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P23902

- KASC1_HORVU

UniProt

P23902 - KASC1_HORVU

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Protein
3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic
Gene
KAS12
Organism
Hordeum vulgare (Barley)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids.

Catalytic activityi

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei213 – 2131 By similarity

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic (EC:2.3.1.41)
Alternative name(s):
Beta-ketoacyl-ACP synthase I
Short name:
KAS I
Gene namesi
Name:KAS12
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeHordeum

Organism-specific databases

GrameneiP23902.

Subcellular locationi

GO - Cellular componenti

  1. chloroplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3535Chloroplast
Add
BLAST
Chaini36 – 4624273-oxoacyl-[acyl-carrier-protein] synthase I, chloroplastic
PRO_0000000587Add
BLAST

Proteomic databases

PRIDEiP23902.

Expressioni

Gene expression databases

GenevestigatoriP23902.

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP23902.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR017568. 3-oxoacyl-ACP_synth-2.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000447. KAS_II. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR03150. fabF. 1 hit.
PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23902-1 [UniParc]FASTAAdd to Basket

« Hide

MHAHAAHALG LRVPPPAFPR RRARPRRRPA AAVLATSAAP QRETDPRKRV    50
VITGMGLASV FGSDVDTFYD RLLAGESGVG PIDRFDASSF PTRFAGQIRG 100
FSSEGYIDGK NDRRLDDCIR YCILSGKKAL ESAGLGAGSD AHVKLDVGRA 150
GVLVGTGMGG LSVFSDGVQN LIEKGYRKIS PFFIPYAITN MGSALLAIDV 200
GFMGPNYSIS TACATSNYCF YAAANHIRRG EADIIVAGGT EAAIIPIGLG 250
GFVACRALSQ RNDDPITACR PWDKERDGFV MGEGAGVLVM ESLEHAMKRD 300
APIIAEYLGG AVNCDAYHMT DPRADGLGVS SCITMSLRDA GVAPEEVNYI 350
NAHATSTLAG DLAEVRAIKQ VFKNPSEIKI NSTKSMIGHC LGAAGGLEAI 400
ATIKSITTGW VHPTINQFNP EPEVDFDTVA NEKKQHEVNV GISNSFGFGG 450
HNSVVVFAPF KP 462
Length:462
Mass (Da):49,016
Last modified:November 1, 1991 - v1
Checksum:iBDFA3622263A7764
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60410 mRNA. Translation: AAA32968.1.
PIRiA39356.
UniGeneiHv.115.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M60410 mRNA. Translation: AAA32968.1 .
PIRi A39356.
UniGenei Hv.115.

3D structure databases

ProteinModelPortali P23902.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P23902.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei P23902.

Gene expression databases

Genevestigatori P23902.

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR017568. 3-oxoacyl-ACP_synth-2.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000447. KAS_II. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
TIGRFAMsi TIGR03150. fabF. 1 hit.
PROSITEi PS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structure of a cerulenin-binding beta-ketoacyl-[acyl carrier protein] synthase from barley chloroplasts."
    Siggaard-Andersen M., Kauppinen S., von Wettstein-Knowles P.
    Proc. Natl. Acad. Sci. U.S.A. 88:4114-4118(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Strain: cv. Bonus.

Entry informationi

Entry nameiKASC1_HORVU
AccessioniPrimary (citable) accession number: P23902
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: October 16, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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