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Protein

Protein SCO1, mitochondrial

Gene

SCO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the accumulation of subunits 1 and 2 of cytochrome c oxidase complex. Thought to play a role in either mitochondrial copper transport or insertion of copper into the active site of COX.1 Publication

Miscellaneous

Present with 2550 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi148CopperBy similarity1
Metal bindingi152CopperBy similarity1
Metal bindingi239CopperBy similarity1

GO - Molecular functioni

  • copper ion binding Source: SGD
  • thioredoxin peroxidase activity Source: SGD

GO - Biological processi

  • cellular copper ion homeostasis Source: InterPro
  • cellular protein-containing complex assembly Source: SGD
  • copper ion transport Source: SGD
  • respiratory chain complex IV assembly Source: InterPro
  • response to redox state Source: SGD

Keywordsi

LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29012-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SCO1, mitochondrial
Gene namesi
Name:SCO1
Ordered Locus Names:YBR037C
ORF Names:YBR0406
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR037C
SGDiS000000241 SCO1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei76 – 92HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000031923? – 295Protein SCO1, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiP23833
PaxDbiP23833
PRIDEiP23833

Interactioni

Protein-protein interaction databases

BioGridi32738, 160 interactors
DIPiDIP-7610N
IntActiP23833, 3 interactors
STRINGi4932.YBR037C

Structurei

Secondary structure

1295
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi120 – 123Combined sources4
Beta strandi128 – 130Combined sources3
Helixi131 – 134Combined sources4
Beta strandi139 – 144Combined sources6
Helixi151 – 170Combined sources20
Beta strandi175 – 181Combined sources7
Turni183 – 185Combined sources3
Helixi188 – 195Combined sources8
Beta strandi203 – 206Combined sources4
Helixi209 – 218Combined sources10
Turni237 – 239Combined sources3
Beta strandi243 – 246Combined sources4
Beta strandi252 – 256Combined sources5
Helixi264 – 275Combined sources12
Beta strandi284 – 291Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B7JX-ray2.30A/B/C/D96-295[»]
2B7KX-ray1.80A/B/C/D96-295[»]
ProteinModelPortaliP23833
SMRiP23833
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23833

Family & Domainsi

Sequence similaritiesi

Belongs to the SCO1/2 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000004323
HOGENOMiHOG000258140
InParanoidiP23833
KOiK07152
OMAiTHTGEPK
OrthoDBiEOG092C4IEC

Family and domain databases

CDDicd02968 SCO, 1 hit
InterProiView protein in InterPro
IPR003782 SCO1/SenC
IPR017276 Synth_of_cyt-c-oxidase_Sco1/2
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR12151 PTHR12151, 1 hit
PfamiView protein in Pfam
PF02630 SCO1-SenC, 1 hit
PIRSFiPIRSF037736 SCO1, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23833-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKLSRSANL RLVQLPAARL SGNGAKLLTQ RGFFTVTRLW QSNGKKPLSR
60 70 80 90 100
VPVGGTPIKD NGKVREGSIE FSTGKAIALF LAVGGALSYF FNREKRRLET
110 120 130 140 150
QKEAEANRGY GKPSLGGPFH LEDMYGNEFT EKNLLGKFSI IYFGFSNCPD
160 170 180 190 200
ICPDELDKLG LWLNTLSSKY GITLQPLFIT CDPARDSPAV LKEYLSDFHP
210 220 230 240 250
SILGLTGTFD EVKNACKKYR VYFSTPPNVK PGQDYLVDHS IFFYLMDPEG
260 270 280 290
QFVDALGRNY DEKTGVDKIV EHVKSYVPAE QRAKQKEAWY SFLFK
Length:295
Mass (Da):33,166
Last modified:November 1, 1991 - v1
Checksum:i500EFD92A0F44DDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17441 Genomic DNA Translation: CAA35490.1
Z35906 Genomic DNA Translation: CAA84979.1
AY557863 Genomic DNA Translation: AAS56189.1
BK006936 Genomic DNA Translation: DAA07157.1
PIRiJE0051
RefSeqiNP_009593.1, NM_001178385.1

Genome annotation databases

EnsemblFungiiYBR037C; YBR037C; YBR037C
GeneIDi852325
KEGGisce:YBR037C

Similar proteinsi

Entry informationi

Entry nameiSCO1_YEAST
AccessioniPrimary (citable) accession number: P23833
Secondary accession number(s): D6VQ37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: April 25, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health