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P23813 (HXD11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-D11
Alternative name(s):
Homeobox protein Hox-4.6
Homeobox protein Hox-5.5
Gene names
Name:Hoxd11
Synonyms:Hox-4.6, Hoxd-11
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Developmental stage

Expressed during development of the posterior part of the body.

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence caution

The sequence CAA42943.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanterior/posterior pattern specification

Inferred from genetic interaction PubMed 12869760. Source: MGI

branching involved in ureteric bud morphogenesis

Inferred from genetic interaction PubMed 11493536. Source: MGI

cartilage development involved in endochondral bone morphogenesis

Inferred from genetic interaction PubMed 14668414. Source: MGI

developmental growth

Inferred from genetic interaction PubMed 14668414. Source: MGI

dorsal/ventral pattern formation

Inferred from genetic interaction PubMed 11493536. Source: MGI

embryonic digit morphogenesis

Inferred from genetic interaction PubMed 12869760PubMed 17714700PubMed 8900279. Source: MGI

embryonic forelimb morphogenesis

Inferred from genetic interaction PubMed 22916278. Source: MGI

embryonic limb morphogenesis

Inferred from genetic interaction PubMed 14668414. Source: MGI

embryonic skeletal joint morphogenesis

Inferred from genetic interaction PubMed 20978074. Source: MGI

metanephros development

Inferred from genetic interaction PubMed 12050119. Source: MGI

organ induction

Inferred from genetic interaction PubMed 12050119. Source: MGI

pattern specification process

Inferred from genetic interaction PubMed 8900279. Source: MGI

positive regulation of cell development

Inferred from genetic interaction PubMed 14668414. Source: MGI

positive regulation of chondrocyte differentiation

Inferred from genetic interaction PubMed 14668414. Source: MGI

proximal/distal pattern formation

Inferred from genetic interaction PubMed 12869760. Source: MGI

regulation of chondrocyte differentiation

Inferred from genetic interaction PubMed 22916278. Source: MGI

regulation of gene expression

Inferred from genetic interaction PubMed 23760953. Source: MGI

single fertilization

Inferred from genetic interaction PubMed 23760953. Source: MGI

skeletal system development

Inferred from mutant phenotype PubMed 7925020. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 323323Homeobox protein Hox-D11
PRO_0000200232

Regions

DNA binding251 – 31060Homeobox
Compositional bias64 – 8724Poly-Gly
Compositional bias93 – 10513Poly-Ala

Sequences

Sequence LengthMass (Da)Tools
P23813 [UniParc].

Last modified December 1, 1992. Version 2.
Checksum: B003D1347F5FE771

FASTA32333,546
        10         20         30         40         50         60 
MYLPGCAYYV APSDFASKPS FLSQPSSCQM TFPYSSNLAP HVQPVREVAF RDYGLERAKW 

        70         80         90        100        110        120 
PYRGGGGGGA GGGGGGGPGG GGGGSGGYAP YYAAAAAAAA AAAAAEEAAM QRDLLPPAGR 

       130        140        150        160        170        180 
RPDVLFKAPE PVCGAPGPPH GPAAAASNFY SAVGRNGILP QGFDQFYEAA PGPPFAGPQP 

       190        200        210        220        230        240 
QPAPAPPQPE GAADKGDPKP GAGGGGGSPC AKATPGPEPK GAAEGGGGEG EGPPGEAGAE 

       250        260        270        280        290        300 
KSGGTVAPQR SRKKRCPYTK YQIRELEREF FFNVYINKEK RLQLSRMLNL TDRQVKIWFQ 

       310        320 
NRRMKEKKLN RDRLQYFTGN PLF 

« Hide

References

[1]"Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body."
Izpisua-Belmonte J.-C., Falkenstein H., Dolle P., Renucci A., Duboule D.
EMBO J. 10:2279-2289(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Structure and activity of regulatory elements involved in the activation of the Hoxd-11 gene during late gastrulation."
Gerard M., Duboule D., Zakany J.
EMBO J. 12:3539-3550(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[3]Takada S., Cook M., Kramlauf R., McMahon A.P.
Submitted (MAY-1991) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X60761, X60762 Genomic DNA. Translation: CAA43173.1.
X71422 Genomic DNA. Translation: CAA50553.1.
X60395 Genomic DNA. Translation: CAA42943.1. Different initiation.
PIRS16318.
RefSeqNP_032299.1. NM_008273.2.
UniGeneMm.207763.

3D structure databases

ProteinModelPortalP23813.
SMRP23813. Positions 251-310.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP23813.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID15431.
KEGGmmu:15431.

Organism-specific databases

CTD3237.
MGIMGI:96203. Hoxd11.

Phylogenomic databases

eggNOGNOG305087.
HOVERGENHBG052048.
InParanoidP23813.
KOK09296.

Gene expression databases

BgeeP23813.
CleanExMM_HOXD11.
GenevestigatorP23813.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR021918. DUF3528.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288194.
PROP23813.
SOURCESearch...

Entry information

Entry nameHXD11_MOUSE
AccessionPrimary (citable) accession number: P23813
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1991
Last sequence update: December 1, 1992
Last modified: April 16, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries