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P23901

- ALDR_HORVU

UniProt

P23901 - ALDR_HORVU

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Protein

Aldose reductase

Gene
N/A
Organism
Hordeum vulgare (Barley)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

Alditol + NAD(P)+ = aldose + NAD(P)H.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei60 – 601Proton donorBy similarity
Sitei88 – 881Lowers pKa of active site TyrBy similarity
Binding sitei121 – 1211SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi215 – 26955NADPBy similarityAdd
BLAST

GO - Molecular functioni

  1. alditol:NADP+ 1-oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. photoperiodism, flowering Source: EnsemblPlants/Gramene
  2. vernalization response Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Stress response

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose reductase (EC:1.1.1.21)
Short name:
AR
Alternative name(s):
Aldehyde reductase
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeHordeum

Organism-specific databases

GrameneiP23901.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Aldose reductasePRO_0000124628Add
BLAST

Expressioni

Inductioni

By abscisic acid (ABA) and gibberellic acid (GA).

Gene expression databases

GenevestigatoriP23901.

Structurei

Secondary structure

1
320
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi15 – 173
Beta strandi23 – 275
Helixi35 – 373
Helixi38 – 4710
Beta strandi53 – 553
Helixi58 – 603
Helixi63 – 7513
Helixi80 – 823
Beta strandi84 – 896
Helixi91 – 933
Helixi96 – 983
Helixi99 – 11012
Beta strandi115 – 1239
Helixi144 – 15613
Beta strandi159 – 1679
Helixi170 – 17910
Beta strandi185 – 1906
Helixi198 – 2069
Beta strandi210 – 2156
Turni219 – 2224
Helixi224 – 2263
Helixi228 – 23710
Helixi241 – 25212
Beta strandi255 – 2573
Helixi263 – 2686
Helixi279 – 2879
Helixi298 – 3014
Turni304 – 3063
Helixi312 – 3154
Turni316 – 3183

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BGQX-ray2.50A2-320[»]
2BGSX-ray1.64A2-320[»]
2VDGX-ray1.92A2-320[»]
ProteinModelPortaliP23901.
SMRiP23901. Positions 13-320.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23901.

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Family and domain databases

Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 1 hit.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23901 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASAKATMGQ GEQDHFVLKS GHAMPAVGLG TWRAGSDTAH SVRTAITEAG
60 70 80 90 100
YRHVDTAAEY GVEKEVGKGL KAAMEAGIDR KDLFVTSKIW CTNLAPERVR
110 120 130 140 150
PALENTLKDL QLDYIDLYHI HWPFRLKDGA HMPPEAGEVL EFDMEGVWKE
160 170 180 190 200
MENLVKDGLV KDIGVCNYTV TKLNRLLRSA KIPPAVCQME MHPGWKNDKI
210 220 230 240 250
FEACKKHGIH VTAYSPLGSS EKNLAHDPVV EKVANKLNKT PGQVLIKWAL
260 270 280 290 300
QRGTSVIPKS SKDERIKENI QVFGWEIPEE DFKVLCSIKD EKRVLTGEEL
310 320
FVNKTHGPYR SAADVWDHEN
Length:320
Mass (Da):35,807
Last modified:November 1, 1991 - v1
Checksum:i5AA72C021E9A93C0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57526 Genomic DNA. Translation: CAA40747.1.
PIRiS15024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57526 Genomic DNA. Translation: CAA40747.1 .
PIRi S15024.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2BGQ X-ray 2.50 A 2-320 [» ]
2BGS X-ray 1.64 A 2-320 [» ]
2VDG X-ray 1.92 A 2-320 [» ]
ProteinModelPortali P23901.
SMRi P23901. Positions 13-320.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei P23901.

Miscellaneous databases

EvolutionaryTracei P23901.

Gene expression databases

Genevestigatori P23901.

Family and domain databases

Gene3Di 3.20.20.100. 1 hit.
InterProi IPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view ]
PANTHERi PTHR11732. PTHR11732. 1 hit.
Pfami PF00248. Aldo_ket_red. 1 hit.
[Graphical view ]
PIRSFi PIRSF000097. AKR. 1 hit.
PRINTSi PR00069. ALDKETRDTASE.
SUPFAMi SSF51430. SSF51430. 1 hit.
PROSITEi PS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "An ABA and GA modulated gene expressed in the barley embryo encodes an aldose reductase related protein."
    Bartels D., Engelhardt K., Roncarati R., Schneider K., Rotter M., Salamini F.
    EMBO J. 10:1037-1043(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Aura.
  2. "Barley aldose reductase: structure, cofactor binding, and substrate recognition in the aldo/keto reductase 4C family."
    Olsen J.G., Pedersen L., Christensen C.L., Olsen O., Henriksen A.
    Proteins 71:1572-1581(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.64 ANGSTROMS) OF 2-320.

Entry informationi

Entry nameiALDR_HORVU
AccessioniPrimary (citable) accession number: P23901
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3