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Protein

GATA-binding factor 2

Gene

GATA2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri281 – 305GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri335 – 359GATA-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-GGA-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
GATA-binding factor 2
Short name:
GATA-2
Alternative name(s):
Transcription factor NF-E1b
Gene namesi
Name:GATA2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 12

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000834061 – 466GATA-binding factor 2Add BLAST466

Proteomic databases

PaxDbiP23824.

Expressioni

Tissue specificityi

Expressed in all developmental stages of erythroid cells but is additionally found in a limited subset of other tissues.

Gene expression databases

BgeeiENSGALG00000005909.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi677582. 1 interactor.
STRINGi9031.ENSGALP00000009491.

Structurei

3D structure databases

ProteinModelPortaliP23824.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 GATA-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri281 – 305GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri335 – 359GATA-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047701.
HOVERGENiHBG051705.
InParanoidiP23824.
KOiK17894.
OMAiNKKGAEC.
OrthoDBiEOG091G0AUR.
PhylomeDBiP23824.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR029522. GATA-2.
IPR016374. TF_GATA-2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF149. PTHR10071:SF149. 1 hit.
PfamiPF00320. GATA. 2 hits.
[Graphical view]
PIRSFiPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23824-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVATDQPRW MTHHAVLNGQ HPESHHPGLA HNYMEPAQLL PPDEVDVFFN
60 70 80 90 100
HLDSQGNPYY ANSAHARARV SYSQAHARLT GSQMCRPHLI HSPGIPWLDS
110 120 130 140 150
SKAALSAHHH NPWTVNPFTK TPLHPSAAGA PGAISVYPGS STSSTASVSS
160 170 180 190 200
LTPASHSGSH LFGFPPTPPK EVSPDPNSTS AASPSSSAGA RQEDKDSIKY
210 220 230 240 250
QVSLSEGMKM ESASPLRSSL TSMGAQPSTH HPIPTYPSYV PAAHDYSSSL
260 270 280 290 300
FHPGSFLGGP ASSFTPKPRS KARSCSEGRE CVNCGATATP LWRRDGTGHY
310 320 330 340 350
LCNACGLYHK MNGQNRPLIK PKRRLSAARR AGTCCANCQT TTTTLWRRNA
360 370 380 390 400
NGDPVCNACG LYYKLHNVNR PLTMKKEGIQ TRNRKMSNKS KKSKKGSECF
410 420 430 440 450
EELSKCMQEK SSPFSAAALA SHMAPMGHLP PFSHSGHILP TPTPIHPSSS
460
ISFGHPHPSS MVTAMG
Length:466
Mass (Da):50,150
Last modified:November 1, 1991 - v1
Checksum:i83F990D25413F3F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56930 mRNA. Translation: CAA40252.1.
PIRiA36389.
RefSeqiNP_001003797.1. NM_001003797.1.
XP_015148565.1. XM_015293079.1.
UniGeneiGga.745.

Genome annotation databases

EnsembliENSGALT00000030746; ENSGALP00000030109; ENSGALG00000005909.
ENSGALT00000060592; ENSGALP00000053966; ENSGALG00000005909.
GeneIDi416018.
KEGGigga:416018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56930 mRNA. Translation: CAA40252.1.
PIRiA36389.
RefSeqiNP_001003797.1. NM_001003797.1.
XP_015148565.1. XM_015293079.1.
UniGeneiGga.745.

3D structure databases

ProteinModelPortaliP23824.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi677582. 1 interactor.
STRINGi9031.ENSGALP00000009491.

Proteomic databases

PaxDbiP23824.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000030746; ENSGALP00000030109; ENSGALG00000005909.
ENSGALT00000060592; ENSGALP00000053966; ENSGALG00000005909.
GeneIDi416018.
KEGGigga:416018.

Organism-specific databases

CTDi2624.

Phylogenomic databases

eggNOGiKOG1601. Eukaryota.
COG5641. LUCA.
GeneTreeiENSGT00760000119221.
HOGENOMiHOG000047701.
HOVERGENiHBG051705.
InParanoidiP23824.
KOiK17894.
OMAiNKKGAEC.
OrthoDBiEOG091G0AUR.
PhylomeDBiP23824.

Enzyme and pathway databases

ReactomeiR-GGA-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

PROiP23824.

Gene expression databases

BgeeiENSGALG00000005909.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR029522. GATA-2.
IPR016374. TF_GATA-2/3.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF149. PTHR10071:SF149. 1 hit.
PfamiPF00320. GATA. 2 hits.
[Graphical view]
PIRSFiPIRSF003027. TF_GATA-1/2/3. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGATA2_CHICK
AccessioniPrimary (citable) accession number: P23824
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: November 1, 1991
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.