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Protein

Ferric enterobactin transport system permease protein FepG

Gene

fepG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for the translocation of the substrate across the membrane.

GO - Molecular functioni

  • ferric-enterobactin transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • ferric-enterobactin transport Source: EcoCyc
  • iron ion homeostasis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciEcoCyc:FEPG-MONOMER.
ECOL316407:JW0581-MONOMER.
MetaCyc:FEPG-MONOMER.

Protein family/group databases

TCDBi3.A.1.14.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferric enterobactin transport system permease protein FepG
Gene namesi
Name:fepG
Ordered Locus Names:b0589, JW0581
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10298. fepG.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7PeriplasmicSequence analysis7
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Topological domaini29 – 62CytoplasmicSequence analysisAdd BLAST34
Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Topological domaini84 – 92PeriplasmicSequence analysis9
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Topological domaini114 – 117CytoplasmicSequence analysis4
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 146PeriplasmicSequence analysis8
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 190CytoplasmicSequence analysisAdd BLAST23
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 235PeriplasmicSequence analysisAdd BLAST24
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 275CytoplasmicSequence analysisAdd BLAST19
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Topological domaini297 – 303PeriplasmicSequence analysis7
Transmembranei304 – 324HelicalSequence analysisAdd BLAST21
Topological domaini325 – 330CytoplasmicSequence analysis6

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000600231 – 330Ferric enterobactin transport system permease protein FepGAdd BLAST330

Proteomic databases

PaxDbiP23877.
PRIDEiP23877.

Expressioni

Inductioni

Controlled in part by the amount of available iron. Induced 1.4-fold by hydroxyurea (PubMed:20005847).1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261377. 419 interactors.
DIPiDIP-9597N.
STRINGi511145.b0589.

Structurei

3D structure databases

ProteinModelPortaliP23877.
SMRiP23877.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105TVJ. Bacteria.
COG4779. LUCA.
HOGENOMiHOG000045409.
InParanoidiP23877.
KOiK02015.
OMAiMVISSIC.
PhylomeDBiP23877.

Family and domain databases

Gene3Di1.10.3470.10. 1 hit.
InterProiIPR029022. ABC_BtuC-like.
IPR000522. ABC_transptr_FecCD.
[Graphical view]
PANTHERiPTHR30472. PTHR30472. 1 hit.
PfamiPF01032. FecCD. 1 hit.
[Graphical view]
SUPFAMiSSF81345. SSF81345. 1 hit.

Sequencei

Sequence statusi: Complete.

P23877-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYVSRRLLI TCLLLVSACV VAGIWGLRSG AVTLETSQVF AALMGDAPRS
60 70 80 90 100
MTMVVTEWRL PRVLMALLIG AALGVSGAIF QSLMRNPLGS PDVMGFNTGA
110 120 130 140 150
WSGVLVAMVL FGQDLTAIAL SAMVGGIVTS LLVWLLAWRN GIDTFRLIII
160 170 180 190 200
GIGVRAMLVA FNTWLLLKAS LETALTAGLW NAGSLNGLTW AKTSPSAPII
210 220 230 240 250
ILMLIAAALL VRRMRLLEMG DDTACALGVS VERSRLLMML VAVVLTAAAT
260 270 280 290 300
ALAGPISFIA LVAPHIARRI SGTARWGLTQ AALCGALLLL AADLCAQQLF
310 320 330
MPYQLPVGVV TVSLGGIYLI VLLIQESRKK
Length:330
Mass (Da):34,910
Last modified:November 1, 1997 - v2
Checksum:iA67FA9513733D3CB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti230 – 231SV → RL in CAA40708 (PubMed:1838574).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57471 Genomic DNA. Translation: CAA40708.1.
U82598 Genomic DNA. Translation: AAB40788.1.
U00096 Genomic DNA. Translation: AAC73690.1.
AP009048 Genomic DNA. Translation: BAE76344.1.
PIRiC64792.
RefSeqiNP_415121.1. NC_000913.3.
WP_000640988.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73690; AAC73690; b0589.
BAE76344; BAE76344; BAE76344.
GeneIDi945209.
KEGGiecj:JW0581.
eco:b0589.
PATRICi32116354. VBIEscCol129921_0617.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57471 Genomic DNA. Translation: CAA40708.1.
U82598 Genomic DNA. Translation: AAB40788.1.
U00096 Genomic DNA. Translation: AAC73690.1.
AP009048 Genomic DNA. Translation: BAE76344.1.
PIRiC64792.
RefSeqiNP_415121.1. NC_000913.3.
WP_000640988.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP23877.
SMRiP23877.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261377. 419 interactors.
DIPiDIP-9597N.
STRINGi511145.b0589.

Protein family/group databases

TCDBi3.A.1.14.2. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP23877.
PRIDEiP23877.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73690; AAC73690; b0589.
BAE76344; BAE76344; BAE76344.
GeneIDi945209.
KEGGiecj:JW0581.
eco:b0589.
PATRICi32116354. VBIEscCol129921_0617.

Organism-specific databases

EchoBASEiEB0294.
EcoGeneiEG10298. fepG.

Phylogenomic databases

eggNOGiENOG4105TVJ. Bacteria.
COG4779. LUCA.
HOGENOMiHOG000045409.
InParanoidiP23877.
KOiK02015.
OMAiMVISSIC.
PhylomeDBiP23877.

Enzyme and pathway databases

BioCyciEcoCyc:FEPG-MONOMER.
ECOL316407:JW0581-MONOMER.
MetaCyc:FEPG-MONOMER.

Miscellaneous databases

PROiP23877.

Family and domain databases

Gene3Di1.10.3470.10. 1 hit.
InterProiIPR029022. ABC_BtuC-like.
IPR000522. ABC_transptr_FecCD.
[Graphical view]
PANTHERiPTHR30472. PTHR30472. 1 hit.
PfamiPF01032. FecCD. 1 hit.
[Graphical view]
SUPFAMiSSF81345. SSF81345. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFEPG_ECOLI
AccessioniPrimary (citable) accession number: P23877
Secondary accession number(s): P77587, Q2MBL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.