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P23880

- PP12_SCHPO

UniProt

P23880 - PP12_SCHPO

Protein

Serine/threonine-protein phosphatase PP1-2

Gene

sds21

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Nov 1991)
      Previous versions | rss
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    Functioni

    Essential role in cell cycle control. PP1 is perhaps required for exit from mitosis.

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi60 – 601Manganese 1By similarity
    Metal bindingi62 – 621Manganese 1By similarity
    Metal bindingi88 – 881Manganese 1By similarity
    Metal bindingi88 – 881Manganese 2By similarity
    Metal bindingi120 – 1201Manganese 2By similarity
    Active sitei121 – 1211Proton donorBy similarity
    Metal bindingi169 – 1691Manganese 2By similarity
    Metal bindingi244 – 2441Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    GO - Biological processi

    1. microtubule cytoskeleton organization Source: PomBase
    2. mitotic nuclear division Source: UniProtKB-KW
    3. rRNA processing Source: PomBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase PP1-2 (EC:3.1.3.16)
    Alternative name(s):
    Suppressor protein SDS21
    Gene namesi
    Name:sds21
    ORF Names:SPCC31H12.05c
    OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    Taxonomic identifieri284812 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
    ProteomesiUP000002485: Chromosome III

    Organism-specific databases

    PomBaseiSPCC31H12.05c.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleolus Source: PomBase
    2. nucleus Source: PomBase
    3. protein phosphatase type 1 complex Source: PomBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 322322Serine/threonine-protein phosphatase PP1-2PRO_0000058819Add
    BLAST

    Proteomic databases

    MaxQBiP23880.
    PRIDEiP23880.

    Interactioni

    Protein-protein interaction databases

    BioGridi275750. 7 interactions.
    MINTiMINT-4687813.
    STRINGi4896.SPCC31H12.05c-1.

    Structurei

    3D structure databases

    ProteinModelPortaliP23880.
    SMRiP23880. Positions 2-300.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0639.
    HOGENOMiHOG000172697.
    KOiK06269.
    OMAiYLVMESR.
    OrthoDBiEOG79KPQ9.
    PhylomeDBiP23880.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23880-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYDIDAIIE KLVKARNGKP SKQVQLSDAE IRYLCTTSRS IFLSQPMLLE    50
    LEAPLKICGD IHGQYSDLLR LFEYGGYPPD ANYLFLGDYV DRGKQSLEVI 100
    CLLFAYKIKY PENFFLLRGN HEFASINRIY GFYDECKRRY SIKLWKTFTD 150
    CFNCMPVAAV IDEKIFCMHG GLSPDLNSLD QIQRIIRPTD IPDTGLLCDL 200
    VWSDPEKDLT GWGENDRGVS YTFGADVVSR FLQKHDLDLI CRAHQVVEDG 250
    YEFFGKRQLV TIFSAPNYCG EFDNVGAMMS VNEDLLCSFQ ILKPAEKRQR 300
    VSQSSIKESK SATNSLKKSK NN 322
    Length:322
    Mass (Da):36,829
    Last modified:November 1, 1991 - v1
    Checksum:iA5EB5991720788B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M27069 Genomic DNA. Translation: AAA35341.1.
    CU329672 Genomic DNA. Translation: CAA21222.1.
    PIRiB32550.
    RefSeqiNP_587898.1. NM_001022890.2.

    Genome annotation databases

    EnsemblFungiiSPCC31H12.05c.1; SPCC31H12.05c.1:pep; SPCC31H12.05c.
    GeneIDi2539179.
    KEGGispo:SPCC31H12.05c.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M27069 Genomic DNA. Translation: AAA35341.1 .
    CU329672 Genomic DNA. Translation: CAA21222.1 .
    PIRi B32550.
    RefSeqi NP_587898.1. NM_001022890.2.

    3D structure databases

    ProteinModelPortali P23880.
    SMRi P23880. Positions 2-300.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 275750. 7 interactions.
    MINTi MINT-4687813.
    STRINGi 4896.SPCC31H12.05c-1.

    Proteomic databases

    MaxQBi P23880.
    PRIDEi P23880.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii SPCC31H12.05c.1 ; SPCC31H12.05c.1:pep ; SPCC31H12.05c .
    GeneIDi 2539179.
    KEGGi spo:SPCC31H12.05c.

    Organism-specific databases

    PomBasei SPCC31H12.05c.

    Phylogenomic databases

    eggNOGi COG0639.
    HOGENOMi HOG000172697.
    KOi K06269.
    OMAi YLVMESR.
    OrthoDBi EOG79KPQ9.
    PhylomeDBi P23880.

    Miscellaneous databases

    NextBioi 20800350.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases."
      Ohkura H., Kinoshita N., Miyatani S., Toda T., Yanagida M.
      Cell 57:997-1007(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The genome sequence of Schizosaccharomyces pombe."
      Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
      , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
      Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 972 / ATCC 24843.

    Entry informationi

    Entry nameiPP12_SCHPO
    AccessioniPrimary (citable) accession number: P23880
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: November 1, 1991
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Schizosaccharomyces pombe
      Schizosaccharomyces pombe: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3