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Protein

Middle operon regulator

Gene

mor

Organism
Enterobacteria phage Mu (Bacteriophage Mu)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Activator of the Pm promoter, which controls middle genes expression. Activation of Pm allows expression of protein C necessary for late gene expression. In addition to Mor binding, activation of Pm might require the interaction of Mor with the C-terminus of host RNAP subunits RpoA and RpoH.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi94 – 114H-T-H motifSequence analysisAdd BLAST21

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Middle operon regulator
Short name:
Mor
Alternative name(s):
GemB
Gene product 17
Short name:
gp17
Gene namesi
Name:mor
Ordered Locus Names:Mup17
OrganismiEnterobacteria phage Mu (Bacteriophage Mu)
Taxonomic identifieri10677 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeMulikevirus
Virus hostiEnterobacteriaceae [TaxID: 543]
Proteomesi
  • UP000002611 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi65G → M, N, R, T or V: Complete loss of DNA-binding and transcription activation ability. 1 Publication1
Mutagenesisi66G → A, H, L, P or R: Complete loss of DNA-binding and transcription activation ability. 1 Publication1
Mutagenesisi68Q → G, F, I, L, K, P or R: Complete loss of DNA-binding and transcription activation ability. 1 Publication1
Mutagenesisi70Y → G, I, R, S or V: Complete loss of DNA-binding and transcription activation ability. 1 Publication1
Mutagenesisi74G → F or W: Partial loss of DNA-binding and transcription activation ability. 1 Publication1
Mutagenesisi74G → I, S, T or Y: Partial loss of DNA-binding and transcription activation ability. 1 Publication1
Mutagenesisi74G → R: Complete loss of DNA-binding and transcription activation ability. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000628031 – 129Middle operon regulatorAdd BLAST129

Expressioni

Inductioni

This protein is constitively expressed from the Pgem promoter unlike most other early proteins which are expressed under the control of the Pe promoter. Its expression seems to escape repression by repressor protein c and thus could occur throughout latency (Probable).1 Publication

Keywords - Developmental stagei

Early protein

Interactioni

Subunit structurei

Homodimer.2 Publications

Structurei

Secondary structure

1129
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi28 – 45Combined sources18
Helixi53 – 64Combined sources12
Helixi75 – 89Combined sources15
Helixi95 – 102Combined sources8
Helixi106 – 118Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RR7X-ray2.20A1-129[»]
ProteinModelPortaliP23848.
SMRiP23848.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23848.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni28 – 64DimerizationAdd BLAST37
Regioni77 – 129DNA-bindingAdd BLAST53

Domaini

The dimerization domain in the N-terminus and the DNA-binding domain in the C-terminus are connected by a linker containing a beta-strand.

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR014875. Mor_transcription_activator.
[Graphical view]
PfamiPF08765. Mor. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.

Sequencei

Sequence statusi: Complete.

P23848-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEDLFGDLQ DDTILAHLDN PAEDTSRFPA LLAELNDLLR GELSRLGVDP
60 70 80 90 100
AHSLEIVVAI CKHLGGGQVY IPRGQALDSL IRDLRIWNDF NGRNVSELTT
110 120
RYGVTFNTVY KAIRRMRRLK YRQYQPSLL
Length:129
Mass (Da):14,714
Last modified:November 1, 1991 - v1
Checksum:iC796C950F1686FBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64097 Genomic DNA. Translation: AAA32408.1.
AF083977 Genomic DNA. Translation: AAF01094.1.
RefSeqiNP_050621.1. NC_000929.1.

Genome annotation databases

GeneIDi2636272.
KEGGivg:2636272.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64097 Genomic DNA. Translation: AAA32408.1.
AF083977 Genomic DNA. Translation: AAF01094.1.
RefSeqiNP_050621.1. NC_000929.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RR7X-ray2.20A1-129[»]
ProteinModelPortaliP23848.
SMRiP23848.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2636272.
KEGGivg:2636272.

Miscellaneous databases

EvolutionaryTraceiP23848.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR009057. Homeodomain-like.
IPR014875. Mor_transcription_activator.
[Graphical view]
PfamiPF08765. Mor. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMOR_BPMU
AccessioniPrimary (citable) accession number: P23848
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.