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Protein

ATP-binding/permease protein CydC

Gene

cydC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi373 – 380ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: EcoCyc
  • ATPase activity, coupled to transmembrane movement of substances Source: EcoCyc
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • cell redox homeostasis Source: InterPro
  • cysteine export across plasma membrane Source: EcoCyc
  • glutathione transmembrane transport Source: EcoCyc
  • regulation of heme biosynthetic process Source: EcoCyc

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:CYDC-MONOMER
MetaCyc:CYDC-MONOMER

Protein family/group databases

TCDBi3.A.1.129.1 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding/permease protein CydC
Gene namesi
Name:cydC
Synonyms:mdrA, mdrH, surB
Ordered Locus Names:b0886, JW0869
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10012 cydC

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei37 – 57HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei137 – 157HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei162 – 182HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei250 – 270HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei277 – 297HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: EcoCyc
  • integral component of membrane Source: EcoCyc
  • integral component of plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000922411 – 573ATP-binding/permease protein CydCAdd BLAST573

Proteomic databases

PaxDbiP23886
PRIDEiP23886

Interactioni

Protein-protein interaction databases

BioGridi4260004, 302 interactors
DIPiDIP-9362N
IntActiP23886, 5 interactors
STRINGi316385.ECDH10B_0956

Structurei

3D structure databases

ProteinModelPortaliP23886
SMRiP23886
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 306ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST289
Domaini339 – 572ABC transporterPROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108JJ8 Bacteria
COG4987 LUCA
InParanoidiP23886
KOiK16012
OMAiQKAELFQ
PhylomeDBiP23886

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR014223 ABC_CydC
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR02868 CydC, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

P23886-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALLPYLAL YKRHKWMLSL GIVLAIVTLL ASIGLLTLSG WFLSASAVAG
60 70 80 90 100
VAGLYSFNYM LPAAGVRGAA ITRTAGRYFE RLVSHDATFR VLQHLRIYTF
110 120 130 140 150
SKLLPLSPAG LARYRQGELL NRVVADVDTL DHLYLRVISP LVGAFVVIMV
160 170 180 190 200
VTIGLSFLDF TLAFTLGGIM LLTLFLMPPL FYRAGKSTGQ NLTHLRGQYR
210 220 230 240 250
QQLTAWLQGQ AELTIFGASD RYRTQLENTE IQWLEAQRRQ SELTALSQAI
260 270 280 290 300
MLLIGALAVI LMLWMASGGV GGNAQPGALI ALFVFCALAA FEALAPVTGA
310 320 330 340 350
FQHLGQVIAS AVRISDLTDQ KPEVTFPDTQ TRVADRVSLT LRDVQFTYPE
360 370 380 390 400
QSQQALKGIS LQVNAGEHIA ILGRTGCGKS TLLQQLTRAW DPQQGEILLN
410 420 430 440 450
DSPIASLNEA ALRQTISVVP QRVHLFSATL RDNLLLASPG SSDEALSEIL
460 470 480 490 500
RRVGLEKLLE DAGLNSWLGE GGRQLSGGEL RRLAIARALL HDAPLVLLDE
510 520 530 540 550
PTEGLDATTE SQILELLAEM MREKTVLMVT HRLRGLSRFQ QIIVMDNGQI
560 570
IEQGTHAELL ARQGRYYQFK QGL
Length:573
Mass (Da):62,920
Last modified:April 1, 1993 - v2
Checksum:iACF4E7087EEEADAD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti289A → R in AAC36864 (PubMed:8276245).Curated1
Sequence conflicti480 – 481LR → PG in AAC36864 (PubMed:8276245).Curated2
Sequence conflicti504G → A in AAC36909 (PubMed:1909328).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10383 Unassigned DNA Translation: AAA03230.1
L25859 Unassigned DNA Translation: AAC36864.1
U00096 Genomic DNA Translation: AAC73972.1
AP009048 Genomic DNA Translation: BAA35611.1
M63145 Genomic DNA Translation: AAC36909.1
L21749 Genomic DNA Translation: AAA66172.1
PIRiB36888
RefSeqiNP_415406.1, NC_000913.3
WP_001202177.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73972; AAC73972; b0886
BAA35611; BAA35611; BAA35611
GeneIDi945504
KEGGiecj:JW0869
eco:b0886
PATRICifig|1411691.4.peg.1392

Similar proteinsi

Entry informationi

Entry nameiCYDC_ECOLI
AccessioniPrimary (citable) accession number: P23886
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: April 1, 1993
Last modified: April 25, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health