P23813 (HXD11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-D11

Alternative name(s):
Homeobox protein Hox-4.6
Homeobox protein Hox-5.5

Gene names

Name:	Hoxd11
Synonyms:	Hox-4.6, Hoxd-11

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Developmental stage	Expressed during development of the posterior part of the body.
Sequence similarities	Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain.
Sequence caution	The sequence CAA42943.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from genetic interaction PubMed 12869760. Source: MGI branching involved in ureteric bud morphogenesis Inferred from genetic interaction PubMed 11493536. Source: MGI cartilage development involved in endochondral bone morphogenesis Inferred from genetic interaction PubMed 14668414. Source: MGI developmental growth Inferred from genetic interaction PubMed 14668414. Source: MGI dorsal/ventral pattern formation Inferred from genetic interaction PubMed 11493536. Source: MGI embryonic digit morphogenesis Inferred from genetic interaction PubMed 12869760PubMed 17714700PubMed 8900279. Source: MGI embryonic forelimb morphogenesis Inferred from genetic interaction PubMed 22916278. Source: MGI embryonic skeletal joint morphogenesis Inferred from genetic interaction PubMed 20978074. Source: MGI metanephros development Inferred from genetic interaction PubMed 12050119. Source: MGI organ induction Inferred from genetic interaction PubMed 12050119. Source: MGI positive regulation of cell development Inferred from genetic interaction PubMed 14668414. Source: MGI positive regulation of chondrocyte differentiation Inferred from genetic interaction PubMed 14668414. Source: MGI proximal/distal pattern formation Inferred from genetic interaction PubMed 12869760. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Homeobox protein Hox-D11		PRO_0000200232
Regions
	DNA binding	251 – 310	60	Homeobox
	Compositional bias	64 – 87	24	Poly-Gly
	Compositional bias	93 – 105	13	Poly-Ala

Sequences

	Sequence		Length	Mass (Da)
	P23813 [UniParc]. Last modified December 1, 1992. Version 2. Checksum: B003D1347F5FE771	FASTA	323	33,546
	10 20 30 40 50 60 MYLPGCAYYV APSDFASKPS FLSQPSSCQM TFPYSSNLAP HVQPVREVAF RDYGLERAKW 70 80 90 100 110 120 PYRGGGGGGA GGGGGGGPGG GGGGSGGYAP YYAAAAAAAA AAAAAEEAAM QRDLLPPAGR 130 140 150 160 170 180 RPDVLFKAPE PVCGAPGPPH GPAAAASNFY SAVGRNGILP QGFDQFYEAA PGPPFAGPQP 190 200 210 220 230 240 QPAPAPPQPE GAADKGDPKP GAGGGGGSPC AKATPGPEPK GAAEGGGGEG EGPPGEAGAE 250 260 270 280 290 300 KSGGTVAPQR SRKKRCPYTK YQIRELEREF FFNVYINKEK RLQLSRMLNL TDRQVKIWFQ 310 320 NRRMKEKKLN RDRLQYFTGN PLF

References

[1]	"Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body." Izpisua-Belmonte J.-C., Falkenstein H., Dolle P., Renucci A., Duboule D. EMBO J. 10:2279-2289(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Structure and activity of regulatory elements involved in the activation of the Hoxd-11 gene during late gastrulation." Gerard M., Duboule D., Zakany J. EMBO J. 12:3539-3550(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
[3]	Takada S., Cook M., Kramlauf R., McMahon A.P. Submitted (MAY-1991) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X60761, X60762 Genomic DNA. Translation: CAA43173.1. X71422 Genomic DNA. Translation: CAA50553.1. X60395 Genomic DNA. Translation: CAA42943.1. Different initiation.
IPI	IPI00989165.
PIR	S16318.
RefSeq	NP_032299.1. NM_008273.2.
UniGene	Mm.207763.
3D structure databases
ProteinModelPortal	P23813.
SMR	P23813. Positions 251-310.
ModBase	Search...
Proteomic databases
PRIDE	P23813.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	15431.
KEGG	mmu:15431.
Organism-specific databases
CTD	3237.
MGI	MGI:96203. Hoxd11.
Phylogenomic databases
eggNOG	NOG305087.
HOVERGEN	HBG052048.
InParanoid	P23813.
KO	K09296.
OrthoDB	EOG4KKZ3X.
Gene expression databases
ArrayExpress	P23813.
Bgee	P23813.
CleanEx	MM_HOXD11.
Genevestigator	P23813.
GermOnline	ENSMUSG00000042499. Mus musculus.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR021918. DUF3528. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF12045. DUF3528. 1 hit. PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	288194.
SOURCE	Search...

Entry information

Entry name

HXD11_MOUSE

Accession

Primary (citable) accession number: P23813

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1991
Last sequence update:	December 1, 1992
Last modified:	May 1, 2013
This is version 114 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program