Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P23909

- MUTS_ECOLI

UniProt

P23909 - MUTS_ECOLI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

DNA mismatch repair protein MutS

Gene

mutS

Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi614 – 6218ATPSequence Analysis

GO - Molecular functioni

  1. adenine/cytosine mispair binding Source: EcoliWiki
  2. ADP binding Source: EcoliWiki
  3. ATPase activity Source: EcoliWiki
  4. ATP binding Source: EcoliWiki
  5. damaged DNA binding Source: RefGenome
  6. DNA binding, bending Source: EcoliWiki
  7. DNA-dependent ATPase activity Source: RefGenome
  8. identical protein binding Source: IntAct
  9. mismatched DNA binding Source: EcoliWiki

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. cellular response to DNA damage stimulus Source: EcoliWiki
  3. mismatch repair Source: EcoliWiki
  4. regulation of DNA recombination Source: EcoliWiki
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG10625-MONOMER.
ECOL316407:JW2703-MONOMER.
MetaCyc:EG10625-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutS
Gene namesi
Name:mutS
Synonyms:fdv
Ordered Locus Names:b2733, JW2703
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG10625. mutS.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: EcoCyc
  2. mismatch repair complex Source: EcoliWiki
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 853853DNA mismatch repair protein MutSPRO_0000115094Add
BLAST

Proteomic databases

PaxDbiP23909.
PRIDEiP23909.

2D gel databases

SWISS-2DPAGEP23909.

Expressioni

Gene expression databases

GenevestigatoriP23909.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-554920,EBI-554920

Protein-protein interaction databases

DIPiDIP-10287N.
IntActiP23909. 10 interactions.
MINTiMINT-1264156.
STRINGi511145.b2733.

Structurei

Secondary structure

1
853
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 93Combined sources
Helixi12 – 2312Combined sources
Beta strandi27 – 337Combined sources
Beta strandi36 – 405Combined sources
Helixi41 – 5111Combined sources
Beta strandi56 – 583Combined sources
Beta strandi61 – 633Combined sources
Beta strandi66 – 727Combined sources
Helixi73 – 753Combined sources
Helixi76 – 8510Combined sources
Beta strandi90 – 956Combined sources
Helixi99 – 1013Combined sources
Beta strandi103 – 1053Combined sources
Beta strandi108 – 1147Combined sources
Turni116 – 1183Combined sources
Helixi122 – 1243Combined sources
Beta strandi133 – 1386Combined sources
Beta strandi143 – 1486Combined sources
Turni150 – 1523Combined sources
Beta strandi155 – 1584Combined sources
Helixi163 – 17311Combined sources
Beta strandi176 – 1816Combined sources
Helixi187 – 1893Combined sources
Turni190 – 1923Combined sources
Beta strandi194 – 1996Combined sources
Helixi201 – 2044Combined sources
Helixi206 – 21712Combined sources
Beta strandi220 – 2223Combined sources
Helixi223 – 2253Combined sources
Helixi231 – 24818Combined sources
Beta strandi258 – 2603Combined sources
Helixi263 – 2653Combined sources
Helixi271 – 2766Combined sources
Beta strandi279 – 2813Combined sources
Beta strandi287 – 2904Combined sources
Helixi291 – 2955Combined sources
Helixi301 – 31212Combined sources
Helixi318 – 33013Combined sources
Helixi332 – 3343Combined sources
Helixi335 – 3439Combined sources
Helixi348 – 3569Combined sources
Helixi362 – 37211Combined sources
Helixi375 – 3839Combined sources
Helixi388 – 39710Combined sources
Helixi401 – 41010Combined sources
Beta strandi419 – 4224Combined sources
Helixi431 – 45828Combined sources
Beta strandi464 – 4685Combined sources
Turni469 – 4713Combined sources
Beta strandi472 – 4787Combined sources
Helixi479 – 4824Combined sources
Beta strandi490 – 4945Combined sources
Beta strandi496 – 5027Combined sources
Helixi504 – 53532Combined sources
Helixi536 – 5383Combined sources
Helixi539 – 56426Combined sources
Beta strandi570 – 5723Combined sources
Beta strandi574 – 5763Combined sources
Beta strandi578 – 5836Combined sources
Helixi588 – 5914Combined sources
Beta strandi592 – 5943Combined sources
Beta strandi599 – 6035Combined sources
Beta strandi605 – 6073Combined sources
Beta strandi609 – 6135Combined sources
Helixi620 – 63415Combined sources
Turni635 – 6373Combined sources
Beta strandi640 – 6478Combined sources
Beta strandi652 – 6576Combined sources
Helixi671 – 68313Combined sources
Beta strandi688 – 6947Combined sources
Beta strandi699 – 7024Combined sources
Helixi703 – 71715Combined sources
Beta strandi722 – 7265Combined sources
Helixi730 – 7345Combined sources
Helixi735 – 7384Combined sources
Beta strandi742 – 75211Combined sources
Beta strandi755 – 76511Combined sources
Helixi772 – 7787Combined sources
Helixi783 – 79715Combined sources
Helixi826 – 8316Combined sources
Turni834 – 8363Combined sources
Helixi839 – 85214Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E3MX-ray2.20A/B1-800[»]
1NG9X-ray2.60A/B1-800[»]
1OH5X-ray2.90A/B1-800[»]
1OH6X-ray2.40A/B1-800[»]
1OH7X-ray2.50A/B1-800[»]
1OH8X-ray2.90A/B1-800[»]
1W7AX-ray2.27A/B1-800[»]
1WB9X-ray2.10A/B1-800[»]
1WBBX-ray2.50A/B1-800[»]
1WBDX-ray2.40A/B1-800[»]
2OK2X-ray2.00A/B820-853[»]
2WTUX-ray3.40A/B1-800[»]
3K0SX-ray2.20A/B2-800[»]
3ZLJX-ray3.10A/B1-800[»]
C/D801-853[»]
ProteinModelPortaliP23909.
SMRiP23909. Positions 2-800, 820-853.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23909.

