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P23813

- HXD11_MOUSE

UniProt

P23813 - HXD11_MOUSE

Protein

Homeobox protein Hox-D11

Gene

Hoxd11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi251 – 31060HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. branching involved in ureteric bud morphogenesis Source: MGI
    3. cartilage development involved in endochondral bone morphogenesis Source: MGI
    4. developmental growth Source: MGI
    5. dorsal/ventral pattern formation Source: MGI
    6. embryonic digit morphogenesis Source: MGI
    7. embryonic forelimb morphogenesis Source: MGI
    8. embryonic limb morphogenesis Source: MGI
    9. embryonic skeletal joint morphogenesis Source: MGI
    10. metanephros development Source: MGI
    11. organ induction Source: MGI
    12. pattern specification process Source: MGI
    13. positive regulation of cell development Source: MGI
    14. positive regulation of chondrocyte differentiation Source: MGI
    15. proximal/distal pattern formation Source: MGI
    16. regulation of chondrocyte differentiation Source: MGI
    17. regulation of gene expression Source: MGI
    18. single fertilization Source: MGI
    19. skeletal system development Source: MGI
    20. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-D11
    Alternative name(s):
    Homeobox protein Hox-4.6
    Homeobox protein Hox-5.5
    Gene namesi
    Name:Hoxd11
    Synonyms:Hox-4.6, Hoxd-11
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:96203. Hoxd11.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 323323Homeobox protein Hox-D11PRO_0000200232Add
    BLAST

    Proteomic databases

    PRIDEiP23813.

    Expressioni

    Developmental stagei

    Expressed during development of the posterior part of the body.

    Gene expression databases

    BgeeiP23813.
    CleanExiMM_HOXD11.
    GenevestigatoriP23813.

    Structurei

    3D structure databases

    ProteinModelPortaliP23813.
    SMRiP23813. Positions 251-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi64 – 8724Poly-GlyAdd
    BLAST
    Compositional biasi93 – 10513Poly-AlaAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG305087.
    HOVERGENiHBG052048.
    InParanoidiP23813.
    KOiK09296.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR021918. DUF3528.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF12045. DUF3528. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P23813-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYLPGCAYYV APSDFASKPS FLSQPSSCQM TFPYSSNLAP HVQPVREVAF    50
    RDYGLERAKW PYRGGGGGGA GGGGGGGPGG GGGGSGGYAP YYAAAAAAAA 100
    AAAAAEEAAM QRDLLPPAGR RPDVLFKAPE PVCGAPGPPH GPAAAASNFY 150
    SAVGRNGILP QGFDQFYEAA PGPPFAGPQP QPAPAPPQPE GAADKGDPKP 200
    GAGGGGGSPC AKATPGPEPK GAAEGGGGEG EGPPGEAGAE KSGGTVAPQR 250
    SRKKRCPYTK YQIRELEREF FFNVYINKEK RLQLSRMLNL TDRQVKIWFQ 300
    NRRMKEKKLN RDRLQYFTGN PLF 323
    Length:323
    Mass (Da):33,546
    Last modified:December 1, 1992 - v2
    Checksum:iB003D1347F5FE771
    GO

    Sequence cautioni

    The sequence CAA42943.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60761, X60762 Genomic DNA. Translation: CAA43173.1.
    X71422 Genomic DNA. Translation: CAA50553.1.
    X60395 Genomic DNA. Translation: CAA42943.1. Different initiation.
    PIRiS16318.
    RefSeqiNP_032299.1. NM_008273.2.
    UniGeneiMm.207763.

    Genome annotation databases

    GeneIDi15431.
    KEGGimmu:15431.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X60761 , X60762 Genomic DNA. Translation: CAA43173.1 .
    X71422 Genomic DNA. Translation: CAA50553.1 .
    X60395 Genomic DNA. Translation: CAA42943.1 . Different initiation.
    PIRi S16318.
    RefSeqi NP_032299.1. NM_008273.2.
    UniGenei Mm.207763.

    3D structure databases

    ProteinModelPortali P23813.
    SMRi P23813. Positions 251-310.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P23813.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 15431.
    KEGGi mmu:15431.

    Organism-specific databases

    CTDi 3237.
    MGIi MGI:96203. Hoxd11.

    Phylogenomic databases

    eggNOGi NOG305087.
    HOVERGENi HBG052048.
    InParanoidi P23813.
    KOi K09296.

    Miscellaneous databases

    NextBioi 288194.
    PROi P23813.
    SOURCEi Search...

    Gene expression databases

    Bgeei P23813.
    CleanExi MM_HOXD11.
    Genevestigatori P23813.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR021918. DUF3528.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF12045. DUF3528. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body."
      Izpisua-Belmonte J.-C., Falkenstein H., Dolle P., Renucci A., Duboule D.
      EMBO J. 10:2279-2289(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Structure and activity of regulatory elements involved in the activation of the Hoxd-11 gene during late gastrulation."
      Gerard M., Duboule D., Zakany J.
      EMBO J. 12:3539-3550(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    3. Takada S., Cook M., Kramlauf R., McMahon A.P.
      Submitted (MAY-1991) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
      Tissue: Liver.

    Entry informationi

    Entry nameiHXD11_MOUSE
    AccessioniPrimary (citable) accession number: P23813
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1991
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3