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P23901 (ALDR_HORVU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldose reductase

Short name=AR
EC=1.1.1.21
Alternative name(s):
Aldehyde reductase
OrganismHordeum vulgare (Barley)
Taxonomic identifier4513 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeHordeum

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Alditol + NAD(P)+ = aldose + NAD(P)H.

Induction

By abscisic acid (ABA) and gibberellic acid (GA).

Sequence similarities

Belongs to the aldo/keto reductase family.

Ontologies

Keywords
   Biological processStress response
   LigandNADP
   Molecular functionOxidoreductase
   Technical term3D-structure
Gene Ontology (GO)
   Biological_processresponse to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionalditol:NADP+ 1-oxidoreductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 320320Aldose reductase
PRO_0000124628

Regions

Nucleotide binding215 – 26955NADP By similarity

Sites

Active site601Proton donor By similarity
Binding site1211Substrate By similarity
Site881Lowers pKa of active site Tyr By similarity

Secondary structure

.......................................................... 320
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P23901 [UniParc].

Last modified November 1, 1991. Version 1.
Checksum: 5AA72C021E9A93C0

FASTA32035,807
        10         20         30         40         50         60 
MASAKATMGQ GEQDHFVLKS GHAMPAVGLG TWRAGSDTAH SVRTAITEAG YRHVDTAAEY 

        70         80         90        100        110        120 
GVEKEVGKGL KAAMEAGIDR KDLFVTSKIW CTNLAPERVR PALENTLKDL QLDYIDLYHI 

       130        140        150        160        170        180 
HWPFRLKDGA HMPPEAGEVL EFDMEGVWKE MENLVKDGLV KDIGVCNYTV TKLNRLLRSA 

       190        200        210        220        230        240 
KIPPAVCQME MHPGWKNDKI FEACKKHGIH VTAYSPLGSS EKNLAHDPVV EKVANKLNKT 

       250        260        270        280        290        300 
PGQVLIKWAL QRGTSVIPKS SKDERIKENI QVFGWEIPEE DFKVLCSIKD EKRVLTGEEL 

       310        320 
FVNKTHGPYR SAADVWDHEN 

« Hide

References

[1]"An ABA and GA modulated gene expressed in the barley embryo encodes an aldose reductase related protein."
Bartels D., Engelhardt K., Roncarati R., Schneider K., Rotter M., Salamini F.
EMBO J. 10:1037-1043(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Aura.
[2]"Barley aldose reductase: structure, cofactor binding, and substrate recognition in the aldo/keto reductase 4C family."
Olsen J.G., Pedersen L., Christensen C.L., Olsen O., Henriksen A.
Proteins 71:1572-1581(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.64 ANGSTROMS) OF 2-320.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X57526 Genomic DNA. Translation: CAA40747.1.
PIRS15024.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2BGQX-ray2.50A2-320[»]
2BGSX-ray1.64A2-320[»]
2VDGX-ray1.92A2-320[»]
ProteinModelPortalP23901.
SMRP23901. Positions 13-320.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneP23901.

Gene expression databases

GenevestigatorP23901.

Family and domain databases

Gene3D3.20.20.100. 1 hit.
InterProIPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERPTHR11732. PTHR11732. 1 hit.
PfamPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFPIRSF000097. AKR. 1 hit.
PRINTSPR00069. ALDKETRDTASE.
SUPFAMSSF51430. SSF51430. 1 hit.
PROSITEPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP23901.

Entry information

Entry nameALDR_HORVU
AccessionPrimary (citable) accession number: P23901
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: October 16, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references