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.Curated

Phylogenomic databases

eggNOGiCOG0249.
HOGENOMiHOG000221407.
InParanoidiP23909.
KOiK03555.
OMAiSIAFMHA.
OrthoDBiEOG6Q5NPV.
PhylomeDBiP23909.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00096. MutS.
InterProiIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsiTIGR01070. mutS1. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23909-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAIENFDAH TPMMQQYLRL KAQHPEILLF YRMGDFYELF YDDAKRASQL
60 70 80 90 100
LDISLTKRGA SAGEPIPMAG IPYHAVENYL AKLVNQGESV AICEQIGDPA
110 120 130 140 150
TSKGPVERKV VRIVTPGTIS DEALLQERQD NLLAAIWQDS KGFGYATLDI
160 170 180 190 200
SSGRFRLSEP ADRETMAAEL QRTNPAELLY AEDFAEMSLI EGRRGLRRRP
210 220 230 240 250
LWEFEIDTAR QQLNLQFGTR DLVGFGVENA PRGLCAAGCL LQYAKDTQRT
260 270 280 290 300
TLPHIRSITM EREQDSIIMD AATRRNLEIT QNLAGGAENT LASVLDCTVT
310 320 330 340 350
PMGSRMLKRW LHMPVRDTRV LLERQQTIGA LQDFTAGLQP VLRQVGDLER
360 370 380 390 400
ILARLALRTA RPRDLARMRH AFQQLPELRA QLETVDSAPV QALREKMGEF
410 420 430 440 450
AELRDLLERA IIDTPPVLVR DGGVIASGYN EELDEWRALA DGATDYLERL
460 470 480 490 500
EVRERERTGL DTLKVGFNAV HGYYIQISRG QSHLAPINYM RRQTLKNAER
510 520 530 540 550
YIIPELKEYE DKVLTSKGKA LALEKQLYEE LFDLLLPHLE ALQQSASALA
560 570 580 590 600
ELDVLVNLAE RAYTLNYTCP TFIDKPGIRI TEGRHPVVEQ VLNEPFIANP
610 620 630 640 650
LNLSPQRRML IITGPNMGGK STYMRQTALI ALMAYIGSYV PAQKVEIGPI
660 670 680 690 700
DRIFTRVGAA DDLASGRSTF MVEMTETANI LHNATEYSLV LMDEIGRGTS
710 720 730 740 750
TYDGLSLAWA CAENLANKIK ALTLFATHYF ELTQLPEKME GVANVHLDAL
760 770 780 790 800
EHGDTIAFMH SVQDGAASKS YGLAVAALAG VPKEVIKRAR QKLRELESIS
810 820 830 840 850
PNAAATQVDG TQMSLLSVPE ETSPAVEALE NLDPDSLTPR QALEWIYRLK

