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Protein

Protein SCO1, mitochondrial

Gene

SCO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for the accumulation of subunits 1 and 2 of cytochrome c oxidase complex. Thought to play a role in either mitochondrial copper transport or insertion of copper into the active site of COX.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi148CopperBy similarity1
Metal bindingi152CopperBy similarity1
Metal bindingi239CopperBy similarity1

GO - Molecular functioni

  • copper ion binding Source: SGD
  • thioredoxin peroxidase activity Source: SGD

GO - Biological processi

  • cellular copper ion homeostasis Source: InterPro
  • copper ion transport Source: SGD
  • protein complex assembly Source: SGD
  • respiratory chain complex IV assembly Source: InterPro
  • response to redox state Source: SGD
Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29012-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SCO1, mitochondrial
Gene namesi
Name:SCO1
Ordered Locus Names:YBR037C
ORF Names:YBR0406
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR037C.
SGDiS000000241. SCO1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei76 – 92HelicalSequence analysisAdd BLAST17

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000031923? – 295Protein SCO1, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiP23833.
PRIDEiP23833.

Interactioni

Protein-protein interaction databases

BioGridi32738. 47 interactors.
DIPiDIP-7610N.
IntActiP23833. 3 interactors.
MINTiMINT-434464.

Structurei

Secondary structure

1295
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi120 – 123Combined sources4
Beta strandi128 – 130Combined sources3
Helixi131 – 134Combined sources4
Beta strandi139 – 144Combined sources6
Helixi151 – 170Combined sources20
Beta strandi175 – 181Combined sources7
Turni183 – 185Combined sources3
Helixi188 – 195Combined sources8
Beta strandi203 – 206Combined sources4
Helixi209 – 218Combined sources10
Turni237 – 239Combined sources3
Beta strandi243 – 246Combined sources4
Beta strandi252 – 256Combined sources5
Helixi264 – 275Combined sources12
Beta strandi284 – 291Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B7JX-ray2.30A/B/C/D96-295[»]
2B7KX-ray1.80A/B/C/D96-295[»]
ProteinModelPortaliP23833.
SMRiP23833.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23833.

Family & Domainsi

Sequence similaritiesi

Belongs to the SCO1/2 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000004323.
HOGENOMiHOG000258140.
InParanoidiP23833.
KOiK07152.
OMAiQPVFITC.
OrthoDBiEOG092C4IEC.

Family and domain databases

CDDicd02968. SCO. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR003782. SCO1/SenC.
IPR017276. Synth_of_cyt-c-oxidase_Sco1/2.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR12151. PTHR12151. 1 hit.
PfamiPF02630. SCO1-SenC. 1 hit.
[Graphical view]
PIRSFiPIRSF037736. SCO1. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23833-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKLSRSANL RLVQLPAARL SGNGAKLLTQ RGFFTVTRLW QSNGKKPLSR
60 70 80 90 100
VPVGGTPIKD NGKVREGSIE FSTGKAIALF LAVGGALSYF FNREKRRLET
110 120 130 140 150
QKEAEANRGY GKPSLGGPFH LEDMYGNEFT EKNLLGKFSI IYFGFSNCPD
160 170 180 190 200
ICPDELDKLG LWLNTLSSKY GITLQPLFIT CDPARDSPAV LKEYLSDFHP
210 220 230 240 250
SILGLTGTFD EVKNACKKYR VYFSTPPNVK PGQDYLVDHS IFFYLMDPEG
260 270 280 290
QFVDALGRNY DEKTGVDKIV EHVKSYVPAE QRAKQKEAWY SFLFK
Length:295
Mass (Da):33,166
Last modified:November 1, 1991 - v1
Checksum:i500EFD92A0F44DDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17441 Genomic DNA. Translation: CAA35490.1.
Z35906 Genomic DNA. Translation: CAA84979.1.
AY557863 Genomic DNA. Translation: AAS56189.1.
BK006936 Genomic DNA. Translation: DAA07157.1.
PIRiJE0051.
RefSeqiNP_009593.1. NM_001178385.1.

Genome annotation databases

EnsemblFungiiYBR037C; YBR037C; YBR037C.
GeneIDi852325.
KEGGisce:YBR037C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17441 Genomic DNA. Translation: CAA35490.1.
Z35906 Genomic DNA. Translation: CAA84979.1.
AY557863 Genomic DNA. Translation: AAS56189.1.
BK006936 Genomic DNA. Translation: DAA07157.1.
PIRiJE0051.
RefSeqiNP_009593.1. NM_001178385.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B7JX-ray2.30A/B/C/D96-295[»]
2B7KX-ray1.80A/B/C/D96-295[»]
ProteinModelPortaliP23833.
SMRiP23833.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32738. 47 interactors.
DIPiDIP-7610N.
IntActiP23833. 3 interactors.
MINTiMINT-434464.

Proteomic databases

MaxQBiP23833.
PRIDEiP23833.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR037C; YBR037C; YBR037C.
GeneIDi852325.
KEGGisce:YBR037C.

Organism-specific databases

EuPathDBiFungiDB:YBR037C.
SGDiS000000241. SCO1.

Phylogenomic databases

GeneTreeiENSGT00390000004323.
HOGENOMiHOG000258140.
InParanoidiP23833.
KOiK07152.
OMAiQPVFITC.
OrthoDBiEOG092C4IEC.

Enzyme and pathway databases

BioCyciYEAST:G3O-29012-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP23833.
PROiP23833.

Family and domain databases

CDDicd02968. SCO. 1 hit.
Gene3Di3.40.30.10. 1 hit.
InterProiIPR003782. SCO1/SenC.
IPR017276. Synth_of_cyt-c-oxidase_Sco1/2.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR12151. PTHR12151. 1 hit.
PfamiPF02630. SCO1-SenC. 1 hit.
[Graphical view]
PIRSFiPIRSF037736. SCO1. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSCO1_YEAST
AccessioniPrimary (citable) accession number: P23833
Secondary accession number(s): D6VQ37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: November 2, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2550 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.