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Protein

Ferric enterobactin transport system permease protein FepG

Gene

fepG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for the translocation of the substrate across the membrane.

GO - Molecular functioni

  • ferric-enterobactin transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • ferric-enterobactin transport Source: EcoCyc
  • iron ion homeostasis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciEcoCyc:FEPG-MONOMER.
ECOL316407:JW0581-MONOMER.
MetaCyc:FEPG-MONOMER.

Protein family/group databases

TCDBi3.A.1.14.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferric enterobactin transport system permease protein FepG
Gene namesi
Name:fepG
Ordered Locus Names:b0589, JW0581
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10298. fepG.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77PeriplasmicSequence analysis
Transmembranei8 – 2821HelicalSequence analysisAdd
BLAST
Topological domaini29 – 6234CytoplasmicSequence analysisAdd
BLAST
Transmembranei63 – 8321HelicalSequence analysisAdd
BLAST
Topological domaini84 – 929PeriplasmicSequence analysis
Transmembranei93 – 11321HelicalSequence analysisAdd
BLAST
Topological domaini114 – 1174CytoplasmicSequence analysis
Transmembranei118 – 13821HelicalSequence analysisAdd
BLAST
Topological domaini139 – 1468PeriplasmicSequence analysis
Transmembranei147 – 16721HelicalSequence analysisAdd
BLAST
Topological domaini168 – 19023CytoplasmicSequence analysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence analysisAdd
BLAST
Topological domaini212 – 23524PeriplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence analysisAdd
BLAST
Topological domaini257 – 27519CytoplasmicSequence analysisAdd
BLAST
Transmembranei276 – 29621HelicalSequence analysisAdd
BLAST
Topological domaini297 – 3037PeriplasmicSequence analysis
Transmembranei304 – 32421HelicalSequence analysisAdd
BLAST
Topological domaini325 – 3306CytoplasmicSequence analysis

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Ferric enterobactin transport system permease protein FepGPRO_0000060023Add
BLAST

Proteomic databases

PaxDbiP23877.
PRIDEiP23877.

Expressioni

Inductioni

Controlled in part by the amount of available iron. Induced 1.4-fold by hydroxyurea (PubMed:20005847).1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261377. 419 interactions.
DIPiDIP-9597N.
STRINGi511145.b0589.

Structurei

3D structure databases

ProteinModelPortaliP23877.
SMRiP23877. Positions 53-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105TVJ. Bacteria.
COG4779. LUCA.
HOGENOMiHOG000045409.
InParanoidiP23877.
KOiK02015.
OMAiTQWRAPR.
OrthoDBiEOG61ZTDC.
PhylomeDBiP23877.

Family and domain databases

Gene3Di1.10.3470.10. 1 hit.
InterProiIPR029022. ABC_BtuC-like.
IPR000522. ABC_transptr_permAse.
[Graphical view]
PANTHERiPTHR30472. PTHR30472. 1 hit.
PfamiPF01032. FecCD. 1 hit.
[Graphical view]
SUPFAMiSSF81345. SSF81345. 1 hit.

Sequencei

Sequence statusi: Complete.

P23877-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYVSRRLLI TCLLLVSACV VAGIWGLRSG AVTLETSQVF AALMGDAPRS
60 70 80 90 100
MTMVVTEWRL PRVLMALLIG AALGVSGAIF QSLMRNPLGS PDVMGFNTGA
110 120 130 140 150
WSGVLVAMVL FGQDLTAIAL SAMVGGIVTS LLVWLLAWRN GIDTFRLIII
160 170 180 190 200
GIGVRAMLVA FNTWLLLKAS LETALTAGLW NAGSLNGLTW AKTSPSAPII
210 220 230 240 250
ILMLIAAALL VRRMRLLEMG DDTACALGVS VERSRLLMML VAVVLTAAAT
260 270 280 290 300
ALAGPISFIA LVAPHIARRI SGTARWGLTQ AALCGALLLL AADLCAQQLF
310 320 330
MPYQLPVGVV TVSLGGIYLI VLLIQESRKK
Length:330
Mass (Da):34,910
Last modified:November 1, 1997 - v2
Checksum:iA67FA9513733D3CB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti230 – 2312SV → RL in CAA40708 (PubMed:1838574).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57471 Genomic DNA. Translation: CAA40708.1.
U82598 Genomic DNA. Translation: AAB40788.1.
U00096 Genomic DNA. Translation: AAC73690.1.
AP009048 Genomic DNA. Translation: BAE76344.1.
PIRiC64792.
RefSeqiNP_415121.1. NC_000913.3.
WP_000640988.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73690; AAC73690; b0589.
BAE76344; BAE76344; BAE76344.
GeneIDi945209.
KEGGiecj:JW0581.
eco:b0589.
PATRICi32116354. VBIEscCol129921_0617.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57471 Genomic DNA. Translation: CAA40708.1.
U82598 Genomic DNA. Translation: AAB40788.1.
U00096 Genomic DNA. Translation: AAC73690.1.
AP009048 Genomic DNA. Translation: BAE76344.1.
PIRiC64792.
RefSeqiNP_415121.1. NC_000913.3.
WP_000640988.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP23877.
SMRiP23877. Positions 53-325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261377. 419 interactions.
DIPiDIP-9597N.
STRINGi511145.b0589.

Protein family/group databases

TCDBi3.A.1.14.2. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP23877.
PRIDEiP23877.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73690; AAC73690; b0589.
BAE76344; BAE76344; BAE76344.
GeneIDi945209.
KEGGiecj:JW0581.
eco:b0589.
PATRICi32116354. VBIEscCol129921_0617.

Organism-specific databases

EchoBASEiEB0294.
EcoGeneiEG10298. fepG.

Phylogenomic databases

eggNOGiENOG4105TVJ. Bacteria.
COG4779. LUCA.
HOGENOMiHOG000045409.
InParanoidiP23877.
KOiK02015.
OMAiTQWRAPR.
OrthoDBiEOG61ZTDC.
PhylomeDBiP23877.

Enzyme and pathway databases

BioCyciEcoCyc:FEPG-MONOMER.
ECOL316407:JW0581-MONOMER.
MetaCyc:FEPG-MONOMER.

Miscellaneous databases

PROiP23877.

Family and domain databases

Gene3Di1.10.3470.10. 1 hit.
InterProiIPR029022. ABC_BtuC-like.
IPR000522. ABC_transptr_permAse.
[Graphical view]
PANTHERiPTHR30472. PTHR30472. 1 hit.
PfamiPF01032. FecCD. 1 hit.
[Graphical view]
SUPFAMiSSF81345. SSF81345. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence and genetic organization of the ferric enterobactin transport system: homology to other periplasmic binding protein-dependent systems in Escherichia coli."
    Shea C.M., McIntosh M.A.
    Mol. Microbiol. 5:1415-1428(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: K12.
  2. "Sequence of minutes 4-25 of Escherichia coli."
    Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M., Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D., Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  4. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  5. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.
  6. "Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia coli."
    Davies B.W., Kohanski M.A., Simmons L.A., Winkler J.A., Collins J.J., Walker G.C.
    Mol. Cell 36:845-860(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY HYDROXYUREA.
    Strain: K12 / MC4100 / ATCC 35695 / DSM 6574.

Entry informationi

Entry nameiFEPG_ECOLI
AccessioniPrimary (citable) accession number: P23877
Secondary accession number(s): P77587, Q2MBL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1997
Last modified: January 20, 2016
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.