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Protein

Protein SCO1, mitochondrial

Gene

SCO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for the accumulation of subunits 1 and 2 of cytochrome c oxidase complex. Thought to play a role in either mitochondrial copper transport or insertion of copper into the active site of COX.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi148 – 1481CopperBy similarity
Metal bindingi152 – 1521CopperBy similarity
Metal bindingi239 – 2391CopperBy similarity

GO - Molecular functioni

  • copper ion binding Source: SGD
  • thioredoxin peroxidase activity Source: SGD

GO - Biological processi

  • cellular copper ion homeostasis Source: InterPro
  • cellular oxidant detoxification Source: GOC
  • copper ion transport Source: SGD
  • protein complex assembly Source: SGD
  • respiratory chain complex IV assembly Source: InterPro
  • response to redox state Source: SGD
Complete GO annotation...

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29012-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SCO1, mitochondrial
Gene namesi
Name:SCO1
Ordered Locus Names:YBR037C
ORF Names:YBR0406
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBR037C.
SGDiS000000241. SCO1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei76 – 9217HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 295Protein SCO1, mitochondrialPRO_0000031923
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiP23833.

Interactioni

Protein-protein interaction databases

BioGridi32738. 47 interactions.
DIPiDIP-7610N.
IntActiP23833. 3 interactions.
MINTiMINT-434464.

Structurei

Secondary structure

1
295
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi120 – 1234Combined sources
Beta strandi128 – 1303Combined sources
Helixi131 – 1344Combined sources
Beta strandi139 – 1446Combined sources
Helixi151 – 17020Combined sources
Beta strandi175 – 1817Combined sources
Turni183 – 1853Combined sources
Helixi188 – 1958Combined sources
Beta strandi203 – 2064Combined sources
Helixi209 – 21810Combined sources
Turni237 – 2393Combined sources
Beta strandi243 – 2464Combined sources
Beta strandi252 – 2565Combined sources
Helixi264 – 27512Combined sources
Beta strandi284 – 2918Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B7JX-ray2.30A/B/C/D96-295[»]
2B7KX-ray1.80A/B/C/D96-295[»]
ProteinModelPortaliP23833.
SMRiP23833. Positions 113-293.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP23833.

Family & Domainsi

Sequence similaritiesi

Belongs to the SCO1/2 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000004323.
HOGENOMiHOG000258140.
InParanoidiP23833.
KOiK07152.
OMAiEFTTWKA.
OrthoDBiEOG7CG79T.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR003782. SCO1/SenC.
IPR017276. Synth_of_cyt-c-oxidase_Sco1/2.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR12151. PTHR12151. 1 hit.
PfamiPF02630. SCO1-SenC. 1 hit.
[Graphical view]
PIRSFiPIRSF037736. SCO1. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23833-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKLSRSANL RLVQLPAARL SGNGAKLLTQ RGFFTVTRLW QSNGKKPLSR
60 70 80 90 100
VPVGGTPIKD NGKVREGSIE FSTGKAIALF LAVGGALSYF FNREKRRLET
110 120 130 140 150
QKEAEANRGY GKPSLGGPFH LEDMYGNEFT EKNLLGKFSI IYFGFSNCPD
160 170 180 190 200
ICPDELDKLG LWLNTLSSKY GITLQPLFIT CDPARDSPAV LKEYLSDFHP
210 220 230 240 250
SILGLTGTFD EVKNACKKYR VYFSTPPNVK PGQDYLVDHS IFFYLMDPEG
260 270 280 290
QFVDALGRNY DEKTGVDKIV EHVKSYVPAE QRAKQKEAWY SFLFK
Length:295
Mass (Da):33,166
Last modified:November 1, 1991 - v1
Checksum:i500EFD92A0F44DDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17441 Genomic DNA. Translation: CAA35490.1.
Z35906 Genomic DNA. Translation: CAA84979.1.
AY557863 Genomic DNA. Translation: AAS56189.1.
BK006936 Genomic DNA. Translation: DAA07157.1.
PIRiJE0051.
RefSeqiNP_009593.1. NM_001178385.1.

Genome annotation databases

EnsemblFungiiYBR037C; YBR037C; YBR037C.
GeneIDi852325.
KEGGisce:YBR037C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17441 Genomic DNA. Translation: CAA35490.1.
Z35906 Genomic DNA. Translation: CAA84979.1.
AY557863 Genomic DNA. Translation: AAS56189.1.
BK006936 Genomic DNA. Translation: DAA07157.1.
PIRiJE0051.
RefSeqiNP_009593.1. NM_001178385.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B7JX-ray2.30A/B/C/D96-295[»]
2B7KX-ray1.80A/B/C/D96-295[»]
ProteinModelPortaliP23833.
SMRiP23833. Positions 113-293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32738. 47 interactions.
DIPiDIP-7610N.
IntActiP23833. 3 interactions.
MINTiMINT-434464.

Proteomic databases

MaxQBiP23833.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBR037C; YBR037C; YBR037C.
GeneIDi852325.
KEGGisce:YBR037C.

Organism-specific databases

EuPathDBiFungiDB:YBR037C.
SGDiS000000241. SCO1.

Phylogenomic databases

GeneTreeiENSGT00390000004323.
HOGENOMiHOG000258140.
InParanoidiP23833.
KOiK07152.
OMAiEFTTWKA.
OrthoDBiEOG7CG79T.

Enzyme and pathway databases

BioCyciYEAST:G3O-29012-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP23833.
NextBioi971029.
PROiP23833.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR003782. SCO1/SenC.
IPR017276. Synth_of_cyt-c-oxidase_Sco1/2.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR12151. PTHR12151. 1 hit.
PfamiPF02630. SCO1-SenC. 1 hit.
[Graphical view]
PIRSFiPIRSF037736. SCO1. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Accumulation of the cytochrome c oxidase subunits I and II in yeast requires a mitochondrial membrane-associated protein, encoded by the nuclear SCO1 gene."
    Schulze M., Roedel G.
    Mol. Gen. Genet. 216:37-43(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete DNA sequence of yeast chromosome II."
    Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C., Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M., Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M., Cziepluch C.
    , Demolis N., Delaveau T., Doignon F., Domdey H., Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D., Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N., Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J., Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C., Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P., Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y., Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F., Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E., Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M., Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B., Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L., Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M., Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S., Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K., Mewes H.-W., Kleine K.
    EMBO J. 13:5795-5809(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Immunological identification of yeast SCO1 protein as a component of the inner mitochondrial membrane."
    Buchwald P., Krummeck G., Roedel G.
    Mol. Gen. Genet. 229:413-420(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 96-295 IN COMPLEX WITH COPPER IONS, FUNCTION.

Entry informationi

Entry nameiSCO1_YEAST
AccessioniPrimary (citable) accession number: P23833
Secondary accession number(s): D6VQ37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: April 13, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 2550 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.