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Protein

Probable endopeptidase NlpC

Gene

nlpC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei62NucleophileBy similarity1
Active sitei115Proton acceptorBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BioCyciEcoCyc:EG11133-MONOMER

Protein family/group databases

MEROPSiC40.A01

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endopeptidase NlpC (EC:3.4.-.-)
Alternative name(s):
ORF-17
Probable lipoprotein NlpC
Gene namesi
Name:nlpC
Ordered Locus Names:b1708, JW1698
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11133 nlpC

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15PROSITE-ProRule annotationAdd BLAST15
ChainiPRO_000001975416 – 154Probable endopeptidase NlpCAdd BLAST139

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi16N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi16S-diacylglycerol cysteinePROSITE-ProRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP23898
PRIDEiP23898

Interactioni

Protein-protein interaction databases

BioGridi4260300, 304 interactors
STRINGi316385.ECDH10B_1844

Structurei

3D structure databases

ProteinModelPortaliP23898
SMRiP23898
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C40 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108QBX Bacteria
COG0791 LUCA
HOGENOMiHOG000229978
InParanoidiP23898
KOiK13695
OMAiWKRAYWQ
PhylomeDBiP23898

Family and domain databases

InterProiView protein in InterPro
IPR000064 NLP_P60_dom
PfamiView protein in Pfam
PF00877 NLPC_P60, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFCLILITA LLLAGCSHHK APPPNARLSD SITVIAGLND QLQSWHGTPY
60 70 80 90 100
RYGGMTRRGV DCSGFVVVTM RDRFDLQLPR ETKQQASIGT QIDKDELLPG
110 120 130 140 150
DLVFFKTGSG QNGLHVGIYD TNNQFIHAST SKGVMRSSLD NVYWQKNFWQ

ARRI
Length:154
Mass (Da):17,283
Last modified:November 1, 1991 - v1
Checksum:iCCAD869AF624BC4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14031 Genomic DNA Translation: AAA23529.1
U00096 Genomic DNA Translation: AAC74778.1
AP009048 Genomic DNA Translation: BAA15476.1
PIRiD64929
RefSeqiNP_416223.1, NC_000913.3
WP_001209795.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74778; AAC74778; b1708
BAA15476; BAA15476; BAA15476
GeneIDi946220
KEGGiecj:JW1698
eco:b1708
PATRICifig|1411691.4.peg.549

Similar proteinsi

Entry informationi

Entry nameiNLPC_ECOLI
AccessioniPrimary (citable) accession number: P23898
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health