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Protein

Periplasmic oligopeptide-binding protein

Gene

oppA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is a component of the oligopeptide permease, a binding protein-dependent transport system, it binds peptides up to five amino acids long with high affinity.

GO - Molecular functioni

  • oligopeptide binding Source: EcoCyc

GO - Biological processi

  • chaperone-mediated protein folding Source: EcoCyc
  • oligopeptide transport Source: EcoCyc
  • protein transport Source: UniProtKB-KW
  • response to heat Source: EcoCyc
  • transmembrane transport Source: InterPro

Keywordsi

Biological processPeptide transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:OPPA-MONOMER
MetaCyc:OPPA-MONOMER

Protein family/group databases

TCDBi3.A.1.5.41 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Periplasmic oligopeptide-binding protein
Gene namesi
Name:oppA
Ordered Locus Names:b1243, JW1235
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10674 oppA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 263 PublicationsAdd BLAST26
ChainiPRO_000003179727 – 543Periplasmic oligopeptide-binding proteinAdd BLAST517

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi297 ↔ 443By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP23843
PaxDbiP23843
PRIDEiP23843

2D gel databases

SWISS-2DPAGEiP23843

Interactioni

Protein-protein interaction databases

BioGridi4263482, 672 interactors
DIPiDIP-10405N
IntActiP23843, 3 interactors
STRINGi316385.ECDH10B_1305

Structurei

Secondary structure

1543
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi40 – 44Combined sources5
Turni54 – 56Combined sources3
Helixi60 – 69Combined sources10
Beta strandi73 – 76Combined sources4
Beta strandi82 – 93Combined sources12
Turni94 – 96Combined sources3
Beta strandi97 – 102Combined sources6
Helixi116 – 127Combined sources12
Turni129 – 131Combined sources3
Helixi136 – 142Combined sources7
Helixi147 – 151Combined sources5
Helixi157 – 159Combined sources3
Beta strandi160 – 166Combined sources7
Beta strandi169 – 176Combined sources8
Helixi181 – 186Combined sources6
Helixi188 – 190Combined sources3
Helixi195 – 201Combined sources7
Helixi202 – 204Combined sources3
Turni208 – 210Combined sources3
Beta strandi215 – 223Combined sources9
Turni224 – 226Combined sources3
Beta strandi227 – 232Combined sources6
Helixi239 – 241Combined sources3
Beta strandi245 – 250Combined sources6
Helixi255 – 263Combined sources9
Helixi276 – 285Combined sources10
Helixi287 – 289Combined sources3
Beta strandi290 – 303Combined sources14
Turni308 – 311Combined sources4
Helixi313 – 322Combined sources10
Helixi325 – 330Combined sources6
Turni331 – 333Combined sources3
Beta strandi341 – 344Combined sources4
Helixi357 – 360Combined sources4
Helixi363 – 376Combined sources14
Beta strandi381 – 383Combined sources3
Beta strandi386 – 393Combined sources8
Helixi395 – 412Combined sources18
Beta strandi415 – 421Combined sources7
Helixi423 – 432Combined sources10
Beta strandi436 – 443Combined sources8
Beta strandi445 – 448Combined sources4
Helixi450 – 453Combined sources4
Helixi454 – 456Combined sources3
Helixi470 – 479Combined sources10
Beta strandi482 – 484Combined sources3
Helixi485 – 501Combined sources17
Beta strandi505 – 517Combined sources13
Beta strandi521 – 523Combined sources3
Helixi535 – 537Combined sources3
Beta strandi539 – 541Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TCFX-ray2.00A/B/C/D/E/F/G/H27-543[»]
3TCGX-ray2.00A/B/C/D/E/F/G/H27-543[»]
3TCHX-ray1.98A27-543[»]
ProteinModelPortaliP23843
SMRiP23843
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23843

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108J59 Bacteria
COG4166 LUCA
HOGENOMiHOG000179191
InParanoidiP23843
KOiK15580
OMAiYDFFTWE
PhylomeDBiP23843

Family and domain databases

InterProiView protein in InterPro
IPR030678 Peptide/Ni-bd
IPR023765 SBP_5_CS
IPR000914 SBP_5_dom
PfamiView protein in Pfam
PF00496 SBP_bac_5, 1 hit
PIRSFiPIRSF002741 MppA, 1 hit
PROSITEiView protein in PROSITE
PS01040 SBP_BACTERIAL_5, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23843-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNITKRSLV AAGVLAALMA GNVALAADVP AGVTLAEKQT LVRNNGSEVQ
60 70 80 90 100
SLDPHKIEGV PESNISRDLF EGLLVSDLDG HPAPGVAESW DNKDAKVWTF
110 120 130 140 150
HLRKDAKWSD GTPVTAQDFV YSWQRSVDPN TASPYASYLQ YGHIAGIDEI
160 170 180 190 200
LEGKKPITDL GVKAIDDHTL EVTLSEPVPY FYKLLVHPST SPVPKAAIEK
210 220 230 240 250
FGEKWTQPGN IVTNGAYTLK DWVVNERIVL ERSPTYWNNA KTVINQVTYL
260 270 280 290 300
PIASEVTDVN RYRSGEIDMT NNSMPIELFQ KLKKEIPDEV HVDPYLCTYY
310 320 330 340 350
YEINNQKPPF NDVRVRTALK LGMDRDIIVN KVKAQGNMPA YGYTPPYTDG
360 370 380 390 400
AKLTQPEWFG WSQEKRNEEA KKLLAEAGYT ADKPLTINLL YNTSDLHKKL
410 420 430 440 450
AIAASSLWKK NIGVNVKLVN QEWKTFLDTR HQGTFDVARA GWCADYNEPT
460 470 480 490 500
SFLNTMLSNS SMNTAHYKSP AFDSIMAETL KVTDEAQRTA LYTKAEQQLD
510 520 530 540
KDSAIVPVYY YVNARLVKPW VGGYTGKDPL DNTYTRNMYI VKH
Length:543
Mass (Da):60,899
Last modified:October 1, 1994 - v2
Checksum:iBBEF9FEBD42254EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti271N → Y in AAA21302 (Ref. 2) Curated1
Sequence conflicti314 – 315RV → LW in AAA21302 (Ref. 2) Curated2
Sequence conflicti487 – 488QR → HG in AAA21302 (Ref. 2) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05433 Genomic DNA Translation: AAA21302.1
M60918 Genomic DNA Translation: AAB00918.1
U00096 Genomic DNA Translation: AAC74325.1
AP009048 Genomic DNA Translation: BAA14775.1
X59501 Genomic DNA Translation: CAA42089.1
D83137 Genomic DNA Translation: BAA11814.1
PIRiF64871
RefSeqiNP_415759.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAC74325; AAC74325; b1243
BAA14775; BAA14775; BAA14775
GeneIDi945830
KEGGiecj:JW1235
eco:b1243
PATRICifig|511145.12.peg.1293

Similar proteinsi

Entry informationi

Entry nameiOPPA_ECOLI
AccessioniPrimary (citable) accession number: P23843
Secondary accession number(s): P76829
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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