SLV
Length:853
Mass (Da):95,247
Last modified:March 1, 1992 - v1
Checksum:i5A1F295362671D55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64730 Genomic DNA. Translation: AAA24188.1.
U29579 Genomic DNA. Translation: AAA69243.1.
U00096 Genomic DNA. Translation: AAC75775.1.
AP009048 Genomic DNA. Translation: BAE76810.1.
AF004287 Genomic DNA. Translation: AAD01197.1.
AF001987 Genomic DNA. Translation: AAD00921.1.
AF001988 Genomic DNA. Translation: AAD00922.1.
AF001989 Genomic DNA. Translation: AAD00923.1.
AF001990 Genomic DNA. Translation: AAD00924.1.
AF001991 Genomic DNA. Translation: AAD00925.1.
AF001992 Genomic DNA. Translation: AAD00926.1.
AF001993 Genomic DNA. Translation: AAD00927.1.
AF001994 Genomic DNA. Translation: AAD00928.1.
AF001995 Genomic DNA. Translation: AAD00929.1.
AF001996 Genomic DNA. Translation: AAD00930.1.
AF001997 Genomic DNA. Translation: AAD00931.1.
AF001998 Genomic DNA. Translation: AAD00932.1.
AF001999 Genomic DNA. Translation: AAD00933.1.
AF002000 Genomic DNA. Translation: AAD00934.1.
AF002001 Genomic DNA. Translation: AAD00935.1.
AF002002 Genomic DNA. Translation: AAD00936.1.
AF002003 Genomic DNA. Translation: AAD00937.1.
AF002004 Genomic DNA. Translation: AAD00938.1.
AF002005 Genomic DNA. Translation: AAD00939.1.
AF002006 Genomic DNA. Translation: AAD00940.1.
AF002007 Genomic DNA. Translation: AAD00941.1.
AF002008 Genomic DNA. Translation: AAD00942.1.
AF002009 Genomic DNA. Translation: AAD00943.1.
AF002010 Genomic DNA. Translation: AAD00944.1.
PIRiI54964.
RefSeqiNP_417213.1. NC_000913.3.
YP_490942.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC75775; AAC75775; b2733.
BAE76810; BAE76810; BAE76810.
GeneIDi12932427.
947206.
KEGGiecj:Y75_p2671.
eco:b2733.
PATRICi32120868. VBIEscCol129921_2826.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64730 Genomic DNA. Translation: AAA24188.1 .
U29579 Genomic DNA. Translation: AAA69243.1 .
U00096 Genomic DNA. Translation: AAC75775.1 .
AP009048 Genomic DNA. Translation: BAE76810.1 .
AF004287 Genomic DNA. Translation: AAD01197.1 .
AF001987 Genomic DNA. Translation: AAD00921.1 .
AF001988 Genomic DNA. Translation: AAD00922.1 .
AF001989 Genomic DNA. Translation: AAD00923.1 .
AF001990 Genomic DNA. Translation: AAD00924.1 .
AF001991 Genomic DNA. Translation: AAD00925.1 .
AF001992 Genomic DNA. Translation: AAD00926.1 .
AF001993 Genomic DNA. Translation: AAD00927.1 .
AF001994 Genomic DNA. Translation: AAD00928.1 .
AF001995 Genomic DNA. Translation: AAD00929.1 .
AF001996 Genomic DNA. Translation: AAD00930.1 .
AF001997 Genomic DNA. Translation: AAD00931.1 .
AF001998 Genomic DNA. Translation: AAD00932.1 .
AF001999 Genomic DNA. Translation: AAD00933.1 .
AF002000 Genomic DNA. Translation: AAD00934.1 .
AF002001 Genomic DNA. Translation: AAD00935.1 .
AF002002 Genomic DNA. Translation: AAD00936.1 .
AF002003 Genomic DNA. Translation: AAD00937.1 .
AF002004 Genomic DNA. Translation: AAD00938.1 .
AF002005 Genomic DNA. Translation: AAD00939.1 .
AF002006 Genomic DNA. Translation: AAD00940.1 .
AF002007 Genomic DNA. Translation: AAD00941.1 .
AF002008 Genomic DNA. Translation: AAD00942.1 .
AF002009 Genomic DNA. Translation: AAD00943.1 .
AF002010 Genomic DNA. Translation: AAD00944.1 .
PIRi I54964.
RefSeqi NP_417213.1. NC_000913.3.
YP_490942.1. NC_007779.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1E3M X-ray 2.20 A/B 1-800 [» ]
1NG9 X-ray 2.60 A/B 1-800 [» ]
1OH5 X-ray 2.90 A/B 1-800 [» ]
1OH6 X-ray 2.40 A/B 1-800 [» ]
1OH7 X-ray 2.50 A/B 1-800 [» ]
1OH8 X-ray 2.90 A/B 1-800 [» ]
1W7A X-ray 2.27 A/B 1-800 [» ]
1WB9 X-ray 2.10 A/B 1-800 [» ]
1WBB X-ray 2.50 A/B 1-800 [» ]
1WBD X-ray 2.40 A/B 1-800 [» ]
2OK2 X-ray 2.00 A/B 820-853 [» ]
2WTU X-ray 3.40 A/B 1-800 [» ]
3K0S X-ray 2.20 A/B 2-800 [» ]
3ZLJ X-ray 3.10 A/B 1-800 [» ]
C/D 801-853 [» ]
ProteinModelPortali P23909.
SMRi P23909. Positions 2-800, 820-853.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-10287N.
IntActi P23909. 10 interactions.
MINTi MINT-1264156.
STRINGi 511145.b2733.

