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Protein

CDP-diacylglycerol--serine O-phosphatidyltransferase

Gene

pssA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

CDP-diacylglycerol + L-serine = CMP + (3-sn-phosphatidyl)-L-serine.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciEcoCyc:PHOSPHASERSYN-MONOMER.
MetaCyc:PHOSPHASERSYN-MONOMER.
BRENDAi2.7.8.8. 2026.

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol--serine O-phosphatidyltransferase (EC:2.7.8.8)
Alternative name(s):
Phosphatidylserine synthase
Gene namesi
Name:pssA
Synonyms:pss
Ordered Locus Names:b2585, JW2569
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10781. pssA.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
  • plasma membrane Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000568241 – 451CDP-diacylglycerol--serine O-phosphatidyltransferaseAdd BLAST451

Proteomic databases

PaxDbiP23830.
PRIDEiP23830.

Interactioni

Subunit structurei

Multimeric. Interacts with ACP, YbgC and PlsB, forming altogether a complex at the inner membrane.1 Publication

Protein-protein interaction databases

BioGridi4259429. 210 interactors.
DIPiDIP-10593N.
IntActiP23830. 35 interactors.
MINTiMINT-1218158.
STRINGi316385.ECDH10B_2753.

Structurei

3D structure databases

ProteinModelPortaliP23830.
SMRiP23830.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 159PLD phosphodiesterase 1PROSITE-ProRule annotationAdd BLAST27
Domaini352 – 379PLD phosphodiesterase 2PROSITE-ProRule annotationAdd BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni119 – 154HydrophobicAdd BLAST36
Regioni239 – 284HydrophobicAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 9Lys-rich (basic)6
Compositional biasi430 – 449Arg/Lys-rich (basic)Add BLAST20

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105JIM. Bacteria.
COG1502. LUCA.
HOGENOMiHOG000270167.
InParanoidiP23830.
KOiK00998.
PhylomeDBiP23830.

Family and domain databases

InterProiView protein in InterPro
IPR016270. PGS1.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
PANTHERiPTHR12586. PTHR12586. 1 hit.
PfamiView protein in Pfam
PF13091. PLDc_2. 2 hits.
SMARTiView protein in SMART
SM00155. PLDc. 2 hits.
PROSITEiView protein in PROSITE
PS50035. PLD. 2 hits.

Sequencei

Sequence statusi: Complete.

P23830-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKFKRNKH QQHLAQLPKI SQSVDDVDFF YAPADFRETL LEKIASAKQR
60 70 80 90 100
ICIVALYLEQ DDGGKGILNA LYEAKRQRPE LDVRVLVDWH RAQRGRIGAA
110 120 130 140 150
ASNTNADWYC RMAQENPGVD VPVYGVPINT REALGVLHFK GFIIDDSVLY
160 170 180 190 200
SGASLNDVYL HQHDKYRYDR YHLIRNRKMS DIMFEWVTQN IMNGRGVNRL
210 220 230 240 250
DDVNRPKSPE IKNDIRLFRQ ELRDAAYHFQ GDADNDQLSV TPLVGLGKSS
260 270 280 290 300
LLNKTIFHLM PCAEQKLTIC TPYFNLPAIL VRNIIQLLRE GKKVEIIVGD
310 320 330 340 350
KTANDFYIPE DEPFKIIGAL PYLYEINLRR FLSRLQYYVN TDQLVVRLWK
360 370 380 390 400
DDDNTYHLKG MWVDDKWMLI TGNNLNPRAW RLDLENAILI HDPQLELAPQ
410 420 430 440 450
REKELELIRE HTTIVKHYRD LQSIADYPVK VRKLIRRLRR IRIDRLISRI

L
Length:451
Mass (Da):52,802
Last modified:November 1, 1997 - v2
Checksum:i9E9A2A5C4B4C814F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32A → R in AAA97504 (PubMed:2002065).Curated1
Sequence conflicti78R → DD in AAA97504 (PubMed:2002065).Curated1
Sequence conflicti165 – 167KYR → NIA in AAA97504 (PubMed:2002065).Curated3
Sequence conflicti287 – 288LL → FV in AAA97504 (PubMed:2002065).Curated2
Sequence conflicti309P → S in AAA97504 (PubMed:2002065).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58699 Genomic DNA. Translation: AAA97504.1.
U00096 Genomic DNA. Translation: AAC75638.2.
AP009048 Genomic DNA. Translation: BAA16470.2.
RefSeqiNP_417080.4. NC_000913.3.
WP_000949265.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75638; AAC75638; b2585.
BAA16470; BAA16470; BAA16470.
GeneIDi947059.
KEGGiecj:JW2569.
eco:b2585.
PATRICifig|1411691.4.peg.4149.

Similar proteinsi

Entry informationi

Entry nameiPSS_ECOLI
AccessioniPrimary (citable) accession number: P23830
Secondary accession number(s): P78100, P78256
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1997
Last modified: August 30, 2017
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families