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Protein

HTH-type transcriptional regulator XapR

Gene

xapR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Positive regulator required for the expression of xapA and xapB. Binds to the inducer xanthosine.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi24 – 43H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: EcoCyc

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG11146-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator XapR
Alternative name(s):
Xanthosine operon regulatory protein
Gene namesi
Name:xapR
Synonyms:pndR, yfeB
Ordered Locus Names:b2405, JW2396
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11146 xapR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001057681 – 294HTH-type transcriptional regulator XapRAdd BLAST294

Proteomic databases

PaxDbiP23841
PRIDEiP23841

Interactioni

Protein-protein interaction databases

BioGridi4262007, 5 interactors
IntActiP23841, 5 interactors
STRINGi316385.ECDH10B_2569

Structurei

3D structure databases

ProteinModelPortaliP23841
SMRiP23841
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 64HTH lysR-typePROSITE-ProRule annotationAdd BLAST58

Phylogenomic databases

eggNOGiENOG4105CN8 Bacteria
ENOG410YMSV LUCA
HOGENOMiHOG000233514
InParanoidiP23841
OMAiVHISQSG
PhylomeDBiP23841

Family and domain databases

CDDicd08449 PBP2_XapR, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005119 LysR_subst-bd
IPR000847 Tscrpt_reg_HTH_LysR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
IPR037409 XapR_PBP2
PfamiView protein in Pfam
PF00126 HTH_1, 1 hit
PF03466 LysR_substrate, 1 hit
PRINTSiPR00039 HTHLYSR
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50931 HTH_LYSR, 1 hit

Sequencei

Sequence statusi: Complete.

P23841-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERVYRTDLK LLRYFLAVAE ELHFGRAAAR LNMSQPPLSI HIKELENQLG
60 70 80 90 100
TQLFIRHSRS VVLTHAGKIL MEESRRLLVN ANNVLARIEQ IGRGEAGRIE
110 120 130 140 150
LGVVGTAMWG RMRPVMRRFL RENPNVDVLF REKMPAMQMA LLERRELDAG
160 170 180 190 200
IWRMATEPPT GFTSLRLHES AFLVAMPEEH HLSSFSTVPL EALRDEYFVT
210 220 230 240 250
MPPVYTDWDF LQRVCQQVGF SPVVIREVNE PQTVLAMVSM GIGITLIADS
260 270 280 290
YAQMNWPGVI FRPLKQRIPA DLYIVYETQQ VTPAMVKLLA ALTQ
Length:294
Mass (Da):33,627
Last modified:November 1, 1991 - v1
Checksum:i6DA7DA040C5D59A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63976 Genomic DNA Translation: CAA45390.1
U00096 Genomic DNA Translation: AAC75458.1
AP009048 Genomic DNA Translation: BAA16273.1
M13687 Genomic DNA Translation: AAA65714.1
X73828 Genomic DNA Translation: CAA52047.1
PIRiS11407
RefSeqiNP_416900.1, NC_000913.3
WP_000442949.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75458; AAC75458; b2405
BAA16273; BAA16273; BAA16273
GeneIDi946862
KEGGiecj:JW2396
eco:b2405
PATRICifig|1411691.4.peg.4328

Similar proteinsi

Entry informationi

Entry nameiXAPR_ECOLI
AccessioniPrimary (citable) accession number: P23841
Secondary accession number(s): P76531
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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