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Protein

Acetylornithine deacetylase

Gene

argE

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Displays a broad specificity and can also deacylate substrates such as acetylarginine, acetylhistidine or acetylglutamate semialdehyde.

Catalytic activityi

N2-acetyl-L-ornithine + H2O = acetate + L-ornithine.

Cofactori

Protein has several cofactor binding sites:

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear).
Proteins known to be involved in this subpathway in this organism are:
  1. Acetylornithine deacetylase (argE)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear), the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi80Cobalt or zinc 1By similarity1
Active sitei82By similarity1
Metal bindingi112Cobalt or zinc 1By similarity1
Metal bindingi112Cobalt or zinc 2By similarity1
Active sitei144Proton acceptorBy similarity1
Metal bindingi145Cobalt or zinc 2By similarity1
Metal bindingi169Cobalt or zinc 1By similarity1
Metal bindingi355Cobalt or zinc 2By similarity1

GO - Molecular functioni

  • acetylornithine deacetylase activity Source: EcoliWiki
  • cobalt ion binding Source: EcoCyc
  • metallopeptidase activity Source: InterPro
  • zinc ion binding Source: EcoCyc

GO - Biological processi

  • arginine biosynthetic process Source: EcoCyc

Keywordsi

Molecular functionHydrolase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandCobalt, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:ACETYLORNDEACET-MONOMER
MetaCyc:ACETYLORNDEACET-MONOMER
BRENDAi3.5.1.16 2026
UniPathwayiUPA00068; UER00110

Protein family/group databases

MEROPSiM20.974

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine deacetylase (EC:3.5.1.16)
Short name:
AO
Short name:
Acetylornithinase
Alternative name(s):
N-acetylornithinase
Short name:
NAO
Gene namesi
Name:argE
Ordered Locus Names:b3957, JW3929
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11286 argE

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001852401 – 383Acetylornithine deacetylaseAdd BLAST383

Proteomic databases

EPDiP23908
PaxDbiP23908
PRIDEiP23908

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi4259568, 71 interactors
STRINGi316385.ECDH10B_4145

Structurei

3D structure databases

ProteinModelPortaliP23908
SMRiP23908
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20A family. ArgE subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105CWC Bacteria
COG0624 LUCA
HOGENOMiHOG000243769
InParanoidiP23908
KOiK01438
OMAiCAHQPGE
PhylomeDBiP23908

Family and domain databases

CDDicd03894 M20_ArgE, 1 hit
HAMAPiMF_01108 ArgE, 1 hit
InterProiView protein in InterPro
IPR010169 AcOrn-deacetyl
IPR001261 ArgE/DapE_CS
IPR036264 Bact_exopeptidase_dim_dom
IPR002933 Peptidase_M20
IPR011650 Peptidase_M20_dimer
PANTHERiPTHR43808:SF1 PTHR43808:SF1, 1 hit
PfamiView protein in Pfam
PF07687 M20_dimer, 1 hit
PF01546 Peptidase_M20, 1 hit
SUPFAMiSSF55031 SSF55031, 1 hit
TIGRFAMsiTIGR01892 AcOrn-deacetyl, 1 hit
PROSITEiView protein in PROSITE
PS00758 ARGE_DAPE_CPG2_1, 1 hit
PS00759 ARGE_DAPE_CPG2_2, 1 hit

Sequencei

Sequence statusi: Complete.

P23908-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNKLPPFIE IYRALIATPS ISATEEALDQ SNADLITLLA DWFKDLGFNV
60 70 80 90 100
EVQPVPGTRN KFNMLASIGQ GAGGLLLAGH TDTVPFDDGR WTRDPFTLTE
110 120 130 140 150
HDGKLYGLGT ADMKGFFAFI LDALRDVDVT KLKKPLYILA TADEETSMAG
160 170 180 190 200
ARYFAETTAL RPDCAIIGEP TSLQPVRAHK GHISNAIRIQ GQSGHSSDPA
210 220 230 240 250
RGVNAIELMH DAIGHILQLR DNLKERYHYE AFTVPYPTLN LGHIHGGDAS
260 270 280 290 300
NRICACCELH MDIRPLPGMT LNELNGLLND ALAPVSERWP GRLTVDELHP
310 320 330 340 350
PIPGYECPPN HQLVEVVEKL LGAKTEVVNY CTEAPFIQTL CPTLVLGPGS
360 370 380
INQAHQPDEY LETRFIKPTR ELITQVIHHF CWH
Length:383
Mass (Da):42,347
Last modified:December 1, 1992 - v2
Checksum:iAFE04B99B296540B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55417 Genomic DNA Translation: CAA39076.1
X62807 Genomic DNA Translation: CAA44625.1
AY330219 Genomic DNA Translation: AAP92671.1
AY331711 Genomic DNA Translation: AAP92815.1
U00006 Genomic DNA Translation: AAC43063.1
U00096 Genomic DNA Translation: AAC76939.1
AP009048 Genomic DNA Translation: BAE77354.1
J01587 Genomic DNA Translation: AAB59145.1
J01589 Genomic DNA Translation: AAA23484.2
PIRiB42377
RefSeqiNP_418392.1, NC_000913.3
WP_001298964.1, NZ_CP014272.1

Genome annotation databases

EnsemblBacteriaiAAC76939; AAC76939; b3957
BAE77354; BAE77354; BAE77354
GeneIDi948456
KEGGiecj:JW3929
eco:b3957
PATRICifig|1411691.4.peg.2748

Similar proteinsi

Entry informationi

Entry nameiARGE_ECOLI
AccessioniPrimary (citable) accession number: P23908
Secondary accession number(s): Q2M8Q2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 1992
Last sequence update: December 1, 1992
Last modified: March 28, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

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