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Protein

Ferric enterobactin transport system permease protein FepD

Gene

fepD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for the translocation of the substrate across the membrane.

GO - Molecular functioni

  • ferric-enterobactin transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • ferric-enterobactin transport Source: EcoCyc
  • iron ion homeostasis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

BioCyciEcoCyc:FEPD-MONOMER.
ECOL316407:JW0582-MONOMER.
MetaCyc:FEPD-MONOMER.

Protein family/group databases

TCDBi3.A.1.14.2. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferric enterobactin transport system permease protein FepD
Gene namesi
Name:fepD
Ordered Locus Names:b0590, JW0582
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10296. fepD.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9PeriplasmicSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 63CytoplasmicSequence analysisAdd BLAST33
Transmembranei64 – 84HelicalSequence analysisAdd BLAST21
Topological domaini85 – 92PeriplasmicSequence analysis8
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Topological domaini114 – 120CytoplasmicSequence analysis7
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 151PeriplasmicSequence analysis10
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Topological domaini173 – 192CytoplasmicSequence analysisAdd BLAST20
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 241PeriplasmicSequence analysisAdd BLAST28
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 279CytoplasmicSequence analysisAdd BLAST17
Transmembranei280 – 300HelicalSequence analysisAdd BLAST21
Topological domaini301 – 305PeriplasmicSequence analysis5
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 334CytoplasmicSequence analysis8

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000600221 – 334Ferric enterobactin transport system permease protein FepDAdd BLAST334

Proteomic databases

PaxDbiP23876.
PRIDEiP23876.

Expressioni

Inductioni

Controlled in part by the amount of available iron. Induced by hydroxyurea (PubMed:20005847).1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4261558. 234 interactors.
STRINGi511145.b0590.

Structurei

3D structure databases

ProteinModelPortaliP23876.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DQ5. Bacteria.
COG0609. LUCA.
HOGENOMiHOG000045410.
InParanoidiP23876.
KOiK02015.
OMAiHIIRILI.
PhylomeDBiP23876.

Family and domain databases

Gene3Di1.10.3470.10. 1 hit.
InterProiIPR029022. ABC_BtuC-like.
IPR000522. ABC_transptr_FecCD.
[Graphical view]
PANTHERiPTHR30472. PTHR30472. 1 hit.
PfamiPF01032. FecCD. 1 hit.
[Graphical view]
SUPFAMiSSF81345. SSF81345. 1 hit.

Sequencei

Sequence statusi: Complete.

P23876-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSVAVTRA IAVPGLLLLL IIATALSLLI GAKSLPASVV LEAFSGTCQS
60 70 80 90 100
ADCTIVLDAR LPRTLAGLLA GGALGLAGAL MQTLTRNPLA DPGLLGVNAG
110 120 130 140 150
ASFAIVLGAA LFGYSSAQEQ LAMAFAGALV ASLIVAFTGS QGGGQLSPVR
160 170 180 190 200
LTLAGVALAA VLEGLTSGIA LLNPDVYDQL RFWQAGSLDI RNLHTLKVVL
210 220 230 240 250
IPVLIAGATA LLLSRALNSL SLGSDTATAL GSRVARTQLI GLLAITVLCG
260 270 280 290 300
SATAIVGPIA FIGLMMPHMA RWLVGADHRW SLPVTLLATP ALLLFADIIG
310 320 330
RVIVPGELRV SVVSAFIGAP VLIFLVRRKT RGGA
Length:334
Mass (Da):33,871
Last modified:November 1, 1991 - v1
Checksum:iBB5C5E939A96951B
GO

Sequence cautioni

The sequence AAB40789 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti233 – 234RV → AL in CAA42043 (PubMed:1787794).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57471 Genomic DNA. Translation: CAA40707.1.
X59402 Genomic DNA. Translation: CAA42043.1.
U82598 Genomic DNA. Translation: AAB40789.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73691.1.
AP009048 Genomic DNA. Translation: BAE76345.1.
PIRiS16296.
RefSeqiNP_415122.1. NC_000913.3.
WP_000016947.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73691; AAC73691; b0590.
BAE76345; BAE76345; BAE76345.
GeneIDi945214.
KEGGiecj:JW0582.
eco:b0590.
PATRICi32116356. VBIEscCol129921_0618.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57471 Genomic DNA. Translation: CAA40707.1.
X59402 Genomic DNA. Translation: CAA42043.1.
U82598 Genomic DNA. Translation: AAB40789.1. Different initiation.
U00096 Genomic DNA. Translation: AAC73691.1.
AP009048 Genomic DNA. Translation: BAE76345.1.
PIRiS16296.
RefSeqiNP_415122.1. NC_000913.3.
WP_000016947.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP23876.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261558. 234 interactors.
STRINGi511145.b0590.

Protein family/group databases

TCDBi3.A.1.14.2. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP23876.
PRIDEiP23876.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73691; AAC73691; b0590.
BAE76345; BAE76345; BAE76345.
GeneIDi945214.
KEGGiecj:JW0582.
eco:b0590.
PATRICi32116356. VBIEscCol129921_0618.

Organism-specific databases

EchoBASEiEB0292.
EcoGeneiEG10296. fepD.

Phylogenomic databases

eggNOGiENOG4105DQ5. Bacteria.
COG0609. LUCA.
HOGENOMiHOG000045410.
InParanoidiP23876.
KOiK02015.
OMAiHIIRILI.
PhylomeDBiP23876.

Enzyme and pathway databases

BioCyciEcoCyc:FEPD-MONOMER.
ECOL316407:JW0582-MONOMER.
MetaCyc:FEPD-MONOMER.

Miscellaneous databases

PROiP23876.

Family and domain databases

Gene3Di1.10.3470.10. 1 hit.
InterProiIPR029022. ABC_BtuC-like.
IPR000522. ABC_transptr_FecCD.
[Graphical view]
PANTHERiPTHR30472. PTHR30472. 1 hit.
PfamiPF01032. FecCD. 1 hit.
[Graphical view]
SUPFAMiSSF81345. SSF81345. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFEPD_ECOLI
AccessioniPrimary (citable) accession number: P23876
Secondary accession number(s): P77097, Q2MBL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.