2D gel databases

SWISS-2DPAGE P23909.

Proteomic databases

PaxDbi P23909.
PRIDEi P23909.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC75775 ; AAC75775 ; b2733 .
BAE76810 ; BAE76810 ; BAE76810 .
GeneIDi 12932427.
947206.
KEGGi ecj:Y75_p2671.
eco:b2733.
PATRICi 32120868. VBIEscCol129921_2826.

Organism-specific databases

EchoBASEi EB0620.
EcoGenei EG10625. mutS.

Phylogenomic databases

eggNOGi COG0249.
HOGENOMi HOG000221407.
InParanoidi P23909.
KOi K03555.
OMAi SIAFMHA.
OrthoDBi EOG6Q5NPV.
PhylomeDBi P23909.

Enzyme and pathway databases

BioCyci EcoCyc:EG10625-MONOMER.
ECOL316407:JW2703-MONOMER.
MetaCyc:EG10625-MONOMER.

Miscellaneous databases

EvolutionaryTracei P23909.
PROi P23909.

Gene expression databases

Genevestigatori P23909.

Family and domain databases

Gene3Di 3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00096. MutS.
InterProi IPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view ]
SMARTi SM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view ]
SUPFAMi SSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsi TIGR01070. mutS1. 1 hit.
PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Escherichia coli fdv gene probably encodes mutS and is located at minute 58.8 adjacent to the hyc-hyp gene cluster."
    Schlensog V., Boeck A.
    J. Bacteriol. 173:7414-7415(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. Denamur E.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 602-731.
    Strain: Various strains.
  5. "Escherichia coli proteome analysis using the gene-protein database."
    VanBogelen R.A., Abshire K.Z., Moldover B., Olson E.R., Neidhardt F.C.
    Electrophoresis 18:1243-1251(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY 2D-GEL.

Entry informationi

Entry nameiMUTS_ECOLI
AccessioniPrimary (citable) accession number: P23909
Secondary accession number(s): P71279, Q2MA96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: March 1, 1992
Last modified: November 26, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3