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Protein

Serine/threonine-protein phosphatase PP1-2

Gene

sds21

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential role in cell cycle control. PP1 is perhaps required for exit from mitosis.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Manganese 1By similarity1
Metal bindingi62Manganese 1By similarity1
Metal bindingi88Manganese 1By similarity1
Metal bindingi88Manganese 2By similarity1
Metal bindingi120Manganese 2By similarity1
Active sitei121Proton donorBy similarity1
Metal bindingi169Manganese 2By similarity1
Metal bindingi244Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
Biological processCell cycle, Cell division, Mitosis
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1-2 (EC:3.1.3.16)
Alternative name(s):
Suppressor protein SDS21
Gene namesi
Name:sds21
ORF Names:SPCC31H12.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:SPCC31H12.05c
PomBaseiSPCC31H12.05c sds21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000588191 – 322Serine/threonine-protein phosphatase PP1-2Add BLAST322

Proteomic databases

MaxQBiP23880
PaxDbiP23880
PRIDEiP23880

PTM databases

iPTMnetiP23880

Interactioni

Protein-protein interaction databases

BioGridi275750, 13 interactors
STRINGi4896.SPCC31H12.05c.1

Structurei

3D structure databases

ProteinModelPortaliP23880
SMRiP23880
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

HOGENOMiHOG000172697
InParanoidiP23880
KOiK06269
OrthoDBiEOG092C37EX
PhylomeDBiP23880

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
IPR031675 STPPase_N
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PF16891 STPPase_N, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

P23880-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYDIDAIIE KLVKARNGKP SKQVQLSDAE IRYLCTTSRS IFLSQPMLLE
60 70 80 90 100
LEAPLKICGD IHGQYSDLLR LFEYGGYPPD ANYLFLGDYV DRGKQSLEVI
110 120 130 140 150
CLLFAYKIKY PENFFLLRGN HEFASINRIY GFYDECKRRY SIKLWKTFTD
160 170 180 190 200
CFNCMPVAAV IDEKIFCMHG GLSPDLNSLD QIQRIIRPTD IPDTGLLCDL
210 220 230 240 250
VWSDPEKDLT GWGENDRGVS YTFGADVVSR FLQKHDLDLI CRAHQVVEDG
260 270 280 290 300
YEFFGKRQLV TIFSAPNYCG EFDNVGAMMS VNEDLLCSFQ ILKPAEKRQR
310 320
VSQSSIKESK SATNSLKKSK NN
Length:322
Mass (Da):36,829
Last modified:November 1, 1991 - v1
Checksum:iA5EB5991720788B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27069 Genomic DNA Translation: AAA35341.1
CU329672 Genomic DNA Translation: CAA21222.1
PIRiB32550
RefSeqiNP_587898.1, NM_001022890.2

Genome annotation databases

EnsemblFungiiSPCC31H12.05c.1; SPCC31H12.05c.1:pep; SPCC31H12.05c
KEGGispo:SPCC31H12.05c

Similar proteinsi

Entry informationi

Entry nameiPP12_SCHPO
AccessioniPrimary (citable) accession number: P23880
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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