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Reviewed, UniProtKB/Swiss-Prot P23826 (LACS_LACSL)

Last modified March 3, 2009. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

Names and origin

Protein namesRecommended name:
    Bacteriocin lactocin-S
Gene names
Name: lasA
Encoded onPlasmid pCIM1
OrganismLactobacillus sakei L45
Taxonomic identifier1634 [NCBI]
Taxonomic lineageBacteriaFirmicutesLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length68 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Inhibits the growth of selected species of the genera Lactobacillus, Pedicoccus, and Leuconostoc.

Ontologies

Keywords
   LigandPyruvate
   Molecular functionAntibiotic
Antimicrobial
Bacteriocin
Lantibiotic
   PTMD-amino acid
Thioether bond
   Technical termDirect protein sequencing
Plasmid
Gene Ontology (GO)
   Biological processcytolysis

Inferred from electronic annotation. Source: UniProtKB-KW

defense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionreceptor binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 3131
PRO_0000002764
Chain32 – 6837Bacteriocin lactocin-S
PRO_0000002765

Amino acid modifications

Modified residue321Pyruvic acid (Ser)
Modified residue3312,3-didehydrobutyrine
Modified residue381D-alanine (Ser)
Modified residue421D-alanine (Ser)
Modified residue501D-alanine (Ser)
Cross-link54 ↔ 59Lanthionine (Ser-Cys) Probable
Cross-link63 ↔ 68Lanthionine (Ser-Cys) Probable

Sequences

Sequence LengthMass (Da)Tools
P23826-1 [UniParc].

Last modified July 19, 2004. Version 2.
Checksum: 5FD203E8506ADC2C

FASTA687,258
        10         20         30         40         50         60 
MKTEKKVLDE LSLHASAKMG ARDVESSMNA DSTPVLASVA VSMELLPTAS VLYSDVAGCF 


KYSAKHHC 

« Hide

References

[1]"In vivo conversion of L-serine to D-alanine in a ribosomally synthesized polypeptide."
Skaugen M., Nissen-Meyer J., Jung G., Stevanovic S., Sletten K., Inger C., Abildgaard C.I., Nes I.F.
J. Biol. Chem. 269:27183-27185(1994) [PubMed: 7961627] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
[2]"Analysis of genes involved in the biosynthesis of the lantibiotic lactocin S."
Skaugen M., Abildgaard C.I., Nes I.F.
Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Purification and amino acid sequence of lactocin S, a bacteriocin produced by Lactobacillus sake L45."
Mortvedt C.I., Nissen-Meyer J., Sletten K., Nes I.F.
Appl. Environ. Microbiol. 57:1829-1834(1991) [PubMed: 1872611] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 43-67.

Cross-references

Sequence databases

X79889 Genomic DNA. Translation: CAA56261.1.
Z54312 Genomic DNA. Translation: CAA91109.1.
PIRA55457.

3D structure databases

ModBaseSearch...

Protein family/group databases

TCDB1.C.23.1.1. lactocin S family.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameLACS_LACSL
AccessionPrimary (citable) accession number: P23826
Secondary accession number(s): Q48848, Q48858
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: July 19, 2004
Last modified: March 3, 2009
This is version 34 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information