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Protein

Periplasmic dipeptide transport protein

Gene

dppA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis.

GO - Molecular functioni

  • peptide binding Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Chemotaxis, Peptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:DPPA-MONOMER.
ECOL316407:JW3513-MONOMER.
MetaCyc:DPPA-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Periplasmic dipeptide transport protein
Alternative name(s):
Dipeptide-binding protein
Short name:
DBP
Gene namesi
Name:dppA
Ordered Locus Names:b3544, JW3513
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10248. dppA.

Subcellular locationi

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: EcoCyc
  • outer membrane-bounded periplasmic space Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 283 PublicationsAdd BLAST28
ChainiPRO_000003178929 – 535Periplasmic dipeptide transport proteinAdd BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 2621 Publication
Disulfide bondi450 ↔ 4631 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP23847.
PaxDbiP23847.
PRIDEiP23847.

2D gel databases

SWISS-2DPAGEP23847.

Interactioni

Protein-protein interaction databases

BioGridi4259528. 143 interactors.
DIPiDIP-9467N.
IntActiP23847. 5 interactors.
MINTiMINT-1240350.
STRINGi511145.b3544.

Structurei

Secondary structure

1535
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 37Combined sources8
Helixi44 – 46Combined sources3
Helixi50 – 55Combined sources6
Helixi57 – 60Combined sources4
Beta strandi64 – 67Combined sources4
Beta strandi74 – 84Combined sources11
Beta strandi90 – 95Combined sources6
Helixi115 – 126Combined sources12
Turni131 – 134Combined sources4
Helixi135 – 137Combined sources3
Helixi141 – 145Combined sources5
Helixi148 – 151Combined sources4
Beta strandi152 – 159Combined sources8
Beta strandi162 – 169Combined sources8
Helixi174 – 177Combined sources4
Helixi181 – 183Combined sources3
Helixi188 – 196Combined sources9
Helixi202 – 205Combined sources4
Beta strandi210 – 219Combined sources10
Turni220 – 222Combined sources3
Beta strandi223 – 228Combined sources6
Beta strandi240 – 246Combined sources7
Helixi250 – 258Combined sources9
Helixi270 – 272Combined sources3
Helixi273 – 278Combined sources6
Beta strandi282 – 288Combined sources7
Beta strandi290 – 297Combined sources8
Turni302 – 305Combined sources4
Helixi307 – 315Combined sources9
Helixi319 – 327Combined sources9
Beta strandi330 – 333Combined sources4
Beta strandi335 – 338Combined sources4
Helixi356 – 365Combined sources10
Beta strandi372 – 377Combined sources6
Helixi389 – 401Combined sources13
Turni402 – 404Combined sources3
Beta strandi405 – 410Combined sources6
Helixi414 – 422Combined sources9
Beta strandi427 – 434Combined sources8
Beta strandi436 – 438Combined sources3
Helixi441 – 448Combined sources8
Helixi450 – 455Combined sources6
Helixi465 – 476Combined sources12
Helixi480 – 497Combined sources18
Beta strandi499 – 513Combined sources15
Beta strandi516 – 518Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DPEX-ray2.00A29-535[»]
1DPPX-ray3.20A/C/E/G29-535[»]
ProteinModelPortaliP23847.
SMRiP23847.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23847.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105DEF. Bacteria.
COG0747. LUCA.
HOGENOMiHOG000164955.
InParanoidiP23847.
KOiK12368.
OMAiHADGFTI.
PhylomeDBiP23847.

