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Protein

GATA-binding factor 2

Gene

GATA2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri281 – 305GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri335 – 359GATA-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
GATA-binding factor 2
Short name:
GATA-2
Alternative name(s):
Transcription factor NF-E1b
Gene namesi
Name:GATA2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000834061 – 466GATA-binding factor 2Add BLAST466

Proteomic databases

PaxDbiP23824
PRIDEiP23824

Expressioni

Tissue specificityi

Expressed in all developmental stages of erythroid cells but is additionally found in a limited subset of other tissues.

Gene expression databases

BgeeiENSGALG00000005909

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi677582, 1 interactor
STRINGi9031.ENSGALP00000009491

Structurei

3D structure databases

ProteinModelPortaliP23824
SMRiP23824
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri281 – 305GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri335 – 359GATA-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1601 Eukaryota
COG5641 LUCA
GeneTreeiENSGT00760000119221
HOGENOMiHOG000047701
HOVERGENiHBG051705
InParanoidiP23824
KOiK17894
OMAiPRWMAHH
OrthoDBiEOG091G0AUR
PhylomeDBiP23824

Family and domain databases

Gene3Di3.30.50.10, 2 hits
InterProiView protein in InterPro
IPR029522 GATA-2
IPR016374 TF_GATA-2/3
IPR000679 Znf_GATA
IPR013088 Znf_NHR/GATA
PANTHERiPTHR10071:SF149 PTHR10071:SF149, 1 hit
PfamiView protein in Pfam
PF00320 GATA, 2 hits
PIRSFiPIRSF003027 TF_GATA-1/2/3, 1 hit
PRINTSiPR00619 GATAZNFINGER
SMARTiView protein in SMART
SM00401 ZnF_GATA, 2 hits
PROSITEiView protein in PROSITE
PS00344 GATA_ZN_FINGER_1, 2 hits
PS50114 GATA_ZN_FINGER_2, 2 hits

Sequencei

Sequence statusi: Complete.

P23824-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVATDQPRW MTHHAVLNGQ HPESHHPGLA HNYMEPAQLL PPDEVDVFFN
60 70 80 90 100
HLDSQGNPYY ANSAHARARV SYSQAHARLT GSQMCRPHLI HSPGIPWLDS
110 120 130 140 150
SKAALSAHHH NPWTVNPFTK TPLHPSAAGA PGAISVYPGS STSSTASVSS
160 170 180 190 200
LTPASHSGSH LFGFPPTPPK EVSPDPNSTS AASPSSSAGA RQEDKDSIKY
210 220 230 240 250
QVSLSEGMKM ESASPLRSSL TSMGAQPSTH HPIPTYPSYV PAAHDYSSSL
260 270 280 290 300
FHPGSFLGGP ASSFTPKPRS KARSCSEGRE CVNCGATATP LWRRDGTGHY
310 320 330 340 350
LCNACGLYHK MNGQNRPLIK PKRRLSAARR AGTCCANCQT TTTTLWRRNA
360 370 380 390 400
NGDPVCNACG LYYKLHNVNR PLTMKKEGIQ TRNRKMSNKS KKSKKGSECF
410 420 430 440 450
EELSKCMQEK SSPFSAAALA SHMAPMGHLP PFSHSGHILP TPTPIHPSSS
460
ISFGHPHPSS MVTAMG
Length:466
Mass (Da):50,150
Last modified:November 1, 1991 - v1
Checksum:i83F990D25413F3F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56930 mRNA Translation: CAA40252.1
PIRiA36389
RefSeqiNP_001003797.1, NM_001003797.1
XP_015148565.1, XM_015293079.1
UniGeneiGga.745

Genome annotation databases

EnsembliENSGALT00000030746; ENSGALP00000030109; ENSGALG00000005909
ENSGALT00000060592; ENSGALP00000053966; ENSGALG00000005909
GeneIDi416018
KEGGigga:416018

Similar proteinsi

Entry informationi

Entry nameiGATA2_CHICK
AccessioniPrimary (citable) accession number: P23824
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: May 23, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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