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P23902

- KASC1_HORVU

UniProt

P23902 - KASC1_HORVU

Protein

3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic

Gene

KAS12

Organism
Hordeum vulgare (Barley)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Nov 1991)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids.

    Catalytic activityi

    Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei213 – 2131PROSITE-ProRule annotation

    GO - Molecular functioni

    1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic (EC:2.3.1.41)
    Alternative name(s):
    Beta-ketoacyl-ACP synthase I
    Short name:
    KAS I
    Gene namesi
    Name:KAS12
    OrganismiHordeum vulgare (Barley)
    Taxonomic identifieri4513 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeHordeum

    Organism-specific databases

    GrameneiP23902.

    Subcellular locationi

    GO - Cellular componenti

    1. chloroplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3535ChloroplastAdd
    BLAST
    Chaini36 – 4624273-oxoacyl-[acyl-carrier-protein] synthase I, chloroplasticPRO_0000000587Add
    BLAST

    Proteomic databases

    PRIDEiP23902.

    Expressioni

    Gene expression databases

    GenevestigatoriP23902.

    Interactioni

    Subunit structurei

    Homodimer.

    Structurei

    3D structure databases

    ProteinModelPortaliP23902.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-ketoacyl-ACP synthases family.Curated

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR017568. 3-oxoacyl-ACP_synth-2.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000447. KAS_II. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    TIGRFAMsiTIGR03150. fabF. 1 hit.
    PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P23902-1 [UniParc]FASTAAdd to Basket

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    MHAHAAHALG LRVPPPAFPR RRARPRRRPA AAVLATSAAP QRETDPRKRV    50
    VITGMGLASV FGSDVDTFYD RLLAGESGVG PIDRFDASSF PTRFAGQIRG 100
    FSSEGYIDGK NDRRLDDCIR YCILSGKKAL ESAGLGAGSD AHVKLDVGRA 150
    GVLVGTGMGG LSVFSDGVQN LIEKGYRKIS PFFIPYAITN MGSALLAIDV 200
    GFMGPNYSIS TACATSNYCF YAAANHIRRG EADIIVAGGT EAAIIPIGLG 250
    GFVACRALSQ RNDDPITACR PWDKERDGFV MGEGAGVLVM ESLEHAMKRD 300
    APIIAEYLGG AVNCDAYHMT DPRADGLGVS SCITMSLRDA GVAPEEVNYI 350
    NAHATSTLAG DLAEVRAIKQ VFKNPSEIKI NSTKSMIGHC LGAAGGLEAI 400
    ATIKSITTGW VHPTINQFNP EPEVDFDTVA NEKKQHEVNV GISNSFGFGG 450
    HNSVVVFAPF KP 462
    Length:462
    Mass (Da):49,016
    Last modified:November 1, 1991 - v1
    Checksum:iBDFA3622263A7764
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60410 mRNA. Translation: AAA32968.1.
    PIRiA39356.
    UniGeneiHv.115.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M60410 mRNA. Translation: AAA32968.1 .
    PIRi A39356.
    UniGenei Hv.115.

    3D structure databases

    ProteinModelPortali P23902.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P23902.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Gramenei P23902.

    Gene expression databases

    Genevestigatori P23902.

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR017568. 3-oxoacyl-ACP_synth-2.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000447. KAS_II. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    TIGRFAMsi TIGR03150. fabF. 1 hit.
    PROSITEi PS00606. B_KETOACYL_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of a cerulenin-binding beta-ketoacyl-[acyl carrier protein] synthase from barley chloroplasts."
      Siggaard-Andersen M., Kauppinen S., von Wettstein-Knowles P.
      Proc. Natl. Acad. Sci. U.S.A. 88:4114-4118(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Strain: cv. Bonus.

    Entry informationi

    Entry nameiKASC1_HORVU
    AccessioniPrimary (citable) accession number: P23902
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3