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P23880 (PP12_SCHPO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase PP1-2

EC=3.1.3.16
Alternative name(s):
Suppressor protein SDS21
Gene names
Name:sds21
ORF Names:SPCC31H12.05c
OrganismSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [Reference proteome]
Taxonomic identifier284812 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential role in cell cycle control. PP1 is perhaps required for exit from mitosis.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 manganese ions per subunit By similarity.

Sequence similarities

Belongs to the PPP phosphatase family. PP-1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322Serine/threonine-protein phosphatase PP1-2
PRO_0000058819

Sites

Active site1211Proton donor By similarity
Metal binding601Manganese 1 By similarity
Metal binding621Manganese 1 By similarity
Metal binding881Manganese 1 By similarity
Metal binding881Manganese 2 By similarity
Metal binding1201Manganese 2 By similarity
Metal binding1691Manganese 2 By similarity
Metal binding2441Manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P23880 [UniParc].

Last modified November 1, 1991. Version 1.
Checksum: A5EB5991720788B7

FASTA32236,829
        10         20         30         40         50         60 
MDYDIDAIIE KLVKARNGKP SKQVQLSDAE IRYLCTTSRS IFLSQPMLLE LEAPLKICGD 

        70         80         90        100        110        120 
IHGQYSDLLR LFEYGGYPPD ANYLFLGDYV DRGKQSLEVI CLLFAYKIKY PENFFLLRGN 

       130        140        150        160        170        180 
HEFASINRIY GFYDECKRRY SIKLWKTFTD CFNCMPVAAV IDEKIFCMHG GLSPDLNSLD 

       190        200        210        220        230        240 
QIQRIIRPTD IPDTGLLCDL VWSDPEKDLT GWGENDRGVS YTFGADVVSR FLQKHDLDLI 

       250        260        270        280        290        300 
CRAHQVVEDG YEFFGKRQLV TIFSAPNYCG EFDNVGAMMS VNEDLLCSFQ ILKPAEKRQR 

       310        320 
VSQSSIKESK SATNSLKKSK NN 

« Hide

References

« Hide 'large scale' references
[1]"The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases."
Ohkura H., Kinoshita N., Miyatani S., Toda T., Yanagida M.
Cell 57:997-1007(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The genome sequence of Schizosaccharomyces pombe."
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M. expand/collapse author list , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 972 / ATCC 24843.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M27069 Genomic DNA. Translation: AAA35341.1.
CU329672 Genomic DNA. Translation: CAA21222.1.
PIRB32550.
RefSeqNP_587898.1. NM_001022890.2.

3D structure databases

ProteinModelPortalP23880.
SMRP23880. Positions 2-300.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid275750. 6 interactions.
MINTMINT-4687813.
STRING4896.SPCC31H12.05c-1.

Proteomic databases

MaxQBP23880.
PRIDEP23880.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiSPCC31H12.05c.1; SPCC31H12.05c.1:pep; SPCC31H12.05c.
GeneID2539179.
KEGGspo:SPCC31H12.05c.

Organism-specific databases

PomBaseSPCC31H12.05c.

Phylogenomic databases

eggNOGCOG0639.
HOGENOMHOG000172697.
KOK06269.
OMAYLVMESR.
OrthoDBEOG79KPQ9.
PhylomeDBP23880.

Family and domain databases

Gene3D3.60.21.10. 1 hit.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMSSF56300. SSF56300. 1 hit.
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20800350.

Entry information

Entry namePP12_SCHPO
AccessionPrimary (citable) accession number: P23880
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: June 11, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Schizosaccharomyces pombe

Schizosaccharomyces pombe: entries and gene names