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Protein

Bacteriocin lactocin-S

Gene

lasA

Organism
Lactobacillus sakei L45
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the growth of selected species of the genera Lactobacillus, Pedicoccus, and Leuconostoc.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Bacteriocin, Lantibiotic
LigandPyruvate

Protein family/group databases

TCDBi1.C.23.1.1. the lactocin s (lactocin s) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Bacteriocin lactocin-S
Gene namesi
Name:lasA
Encoded oniPlasmid pCIM10 Publication
OrganismiLactobacillus sakei L45
Taxonomic identifieri1634 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000027641 – 31Add BLAST31
ChainiPRO_000000276532 – 68Bacteriocin lactocin-SAdd BLAST37

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32Pyruvic acid (Ser)1
Modified residuei332,3-didehydrobutyrine1 Publication1
Modified residuei38D-alanine (Ser)1 Publication1
Modified residuei42D-alanine (Ser)1 Publication1
Modified residuei50D-alanine (Ser)1 Publication1
Cross-linki54 ↔ 59Lanthionine (Ser-Cys)1 Publication
Cross-linki63 ↔ 68Lanthionine (Ser-Cys)1 Publication

Post-translational modificationi

It is not established whether the 2,3-didehydrobutyrine is the E- or Z-isomer.1 Publication

Keywords - PTMi

D-amino acid, Thioether bond

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiP23826.
ModBaseiSearch...
MobiDBiSearch...

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P23826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTEKKVLDE LSLHASAKMG ARDVESSMNA DSTPVLASVA VSMELLPTAS
60
VLYSDVAGCF KYSAKHHC
Length:68
Mass (Da):7,258
Last modified:July 19, 2004 - v2
Checksum:i5FD203E8506ADC2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79889 Genomic DNA. Translation: CAA56261.1.
Z54312 Genomic DNA. Translation: CAA91109.1.
PIRiA55457.

Similar proteinsi

Entry informationi

Entry nameiLACS_LACSL
AccessioniPrimary (citable) accession number: P23826
Secondary accession number(s): Q48848, Q48858
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: July 19, 2004
Last modified: November 22, 2017
This is version 45 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Plasmid