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P23901

- ALDR_HORVU

UniProt

P23901 - ALDR_HORVU

Protein

Aldose reductase

Gene
N/A
Organism
Hordeum vulgare (Barley)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Nov 1991)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Alditol + NAD(P)+ = aldose + NAD(P)H.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei60 – 601Proton donorBy similarity
    Sitei88 – 881Lowers pKa of active site TyrBy similarity
    Binding sitei121 – 1211SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi215 – 26955NADPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. alditol:NADP+ 1-oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to stress Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldose reductase (EC:1.1.1.21)
    Short name:
    AR
    Alternative name(s):
    Aldehyde reductase
    OrganismiHordeum vulgare (Barley)
    Taxonomic identifieri4513 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeHordeum

    Organism-specific databases

    GrameneiP23901.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 320320Aldose reductasePRO_0000124628Add
    BLAST

    Expressioni

    Inductioni

    By abscisic acid (ABA) and gibberellic acid (GA).

    Gene expression databases

    GenevestigatoriP23901.

    Structurei

    Secondary structure

    1
    320
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi15 – 173
    Beta strandi23 – 275
    Helixi35 – 373
    Helixi38 – 4710
    Beta strandi53 – 553
    Helixi58 – 603
    Helixi63 – 7513
    Helixi80 – 823
    Beta strandi84 – 896
    Helixi91 – 933
    Helixi96 – 983
    Helixi99 – 11012
    Beta strandi115 – 1239
    Helixi144 – 15613
    Beta strandi159 – 1679
    Helixi170 – 17910
    Beta strandi185 – 1906
    Helixi198 – 2069
    Beta strandi210 – 2156
    Turni219 – 2224
    Helixi224 – 2263
    Helixi228 – 23710
    Helixi241 – 25212
    Beta strandi255 – 2573
    Helixi263 – 2686
    Helixi279 – 2879
    Helixi298 – 3014
    Turni304 – 3063
    Helixi312 – 3154
    Turni316 – 3183

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2BGQX-ray2.50A2-320[»]
    2BGSX-ray1.64A2-320[»]
    2VDGX-ray1.92A2-320[»]
    ProteinModelPortaliP23901.
    SMRiP23901. Positions 13-320.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP23901.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldo/keto reductase family.Curated

    Family and domain databases

    Gene3Di3.20.20.100. 1 hit.
    InterProiIPR001395. Aldo/ket_red.
    IPR018170. Aldo/ket_reductase_CS.
    IPR020471. Aldo/keto_reductase_subgr.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view]
    PANTHERiPTHR11732. PTHR11732. 1 hit.
    PfamiPF00248. Aldo_ket_red. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000097. AKR. 1 hit.
    PRINTSiPR00069. ALDKETRDTASE.
    SUPFAMiSSF51430. SSF51430. 1 hit.
    PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
    PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
    PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23901-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASAKATMGQ GEQDHFVLKS GHAMPAVGLG TWRAGSDTAH SVRTAITEAG    50
    YRHVDTAAEY GVEKEVGKGL KAAMEAGIDR KDLFVTSKIW CTNLAPERVR 100
    PALENTLKDL QLDYIDLYHI HWPFRLKDGA HMPPEAGEVL EFDMEGVWKE 150
    MENLVKDGLV KDIGVCNYTV TKLNRLLRSA KIPPAVCQME MHPGWKNDKI 200
    FEACKKHGIH VTAYSPLGSS EKNLAHDPVV EKVANKLNKT PGQVLIKWAL 250
    QRGTSVIPKS SKDERIKENI QVFGWEIPEE DFKVLCSIKD EKRVLTGEEL 300
    FVNKTHGPYR SAADVWDHEN 320
    Length:320
    Mass (Da):35,807
    Last modified:November 1, 1991 - v1
    Checksum:i5AA72C021E9A93C0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57526 Genomic DNA. Translation: CAA40747.1.
    PIRiS15024.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57526 Genomic DNA. Translation: CAA40747.1 .
    PIRi S15024.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2BGQ X-ray 2.50 A 2-320 [» ]
    2BGS X-ray 1.64 A 2-320 [» ]
    2VDG X-ray 1.92 A 2-320 [» ]
    ProteinModelPortali P23901.
    SMRi P23901. Positions 13-320.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Gramenei P23901.

    Miscellaneous databases

    EvolutionaryTracei P23901.

    Gene expression databases

    Genevestigatori P23901.

    Family and domain databases

    Gene3Di 3.20.20.100. 1 hit.
    InterProi IPR001395. Aldo/ket_red.
    IPR018170. Aldo/ket_reductase_CS.
    IPR020471. Aldo/keto_reductase_subgr.
    IPR023210. NADP_OxRdtase_dom.
    [Graphical view ]
    PANTHERi PTHR11732. PTHR11732. 1 hit.
    Pfami PF00248. Aldo_ket_red. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000097. AKR. 1 hit.
    PRINTSi PR00069. ALDKETRDTASE.
    SUPFAMi SSF51430. SSF51430. 1 hit.
    PROSITEi PS00798. ALDOKETO_REDUCTASE_1. 1 hit.
    PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
    PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An ABA and GA modulated gene expressed in the barley embryo encodes an aldose reductase related protein."
      Bartels D., Engelhardt K., Roncarati R., Schneider K., Rotter M., Salamini F.
      EMBO J. 10:1037-1043(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. Aura.
    2. "Barley aldose reductase: structure, cofactor binding, and substrate recognition in the aldo/keto reductase 4C family."
      Olsen J.G., Pedersen L., Christensen C.L., Olsen O., Henriksen A.
      Proteins 71:1572-1581(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.64 ANGSTROMS) OF 2-320.

    Entry informationi

    Entry nameiALDR_HORVU
    AccessioniPrimary (citable) accession number: P23901
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3