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Protein

ATP-binding/permease protein CydC

Gene

cydC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi373 – 3808ATPPROSITE-ProRule annotation

GO - Molecular functioni

  • ATPase activity Source: EcoCyc
  • ATPase activity, coupled to transmembrane movement of substances Source: EcoCyc
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • cysteine export Source: EcoCyc
  • glutathione transmembrane transport Source: EcoCyc
  • regulation of heme biosynthetic process Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:CYDC-MONOMER.
ECOL316407:JW0869-MONOMER.
MetaCyc:CYDC-MONOMER.

Protein family/group databases

TCDBi3.A.1.129.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding/permease protein CydC
Gene namesi
Name:cydC
Synonyms:mdrA, mdrH, surB
Ordered Locus Names:b0886, JW0869
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10012. cydC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei37 – 5721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei137 – 15721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei162 – 18221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei250 – 27021HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei277 – 29721HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: EcoCyc
  • integral component of membrane Source: EcoCyc
  • integral component of plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573ATP-binding/permease protein CydCPRO_0000092241Add
BLAST

Proteomic databases

PaxDbiP23886.
PRIDEiP23886.

Interactioni

Protein-protein interaction databases

BioGridi4260004. 250 interactions.
DIPiDIP-9362N.
IntActiP23886. 5 interactions.
STRINGi511145.b0886.

Structurei

3D structure databases

ProteinModelPortaliP23886.
SMRiP23886. Positions 1-569.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 306289ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST
Domaini339 – 572234ABC transporterPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108JJ8. Bacteria.
COG4987. LUCA.
InParanoidiP23886.
KOiK16012.
OMAiFASADKI.
OrthoDBiEOG6T7N3V.
PhylomeDBiP23886.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR014223. ABC_CydC.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02868. CydC. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23886-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALLPYLAL YKRHKWMLSL GIVLAIVTLL ASIGLLTLSG WFLSASAVAG
60 70 80 90 100
VAGLYSFNYM LPAAGVRGAA ITRTAGRYFE RLVSHDATFR VLQHLRIYTF
110 120 130 140 150
SKLLPLSPAG LARYRQGELL NRVVADVDTL DHLYLRVISP LVGAFVVIMV
160 170 180 190 200
VTIGLSFLDF TLAFTLGGIM LLTLFLMPPL FYRAGKSTGQ NLTHLRGQYR
210 220 230 240 250
QQLTAWLQGQ AELTIFGASD RYRTQLENTE IQWLEAQRRQ SELTALSQAI
260 270 280 290 300
MLLIGALAVI LMLWMASGGV GGNAQPGALI ALFVFCALAA FEALAPVTGA
310 320 330 340 350
FQHLGQVIAS AVRISDLTDQ KPEVTFPDTQ TRVADRVSLT LRDVQFTYPE
360 370 380 390 400
QSQQALKGIS LQVNAGEHIA ILGRTGCGKS TLLQQLTRAW DPQQGEILLN
410 420 430 440 450
DSPIASLNEA ALRQTISVVP QRVHLFSATL RDNLLLASPG SSDEALSEIL
460 470 480 490 500
RRVGLEKLLE DAGLNSWLGE GGRQLSGGEL RRLAIARALL HDAPLVLLDE
510 520 530 540 550
PTEGLDATTE SQILELLAEM MREKTVLMVT HRLRGLSRFQ QIIVMDNGQI
560 570
IEQGTHAELL ARQGRYYQFK QGL
Length:573
Mass (Da):62,920
Last modified:April 1, 1993 - v2
Checksum:iACF4E7087EEEADAD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti289 – 2891A → R in AAC36864 (PubMed:8276245).Curated
Sequence conflicti480 – 4812LR → PG in AAC36864 (PubMed:8276245).Curated
Sequence conflicti504 – 5041G → A in AAC36909 (PubMed:1909328).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10383 Unassigned DNA. Translation: AAA03230.1.
L25859 Unassigned DNA. Translation: AAC36864.1.
U00096 Genomic DNA. Translation: AAC73972.1.
AP009048 Genomic DNA. Translation: BAA35611.1.
M63145 Genomic DNA. Translation: AAC36909.1.
L21749 Genomic DNA. Translation: AAA66172.1.
PIRiB36888.
RefSeqiNP_415406.1. NC_000913.3.
WP_001202177.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73972; AAC73972; b0886.
BAA35611; BAA35611; BAA35611.
GeneIDi945504.
KEGGiecj:JW0869.
eco:b0886.
PATRICi32116981. VBIEscCol129921_0915.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10383 Unassigned DNA. Translation: AAA03230.1.
L25859 Unassigned DNA. Translation: AAC36864.1.
U00096 Genomic DNA. Translation: AAC73972.1.
AP009048 Genomic DNA. Translation: BAA35611.1.
M63145 Genomic DNA. Translation: AAC36909.1.
L21749 Genomic DNA. Translation: AAA66172.1.
PIRiB36888.
RefSeqiNP_415406.1. NC_000913.3.
WP_001202177.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP23886.
SMRiP23886. Positions 1-569.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260004. 250 interactions.
DIPiDIP-9362N.
IntActiP23886. 5 interactions.
STRINGi511145.b0886.

Protein family/group databases

TCDBi3.A.1.129.1. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP23886.
PRIDEiP23886.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73972; AAC73972; b0886.
BAA35611; BAA35611; BAA35611.
GeneIDi945504.
KEGGiecj:JW0869.
eco:b0886.
PATRICi32116981. VBIEscCol129921_0915.

Organism-specific databases

EchoBASEiEB0012.
EcoGeneiEG10012. cydC.

Phylogenomic databases

eggNOGiENOG4108JJ8. Bacteria.
COG4987. LUCA.
InParanoidiP23886.
KOiK16012.
OMAiFASADKI.
OrthoDBiEOG6T7N3V.
PhylomeDBiP23886.

Enzyme and pathway databases

BioCyciEcoCyc:CYDC-MONOMER.
ECOL316407:JW0869-MONOMER.
MetaCyc:CYDC-MONOMER.

Miscellaneous databases

PROiP23886.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR014223. ABC_CydC.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02868. CydC. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The N-end rule in Escherichia coli: cloning and analysis of the leucyl, phenylalanyl-tRNA-protein transferase gene aat."
    Shrader T.E., Tobias J.W., Varshavsky A.
    J. Bacteriol. 175:4364-4374(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12 / MC1061 / ATCC 53338 / DSM 7140.
  2. "Isolation and characterization of an Escherichia coli mutant defective in resuming growth after starvation."
    Siegele D.D., Kolter R.
    Genes Dev. 7:2629-2640(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  6. "Cytochrome bd biosynthesis in Escherichia coli: the sequences of the cydC and cydD genes suggest that they encode the components of an ABC membrane transporter."
    Poole R.K., Hatch L., Cleeter M.W.J., Gibson F., Cox G.B., Wu G.
    Mol. Microbiol. 10:421-430(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-453.
  7. "Structure and expression of the infA operon encoding translational initiation factor IF1. Transcriptional control by growth rate."
    Cummings H.S., Sands J.F., Foreman P.C., Fraser J., Hershey J.W.B.
    J. Biol. Chem. 266:16491-16498(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 449-504.
  8. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiCYDC_ECOLI
AccessioniPrimary (citable) accession number: P23886
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: April 1, 1993
Last modified: January 20, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.