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Protein

Homeobox protein Hox-D11

Gene

Hoxd11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi251 – 31060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • branching involved in ureteric bud morphogenesis Source: MGI
  • cartilage development involved in endochondral bone morphogenesis Source: MGI
  • developmental growth Source: MGI
  • dorsal/ventral pattern formation Source: MGI
  • embryonic digit morphogenesis Source: MGI
  • embryonic forelimb morphogenesis Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • embryonic skeletal joint morphogenesis Source: MGI
  • metanephros development Source: MGI
  • organ induction Source: MGI
  • pattern specification process Source: MGI
  • positive regulation of cell development Source: MGI
  • positive regulation of chondrocyte differentiation Source: MGI
  • proximal/distal pattern formation Source: MGI
  • regulation of chondrocyte differentiation Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • single fertilization Source: MGI
  • skeletal system development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D11
Alternative name(s):
Homeobox protein Hox-4.6
Homeobox protein Hox-5.5
Gene namesi
Name:Hoxd11
Synonyms:Hox-4.6, Hoxd-11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96203. Hoxd11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Homeobox protein Hox-D11PRO_0000200232Add
BLAST

Proteomic databases

PRIDEiP23813.

Expressioni

Developmental stagei

Expressed during development of the posterior part of the body.

Gene expression databases

BgeeiP23813.
CleanExiMM_HOXD11.
ExpressionAtlasiP23813. baseline and differential.
GenevisibleiP23813. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000122582.

Structurei

3D structure databases

ProteinModelPortaliP23813.
SMRiP23813. Positions 251-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi64 – 8724Poly-GlyAdd
BLAST
Compositional biasi93 – 10513Poly-AlaAdd
BLAST

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG305087.
HOVERGENiHBG052048.
InParanoidiP23813.
KOiK09296.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR021918. DUF3528.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P23813-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLPGCAYYV APSDFASKPS FLSQPSSCQM TFPYSSNLAP HVQPVREVAF
60 70 80 90 100
RDYGLERAKW PYRGGGGGGA GGGGGGGPGG GGGGSGGYAP YYAAAAAAAA
110 120 130 140 150
AAAAAEEAAM QRDLLPPAGR RPDVLFKAPE PVCGAPGPPH GPAAAASNFY
160 170 180 190 200
SAVGRNGILP QGFDQFYEAA PGPPFAGPQP QPAPAPPQPE GAADKGDPKP
210 220 230 240 250
GAGGGGGSPC AKATPGPEPK GAAEGGGGEG EGPPGEAGAE KSGGTVAPQR
260 270 280 290 300
SRKKRCPYTK YQIRELEREF FFNVYINKEK RLQLSRMLNL TDRQVKIWFQ
310 320
NRRMKEKKLN RDRLQYFTGN PLF
Length:323
Mass (Da):33,546
Last modified:December 1, 1992 - v2
Checksum:iB003D1347F5FE771
GO

Sequence cautioni

The sequence CAA42943.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60761, X60762 Genomic DNA. Translation: CAA43173.1.
X71422 Genomic DNA. Translation: CAA50553.1.
X60395 Genomic DNA. Translation: CAA42943.1. Different initiation.
PIRiS16318.
RefSeqiNP_032299.1. NM_008273.2.
UniGeneiMm.207763.

Genome annotation databases

GeneIDi15431.
KEGGimmu:15431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60761, X60762 Genomic DNA. Translation: CAA43173.1.
X71422 Genomic DNA. Translation: CAA50553.1.
X60395 Genomic DNA. Translation: CAA42943.1. Different initiation.
PIRiS16318.
RefSeqiNP_032299.1. NM_008273.2.
UniGeneiMm.207763.

3D structure databases

ProteinModelPortaliP23813.
SMRiP23813. Positions 251-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000122582.

Proteomic databases

PRIDEiP23813.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi15431.
KEGGimmu:15431.

Organism-specific databases

CTDi3237.
MGIiMGI:96203. Hoxd11.

Phylogenomic databases

eggNOGiNOG305087.
HOVERGENiHBG052048.
InParanoidiP23813.
KOiK09296.

Miscellaneous databases

NextBioi288194.
PROiP23813.
SOURCEiSearch...

Gene expression databases

BgeeiP23813.
CleanExiMM_HOXD11.
ExpressionAtlasiP23813. baseline and differential.
GenevisibleiP23813. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR021918. DUF3528.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body."
    Izpisua-Belmonte J.-C., Falkenstein H., Dolle P., Renucci A., Duboule D.
    EMBO J. 10:2279-2289(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Structure and activity of regulatory elements involved in the activation of the Hoxd-11 gene during late gastrulation."
    Gerard M., Duboule D., Zakany J.
    EMBO J. 12:3539-3550(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. Takada S., Cook M., Kramlauf R., McMahon A.P.
    Submitted (MAY-1991) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
    Tissue: Liver.

Entry informationi

Entry nameiHXD11_MOUSE
AccessioniPrimary (citable) accession number: P23813
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: December 1, 1992
Last modified: June 24, 2015
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.