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Protein

Ferric enterobactin transport ATP-binding protein FepC

Gene

fepC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for energy coupling to the transport system.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 47ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

ATP-binding, Iron, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:FEPC-MONOMER.
ECOL316407:JW0580-MONOMER.
MetaCyc:FEPC-MONOMER.

Protein family/group databases

TCDBi3.A.1.14.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferric enterobactin transport ATP-binding protein FepC
Gene namesi
Name:fepC
Ordered Locus Names:b0588, JW0580
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10295. fepC.

Subcellular locationi

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000923251 – 271Ferric enterobactin transport ATP-binding protein FepCAdd BLAST271

Proteomic databases

PaxDbiP23878.
PRIDEiP23878.

Expressioni

Inductioni

Induced 1.5-fold by hydroxyurea.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4259899. 380 interactors.
IntActiP23878. 14 interactors.
STRINGi511145.b0588.

Structurei

3D structure databases

ProteinModelPortaliP23878.
SMRiP23878.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 244ABC transporterPROSITE-ProRule annotationAdd BLAST237

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105E0A. Bacteria.
COG1120. LUCA.
InParanoidiP23878.
KOiK02013.
OMAiPCRVIDD.
PhylomeDBiP23878.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23878-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTESVARLRG EQLTLGYGKY TVAENLTVEI PDGHFTAIIG PNGCGKSTLL
60 70 80 90 100
RTLSRLMTPA HGHVWLDGEH IQHYASKEVA RRIGLLAQNA TTPGDITVQE
110 120 130 140 150
LVARGRYPHQ PLFTRWRKED EEAVTKAMQA TGITHLADQS VDTLSGGQRQ
160 170 180 190 200
RAWIAMVLAQ ETAIMLLDEP TTWLDISHQI DLLELLSELN REKGYTLAAV
210 220 230 240 250
LHDLNQACRY ASHLIALREG KIVAQGAPKE IVTAELIERI YGLRCMIIDD
260 270
PVAGTPLVVP LGRTAPSTAN S
Length:271
Mass (Da):29,784
Last modified:November 1, 1997 - v2
Checksum:iB734924A31F06CE1
GO

Sequence cautioni

The sequence AAB40787 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti227A → R in CAA40709 (PubMed:1838574).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57471 Genomic DNA. Translation: CAA40709.1.
U82598 Genomic DNA. Translation: AAB40787.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73689.1.
AP009048 Genomic DNA. Translation: BAE76343.1.
PIRiB64792.
RefSeqiNP_415120.1. NC_000913.3.
WP_000140647.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73689; AAC73689; b0588.
BAE76343; BAE76343; BAE76343.
GeneIDi945201.
KEGGiecj:JW0580.
eco:b0588.
PATRICi32116352. VBIEscCol129921_0616.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57471 Genomic DNA. Translation: CAA40709.1.
U82598 Genomic DNA. Translation: AAB40787.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73689.1.
AP009048 Genomic DNA. Translation: BAE76343.1.
PIRiB64792.
RefSeqiNP_415120.1. NC_000913.3.
WP_000140647.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP23878.
SMRiP23878.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259899. 380 interactors.
IntActiP23878. 14 interactors.
STRINGi511145.b0588.

Protein family/group databases

TCDBi3.A.1.14.2. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP23878.
PRIDEiP23878.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73689; AAC73689; b0588.
BAE76343; BAE76343; BAE76343.
GeneIDi945201.
KEGGiecj:JW0580.
eco:b0588.
PATRICi32116352. VBIEscCol129921_0616.

Organism-specific databases

EchoBASEiEB0291.
EcoGeneiEG10295. fepC.

Phylogenomic databases

eggNOGiENOG4105E0A. Bacteria.
COG1120. LUCA.
InParanoidiP23878.
KOiK02013.
OMAiPCRVIDD.
PhylomeDBiP23878.

Enzyme and pathway databases

BioCyciEcoCyc:FEPC-MONOMER.
ECOL316407:JW0580-MONOMER.
MetaCyc:FEPC-MONOMER.

Miscellaneous databases

PROiP23878.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFEPC_ECOLI
AccessioniPrimary (citable) accession number: P23878
Secondary accession number(s): P75724, P77096, Q2MBL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.