Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein phosphatase PP1-2

Gene

sds21

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Essential role in cell cycle control. PP1 is perhaps required for exit from mitosis.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Manganese 1By similarity1
Metal bindingi62Manganese 1By similarity1
Metal bindingi88Manganese 1By similarity1
Metal bindingi88Manganese 2By similarity1
Metal bindingi120Manganese 2By similarity1
Active sitei121Proton donorBy similarity1
Metal bindingi169Manganese 2By similarity1
Metal bindingi244Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1-2 (EC:3.1.3.16)
Alternative name(s):
Suppressor protein SDS21
Gene namesi
Name:sds21
ORF Names:SPCC31H12.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC31H12.05c.
PomBaseiSPCC31H12.05c. sds21.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: PomBase
  • nucleus Source: PomBase
  • protein phosphatase type 1 complex Source: PomBase
  • PTW/PP1 phosphatase complex Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588191 – 322Serine/threonine-protein phosphatase PP1-2Add BLAST322

Proteomic databases

MaxQBiP23880.
PRIDEiP23880.

Interactioni

Protein-protein interaction databases

BioGridi275750. 13 interactors.
MINTiMINT-4687813.

Structurei

3D structure databases

ProteinModelPortaliP23880.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000172697.
InParanoidiP23880.
KOiK06269.
OMAiGFEFFAN.
OrthoDBiEOG092C37EX.
PhylomeDBiP23880.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR031675. STPPase_N.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF16891. STPPase_N. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23880-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYDIDAIIE KLVKARNGKP SKQVQLSDAE IRYLCTTSRS IFLSQPMLLE
60 70 80 90 100
LEAPLKICGD IHGQYSDLLR LFEYGGYPPD ANYLFLGDYV DRGKQSLEVI
110 120 130 140 150
CLLFAYKIKY PENFFLLRGN HEFASINRIY GFYDECKRRY SIKLWKTFTD
160 170 180 190 200
CFNCMPVAAV IDEKIFCMHG GLSPDLNSLD QIQRIIRPTD IPDTGLLCDL
210 220 230 240 250
VWSDPEKDLT GWGENDRGVS YTFGADVVSR FLQKHDLDLI CRAHQVVEDG
260 270 280 290 300
YEFFGKRQLV TIFSAPNYCG EFDNVGAMMS VNEDLLCSFQ ILKPAEKRQR
310 320
VSQSSIKESK SATNSLKKSK NN
Length:322
Mass (Da):36,829
Last modified:November 1, 1991 - v1
Checksum:iA5EB5991720788B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27069 Genomic DNA. Translation: AAA35341.1.
CU329672 Genomic DNA. Translation: CAA21222.1.
PIRiB32550.
RefSeqiNP_587898.1. NM_001022890.2.

Genome annotation databases

EnsemblFungiiSPCC31H12.05c.1; SPCC31H12.05c.1:pep; SPCC31H12.05c.
GeneIDi2539179.
KEGGispo:SPCC31H12.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27069 Genomic DNA. Translation: AAA35341.1.
CU329672 Genomic DNA. Translation: CAA21222.1.
PIRiB32550.
RefSeqiNP_587898.1. NM_001022890.2.

3D structure databases

ProteinModelPortaliP23880.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi275750. 13 interactors.
MINTiMINT-4687813.

Proteomic databases

MaxQBiP23880.
PRIDEiP23880.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPCC31H12.05c.1; SPCC31H12.05c.1:pep; SPCC31H12.05c.
GeneIDi2539179.
KEGGispo:SPCC31H12.05c.

Organism-specific databases

EuPathDBiFungiDB:SPCC31H12.05c.
PomBaseiSPCC31H12.05c. sds21.

Phylogenomic databases

HOGENOMiHOG000172697.
InParanoidiP23880.
KOiK06269.
OMAiGFEFFAN.
OrthoDBiEOG092C37EX.
PhylomeDBiP23880.

Miscellaneous databases

PROiP23880.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR031675. STPPase_N.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF16891. STPPase_N. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP12_SCHPO
AccessioniPrimary (citable) accession number: P23880
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.