Family and domain databases

InterProiIPR030678. Peptide/Ni-bd.
IPR023765. SBP_5_CS.
IPR000914. SBP_5_dom.
[Graphical view]
PfamiPF00496. SBP_bac_5. 1 hit.
[Graphical view]
PIRSFiPIRSF002741. MppA. 1 hit.
PROSITEiPS01040. SBP_BACTERIAL_5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23847-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRISLKKSGM LKLGLSLVAM TVAASVQAKT LVYCSEGSPE GFNPQLFTSG
60 70 80 90 100
TTYDASSVPL YNRLVEFKIG TTEVIPGLAE KWEVSEDGKT YTFHLRKGVK
110 120 130 140 150
WHDNKEFKPT RELNADDVVF SFDRQKNAQN PYHKVSGGSY EYFEGMGLPE
160 170 180 190 200
LISEVKKVDD NTVQFVLTRP EAPFLADLAM DFASILSKEY ADAMMKAGTP
210 220 230 240 250
EKLDLNPIGT GPFQLQQYQK DSRIRYKAFD GYWGTKPQID TLVFSITPDA
260 270 280 290 300
SVRYAKLQKN ECQVMPYPNP ADIARMKQDK SINLMEMPGL NVGYLSYNVQ
310 320 330 340 350
KKPLDDVKVR QALTYAVNKD AIIKAVYQGA GVSAKNLIPP TMWGYNDDVQ
360 370 380 390 400
DYTYDPEKAK ALLKEAGLEK GFSIDLWAMP VQRPYNPNAR RMAEMIQADW
410 420 430 440 450
AKVGVQAKIV TYEWGEYLKR AKDGEHQTVM MGWTGDNGDP DNFFATLFSC
460 470 480 490 500
AASEQGSNYS KWCYKPFEDL IQPARATDDH NKRVELYKQA QVVMHDQAPA
510 520 530
LIIAHSTVFE PVRKEVKGYV VDPLGKHHFE NVSIE
Length:535
Mass (Da):60,294
Last modified:November 1, 1991 - v1
Checksum:i3F7C4756EEA8C2F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35045 Genomic DNA. Translation: AAA23707.1.
X58051 Genomic DNA. Translation: CAA41090.1.
L08399 Genomic DNA. Translation: AAA23702.1.
U00039 Genomic DNA. Translation: AAB18522.1.
U00096 Genomic DNA. Translation: AAC76569.1.
AP009048 Genomic DNA. Translation: BAE77750.1.
PIRiA39194.
RefSeqiNP_418001.1. NC_000913.3.
WP_001222883.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76569; AAC76569; b3544.
BAE77750; BAE77750; BAE77750.
GeneIDi948062.
KEGGiecj:JW3513.
eco:b3544.
PATRICi32122558. VBIEscCol129921_3657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35045 Genomic DNA. Translation: AAA23707.1.
X58051 Genomic DNA. Translation: CAA41090.1.
L08399 Genomic DNA. Translation: AAA23702.1.
U00039 Genomic DNA. Translation: AAB18522.1.
U00096 Genomic DNA. Translation: AAC76569.1.
AP009048 Genomic DNA. Translation: BAE77750.1.
PIRiA39194.
RefSeqiNP_418001.1. NC_000913.3.
WP_001222883.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DPEX-ray2.00A29-535[»]
1DPPX-ray3.20A/C/E/G29-535[»]
ProteinModelPortaliP23847.
SMRiP23847.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259528. 143 interactors.
DIPiDIP-9467N.
IntActiP23847. 5 interactors.
MINTiMINT-1240350.
STRINGi511145.b3544.

2D gel databases

SWISS-2DPAGEP23847.

Proteomic databases

EPDiP23847.
PaxDbiP23847.
PRIDEiP23847.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76569; AAC76569; b3544.
BAE77750; BAE77750; BAE77750.
GeneIDi948062.
KEGGiecj:JW3513.
eco:b3544.
PATRICi32122558. VBIEscCol129921_3657.

Organism-specific databases

EchoBASEiEB0244.
EcoGeneiEG10248. dppA.

Phylogenomic databases

eggNOGiENOG4105DEF. Bacteria.
COG0747. LUCA.
HOGENOMiHOG000164955.
InParanoidiP23847.
KOiK12368.
OMAiHADGFTI.
PhylomeDBiP23847.

Enzyme and pathway databases

BioCyciEcoCyc:DPPA-MONOMER.
ECOL316407:JW3513-MONOMER.
MetaCyc:DPPA-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP23847.
PROiP23847.

Family and domain databases

InterProiIPR030678. Peptide/Ni-bd.
IPR023765. SBP_5_CS.
IPR000914. SBP_5_dom.
[Graphical view]
PfamiPF00496. SBP_bac_5. 1 hit.
[Graphical view]
PIRSFiPIRSF002741. MppA. 1 hit.
PROSITEiPS01040. SBP_BACTERIAL_5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPPA_ECOLI
AccessioniPrimary (citable) accession number: P23847
Secondary accession number(s): Q2M7K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: November 2, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.