Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Periplasmic dipeptide transport protein

Gene

dppA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis.

GO - Molecular functioni

  • peptide binding Source: EcoCyc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Chemotaxis, Peptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:DPPA-MONOMER.
ECOL316407:JW3513-MONOMER.
MetaCyc:DPPA-MONOMER.
RETL1328306-WGS:GSTH-748-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Periplasmic dipeptide transport protein
Alternative name(s):
Dipeptide-binding protein
Short name:
DBP
Gene namesi
Name:dppA
Ordered Locus Names:b3544, JW3513
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10248. dppA.

Subcellular locationi

GO - Cellular componenti

  • ATP-binding cassette (ABC) transporter complex Source: EcoCyc
  • outer membrane-bounded periplasmic space Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28283 PublicationsAdd
BLAST
Chaini29 – 535507Periplasmic dipeptide transport proteinPRO_0000031789Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 2621 Publication
Disulfide bondi450 ↔ 4631 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP23847.
PaxDbiP23847.
PRIDEiP23847.

2D gel databases

SWISS-2DPAGEP23847.

Interactioni

Protein-protein interaction databases

BioGridi4259528. 143 interactions.
DIPiDIP-9467N.
IntActiP23847. 5 interactions.
MINTiMINT-1240350.
STRINGi511145.b3544.

Structurei

Secondary structure

1
535
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 378Combined sources
Helixi44 – 463Combined sources
Helixi50 – 556Combined sources
Helixi57 – 604Combined sources
Beta strandi64 – 674Combined sources
Beta strandi74 – 8411Combined sources
Beta strandi90 – 956Combined sources
Helixi115 – 12612Combined sources
Turni131 – 1344Combined sources
Helixi135 – 1373Combined sources
Helixi141 – 1455Combined sources
Helixi148 – 1514Combined sources
Beta strandi152 – 1598Combined sources
Beta strandi162 – 1698Combined sources
Helixi174 – 1774Combined sources
Helixi181 – 1833Combined sources
Helixi188 – 1969Combined sources
Helixi202 – 2054Combined sources
Beta strandi210 – 21910Combined sources
Turni220 – 2223Combined sources
Beta strandi223 – 2286Combined sources
Beta strandi240 – 2467Combined sources
Helixi250 – 2589Combined sources
Helixi270 – 2723Combined sources
Helixi273 – 2786Combined sources
Beta strandi282 – 2887Combined sources
Beta strandi290 – 2978Combined sources
Turni302 – 3054Combined sources
Helixi307 – 3159Combined sources
Helixi319 – 3279Combined sources
Beta strandi330 – 3334Combined sources
Beta strandi335 – 3384Combined sources
Helixi356 – 36510Combined sources
Beta strandi372 – 3776Combined sources
Helixi389 – 40113Combined sources
Turni402 – 4043Combined sources
Beta strandi405 – 4106Combined sources
Helixi414 – 4229Combined sources
Beta strandi427 – 4348Combined sources
Beta strandi436 – 4383Combined sources
Helixi441 – 4488Combined sources
Helixi450 – 4556Combined sources
Helixi465 – 47612Combined sources
Helixi480 – 49718Combined sources
Beta strandi499 – 51315Combined sources
Beta strandi516 – 5183Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DPEX-ray2.00A29-535[»]
1DPPX-ray3.20A/C/E/G29-535[»]
ProteinModelPortaliP23847.
SMRiP23847. Positions 29-535.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23847.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105DEF. Bacteria.
COG0747. LUCA.
HOGENOMiHOG000164955.
InParanoidiP23847.
KOiK12368.
OMAiHADGFTI.
PhylomeDBiP23847.

