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Protein

Ferric enterobactin transport ATP-binding protein FepC

Gene

fepC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for energy coupling to the transport system.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 47ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: InterPro
  • ATP binding Source: EcoCyc
  • ferric-enterobactin transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • ferric-enterobactin transport Source: EcoCyc
  • iron ion homeostasis Source: UniProtKB-KW

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandATP-binding, Iron, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:FEPC-MONOMER
MetaCyc:FEPC-MONOMER

Protein family/group databases

TCDBi3.A.1.14.2 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Ferric enterobactin transport ATP-binding protein FepC
Gene namesi
Name:fepC
Ordered Locus Names:b0588, JW0580
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10295 fepC

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000923251 – 271Ferric enterobactin transport ATP-binding protein FepCAdd BLAST271

Proteomic databases

PaxDbiP23878
PRIDEiP23878

Expressioni

Inductioni

Induced 1.5-fold by hydroxyurea.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4259899, 380 interactors
IntActiP23878, 14 interactors
STRINGi316385.ECDH10B_0656

Structurei

3D structure databases

ProteinModelPortaliP23878
SMRiP23878
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 244ABC transporterPROSITE-ProRule annotationAdd BLAST237

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated

Phylogenomic databases

eggNOGiENOG4105E0A Bacteria
COG1120 LUCA
InParanoidiP23878
KOiK02013
OMAiFHIDAEI
PhylomeDBiP23878

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

P23878-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTESVARLRG EQLTLGYGKY TVAENLTVEI PDGHFTAIIG PNGCGKSTLL
60 70 80 90 100
RTLSRLMTPA HGHVWLDGEH IQHYASKEVA RRIGLLAQNA TTPGDITVQE
110 120 130 140 150
LVARGRYPHQ PLFTRWRKED EEAVTKAMQA TGITHLADQS VDTLSGGQRQ
160 170 180 190 200
RAWIAMVLAQ ETAIMLLDEP TTWLDISHQI DLLELLSELN REKGYTLAAV
210 220 230 240 250
LHDLNQACRY ASHLIALREG KIVAQGAPKE IVTAELIERI YGLRCMIIDD
260 270
PVAGTPLVVP LGRTAPSTAN S
Length:271
Mass (Da):29,784
Last modified:November 1, 1997 - v2
Checksum:iB734924A31F06CE1
GO

Sequence cautioni

The sequence AAB40787 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti227A → R in CAA40709 (PubMed:1838574).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57471 Genomic DNA Translation: CAA40709.1
U82598 Genomic DNA Translation: AAB40787.1 Different initiation.
U00096 Genomic DNA Translation: AAC73689.1
AP009048 Genomic DNA Translation: BAE76343.1
PIRiB64792
RefSeqiNP_415120.1, NC_000913.3
WP_000140647.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73689; AAC73689; b0588
BAE76343; BAE76343; BAE76343
GeneIDi945201
KEGGiecj:JW0580
eco:b0588
PATRICifig|1411691.4.peg.1681

Similar proteinsi

Entry informationi

Entry nameiFEPC_ECOLI
AccessioniPrimary (citable) accession number: P23878
Secondary accession number(s): P75724, P77096, Q2MBL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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