BAE76810.
GeneID12932427.
947206.
KEGGecj:Y75_p2671.
eco:b2733.
PATRIC32120868. VBIEscCol129921_2826.

Organism-specific databases

EchoBASEEB0620.
EcoGeneEG10625. mutS.

Phylogenomic databases

eggNOGCOG0249.
HOGENOMHOG000221407.
KOK03555.
OMAITQTVRD.
ProtClustDBPRK05399.

Enzyme and pathway databases

BioCycEcoCyc:EG10625-MONOMER.
ECOL316407:JW2703-MONOMER.
MetaCyc:EG10625-MONOMER.

Gene expression databases

GenevestigatorP23909.

Family and domain databases

Gene3D3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
HAMAPMF_00096. MutS.
InterProIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
[Graphical view]
PANTHERPTHR11361:SF34. PTHR11361:SF34. 1 hit.
PfamPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMSSF53150. DNA_mismatch_repair_MutS_connt. 1 hit.
SSF55271. DNA_mismatch_repair_MutS_N. 1 hit.
SSF48334. DNA_repair_MutS_domIII. 1 hit.
TIGRFAMsTIGR01070. mutS1. 1 hit.
PROSITEPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP23909.

Entry information

Entry nameMUTS_ECOLI
AccessionPrimary (citable) accession number: P23909
Secondary accession number(s): P71279, Q2MA96
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: May 1, 2013
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents