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Protein

Probable endopeptidase NlpC

Gene

nlpC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621NucleophileBy similarity
Active sitei115 – 1151Proton acceptorBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BioCyciEcoCyc:EG11133-MONOMER.
ECOL316407:JW1698-MONOMER.

Protein family/group databases

MEROPSiC40.A01.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endopeptidase NlpC (EC:3.4.-.-)
Alternative name(s):
ORF-17
Probable lipoprotein NlpC
Gene namesi
Name:nlpC
Ordered Locus Names:b1708, JW1698
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11133. nlpC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515PROSITE-ProRule annotationAdd
BLAST
Chaini16 – 154139Probable endopeptidase NlpCPRO_0000019754Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi16 – 161N-palmitoyl cysteinePROSITE-ProRule annotation
Lipidationi16 – 161S-diacylglycerol cysteinePROSITE-ProRule annotation

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP23898.

Interactioni

Protein-protein interaction databases

BioGridi4260300. 301 interactions.
STRINGi511145.b1708.

Structurei

3D structure databases

ProteinModelPortaliP23898.
SMRiP23898. Positions 31-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C40 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108QBX. Bacteria.
COG0791. LUCA.
HOGENOMiHOG000229978.
InParanoidiP23898.
KOiK13695.
OMAiDSIMVMV.
OrthoDBiEOG60CWQW.
PhylomeDBiP23898.

Family and domain databases

Gene3Di3.90.1720.10. 1 hit.
InterProiIPR000064. NLP_P60_dom.
[Graphical view]
PfamiPF00877. NLPC_P60. 1 hit.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFCLILITA LLLAGCSHHK APPPNARLSD SITVIAGLND QLQSWHGTPY
60 70 80 90 100
RYGGMTRRGV DCSGFVVVTM RDRFDLQLPR ETKQQASIGT QIDKDELLPG
110 120 130 140 150
DLVFFKTGSG QNGLHVGIYD TNNQFIHAST SKGVMRSSLD NVYWQKNFWQ

ARRI
Length:154
Mass (Da):17,283
Last modified:November 1, 1991 - v1
Checksum:iCCAD869AF624BC4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14031 Genomic DNA. Translation: AAA23529.1.
U00096 Genomic DNA. Translation: AAC74778.1.
AP009048 Genomic DNA. Translation: BAA15476.1.
PIRiD64929.
RefSeqiNP_416223.1. NC_000913.3.
WP_001209795.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74778; AAC74778; b1708.
BAA15476; BAA15476; BAA15476.
GeneIDi946220.
KEGGiecj:JW1698.
eco:b1708.
PATRICi32118722. VBIEscCol129921_1779.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14031 Genomic DNA. Translation: AAA23529.1.
U00096 Genomic DNA. Translation: AAC74778.1.
AP009048 Genomic DNA. Translation: BAA15476.1.
PIRiD64929.
RefSeqiNP_416223.1. NC_000913.3.
WP_001209795.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP23898.
SMRiP23898. Positions 31-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260300. 301 interactions.
STRINGi511145.b1708.

Protein family/group databases

MEROPSiC40.A01.

Proteomic databases

PaxDbiP23898.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74778; AAC74778; b1708.
BAA15476; BAA15476; BAA15476.
GeneIDi946220.
KEGGiecj:JW1698.
eco:b1708.
PATRICi32118722. VBIEscCol129921_1779.

Organism-specific databases

EchoBASEiEB1123.
EcoGeneiEG11133. nlpC.

Phylogenomic databases

eggNOGiENOG4108QBX. Bacteria.
COG0791. LUCA.
HOGENOMiHOG000229978.
InParanoidiP23898.
KOiK13695.
OMAiDSIMVMV.
OrthoDBiEOG60CWQW.
PhylomeDBiP23898.

Enzyme and pathway databases

BioCyciEcoCyc:EG11133-MONOMER.
ECOL316407:JW1698-MONOMER.

Miscellaneous databases

PROiP23898.

Family and domain databases

Gene3Di3.90.1720.10. 1 hit.
InterProiIPR000064. NLP_P60_dom.
[Graphical view]
PfamiPF00877. NLPC_P60. 1 hit.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Kadner R.J.
    Submitted (FEB-1989) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiNLPC_ECOLI
AccessioniPrimary (citable) accession number: P23898
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: January 20, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.