P23878 (FEPC_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferric enterobactin transport ATP-binding protein FepC

Gene names

Name:	fepC
Ordered Locus Names:	b0588, JW0580

Organism

Escherichia coli (strain K12)

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for energy coupling to the transport system.
Subcellular location	Cell inner membrane; Peripheral membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. Contains 1 ABC transporter domain.
Sequence caution	The sequence AAB40787.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ion transport Iron transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Iron Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ion transport Inferred from electronic annotation. Source: UniProtKB-KW iron ion homeostasis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Ferric enterobactin transport ATP-binding protein FepC		PRO_0000092325
Regions
	Domain	8 – 244	237	ABC transporter
	Nucleotide binding	40 – 47	8	ATP Potential
Experimental info
	Sequence conflict	227	1	A → R in CAA40709. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P23878 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: B734924A31F06CE1	FASTA	271	29,784
	10 20 30 40 50 60 MTESVARLRG EQLTLGYGKY TVAENLTVEI PDGHFTAIIG PNGCGKSTLL RTLSRLMTPA 70 80 90 100 110 120 HGHVWLDGEH IQHYASKEVA RRIGLLAQNA TTPGDITVQE LVARGRYPHQ PLFTRWRKED 130 140 150 160 170 180 EEAVTKAMQA TGITHLADQS VDTLSGGQRQ RAWIAMVLAQ ETAIMLLDEP TTWLDISHQI 190 200 210 220 230 240 DLLELLSELN REKGYTLAAV LHDLNQACRY ASHLIALREG KIVAQGAPKE IVTAELIERI 250 260 270 YGLRCMIIDD PVAGTPLVVP LGRTAPSTAN S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence and genetic organization of the ferric enterobactin transport system: homology to other periplasmic binding protein-dependent systems in Escherichia coli." Shea C.M., McIntosh M.A. Mol. Microbiol. 5:1415-1428(1991) [PubMed: 1838574] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: K12.
[2]	"Sequence of minutes 4-25 of Escherichia coli." Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[4]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X57471 Genomic DNA. Translation: CAA40709.1. U82598 Genomic DNA. Translation: AAB40787.1. Different initiation. U00096 Genomic DNA. Translation: AAC73689.1. AP009048 Genomic DNA. Translation: BAE76343.1.
PIR	B64792.
RefSeq	NP_415120.1. NC_000913.2.
3D structure databases
ProteinModelPortal	P23878.
SMR	P23878. Positions 5-259.
ModBase	Search...
Protein-protein interaction databases
IntAct	P23878. 13 interactions.
Protein family/group databases
TCDB	3.A.1.14.2. ATP-binding cassette (ABC) superfamily.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000005008; EBESCP00000005008; EBESCG00000004089. EBESCT00000005009; EBESCP00000005009; EBESCG00000004089. EBESCT00000016812; EBESCP00000016103; EBESCG00000015871.
GeneID	945201.
GenomeReviews	Gene locus JW0580 in contig AP009048_GR. Gene locus b0588 in contig U00096_GR.
KEGG	ecj:JW0580. eco:b0588.
PATRIC	32116352. VBIEscCol129921_0616.
Organism-specific databases
EchoBASE	EB0291.
EcoGene	EG10295. fepC.
Phylogenomic databases
eggNOG	COG1120.
GeneTree	EBGT00050000008237.
HOGENOM	HBG758042.
OMA	ATHIRRA.
PhylomeDB	P23878.
ProtClustDB	PRK10253.
Enzyme and pathway databases
BioCyc	EcoCyc:FEPC-MONOMER.
Gene expression databases
Genevestigator	P23878.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR003593. ATPase_AAA+_core. [Graphical view]
KO	K02013.
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FEPC_ECOLI

Accession

Primary (citable) accession number: P23878
Secondary accession number(s): P75724, P77096, Q2MBL3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	November 1, 1997
Last modified:	January 25, 2012
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program