ID   HXD12_MOUSE             Reviewed;         268 AA.
AC   P23812; Q8BSN0;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   24-JAN-2024, entry version 171.
DE   RecName: Full=Homeobox protein Hox-D12;
DE   AltName: Full=Homeobox protein Hox-4.7;
DE   AltName: Full=Homeobox protein Hox-5.6;
GN   Name=Hoxd12; Synonyms=Hox-4.7, Hoxd-12;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1676674; DOI=10.1002/j.1460-2075.1991.tb07764.x;
RA   Izpisua-Belmonte J.-C., Falkenstein H., Dolle P., Renucci A., Duboule D.;
RT   "Murine genes related to the Drosophila AbdB homeotic genes are
RT   sequentially expressed during development of the posterior part of the
RT   body.";
RL   EMBO J. 10:2279-2289(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Forelimb;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Expressed during development of the posterior part
CC       of the body.
CC   -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA41654.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; X58849; CAA41654.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AK031206; BAC27299.1; -; mRNA.
DR   EMBL; AL928644; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466519; EDL27169.1; -; Genomic_DNA.
DR   EMBL; BC145656; AAI45657.1; -; mRNA.
DR   CCDS; CCDS38147.1; -.
DR   PIR; S16317; S16317.
DR   RefSeq; NP_032300.2; NM_008274.3.
DR   AlphaFoldDB; P23812; -.
DR   SMR; P23812; -.
DR   BioGRID; 200394; 9.
DR   IntAct; P23812; 10.
DR   STRING; 10090.ENSMUSP00000001878; -.
DR   iPTMnet; P23812; -.
DR   PhosphoSitePlus; P23812; -.
DR   MaxQB; P23812; -.
DR   PaxDb; 10090-ENSMUSP00000001878; -.
DR   Antibodypedia; 10810; 285 antibodies from 32 providers.
DR   DNASU; 15432; -.
DR   Ensembl; ENSMUST00000001878.6; ENSMUSP00000001878.5; ENSMUSG00000001823.6.
DR   GeneID; 15432; -.
DR   KEGG; mmu:15432; -.
DR   UCSC; uc008kdv.2; mouse.
DR   AGR; MGI:96204; -.
DR   CTD; 3238; -.
DR   MGI; MGI:96204; Hoxd12.
DR   VEuPathDB; HostDB:ENSMUSG00000001823; -.
DR   eggNOG; KOG0487; Eukaryota.
DR   GeneTree; ENSGT00940000159938; -.
DR   HOGENOM; CLU_087968_0_0_1; -.
DR   InParanoid; P23812; -.
DR   OMA; FEVNSCN; -.
DR   OrthoDB; 5346412at2759; -.
DR   PhylomeDB; P23812; -.
DR   TreeFam; TF351604; -.
DR   BioGRID-ORCS; 15432; 3 hits in 77 CRISPR screens.
DR   PRO; PR:P23812; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; P23812; Protein.
DR   Bgee; ENSMUSG00000001823; Expressed in undifferentiated genital tubercle and 76 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IDA:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0042733; P:embryonic digit morphogenesis; IGI:MGI.
DR   GO; GO:0007389; P:pattern specification process; IGI:MGI.
DR   GO; GO:0001501; P:skeletal system development; IMP:MGI.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR46440:SF1; HOMEOBOX PROTEIN HOX-D12; 1.
DR   PANTHER; PTHR46440; HOMEOBOX PROTEIN HOX-D12-RELATED; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   Genevisible; P23812; MM.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..268
FT                   /note="Homeobox protein Hox-D12"
FT                   /id="PRO_0000200239"
FT   DNA_BIND        200..259
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          102..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   268 AA;  29198 MW;  5EA04C2B59336AC4 CRC64;
     MCERSLYRAG YVGSLLNLQS PDSFYFSNLR ANGSQLAALP PISYPRSALP WATTPASCTP
     AQPATASAFG GFSQPYLTGS GPIGLQSPGA KDGPEDQVKF YTPDAPTASE ERSRTRPPFA
     PESSLVHSAL KGTKYDYAGV GRTAPGSATL LQGAPCASSF KEDTKGPLNL NMAVQVAGVA
     SCLRSSLPDG LPWGAAPGRA RKKRKPYTKQ QIAELENEFL VNEFINRQKR KELSNRLNLS
     DQQVKIWFQN RRMKKKRVVQ REQALALY
//