Family and domain databases

InterProiIPR030678. Peptide/Ni-bd.
IPR023765. SBP_5_CS.
IPR000914. SBP_5_dom.
[Graphical view]
PfamiPF00496. SBP_bac_5. 1 hit.
[Graphical view]
PIRSFiPIRSF002741. MppA. 1 hit.
PROSITEiPS01040. SBP_BACTERIAL_5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23847-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRISLKKSGM LKLGLSLVAM TVAASVQAKT LVYCSEGSPE GFNPQLFTSG
60 70 80 90 100
TTYDASSVPL YNRLVEFKIG TTEVIPGLAE KWEVSEDGKT YTFHLRKGVK
110 120 130 140 150
WHDNKEFKPT RELNADDVVF SFDRQKNAQN PYHKVSGGSY EYFEGMGLPE
160 170 180 190 200
LISEVKKVDD NTVQFVLTRP EAPFLADLAM DFASILSKEY ADAMMKAGTP
210 220 230 240 250
EKLDLNPIGT GPFQLQQYQK DSRIRYKAFD GYWGTKPQID TLVFSITPDA
260 270 280 290 300
SVRYAKLQKN ECQVMPYPNP ADIARMKQDK SINLMEMPGL NVGYLSYNVQ
310 320 330 340 350
KKPLDDVKVR QALTYAVNKD AIIKAVYQGA GVSAKNLIPP TMWGYNDDVQ
360 370 380 390 400
DYTYDPEKAK ALLKEAGLEK GFSIDLWAMP VQRPYNPNAR RMAEMIQADW
410 420 430 440 450
AKVGVQAKIV TYEWGEYLKR AKDGEHQTVM MGWTGDNGDP DNFFATLFSC
460 470 480 490 500
AASEQGSNYS KWCYKPFEDL IQPARATDDH NKRVELYKQA QVVMHDQAPA
510 520 530
LIIAHSTVFE PVRKEVKGYV VDPLGKHHFE NVSIE
Length:535
Mass (Da):60,294
Last modified:November 1, 1991 - v1
Checksum:i3F7C4756EEA8C2F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35045 Genomic DNA. Translation: AAA23707.1.
X58051 Genomic DNA. Translation: CAA41090.1.
L08399 Genomic DNA. Translation: AAA23702.1.
U00039 Genomic DNA. Translation: AAB18522.1.
U00096 Genomic DNA. Translation: AAC76569.1.
AP009048 Genomic DNA. Translation: BAE77750.1.
PIRiA39194.
RefSeqiNP_418001.1. NC_000913.3.
WP_001222883.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76569; AAC76569; b3544.
BAE77750; BAE77750; BAE77750.
GeneIDi948062.
KEGGiecj:JW3513.
eco:b3544.
PATRICi32122558. VBIEscCol129921_3657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35045 Genomic DNA. Translation: AAA23707.1.
X58051 Genomic DNA. Translation: CAA41090.1.
L08399 Genomic DNA. Translation: AAA23702.1.
U00039 Genomic DNA. Translation: AAB18522.1.
U00096 Genomic DNA. Translation: AAC76569.1.
AP009048 Genomic DNA. Translation: BAE77750.1.
PIRiA39194.
RefSeqiNP_418001.1. NC_000913.3.
WP_001222883.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DPEX-ray2.00A29-535[»]
1DPPX-ray3.20A/C/E/G29-535[»]
ProteinModelPortaliP23847.
SMRiP23847. Positions 29-535.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259528. 143 interactions.
DIPiDIP-9467N.
IntActiP23847. 5 interactions.
MINTiMINT-1240350.
STRINGi511145.b3544.

2D gel databases

SWISS-2DPAGEP23847.

Proteomic databases

EPDiP23847.
PaxDbiP23847.
PRIDEiP23847.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76569; AAC76569; b3544.
BAE77750; BAE77750; BAE77750.
GeneIDi948062.
KEGGiecj:JW3513.
eco:b3544.
PATRICi32122558. VBIEscCol129921_3657.

Organism-specific databases

EchoBASEiEB0244.
EcoGeneiEG10248. dppA.

Phylogenomic databases

eggNOGiENOG4105DEF. Bacteria.
COG0747. LUCA.
HOGENOMiHOG000164955.
InParanoidiP23847.
KOiK12368.
OMAiHADGFTI.
PhylomeDBiP23847.

Enzyme and pathway databases

BioCyciEcoCyc:DPPA-MONOMER.
ECOL316407:JW3513-MONOMER.
MetaCyc:DPPA-MONOMER.
RETL1328306-WGS:GSTH-748-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP23847.
PROiP23847.

Family and domain databases

InterProiIPR030678. Peptide/Ni-bd.
IPR023765. SBP_5_CS.
IPR000914. SBP_5_dom.
[Graphical view]
PfamiPF00496. SBP_bac_5. 1 hit.
[Graphical view]
PIRSFiPIRSF002741. MppA. 1 hit.
PROSITEiPS01040. SBP_BACTERIAL_5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPPA_ECOLI
AccessioniPrimary (citable) accession number: P23847
Secondary accession number(s): Q2M7K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: September 7, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.