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Protein

GATA-binding factor 3

Gene

GATA3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri264 – 28825GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri318 – 34225GATA-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-GGA-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
GATA-binding factor 3
Short name:
GATA-3
Alternative name(s):
Transcription factor NF-E1c
Gene namesi
Name:GATA3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444GATA-binding factor 3PRO_0000083410Add
BLAST

Proteomic databases

PaxDbiP23825.

Expressioni

Tissue specificityi

Expressed only in definitive (adult) erythrocytes within the red cell lineage, and is also abundantly expressed in T-lymphocytes and brain.

Gene expression databases

BgeeiENSGALG00000006726.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi680262. 1 interaction.
STRINGi9031.ENSGALP00000010868.

Structurei

3D structure databases

ProteinModelPortaliP23825.
SMRiP23825. Positions 259-303, 309-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi323 – 3275Poly-Thr

Domaini

Binds DNA via the 2 GATA-type zinc fingers.By similarity

Sequence similaritiesi

Contains 2 GATA-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri264 – 28825GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri318 – 34225GATA-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047701.
HOVERGENiHBG051705.
InParanoidiP23825.
KOiK17895.
OMAiQRYPPTH.
OrthoDBiEOG091G0AUR.
PhylomeDBiP23825.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR029521. GATA-3.
IPR016374. TF_GATA-2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF106. PTHR10071:SF106. 1 hit.
PfamiPF00320. GATA. 2 hits.
[Graphical view]
PIRSFiPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23825-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVSTDQPRW VSHHHPAVLN GQHPDSHHPT LGHTYMDPTQ YPLAEEVDVL
60 70 80 90 100
FNIDGQGNPV PPYYGNSVRA TVQRYPTAHH GSQVCRPPLL HGSLPWLDGS
110 120 130 140 150
KALSSHHSAS PWNLSPFSKT SIHHSSPGPL SVYPPASSST LSAGHSSPHL
160 170 180 190 200
FTFPPTPPKD VSPDPSISTP GSTGSTRQDE KECIKYQVSL ADTMKLESSH
210 220 230 240 250
SRSSMASLGG ATSSAHHPIT TYPPYVPEYS SGLFPPSSLL GGSPTGFGCK
260 270 280 290 300
SRPKARSSTE GRECVNCGAT STPLWRRDGT GHYLCNACGL YHKMNGQNRP
310 320 330 340 350
LIKPKRRLSA ARRAGTSCAN CQTTTTTLWR RNANGDPVCN ACGLYYKLHN
360 370 380 390 400
INRPLTMKKE GIQTRNRKMS SKSKKCKKVH DNLEDFPKSS SFNPAALSRH
410 420 430 440
MSSISHISPF SHSSHMLTTP TPMHPPSSLS FGPHHPSSMV TAMG
Length:444
Mass (Da):48,197
Last modified:November 1, 1991 - v1
Checksum:iD8A6858B0CD953E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56931 mRNA. Translation: CAA40253.1.
S78787 Genomic DNA. Translation: AAD14293.1.
PIRiB36389.
RefSeqiNP_001008444.1. NM_001008444.1.
XP_015148775.1. XM_015293289.1.
XP_015148823.1. XM_015293337.1.
XP_015148857.1. XM_015293371.1.
UniGeneiGga.744.

Genome annotation databases

EnsembliENSGALT00000010882; ENSGALP00000010868; ENSGALG00000006726.
GeneIDi419106.
KEGGigga:419106.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56931 mRNA. Translation: CAA40253.1.
S78787 Genomic DNA. Translation: AAD14293.1.
PIRiB36389.
RefSeqiNP_001008444.1. NM_001008444.1.
XP_015148775.1. XM_015293289.1.
XP_015148823.1. XM_015293337.1.
XP_015148857.1. XM_015293371.1.
UniGeneiGga.744.

3D structure databases

ProteinModelPortaliP23825.
SMRiP23825. Positions 259-303, 309-366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi680262. 1 interaction.
STRINGi9031.ENSGALP00000010868.

Proteomic databases

PaxDbiP23825.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000010882; ENSGALP00000010868; ENSGALG00000006726.
GeneIDi419106.
KEGGigga:419106.

Organism-specific databases

CTDi2625.

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047701.
HOVERGENiHBG051705.
InParanoidiP23825.
KOiK17895.
OMAiQRYPPTH.
OrthoDBiEOG091G0AUR.
PhylomeDBiP23825.

Enzyme and pathway databases

ReactomeiR-GGA-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

PROiP23825.

Gene expression databases

BgeeiENSGALG00000006726.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR029521. GATA-3.
IPR016374. TF_GATA-2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF106. PTHR10071:SF106. 1 hit.
PfamiPF00320. GATA. 2 hits.
[Graphical view]
PIRSFiPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGATA3_CHICK
AccessioniPrimary (citable) accession number: P23825
Secondary accession number(s): Q6LD66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.